Detailed information for compound 1445546

Basic information

Technical information
  • TDR Targets ID: 1445546
  • Name: 1-[4-[4-[3-(4-chlorophenyl)-[1,2]oxazolo[4,5- e]pyrimidin-4-yl]piperazin-1-yl]phenyl]ethano ne
  • MW: 433.89 | Formula: C23H20ClN5O2
  • H donors: 0 H acceptors: 4 LogP: 4.34 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)c1noc2c1c(ncn2)N1CCN(CC1)c1ccc(cc1)C(=O)C
  • InChi: 1S/C23H20ClN5O2/c1-15(30)16-4-8-19(9-5-16)28-10-12-29(13-11-28)22-20-21(17-2-6-18(24)7-3-17)27-31-23(20)26-14-25-22/h2-9,14H,10-13H2,1H3
  • InChiKey: YIDUIQXZXUVAEQ-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 1-[4-[4-[3-(4-chlorophenyl)isoxazolo[4,5-e]pyrimidin-4-yl]piperazin-1-yl]phenyl]ethanone
  • 1-[4-[4-[3-(4-chlorophenyl)-4-isoxazolo[4,5-e]pyrimidinyl]-1-piperazinyl]phenyl]ethanone
  • C660-0739
  • NCGC00111258-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0809 0.0814
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0844 0.9366 1
Giardia lamblia Cathepsin L precursor 0.0156 0.1693 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0844 0.9366 1
Echinococcus granulosus cysteine protease 0.0435 0.4803 0.5112
Echinococcus granulosus cathepsin b 0.0156 0.1693 0.1779
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0156 0.1693 0.1807
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0156 0.1693 0.1807
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0844 0.9366 1
Loa Loa (eye worm) hypothetical protein 0.0279 0.3067 0.3238
Brugia malayi Cathepsin L-like precursor 0.0844 0.9366 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0156 0.1693 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0156 0.1693 0.1785
Trypanosoma cruzi cysteine peptidase, putative 0.09 1 1
Onchocerca volvulus Cathepsin L homolog 0.0844 0.9366 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0844 0.9366 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0156 0.1693 0.1807
Leishmania major cathepsin L-like protease 0.09 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0844 0.9366 1
Brugia malayi RNA binding protein 0.0076 0.0809 0.0815
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0844 0.9366 1
Echinococcus granulosus dnaJ subfamily B 0.0392 0.4324 0.4598
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0844 0.9366 1
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.05 0.0508
Trypanosoma cruzi major cysteine proteinase, putative 0.0212 0.2326 0.1922
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0032 0.0034
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0156 0.1693 0.1807
Onchocerca volvulus 0.0156 0.1693 0.1571
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.09 1 1
Loa Loa (eye worm) hypothetical protein 0.0565 0.6255 0.666
Entamoeba histolytica cysteine protease, putative 0.0435 0.4803 0.4054
Plasmodium falciparum cysteine proteinase falcipain 1 0.0435 0.4803 0.4054
Toxoplasma gondii cathepsin CPC1 0.0156 0.1693 0.1345
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0809 0.0864
Onchocerca volvulus 0.0844 0.9366 1
Giardia lamblia Cathepsin B precursor 0.0156 0.1693 1
Schistosoma mansoni cathepsin C 0.0156 0.1693 0.1807
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0435 0.4803 0.453
Onchocerca volvulus 0.0844 0.9366 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0156 0.1693 0.1785
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0844 0.9366 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0124 0.0099
Echinococcus multilocularis cathepsin L 0.0156 0.1693 0.1779
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0058 0.0607 0.0648
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.1693 0.1785
Giardia lamblia Cathepsin L precursor 0.0156 0.1693 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0488 0.047
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0565 0.6255 0.6669
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0156 0.1693 0.1807
Brugia malayi Cathepsin L-like precursor 0.0844 0.9366 1
Giardia lamblia Cathepsin B precursor 0.0156 0.1693 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0435 0.4803 0.5115
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0844 0.9366 1
Giardia lamblia Cathepsin L precursor 0.0156 0.1693 1
Loa Loa (eye worm) hypothetical protein 0.0156 0.1693 0.1762
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0279 0.3067 0.3238
Brugia malayi Cathepsin L-like cysteine proteinase 0.0565 0.6255 0.6661
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0844 0.9366 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0124 0.0079
Giardia lamblia Encystation-specific protease 0.0156 0.1693 1
Loa Loa (eye worm) hypothetical protein 0.0565 0.6255 0.666
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0844 0.9366 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0844 0.9366 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0844 0.9366 1
Giardia lamblia Cysteine protease 0.0156 0.1693 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.09 1 1
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0156 0.1693 0.1807
Loa Loa (eye worm) hypothetical protein 0.0033 0.032 0.0289
Echinococcus multilocularis cysteine protease 0.0844 0.9366 1
Brugia malayi cathepsin B-like cysteine proteinase 0.0156 0.1693 0.1763
Brugia malayi MAP kinase sur-1 0.0049 0.05 0.0484
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0844 0.9366 1
Schistosoma mansoni hypothetical protein 0.0015 0.0124 0.0133
Echinococcus granulosus GPCR family 2 0.0015 0.0124 0.0099
Echinococcus multilocularis cathepsin L cysteine protease 0.0844 0.9366 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0435 0.4803 0.5115
Giardia lamblia Cysteine protease 0.0156 0.1693 1
Onchocerca volvulus 0.0844 0.9366 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0809 0.0864
Loa Loa (eye worm) ctsf protein 0.0844 0.9366 1
Entamoeba histolytica cysteine proteinase, putative 0.0435 0.4803 0.4054
Toxoplasma gondii cathepsin CPL 0.0844 0.9366 1
Brugia malayi cathepsin L precursor 0.0156 0.1693 0.1763
Entamoeba histolytica cysteine protease, putative 0.0435 0.4803 0.4054
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0156 0.1693 0.1807
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0844 0.9366 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0445 0.0475
Trypanosoma cruzi cysteine proteinase, putative 0.0435 0.4803 0.453
Entamoeba histolytica cysteine protease, putative 0.0435 0.4803 0.4054
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0809 0.0864
Entamoeba histolytica cysteine proteinase 1, putative 0.0435 0.4803 0.4054
Leishmania major cysteine peptidase A (CPA) 0.0844 0.9366 0.9333
Onchocerca volvulus Cathepsin L homolog 0.0844 0.9366 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0844 0.9366 1
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0809 0.0815
Giardia lamblia Cathepsin L-like protease 0.0156 0.1693 1
Echinococcus granulosus mitogen activated protein kinase 3 0.0049 0.05 0.0501
Echinococcus multilocularis cathepsin b 0.0156 0.1693 0.1779
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0156 0.1693 0.1785
Loa Loa (eye worm) hypothetical protein 0.0156 0.1693 0.1762
Loa Loa (eye worm) hypothetical protein 0.0156 0.1693 0.1762
Leishmania major cathepsin L-like protease 0.0844 0.9366 0.9333
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0156 0.1693 0.1785
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.09 1 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0435 0.4803 0.5129
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.1693 0.1785
Schistosoma mansoni hypothetical protein 0.0015 0.0124 0.0133
Entamoeba histolytica cysteine proteinase, putative 0.0565 0.6255 0.5946
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.1693 0.1785
Brugia malayi Cathepsin L-like precursor 0.0844 0.9366 1
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0279 0.3067 0.3239
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.09 1 1
Loa Loa (eye worm) cysteine protease 0.0844 0.9366 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0844 0.9366 1
Schistosoma mansoni cathepsin s 0.0279 0.3067 0.3274
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0156 0.1693 0.1255
Loa Loa (eye worm) hypothetical protein 0.0156 0.1693 0.1762
Entamoeba histolytica cysteine protease, putative 0.0435 0.4803 0.4054
Toxoplasma gondii cathepsin B 0.0156 0.1693 0.1345
Onchocerca volvulus 0.0844 0.9366 1
Trypanosoma cruzi cysteine peptidase, putative 0.09 1 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0156 0.1693 0.1762
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0844 0.9366 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0027 0.0263 0.0227
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.09 1 1
Schistosoma mansoni cpg binding protein 0.0029 0.028 0.0299
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0156 0.1693 0.1785
Echinococcus multilocularis mitogen activated protein kinase 3 0.0049 0.05 0.0501
Leishmania major cathepsin L-like protease 0.0844 0.9366 0.9333
Brugia malayi Papain family cysteine protease containing protein 0.0435 0.4803 0.5103
Onchocerca volvulus 0.0565 0.6255 0.6583
Schistosoma mansoni hypothetical protein 0.0015 0.0124 0.0133
Giardia lamblia Cathepsin B precursor 0.0156 0.1693 1
Brugia malayi Cathepsin L-like precursor 0.0279 0.3067 0.3239
Schistosoma mansoni hypothetical protein 0.0392 0.4324 0.4617
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0488 0.0471
Loa Loa (eye worm) hypothetical protein 0.0156 0.1693 0.1762
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0844 0.9366 1
Brugia malayi Papain family cysteine protease containing protein 0.0435 0.4803 0.5103
Entamoeba histolytica cysteine protease, putative 0.0435 0.4803 0.4054
Entamoeba histolytica cysteine proteinase, putative 0.0435 0.4803 0.4054
Brugia malayi Cathepsin L-like precursor 0.0844 0.9366 1
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.05 0.0508
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0156 0.1693 0.1807
Brugia malayi cathepsin Z-like cysteine proteinase 0.0156 0.1693 0.1763
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0435 0.4803 0.5129
Giardia lamblia Cathepsin L precursor 0.0156 0.1693 1
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0049 0.05 0.0482
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0156 0.1693 0.1785
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0435 0.4803 0.5129
Echinococcus multilocularis cpg binding protein 0.0029 0.028 0.0266
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.05 0.0534
Plasmodium vivax vivapain-3 0.0435 0.4803 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0844 0.9366 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0124 0.0099
Giardia lamblia Cathepsin B precursor 0.0156 0.1693 1
Echinococcus multilocularis cathepsin L 0.0435 0.4803 0.5112
Giardia lamblia Cathepsin B precursor 0.0156 0.1693 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.09 1 1
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0156 0.1693 0.1762
Echinococcus multilocularis GPCR, family 2 0.0015 0.0124 0.0099
Echinococcus granulosus cathepsin b 0.0156 0.1693 0.1779
Trichomonas vaginalis conserved hypothetical protein 0.0156 0.1693 0.1785
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0844 0.9366 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0156 0.1693 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0156 0.1693 0.1785
Echinococcus granulosus cpg binding protein 0.0029 0.028 0.0266
Giardia lamblia Cathepsin B precursor 0.0156 0.1693 1
Toxoplasma gondii cathepsin CPC2 0.0156 0.1693 0.1345
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0156 0.1693 0.1762
Loa Loa (eye worm) fibroinase 0.0844 0.9366 1
Trypanosoma cruzi cysteine protease, putative 0.0435 0.4803 0.453
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0445 0.0475
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.1693 0.1785
Entamoeba histolytica cysteine protease, putative 0.0435 0.4803 0.4054
Giardia lamblia Cathepsin B precursor 0.0156 0.1693 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0844 0.9366 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0488 0.0471
Onchocerca volvulus Cathepsin F homolog 0.0844 0.9366 1
Entamoeba histolytica cysteine protease, putative 0.0435 0.4803 0.4054
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0156 0.1693 0.1763
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0844 0.9366 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0156 0.1693 0.1807
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0445 0.0442
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0051 0.002
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0156 0.1693 0.1255
Trypanosoma cruzi cruzipain precursor, putative 0.0279 0.3067 0.2702
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0809 0.0833
Giardia lamblia Cysteine protease 0.0156 0.1693 1
Entamoeba histolytica cysteine protease, putative 0.0435 0.4803 0.4054
Loa Loa (eye worm) cathepsin B 0.0156 0.1693 0.1762
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.09 1 1
Plasmodium vivax unspecified product 0.0435 0.4803 0.4054
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.05 0.0508
Schistosoma mansoni cathepsin F (C01 family) 0.0844 0.9366 1
Brugia malayi cathepsin L-like precursor 0.0565 0.6255 0.6661
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0445 0.0442
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0445 0.0442
Plasmodium vivax vivapain-2 0.0844 0.9366 1
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0124 0.008
Leishmania major cathepsin L-like protease 0.0844 0.9366 0.9333
Plasmodium falciparum cysteine proteinase falcipain 3 0.0844 0.9366 1
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0156 0.1693 0.1807
Toxoplasma gondii preprocathepsin c precursor, putative 0.0156 0.1693 0.1345
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0844 0.9366 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.09 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0844 0.9366 0.9333
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0844 0.9366 1
Giardia lamblia Cysteine protease 0.0156 0.1693 1
Entamoeba histolytica cysteine proteinase, putative 0.0435 0.4803 0.4054
Trichomonas vaginalis conserved hypothetical protein 0.0156 0.1693 0.1785
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0445 0.0423
Brugia malayi Cathepsin L-like precursor 0.0844 0.9366 1
Brugia malayi Papain family cysteine protease containing protein 0.0156 0.1693 0.1763
Trypanosoma cruzi cysteine peptidase, putative 0.09 1 1
Entamoeba histolytica cysteine proteinase 2 0.0435 0.4803 0.4054
Echinococcus granulosus cathepsin l1 0.0565 0.6255 0.6667
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0156 0.1693 0.1807
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0124 0.0099
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0435 0.4803 0.453
Loa Loa (eye worm) hypothetical protein 0.0565 0.6255 0.666
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0156 0.1693 0.1807
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0809 0.0814
Onchocerca volvulus 0.0844 0.9366 1
Trypanosoma cruzi cysteine peptidase, putative 0.0435 0.4803 0.453
Giardia lamblia Cathepsin B precursor 0.0156 0.1693 1
Entamoeba histolytica cysteine protease, putative 0.0435 0.4803 0.4054
Onchocerca volvulus 0.0844 0.9366 1
Echinococcus multilocularis mitogen activated protein kinase 0.0049 0.05 0.0501
Entamoeba histolytica cysteine protease, putative 0.0844 0.9366 1
Echinococcus multilocularis cathepsin b 0.0156 0.1693 0.1779
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0844 0.9366 1
Giardia lamblia Cathepsin L precursor 0.0156 0.1693 1
Brugia malayi Papain family cysteine protease containing protein 0.0156 0.1693 0.1763
Brugia malayi Cathepsin L-like precursor 0.0844 0.9366 1
Schistosoma mansoni cathepsin F (C01 family) 0.0565 0.6255 0.6679
Leishmania major cathepsin L-like protease 0.0844 0.9366 0.9333
Entamoeba histolytica cysteine proteinase, putative 0.0844 0.9366 1
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0156 0.1693 0.1255
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0844 0.9366 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.09 1 1
Loa Loa (eye worm) RNA binding protein 0.0076 0.0809 0.0814
Brugia malayi TAR-binding protein 0.0076 0.0809 0.0815
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0156 0.1693 0.1785
Schistosoma mansoni cpg binding protein 0.0027 0.0263 0.0281
Leishmania major cathepsin L-like protease 0.09 1 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0622 0.6889 0.6725
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0124 0.008
Plasmodium vivax unspecified product 0.0279 0.3067 0.1791
Loa Loa (eye worm) hypothetical protein 0.0279 0.3067 0.3238
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.1693 0.1785
Toxoplasma gondii histone lysine methyltransferase SET1 0.0052 0.0537 0.0042
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0435 0.4803 0.453
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0156 0.1693 0.1785
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.032 0.029
Echinococcus granulosus mitogen activated protein kinase 0.0049 0.05 0.0501
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0445 0.0424
Schistosoma mansoni cathepsin B (C01 family) 0.0156 0.1693 0.1807
Loa Loa (eye worm) hypothetical protein 0.0156 0.1693 0.1762
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.09 1 1
Echinococcus granulosus cathepsin l1 0.0844 0.9366 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0279 0.3067 0.3239
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.09 1 1
Schistosoma mansoni cathepsin F (C01 family) 0.0844 0.9366 1
Trypanosoma brucei cysteine peptidase C (CPC) 0.0156 0.1693 0.1255
Entamoeba histolytica cysteine protease, putative 0.0435 0.4803 0.4054
Entamoeba histolytica cysteine proteinase, putative 0.0435 0.4803 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0844 0.9366 1
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0156 0.1693 1
Echinococcus granulosus tar DNA binding protein 0.0076 0.0809 0.0833
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0809 0.0864
Giardia lamblia Cathepsin L-like protease 0.0156 0.1693 1
Trypanosoma cruzi cruzipain precursor, putative 0.09 1 1
Echinococcus multilocularis cysteine protease 0.0844 0.9366 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0488 0.047
Schistosoma mansoni cathepsin S (C01 family) 0.0156 0.1693 0.1807
Loa Loa (eye worm) hypothetical protein 0.0279 0.3067 0.3238
Onchocerca volvulus 0.0844 0.9366 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0844 0.9366 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0565 0.6255 0.6669
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0124 0.0099
Brugia malayi Papain family cysteine protease containing protein 0.0156 0.1693 0.1763
Brugia malayi Cathepsin L-like precursor 0.0565 0.6255 0.6661
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0844 0.9366 1
Loa Loa (eye worm) hypothetical protein 0.0156 0.1693 0.1762
Giardia lamblia Hypothetical protein 0.0156 0.1693 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0844 0.9366 1
Entamoeba histolytica cysteine proteinase, putative 0.0844 0.9366 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0156 0.1693 0.1807
Echinococcus multilocularis dnaJ subfamily B 0.0392 0.4324 0.4598
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0445 0.0475
Onchocerca volvulus Cathepsin L homolog 0.0156 0.1693 0.1571
Echinococcus granulosus cathepsin L 0.0156 0.1693 0.1779
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0156 0.1693 1
Giardia lamblia Cathepsin L precursor 0.0156 0.1693 1
Brugia malayi Papain family cysteine protease containing protein 0.0844 0.9366 1
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0156 0.1693 0.1785
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0156 0.1693 0.1785
Loa Loa (eye worm) hypothetical protein 0.0015 0.0124 0.0079
Trypanosoma cruzi major cysteine proteinase, putative 0.0156 0.1693 0.1255
Loa Loa (eye worm) hypothetical protein 0.0844 0.9366 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0156 0.1693 0.1785
Trypanosoma cruzi cysteine peptidase, putative 0.0279 0.3067 0.2702
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0809 0.0864
Brugia malayi CXXC zinc finger family protein 0.0027 0.0263 0.0229
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0051 0.002
Echinococcus granulosus cathepsin L cysteine protease 0.0435 0.4803 0.5112
Brugia malayi fibroinase precursor 0.0156 0.1693 0.1763
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0844 0.9366 1
Trypanosoma cruzi cysteine proteinase, putative 0.0435 0.4803 0.453
Brugia malayi cathepsin F-like cysteine proteinase 0.0156 0.1693 0.1763
Plasmodium vivax vivapain-2 0.0844 0.9366 1
Entamoeba histolytica cysteine protease, putative 0.0435 0.4803 0.4054
Schistosoma mansoni hypothetical protein 0.0033 0.032 0.0342
Brugia malayi cathepsin Z-like cysteine proteinase 0.0156 0.1693 0.1763
Brugia malayi Cathepsin L-like precursor 0.0565 0.6255 0.6661
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.05 0.0508
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0844 0.9366 1
Leishmania major cathepsin L-like protease 0.0844 0.9366 0.9333
Schistosoma mansoni cpg binding protein 0.0029 0.028 0.0299
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0445 0.0442
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.1693 0.1785
Entamoeba histolytica cysteine protease, putative 0.0435 0.4803 0.4054
Echinococcus granulosus cathepsin L 0.0435 0.4803 0.5112
Schistosoma mansoni hypothetical protein 0.0015 0.0124 0.0133
Brugia malayi cathepsin L-like cysteine proteinase 0.0156 0.1693 0.1763
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0156 0.1693 0.1807
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0844 0.9366 1
Giardia lamblia Hypothetical protein 0.0156 0.1693 1
Plasmodium vivax vivapain-1 0.0435 0.4803 0.4054
Entamoeba histolytica cysteine protease, putative 0.0435 0.4803 0.4054

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.2512 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 7.0795 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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