Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | galactosylceramidase | No references | |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4468 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4468 | 1 |
Onchocerca volvulus | 0.0022 | 0 | 0.5 | |
Onchocerca volvulus | 0.0022 | 0 | 0.5 | |
Onchocerca volvulus | 0.0022 | 0 | 0.5 | |
Brugia malayi | TAR-binding protein | 0.0076 | 0.4468 | 0.4468 |
Onchocerca volvulus | 0.0022 | 0 | 0.5 | |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.4468 | 0.4468 |
Onchocerca volvulus | 0.0022 | 0 | 0.5 | |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.4468 | 1 |
Onchocerca volvulus | 0.0022 | 0 | 0.5 | |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.4468 | 0.4468 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.4468 | 0.4468 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.4468 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.4468 | 0.4468 |
Brugia malayi | RNA binding protein | 0.0076 | 0.4468 | 0.4468 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4468 | 1 |
Onchocerca volvulus | 0.0022 | 0 | 0.5 | |
Onchocerca volvulus | 0.0022 | 0 | 0.5 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4468 | 1 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0022 | 0 | 0.5 |
Onchocerca volvulus | 0.0022 | 0 | 0.5 | |
Onchocerca volvulus | 0.0022 | 0 | 0.5 | |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0022 | 0 | 0.5 |
Onchocerca volvulus | 0.0022 | 0 | 0.5 | |
Onchocerca volvulus | 0.0022 | 0 | 0.5 | |
Onchocerca volvulus | 0.0022 | 0 | 0.5 | |
Onchocerca volvulus | 0.0022 | 0 | 0.5 | |
Onchocerca volvulus | 0.0022 | 0 | 0.5 | |
Onchocerca volvulus | 0.0022 | 0 | 0.5 | |
Onchocerca volvulus | 0.0022 | 0 | 0.5 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4468 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.1 uM | PubChem BioAssay. A Novel Cell-Based Assay to Identify Small Molecules for B -Galactocerebrosidase. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 3.1623 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (binding) | = 22.3872 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (functional) | 23.2809 uM | PUBCHEM_BIOASSAY: IN Cell qHTS Assay for Inhibitors of the mTORC1 Signaling Pathway in MEF (Tsc2-/-, p53-/-) Cells: Sytravon. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2660, AID2666, AID2667, AID2668, AID2681, AID493208] | ChEMBL. | No reference |
Potency (functional) | 26.1216 uM | PUBCHEM_BIOASSAY: Acumen qHTS Assay for Inhibitors of the mTORC1 Signaling Pathway in MEF (Tsc2-/-, p53-/-) Cells: Sytravon. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2660, AID2666, AID2667, AID2668, AID2681, AID504465] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.