Detailed information for compound 144544

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 352.344 | Formula: C18H16N4O4
  • H donors: 1 H acceptors: 4 LogP: 1.77 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CNC(=O)CN1C(=O)CN=C(c2c1ccc(c2)[N+](=O)[O-])c1ccccc1
  • InChi: 1S/C18H16N4O4/c1-19-16(23)11-21-15-8-7-13(22(25)26)9-14(15)18(20-10-17(21)24)12-5-3-2-4-6-12/h2-9H,10-11H2,1H3,(H,19,23)
  • InChiKey: SVLQGKVFJJAZTC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0054 0.0472 0.1307
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0166 0.0471
Brugia malayi hypothetical protein 0.0061 0.0551 0.1524
Loa Loa (eye worm) hypothetical protein 0.0054 0.0472 0.1307
Echinococcus granulosus X box binding protein 1 0.0279 0.3165 1
Loa Loa (eye worm) hypothetical protein 0.0115 0.1203 0.333
Loa Loa (eye worm) hypothetical protein 0.0061 0.0551 0.1524
Schistosoma mansoni ap endonuclease 0.002 0.0054 0.0115
Schistosoma mansoni hypothetical protein 0.008 0.0781 0.2425
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0054 0.2444
Brugia malayi MH2 domain containing protein 0.012 0.126 0.3486
Brugia malayi Nuclear hormone receptor-like 1 0.0061 0.0551 0.1524
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0053 0.0112
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0062 0.0172
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0115 0.1203 0.3767
Loa Loa (eye worm) hypothetical protein 0.008 0.0781 0.2162
Loa Loa (eye worm) transcription factor SMAD2 0.012 0.126 0.3486
Loa Loa (eye worm) hypothetical protein 0.0061 0.0551 0.1524
Loa Loa (eye worm) TAR-binding protein 0.0271 0.3064 0.8478
Brugia malayi Nuclear hormone receptor E75 0.0054 0.0472 0.1307
Brugia malayi hypothetical protein 0.0054 0.0472 0.1307
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0115 0.1203 0.3767
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0062 0.6014
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0054 0.0472 0.1444
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0115 0.1203 0.333
Echinococcus multilocularis GPCR, family 2 0.008 0.0781 0.0764
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0115 0.1203 0.1187
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.008 0.0781 0.0764
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0115 0.1203 0.333
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0115 0.1203 0.333
Echinococcus granulosus FTZ F1 alpha 0.0115 0.1203 0.3767
Echinococcus multilocularis RUN 0.0019 0.0053 0.0035
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0053 0.0148
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0115 0.1203 0.3767
Onchocerca volvulus 0.0229 0.257 0.7068
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0062 0.6014
Brugia malayi tailless protein 0.0054 0.0472 0.1307
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0075 0.0716 0.2217
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0062 0.6014
Schistosoma mansoni rab6-interacting 0.0019 0.0053 0.0112
Onchocerca volvulus 0.0028 0.0156 0.0289
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0062 0.6014
Leishmania major DNA polymerase kappa, putative 0.002 0.0062 0.6014
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0166 0.0471
Loa Loa (eye worm) hypothetical protein 0.0019 0.0053 0.0148
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0166 0.0471
Echinococcus multilocularis FTZ F1 alpha 0.0115 0.1203 0.1187
Schistosoma mansoni hypothetical protein 0.008 0.0781 0.2425
Echinococcus granulosus RUN 0.0019 0.0053 0.0112
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0115 0.1203 0.333
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0115 0.1203 0.333
Echinococcus multilocularis ecdysone induced protein 78C 0.0115 0.1203 0.1187
Brugia malayi nuclear receptor RXR 0.0054 0.0472 0.1307
Brugia malayi Cytochrome P450 family protein 0.0052 0.0439 0.1216
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0054 0.0472 0.0455
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0156 0.0432
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0054 0.0472 0.1307
Brugia malayi Nuclear hormone receptor-like 1 0.0115 0.1203 0.333
Brugia malayi hypothetical protein 0.0075 0.0716 0.198
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0115 0.1203 0.3767
Onchocerca volvulus Bile acid receptor homolog 0.0115 0.1203 0.323
Schistosoma mansoni tar DNA-binding protein 0.0271 0.3064 0.968
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0089 0.0893 0.2779
Loa Loa (eye worm) nuclear receptor NHR-67 0.0054 0.0472 0.1307
Loa Loa (eye worm) CYP4Cod1 0.0023 0.0091 0.0252
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0061 0.0551 0.0534
Echinococcus granulosus nuclear receptor nhr 48 0.0054 0.0472 0.1444
Loa Loa (eye worm) hypothetical protein 0.0115 0.1203 0.333
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0117 0.1217 0.3809
Loa Loa (eye worm) latrophilin receptor protein 2 0.008 0.0781 0.2162
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0115 0.1203 0.3767
Schistosoma mansoni hypothetical protein 0.008 0.0781 0.2425
Loa Loa (eye worm) hypothetical protein 0.0054 0.0472 0.1307
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.2236 0.6187
Brugia malayi Cytochrome P450 family protein 0.0023 0.0091 0.0252
Brugia malayi Pre-SET motif family protein 0.0202 0.2236 0.6187
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0091 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0053 0.0112
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0156 0.0432
Schistosoma mansoni coup transcription factor 0.0115 0.1203 0.3767
Loa Loa (eye worm) nuclear hormone receptor 0.0054 0.0472 0.1307
Loa Loa (eye worm) hypothetical protein 0.0061 0.0551 0.1524
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0062 0.2094
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0062 0.6014
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0089 0.0893 0.247
Brugia malayi ecdysteroid receptor 0.0115 0.1203 0.333
Echinococcus granulosus Nuclear hormone receptor HR96 0.0054 0.0472 0.1444
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.008 0.0781 0.0764
Loa Loa (eye worm) hypothetical protein 0.0061 0.0551 0.1524
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0893 0.2779
Brugia malayi nuclear hormone receptor family member odr-7 0.0054 0.0472 0.1307
Loa Loa (eye worm) hypothetical protein 0.0115 0.1203 0.333
Loa Loa (eye worm) hypothetical protein 0.0054 0.0472 0.1307
Brugia malayi isocitrate dehydrogenase 0.0017 0.0018 0.005
Echinococcus granulosus tar DNA binding protein 0.0271 0.3064 0.968
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0062 0.014
Brugia malayi TAR-binding protein 0.0271 0.3064 0.8478
Brugia malayi nuclear receptor NHR-88 0.0054 0.0472 0.1307
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0091 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0166 0.0148
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0893 0.2779
Loa Loa (eye worm) hypothetical protein 0.0054 0.0472 0.1307
Brugia malayi nuclear hormone receptor 0.0054 0.0472 0.1307
Echinococcus multilocularis X box binding protein 1 0.0279 0.3165 0.3152
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0054 0.0472 0.0455
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0115 0.1203 0.333
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0062 1
Echinococcus granulosus lamin dm0 0.0028 0.0156 0.0439
Schistosoma mansoni polycystin 1-related 0.0019 0.0053 0.0112
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0053 0.0035
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0115 0.1203 0.1187
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0156 0.0432
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0062 0.6014
Echinococcus multilocularis lamin 0.0028 0.0156 0.0138
Brugia malayi hypothetical protein 0.0061 0.0551 0.1524
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0062 0.2094
Echinococcus multilocularis dna polymerase eta 0.002 0.0062 0.0044
Loa Loa (eye worm) hypothetical protein 0.0054 0.0472 0.1307
Schistosoma mansoni nuclear hormone receptor 0.0054 0.0472 0.1444
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0054 0.0036
Brugia malayi Cytochrome P450 family protein 0.0023 0.0091 0.0252
Brugia malayi nuclear receptor NHR-88 0.0115 0.1203 0.333
Brugia malayi nuclear receptor RXR 0.0061 0.0551 0.1524
Schistosoma mansoni hypothetical protein 0.0177 0.1947 0.6131
Loa Loa (eye worm) hypothetical protein 0.0054 0.0472 0.1307
Brugia malayi nuclear hormone receptor 0.0115 0.1203 0.333
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0115 0.1203 0.333
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0054 0.0472 0.1444
Loa Loa (eye worm) hypothetical protein 0.0317 0.3614 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0089 0.0893 0.0876
Echinococcus granulosus GPCR family 2 0.008 0.0781 0.2425
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0115 0.1203 0.3767
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0053 0.9704
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.008 0.0781 0.2425
Brugia malayi RNA binding protein 0.0271 0.3064 0.8478
Schistosoma mansoni tar DNA-binding protein 0.0271 0.3064 0.968
Brugia malayi hypothetical protein 0.0019 0.0053 0.0148
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0054 0.4958
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0115 0.1203 0.1187
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0115 0.1203 0.1187
Brugia malayi hypothetical protein 0.0019 0.0053 0.0148
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0115 0.1203 0.3767
Trypanosoma brucei unspecified product 0.002 0.0062 0.6014
Brugia malayi Nuclear hormone receptor E75 0.0054 0.0472 0.1307
Echinococcus granulosus Nuclear hormone receptor HR96 0.0054 0.0472 0.1444
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0054 0.0472 0.1444
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0061 0.0551 0.1693
Trichomonas vaginalis set domain proteins, putative 0.0229 0.257 1
Schistosoma mansoni nuclear receptor nhr-48 0.0054 0.0472 0.1444
Echinococcus multilocularis tar DNA binding protein 0.0271 0.3064 0.3051
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0062 0.6014
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0254 0.2858 0.7909
Echinococcus granulosus thyroid hormone receptor alpha 0.0054 0.0472 0.1444
Onchocerca volvulus 0.0317 0.3614 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0115 0.1203 0.333
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0115 0.1203 0.323
Loa Loa (eye worm) hypothetical protein 0.0115 0.1203 0.333
Brugia malayi ecdysone receptor 0.0054 0.0472 0.1307
Loa Loa (eye worm) hypothetical protein 0.0029 0.0166 0.046
Entamoeba histolytica hypothetical protein 0.0075 0.0716 1
Brugia malayi hypothetical protein 0.0054 0.0472 0.1307
Brugia malayi Latrophilin receptor protein 2 0.008 0.0781 0.2162
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0054 0.0472 0.0455
Schistosoma mansoni rab6-interacting 0.0019 0.0053 0.0112
Schistosoma mansoni tar DNA-binding protein 0.0271 0.3064 0.968
Brugia malayi Nuclear hormone receptor-like 1 0.0061 0.0551 0.1524
Schistosoma mansoni RAR-like nuclear receptor 0.0115 0.1203 0.3767
Loa Loa (eye worm) hypothetical protein 0.0115 0.1203 0.333
Loa Loa (eye worm) hypothetical protein 0.0054 0.0472 0.1307
Loa Loa (eye worm) hypothetical protein 0.0173 0.1897 0.5249
Brugia malayi Calcitonin receptor-like protein seb-1 0.0254 0.2858 0.7909
Loa Loa (eye worm) hypothetical protein 0.002 0.0062 0.0172
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0115 0.1203 0.3767
Loa Loa (eye worm) hypothetical protein 0.0054 0.0472 0.1307
Brugia malayi Pre-SET motif family protein 0.0029 0.0166 0.046
Schistosoma mansoni thyroid hormone receptor 0.0115 0.1203 0.3767
Loa Loa (eye worm) hypothetical protein 0.0115 0.1203 0.333
Loa Loa (eye worm) hypothetical protein 0.0054 0.0472 0.1307
Leishmania major DNA polymerase eta, putative 0.002 0.0062 0.6014
Toxoplasma gondii exonuclease III APE 0.002 0.0054 0.2444
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0115 0.1203 0.333
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0054 0.8244
Echinococcus granulosus lamin 0.0028 0.0156 0.0439
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0062 0.6014
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0115 0.1203 0.1187
Echinococcus granulosus geminin 0.0177 0.1947 0.6131
Brugia malayi photoreceptor-specific nuclear receptor 0.0115 0.1203 0.333
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0062 0.0031
Loa Loa (eye worm) hypothetical protein 0.0061 0.0551 0.1524
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0115 0.1203 0.333
Plasmodium vivax SET domain protein, putative 0.0029 0.0166 1
Schistosoma mansoni hypothetical protein 0.008 0.0781 0.2425
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0054 0.0472 0.0455
Onchocerca volvulus 0.0115 0.1203 0.323
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0115 0.1203 0.3767
Echinococcus granulosus dna polymerase eta 0.002 0.0062 0.014
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0115 0.1203 0.333
Loa Loa (eye worm) hypothetical protein 0.0054 0.0472 0.1307
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0054 0.4958
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0062 0.0172
Onchocerca volvulus 0.0029 0.0166 0.0318
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0062 0.6014
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0054 0.5
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0089 0.0893 0.0876
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0115 0.1203 0.333
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0061 0.0551 0.1693
Schistosoma mansoni tar DNA-binding protein 0.0271 0.3064 0.968
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0091 0.0252
Brugia malayi nuclear receptor NHR-67 0.0054 0.0472 0.1307
Entamoeba histolytica hypothetical protein 0.0075 0.0716 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0062 0.6014
Schistosoma mansoni hypothetical protein 0.0279 0.3165 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0061 0.0551 0.1524
Trypanosoma brucei cytochrome P450, putative 0.0023 0.0091 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0054 0.4958
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0062 0.6014
Schistosoma mansoni lamin 0.0028 0.0156 0.0439
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0115 0.1203 0.333
Schistosoma mansoni transcription factor LCR-F1 0.0075 0.0716 0.2217
Schistosoma mansoni nuclear hormone receptor 0.0115 0.1203 0.3767
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0062 0.6014
Brugia malayi nuclear hormone receptor family member nhr-6 0.0054 0.0472 0.1307
Schistosoma mansoni lipoxygenase 0.0081 0.0796 0.2473
Schistosoma mansoni lipoxygenase 0.0117 0.1217 0.3809
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0062 0.0117
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0062 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0054 0.0472 0.1444
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0115 0.1203 0.1187
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0053 0.0112
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0115 0.1203 0.333
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0062 0.6014
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0054 0.0472 0.0455
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0062 0.0172
Onchocerca volvulus 0.0028 0.0156 0.0289
Loa Loa (eye worm) hypothetical protein 0.0028 0.015 0.0415
Loa Loa (eye worm) RNA binding protein 0.0271 0.3064 0.8478
Brugia malayi latrophilin 2 splice variant baaae 0.0173 0.1897 0.5249
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0115 0.1203 0.333
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0271 0.3064 0.8478
Schistosoma mansoni intermediate filament proteins 0.0028 0.0156 0.0439
Echinococcus multilocularis geminin 0.0177 0.1947 0.1932
Schistosoma mansoni loxhd1 0.0019 0.0053 0.0112
Brugia malayi conserved hypotetical protein 0.0054 0.0472 0.1307
Echinococcus granulosus ecdysone induced protein 78C 0.0115 0.1203 0.3767
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0115 0.1203 0.333
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0062 0.6014
Schistosoma mansoni nuclear receptor 0.0054 0.0472 0.1444
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0115 0.1203 0.3767
Schistosoma mansoni tar DNA-binding protein 0.0271 0.3064 0.968
Onchocerca volvulus 0.0054 0.0472 0.1177
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0053 0.0035
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.008 0.0781 0.2162
Brugia malayi steroid hormone receptor 0.0115 0.1203 0.333
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0062 0.6014
Schistosoma mansoni thyroid hormone receptor 0.0115 0.1203 0.3767
Schistosoma mansoni retinoic acid receptor RXR 0.0115 0.1203 0.3767
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0115 0.1203 0.333
Schistosoma mansoni hypothetical protein 0.0173 0.1897 0.5971
Echinococcus multilocularis thyroid hormone receptor alpha 0.0115 0.1203 0.1187
Loa Loa (eye worm) hypothetical protein 0.0115 0.1203 0.333
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0062 0.014
Leishmania major cytochrome p450-like protein 0.0023 0.0091 1
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0053 0.2371
Echinococcus multilocularis dna polymerase kappa 0.002 0.0062 0.0044
Schistosoma mansoni lamin 0.0028 0.0156 0.0439
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0023 0.0091 1
Echinococcus multilocularis musashi 0.0028 0.0156 0.0138
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0018 0.005
Giardia lamblia DINP protein human, muc B family 0.002 0.0062 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0089 0.0893 0.2779
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0166 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0893 0.2779
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0018 0.005
Brugia malayi RNA recognition motif domain containing protein 0.0271 0.3064 0.8478
Brugia malayi Steroid receptor seven-up type 2 0.0115 0.1203 0.333
Loa Loa (eye worm) MH2 domain-containing protein 0.012 0.126 0.3486
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0062 0.014
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0115 0.1203 0.3767
Schistosoma mansoni hypothetical protein 0.0075 0.0716 0.2217
Loa Loa (eye worm) hypothetical protein 0.0054 0.0472 0.1307
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0115 0.1203 0.333
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0054 0.015
Schistosoma mansoni DNA polymerase eta 0.002 0.0062 0.014
Echinococcus multilocularis lamin dm0 0.0028 0.0156 0.0138
Echinococcus multilocularis nuclear receptor nhr 48 0.0054 0.0472 0.0455
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0054 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0054 0.4958
Brugia malayi hypothetical protein 0.0317 0.3614 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0089 0.0893 0.247
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0154 0.0431
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0062 0.6014
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0091 0.0252
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0054 0.015
Loa Loa (eye worm) hypothetical protein 0.0019 0.0053 0.0148
Schistosoma mansoni steroid hormone receptor ad4bp 0.0115 0.1203 0.3767
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0075 0.0716 0.0699
Schistosoma mansoni hypothetical protein 0.0019 0.0053 0.0112
Schistosoma mansoni ap endonuclease 0.002 0.0054 0.0115
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0166 0.0471
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0054 0.0472 0.1177
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0115 0.1203 0.333
Schistosoma mansoni zinc finger protein 0.0054 0.0472 0.1444
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0166 0.0148
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0062 0.6014
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0062 0.6014
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0117 0.1217 0.1201
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0254 0.2858 0.7909
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0053 0.0035
Loa Loa (eye worm) hypothetical protein 0.0028 0.0156 0.0432
Entamoeba histolytica hypothetical protein 0.0075 0.0716 1
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0062 0.0031
Echinococcus granulosus dna polymerase kappa 0.002 0.0062 0.014
Brugia malayi orphan nuclear receptor NR2E1 0.0054 0.0472 0.1307
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.008 0.0781 0.2425
Schistosoma mansoni nuclear receptor 0.0054 0.0472 0.1444
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0054 0.0115
Onchocerca volvulus 0.0054 0.0472 0.1177
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0115 0.1203 0.3767
Loa Loa (eye worm) cytochrome P450 family protein 0.0052 0.0439 0.1216
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0166 0.0471
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0062 0.6014
Brugia malayi Doublecortin family protein 0.0019 0.0053 0.0148
Schistosoma mansoni hypothetical protein 0.0177 0.1947 0.6131
Schistosoma mansoni nuclear hormone receptor 0.0054 0.0472 0.1444
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0062 0.0044
Onchocerca volvulus Protein ultraspiracle homolog 0.0115 0.1203 0.323
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0061 0.0551 0.1693
Loa Loa (eye worm) steroid hormone receptor 0.0115 0.1203 0.333
Loa Loa (eye worm) hypothetical protein 0.0054 0.0472 0.1307
Loa Loa (eye worm) hypothetical protein 0.0115 0.1203 0.333
Entamoeba histolytica hypothetical protein 0.0075 0.0716 1
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0062 0.6014
Brugia malayi intermediate filament protein 0.0028 0.0156 0.0432
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0115 0.1203 0.3767
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0054 0.0472 0.1307
Echinococcus granulosus intermediate filament protein 0.0028 0.0156 0.0439
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0054 0.0472 0.1177
Loa Loa (eye worm) DR-78 0.0054 0.0472 0.1307
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0054 0.5
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0115 0.1203 0.333
Loa Loa (eye worm) hypothetical protein 0.0254 0.2858 0.7909

Activities

Activity type Activity value Assay description Source Reference
Anti-fighting behaviour (functional) = 4.55 Compound was evaluated for the Anti-fighting behavior. ChEMBL. 2202830
Anti-pent effect (functional) = 5.29 Evaluation for the Anti-pentylenetetrazole effect. ChEMBL. 2202830
Clined screen test (functional) = 3.07 Evaluation of inclined screen test. ChEMBL. 2202830

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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