Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.3252 | 0.266 |
Brugia malayi | N-terminal motif family protein | 0.0179 | 0.9806 | 0.98 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.1998 | 0.6639 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0067 | 0.3252 | 0.3052 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.1153 | 0.383 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.1153 | 0.3545 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.1998 | 0.6145 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0807 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.1153 | 0.3545 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.1998 | 0.6145 |
Loa Loa (eye worm) | TAR-binding protein | 0.0063 | 0.301 | 0.2397 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.301 | 0.9256 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.1998 | 0.6639 |
Echinococcus granulosus | tar DNA binding protein | 0.0063 | 0.301 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.1153 | 0.383 |
Loa Loa (eye worm) | hypothetical protein | 0.0179 | 0.9806 | 0.9789 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0098 | 0.5061 | 0.4915 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.5061 | 0.4628 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0098 | 0.5061 | 0.4915 |
Schistosoma mansoni | hypothetical protein | 0.0067 | 0.3252 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0807 | 0.5 |
Onchocerca volvulus | 0.0182 | 1 | 1 | |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.1153 | 0.383 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.0807 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0807 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0098 | 0.5061 | 0.4628 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.1153 | 0.383 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0807 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.301 | 0.9256 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.1153 | 0.0377 |
Loa Loa (eye worm) | RNA binding protein | 0.0063 | 0.301 | 0.2397 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.0807 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.1153 | 0.3545 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.0807 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.1998 | 0.6145 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.1998 | 0.1761 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0031 | 0.1153 | 0.089 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0063 | 0.301 | 0.2397 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.301 | 0.9256 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.301 | 0.9256 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 1 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0031 | 0.1153 | 0.383 |
Brugia malayi | RNA binding protein | 0.0063 | 0.301 | 0.2803 |
Echinococcus granulosus | GPCR family 2 | 0.0031 | 0.1153 | 0.383 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.1998 | 0.6639 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0031 | 0.1153 | 0.0377 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.1153 | 0.3545 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.1998 | 0.6639 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0031 | 0.1153 | 0.089 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.0807 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0063 | 0.301 | 0.2803 |
Echinococcus multilocularis | tar DNA binding protein | 0.0063 | 0.301 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0063 | 0.301 | 0.2803 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0807 | 0.0534 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.301 | 0.9256 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.1998 | 0.1296 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 16.5113 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 16.5113 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 23.1093 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.081 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.