Detailed information for compound 1446397

Basic information

Technical information
  • TDR Targets ID: 1446397
  • Name: N-[2-(1H-indol-3-yl)ethyl]-1-phenylsulfonylpi peridine-4-carboxamide
  • MW: 411.517 | Formula: C22H25N3O3S
  • H donors: 2 H acceptors: 3 LogP: 2.92 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C1CCN(CC1)S(=O)(=O)c1ccccc1)NCCc1c[nH]c2c1cccc2
  • InChi: 1S/C22H25N3O3S/c26-22(23-13-10-18-16-24-21-9-5-4-8-20(18)21)17-11-14-25(15-12-17)29(27,28)19-6-2-1-3-7-19/h1-9,16-17,24H,10-15H2,(H,23,26)
  • InChiKey: MNJHRWXOXGBWRW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[2-(1H-indol-3-yl)ethyl]-1-phenylsulfonyl-piperidine-4-carboxamide
  • N-[2-(1H-indol-3-yl)ethyl]-1-phenylsulfonyl-4-piperidinecarboxamide
  • N-[2-(1H-indol-3-yl)ethyl]-1-phenylsulfonyl-isonipecotamide
  • ZINC06662587

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens peptidylprolyl cis/trans isomerase, NIMA-interacting 1 Starlite/ChEMBL No references
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Theileria parva peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma brucei gambiense peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma congolense peptidyl-prolyl cis-trans isomerase/rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trichomonas vaginalis rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania mexicana peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_128367 All targets in OG5_128367
Echinococcus granulosus expressed protein Get druggable targets OG5_128367 All targets in OG5_128367
Trichomonas vaginalis rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Candida albicans peptidylprolyl cis/trans isomerase isolated by functional complementation of S. cerevisiae ESS1 (YJR017C) which interacts with t Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Echinococcus multilocularis expressed protein Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania infantum peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 Get druggable targets OG5_128367 All targets in OG5_128367
Neospora caninum peptidyl-prolyl cis-trans isomerase NIMA- interacting 1, putative Get druggable targets OG5_128367 All targets in OG5_128367
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Leishmania braziliensis peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Toxoplasma gondii peptidylprolyl isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Schistosoma mansoni rotamase Get druggable targets OG5_128367 All targets in OG5_128367
Candida albicans peptidylprolyl cis/trans isomerase isolated by functional complementation of S. cerevisiae ESS1 (YJR017C) which interacts with t Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania donovani peptidyl-prolyl cis-trans isomerase/rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Babesia bovis peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Schistosoma japonicum ko:K09578 peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, putative Get druggable targets OG5_128367 All targets in OG5_128367
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Leishmania major peptidyl-prolyl cis-trans isomerase, putative peptidylprolyl cis/trans isomerase, NIMA-interacting 1 163 aa 133 aa 27.8 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major heat shock protein 83-1 0.0039 0.1335 0.1612
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0023 0.0587 0.0699
Onchocerca volvulus 0.0035 0.1153 0.1287
Trichomonas vaginalis heat shock protein, putative 0.0031 0.0967 0.1234
Trypanosoma brucei protein phosphatase 2B, putative 0.005 0.1857 0.2367
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0033 0.1073 0.128
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0421 0.0421
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.1515 0.1933
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.0012 0.0103 0.0023
Schistosoma mansoni aminopeptidase A (M01 family) 0.0012 0.0085 0.0085
Brugia malayi Serine/threonine protein phosphatase 2B catalytic subunit 2 0.005 0.1857 0.2215
Echinococcus granulosus agrin 0.0023 0.0587 0.0587
Loa Loa (eye worm) hypothetical protein 0.0182 0.8074 0.8074
Trypanosoma brucei unspecified product 0.0012 0.0084 0.0105
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0039 0.1373 0.1736
Echinococcus granulosus ecdysone induced protein 78C 0.0033 0.1073 0.1073
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0039 0.1376 0.0948
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.1386 0.1768
Schistosoma mansoni immunophilin 0.0139 0.6056 0.6056
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0012 0.0085 0.0085
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0012 0.0085 0.0107
Loa Loa (eye worm) hypothetical protein 0.0037 0.1256 0.1255
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0025 0.07 0.0793
Schistosoma mansoni hypothetical protein 0.0201 0.8944 0.8944
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.0039 0.1376 0.1665
Brugia malayi prostaglandin transporter 0.0033 0.1078 0.1285
Echinococcus granulosus Nuclear hormone receptor HR96 0.0016 0.0257 0.0257
Loa Loa (eye worm) hypothetical protein 0.0017 0.0345 0.0344
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0053 0.2026 0.2503
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0039 0.1376 0.0948
Trypanosoma brucei heat shock protein 84, putative 0.0016 0.0269 0.0342
Onchocerca volvulus 0.0033 0.1078 0.1197
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.2026 0.2585
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0012 0.0085 0.0085
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.1386 0.1768
Brugia malayi nuclear hormone receptor family member odr-7 0.0016 0.0257 0.0306
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type (slyD) 0.0039 0.1376 0.1756
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0016 0.0257 0.0257
Onchocerca volvulus 0.0023 0.0587 0.0605
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0039 0.1376 0.174
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0177 0.7839 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0049 0.1811 0.2309
Toxoplasma gondii heat shock protein HSP90 0.0039 0.1335 0.5121
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.001 0.0001 0.0001
Schistosoma mansoni organic anion transporter 0.0033 0.1078 0.1078
Brugia malayi Peptidase family M1 containing protein 0.0012 0.0085 0.01
Echinococcus multilocularis serine protein kinase ATM 0.001 0.0001 0.0001
Trichomonas vaginalis immunophilin, putative 0.0177 0.7839 1
Trypanosoma cruzi heat shock protein 90, putative 0.0039 0.1335 0.1702
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0016 0.0269 0.0339
Plasmodium falciparum endoplasmin, putative 0.0024 0.0637 0.0711
Loa Loa (eye worm) hypothetical protein 0.0017 0.0345 0.0344
Trypanosoma brucei DNA polymerase kappa, putative 0.0049 0.1811 0.2309
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0012 0.0085 0.0085
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0016 0.0269 0.0269
Echinococcus multilocularis thyroid hormone receptor alpha 0.0033 0.1073 0.1073
Onchocerca volvulus 0.0033 0.1078 0.1197
Onchocerca volvulus Putative organic anion transporter 0.0033 0.1078 0.1197
Echinococcus granulosus heat shock protein 90 0.0031 0.0967 0.0967
Trypanosoma cruzi cytochrome P450, putative 0.0029 0.0896 0.1142
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0877 0.1119
Plasmodium falciparum serine/threonine protein phosphatase 2B catalytic subunit A 0.005 0.1857 0.2285
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0033 0.1073 0.1073
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0012 0.0085 0.0085
Loa Loa (eye worm) heat shock protein 90 0.0039 0.1335 0.1334
Leishmania major peptidyl-prolyl cis-trans isomerase, macrophage infectivity potentiator precursor, putative 0.0039 0.1376 0.1665
Schistosoma mansoni fkbp-rapamycin associated protein 0.001 0.0001 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.2026 0.2585
Toxoplasma gondii peptidyl-prolyl isomerase FKBP12, putative 0.0039 0.1376 0.5279
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.2348 0.2347
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0033 0.1073 0.1073
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0177 0.7839 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.1256 0.1601
Echinococcus multilocularis serine:threonine protein phosphatase 2B 0.005 0.1857 0.1857
Trypanosoma cruzi serine/threonine protein phosphatase 2B catalytic subunit A2, putative 0.005 0.1857 0.2367
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.1386 0.1768
Trypanosoma brucei heat shock protein, putative 0.0039 0.1335 0.1702
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0012 0.0085 0.0107
Trypanosoma cruzi heat shock protein 85, putative 0.0031 0.0967 0.1232
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0039 0.1376 0.1754
Echinococcus granulosus dna polymerase eta 0.0017 0.0333 0.0333
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0366 0.0467
Echinococcus granulosus serine:threonine protein phosphatase 2B 0.005 0.1857 0.1857
Entamoeba histolytica CPSF A subunit region protein, putative 0.0033 0.1078 0.1362
Onchocerca volvulus Bile acid receptor homolog 0.0033 0.1073 0.1191
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0366 0.0467
Schistosoma mansoni hypothetical protein 0.0061 0.2403 0.2403
Loa Loa (eye worm) hypothetical protein 0.0033 0.1078 0.1077
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0053 0.2026 0.2583
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0012 0.0103 0.013
Plasmodium falciparum heat shock protein 90, putative 0.0016 0.0269 0.0237
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0033 0.1073 0.1073
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0012 0.0085 0.0107
Echinococcus multilocularis follistatin 0.0023 0.0587 0.0587
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0039 0.1376 0.0948
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0012 0.0085 0.0085
Entamoeba histolytica calcineurin catalytic subunit A, putative 0.005 0.1857 0.2348
Loa Loa (eye worm) cytochrome P450 family protein 0.0029 0.0896 0.0895
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.1376 0.1754
Brugia malayi hypothetical protein 0.0182 0.8074 0.9636
Echinococcus multilocularis 0.0138 0.5969 0.5969
Echinococcus granulosus FK506 binding protein 8 38 kDa 0.0039 0.1376 0.1376
Echinococcus granulosus geminin 0.0201 0.8944 0.8944
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.2026 0.2585
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0421 0.0501
Schistosoma mansoni rotamase 0.004 0.1418 0.1418
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.0366 0.0366
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0177 0.7839 1
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0055 0.007
Loa Loa (eye worm) hypothetical protein 0.0023 0.0587 0.0586
Onchocerca volvulus Phospholipase A2 homolog 0.0189 0.8379 1
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0053 0.2026 0.2026
Plasmodium vivax heat shock protein 86, putative 0.0039 0.1335 0.1612
Echinococcus granulosus serine:threonine protein phosphatase 2B 0.005 0.1857 0.1857
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0031 0.0967 0.7028
Brugia malayi nuclear hormone receptor family member nhr-6 0.0016 0.0257 0.0306
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0224 1 1
Plasmodium vivax peptidyl-prolyl cis-trans isomerase, putative 0.0039 0.1376 0.1665
Onchocerca volvulus 0.0033 0.1073 0.1191
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0018 0.0366 0.0363
Giardia lamblia Heat shock protein HSP 90-alpha 0.0039 0.1335 0.089
Leishmania major phosphatidylinositol 3-kinase, putative 0.0018 0.0366 0.0363
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0421 0.042
Giardia lamblia Heat shock protein HSP 90-alpha 0.0031 0.0967 0.0375
Mycobacterium tuberculosis Conserved hypothetical protein 0.0017 0.0333 0.2421
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0033 0.1073 0.1073
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.1376 0.1756
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0053 0.2026 0.2583
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0053 0.2026 0.2026
Echinococcus granulosus cpg binding protein 0.0037 0.1246 0.1246
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.2606 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0049 0.1811 0.2309
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0877 0.1119
Onchocerca volvulus 0.0039 0.1376 0.1557
Loa Loa (eye worm) hypothetical protein 0.0016 0.0257 0.0256
Loa Loa (eye worm) nuclear hormone receptor 0.0016 0.0257 0.0256
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0042 0.1517 0.1934
Brugia malayi hypothetical protein 0.0012 0.0085 0.01
Loa Loa (eye worm) phosphatidylinositol 3 0.0053 0.2026 0.2025
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0033 0.1073 0.1073
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0033 0.1073 0.128
Loa Loa (eye worm) hypothetical protein 0.0016 0.0257 0.0256
Trichomonas vaginalis DNA polymerase eta, putative 0.0049 0.1811 0.231
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.0023 0.0587 0.0586
Brugia malayi Peptidase family M1 containing protein 0.0012 0.0085 0.01
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0049 0.1811 0.231
Onchocerca volvulus 0.0016 0.0257 0.0208
Toxoplasma gondii peptidylprolyl isomerase 0.0039 0.1373 0.5268
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0177 0.7839 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0503 0.0501
Schistosoma mansoni cpg binding protein 0.0037 0.1246 0.1246
Onchocerca volvulus 0.0039 0.1376 0.1557
Mycobacterium leprae PROBABLE TRIGGER FACTOR (TF) PROTEIN TIG 0.0039 0.1376 1
Trichomonas vaginalis fk506-binding protein, putative 0.0177 0.7839 1
Schistosoma mansoni thyroid hormone receptor 0.0033 0.1073 0.1073
Loa Loa (eye worm) hypothetical protein 0.0019 0.0421 0.042
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0421 0.0421
Leishmania major heat shock protein 83-1 0.0039 0.1335 0.1612
Echinococcus multilocularis heat shock protein 90 0.0031 0.0967 0.0967
Trypanosoma brucei heat shock protein, putative 0.0039 0.1335 0.1702
Trypanosoma brucei DNA polymerase IV, putative 0.0049 0.1811 0.2309
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0224 1 1
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0016 0.0257 0.0256
Onchocerca volvulus Putative organic anion transporter 0.0033 0.1078 0.1197
Brugia malayi Endoplasmin precursor 0.0039 0.1335 0.1592
Echinococcus multilocularis FTZ F1 alpha 0.0033 0.1073 0.1073
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0039 0.1376 0.1754
Schistosoma mansoni nuclear hormone receptor 0.0016 0.0257 0.0257
Onchocerca volvulus 0.0033 0.1078 0.1197
Trypanosoma brucei heat shock protein, putative 0.0039 0.1335 0.1702
Loa Loa (eye worm) hypothetical protein 0.0033 0.1073 0.1072
Wolbachia endosymbiont of Brugia malayi FKBP-type peptidylprolyl isomerase 0.0039 0.1376 1
Echinococcus granulosus Solute carrier organic anion transporter family 0.0033 0.1078 0.1078
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.1444 0.1841
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0039 0.1373 0.1751
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0012 0.0085 0.0085
Schistosoma mansoni RAR-like nuclear receptor 0.0033 0.1073 0.1073
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0421 0.0421
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0025 0.071 0.0904
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0177 0.7839 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0049 0.1811 0.2309
Trypanosoma brucei Aminopeptidase M1, putative 0.0012 0.0085 0.0107
Mycobacterium ulcerans DNA polymerase IV 0.0049 0.1811 0.231
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0012 0.0085 0.0085
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0033 0.1073 0.1073
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0033 0.1073 0.128
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0179 0.7904 1
Giardia lamblia GTOR 0.0053 0.2026 0.1858
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0033 0.1073 0.128
Brugia malayi Peptidase family M1 containing protein 0.0012 0.0085 0.01
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.2348 0.2801
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0033 0.1073 0.128
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0139 0.6056 0.6056
Loa Loa (eye worm) TATA binding protein associated factor 0.0012 0.0085 0.0084
Echinococcus granulosus nuclear receptor nhr 48 0.0016 0.0257 0.0257
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0224 1 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0421 0.0421
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase, putative 0.0039 0.1376 0.1665
Entamoeba histolytica calcineurin catalytic subunit A, putative 0.005 0.1857 0.2348
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0031 0.0967 0.1137
Loa Loa (eye worm) hypothetical protein 0.0017 0.0333 0.0332
Loa Loa (eye worm) hypothetical protein 0.0016 0.0257 0.0256
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0017 0.0333 0.0333
Echinococcus multilocularis expressed protein 0.0023 0.0587 0.0587
Schistosoma mansoni retinoic acid receptor RXR 0.0033 0.1073 0.1073
Loa Loa (eye worm) CYP4Cod1 0.0029 0.0896 0.0895
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0875 0.1117
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0053 0.2026 0.2417
Loa Loa (eye worm) hypothetical protein 0.0033 0.1073 0.1072
Mycobacterium ulcerans heat shock protein 90 0.0031 0.0967 0.1234
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0017 0.0345 0.0345
Echinococcus granulosus serine protein kinase ATM 0.001 0.0001 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.0049 0.1811 0.2309
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0177 0.7839 1
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0031 0.003
Trypanosoma brucei heat shock protein, putative 0.0039 0.1335 0.1702
Toxoplasma gondii aminopeptidase N protein 0.0012 0.0085 0.0323
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0031 0.0967 0.0967
Entamoeba histolytica deoxycytidyl transferase, putative 0.0017 0.0333 0.042
Wolbachia endosymbiont of Brugia malayi FKBP-type peptidylprolyl isomerase 0.0039 0.1376 1
Trichomonas vaginalis heat shock protein, putative 0.0031 0.0967 0.1234
Schistosoma mansoni nuclear hormone receptor 0.0033 0.1073 0.1073
Loa Loa (eye worm) heat shock protein 75 0.0016 0.0269 0.0268
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0016 0.0257 0.0257
Brugia malayi ImpB/MucB/SamB family protein 0.0017 0.0333 0.0396
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.1006 0.1284
Loa Loa (eye worm) hypothetical protein 0.0016 0.0257 0.0256
Brugia malayi Nuclear hormone receptor-like 1 0.0033 0.1073 0.128
Onchocerca volvulus 0.0033 0.1078 0.1197
Trichomonas vaginalis heat shock protein, putative 0.0024 0.0637 0.0812
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0012 0.0085 0.0085
Schistosoma mansoni fk506 binding protein 0.0039 0.1376 0.1376
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.0033 0.1078 0.1078
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0012 0.0085 0.0109
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0023 0.0587 0.0699
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein 0.0039 0.1376 0.5279
Echinococcus granulosus endoplasmin 0.0031 0.0967 0.0967
Brugia malayi Phospholipase A2 family protein 0.0189 0.8379 1
Leishmania major heat shock protein, putative 0.0016 0.0269 0.0237
Brugia malayi sodium-independent organic anion transporter family protein 0.0033 0.1078 0.1285
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.2348 0.2801
Brugia malayi hypothetical protein 0.0016 0.0257 0.0306
Trypanosoma cruzi MFS transporter, putative 0.0033 0.1078 0.1374
Trichomonas vaginalis rotamase, putative 0.0039 0.1373 0.1752
Leishmania major FKBP-type peptidyl-prolyl cis-trans isomerase, putative 0.0138 0.5969 0.7588
Brugia malayi hypothetical protein 0.0012 0.0085 0.01
Brugia malayi SPARC precursor 0.0023 0.0587 0.0699
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0053 0.2026 0.2503
Echinococcus granulosus FTZ F1 alpha 0.0033 0.1073 0.1073
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0017 0.0345 0.0345
Leishmania major DNA polymerase eta, putative 0.0017 0.0333 0.032
Trypanosoma brucei DNA polymerase kappa, putative 0.0049 0.1811 0.2309
Trypanosoma brucei DNA polymerase kappa, putative 0.0049 0.1811 0.2309
Echinococcus multilocularis serine:threonine protein phosphatase 2B 0.005 0.1857 0.1857
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0031 0.0031
Loa Loa (eye worm) cytochrome P450 family protein 0.0029 0.0896 0.0895
Onchocerca volvulus Putative organic anion transporter 0.0033 0.1078 0.1197
Echinococcus granulosus thyroid hormone receptor alpha 0.0016 0.0257 0.0257
Entamoeba histolytica calcineurin catalytic subunit A, putative 0.005 0.1857 0.2348
Leishmania major heat shock protein 83-1 0.0039 0.1335 0.1612
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0013 0.0145 0.0553
Trypanosoma brucei DNA polymerase kappa, putative 0.0049 0.1811 0.2309
Schistosoma mansoni hypothetical protein 0.0039 0.1376 0.1376
Schistosoma mansoni nuclear receptor 0.0016 0.0257 0.0257
Schistosoma mansoni DNA polymerase eta 0.0017 0.0333 0.0333
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0033 0.1073 0.1073
Plasmodium vivax heat shock protein 90, putative 0.0016 0.0269 0.0237
Leishmania major heat shock protein 83-1 0.0039 0.1335 0.1612
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0016 0.0257 0.0257
Chlamydia trachomatis peptidyl-prolyl cis-trans isomerase 0.0039 0.1376 0.5
Loa Loa (eye worm) steroid hormone receptor 0.0033 0.1073 0.1072
Plasmodium vivax splicing factor 3B subunit 3, putative 0.0033 0.1078 0.128
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0012 0.0103 0.013
Schistosoma mansoni protein phosphatase-2b 0.005 0.1857 0.1857
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.1335 0.1702
Echinococcus multilocularis endoplasmin 0.0031 0.0967 0.0967
Trypanosoma brucei unspecified product 0.0012 0.0084 0.0105
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0012 0.0085 0.0109
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0033 0.1073 0.1073
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-30, BmFKBP-30 0.0039 0.1376 0.1641
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0875 0.1117
Brugia malayi nuclear receptor NHR-67 0.0016 0.0257 0.0306
Trypanosoma cruzi serine/threonine protein phosphatase, putative 0.005 0.1857 0.2367
Mycobacterium ulcerans aminopeptidase N PepN 0.0012 0.0085 0.0109
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0017 0.0333 0.0332
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0053 0.2026 0.2583
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-30 0.0039 0.1376 0.1375
Trypanosoma cruzi aminopeptidase, putative 0.0012 0.0085 0.0107
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.1386 0.1768
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0177 0.7839 0.7839
Brugia malayi orphan nuclear receptor NR2E1 0.0016 0.0257 0.0306
Trypanosoma cruzi heat shock protein 90, putative 0.0031 0.0967 0.1232
Giardia lamblia Hypothetical protein 0.0039 0.1376 0.0948
Schistosoma mansoni immunophilin 0.0179 0.7904 0.7904
Entamoeba histolytica aminopeptidase, putative 0.0012 0.0085 0.0106
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.1386 0.1768
Loa Loa (eye worm) hypothetical protein 0.0012 0.0085 0.0084
Loa Loa (eye worm) hypothetical protein 0.0023 0.0587 0.0586
Echinococcus granulosus heat shock protein 0.0039 0.1335 0.1335
Loa Loa (eye worm) hypothetical protein 0.0189 0.8379 0.8379
Plasmodium falciparum heat shock protein 90, putative 0.0016 0.0269 0.0237
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0179 0.7904 1
Leishmania major DNA polymerase kappa, putative 0.0025 0.07 0.0793
Schistosoma mansoni steroid hormone receptor ad4bp 0.0033 0.1073 0.1073
Schistosoma mansoni follistatin 0.0023 0.0587 0.0587
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-33, BmFKBP-33 0.0039 0.1376 0.1641
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0033 0.1073 0.1073
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.2974 0.2974
Echinococcus multilocularis nuclear receptor nhr 48 0.0016 0.0257 0.0257
Toxoplasma gondii aminopeptidase n, putative 0.0012 0.0085 0.0323
Loa Loa (eye worm) hypothetical protein 0.0016 0.0257 0.0256
Schistosoma mansoni heat shock protein 0.0039 0.1335 0.1335
Trypanosoma cruzi DNA polymerase eta, putative 0.0017 0.0333 0.0424
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.1386 0.1768
Echinococcus granulosus dna polymerase kappa 0.0049 0.1811 0.1811
Trypanosoma brucei heat shock protein, putative 0.0039 0.1335 0.1702
Echinococcus granulosus follistatin 0.0023 0.0587 0.0587
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0033 0.1073 0.128
Loa Loa (eye worm) hypothetical protein 0.0033 0.1078 0.1077
Loa Loa (eye worm) hypothetical protein 0.005 0.1857 0.1856
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0017 0.0345 0.0345
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0053 0.2026 0.2583
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0033 0.1073 0.1072
Brugia malayi hypothetical protein 0.0017 0.0345 0.041
Loa Loa (eye worm) hypothetical protein 0.0033 0.1078 0.1077
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0177 0.7839 1
Brugia malayi splicing factor 3B subunit 3 0.0033 0.1078 0.1285
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0366 0.0466
Toxoplasma gondii transporter, major facilitator family protein 0.0033 0.1078 0.4135
Loa Loa (eye worm) hypothetical protein 0.0049 0.1824 0.1823
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0016 0.0257 0.0208
Toxoplasma gondii splicing factor 3b, subunit 3, putative 0.0033 0.1078 0.4134
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0033 0.1073 0.1072
Loa Loa (eye worm) hypothetical protein 0.0033 0.1073 0.1072
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0199 0.0254
Schistosoma mansoni hypothetical protein 0.0019 0.0421 0.0421
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0366 0.0466
Plasmodium vivax endoplasmin, putative 0.0039 0.1335 0.1612
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0177 0.7839 1
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0016 0.0257 0.0257
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.1376 0.1756
Leishmania major heat shock protein 83-1 0.0039 0.1335 0.1612
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.1021 0.1303
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0016 0.0257 0.0306
Loa Loa (eye worm) hypothetical protein 0.0017 0.0345 0.0344
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0016 0.0257 0.0257
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0039 0.1376 0.1754
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0033 0.1073 0.128
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.1386 0.1768
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0012 0.0085 0.0085
Brugia malayi TATA binding protein associated factor 0.0012 0.0085 0.01
Loa Loa (eye worm) hypothetical protein 0.0011 0.0055 0.0054
Schistosoma mansoni zinc finger protein 0.0016 0.0257 0.0257
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein 0.0039 0.1376 0.5279
Echinococcus multilocularis ecdysone induced protein 78C 0.0033 0.1073 0.1073
Trypanosoma brucei DNA polymerase eta, putative 0.0017 0.0333 0.0424
Schistosoma mansoni hypothetical protein 0.0019 0.0421 0.0421
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0016 0.0269 0.0222
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0366 0.0467
Mycobacterium ulcerans hypothetical protein 0.0138 0.5969 0.7615
Onchocerca volvulus 0.0016 0.0257 0.0208
Brugia malayi Steroid receptor seven-up type 2 0.0033 0.1073 0.128
Echinococcus granulosus GPCR family 2 0.0019 0.0421 0.0421
Schistosoma mansoni immunophilin 0.0179 0.7904 0.7904
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0877 0.1119
Brugia malayi hypothetical protein 0.0103 0.4343 0.5183
Onchocerca volvulus Phospholipase A2 homolog 0.0189 0.8379 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.001 0.0001 0.0002
Trypanosoma cruzi FKBP-type peptidylprolyl cis-trans isomerase, putative 0.0039 0.1376 0.1754
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0366 0.0467
Trichomonas vaginalis heat shock protein, putative 0.0031 0.0967 0.1234
Brugia malayi conserved hypotetical protein 0.0016 0.0257 0.0306
Brugia malayi ecdysteroid receptor 0.0033 0.1073 0.128
Echinococcus granulosus FK506 binding protein 2 0.0138 0.5969 0.5969
Brugia malayi hypothetical protein 0.0033 0.1078 0.1285
Trichomonas vaginalis heat shock protein, putative 0.0016 0.0269 0.0343
Leishmania major heat shock protein 83-1 0.0039 0.1335 0.1612
Schistosoma mansoni terminal deoxycytidyl transferase 0.0017 0.0333 0.0333
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0017 0.0345 0.0345
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0025 0.0028
Brugia malayi sodium-independent organic anion transporter family protein 0.0033 0.1078 0.1285
Schistosoma mansoni cpg binding protein 0.0035 0.1153 0.1153
Echinococcus granulosus aminopeptidase N 0.0012 0.0085 0.0085
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0012 0.0085 0.0085
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0345 0.041
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0177 0.7839 0.7839
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.1006 0.1284
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-13, BmFKBP-13 0.0138 0.5969 0.7123
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0023 0.0587 0.2248
Trichomonas vaginalis PIKK family atypical protein kinase 0.001 0.0001 0.0002
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0033 0.1073 0.1191
Trypanosoma cruzi aminopeptidase, putative 0.0012 0.0085 0.0107
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0033 0.1073 0.1073
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0017 0.0333 0.0333
Echinococcus multilocularis geminin 0.0201 0.8944 0.8944
Loa Loa (eye worm) hypothetical protein 0.0016 0.0257 0.0256
Brugia malayi hypothetical protein 0.0017 0.0345 0.041
Plasmodium vivax serine/threonine protein phosphatase 2B catalytic subunit A, putative 0.005 0.1857 0.2285
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0012 0.0103 0.013
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0366 0.0365
Loa Loa (eye worm) hypothetical protein 0.0033 0.1073 0.1072
Trypanosoma cruzi cytochrome P450, putative 0.0029 0.0896 0.1142
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0421 0.0501
Trichomonas vaginalis fk506-binding protein, putative 0.0039 0.1376 0.1756
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0875 0.1117
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0033 0.1073 0.128
Loa Loa (eye worm) hypothetical protein 0.0041 0.1456 0.1455
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0039 0.1373 0.1751
Leishmania major peptidylprolyl isomerase-like protein 0.0177 0.7839 1
Echinococcus multilocularis fk506 binding protein 0.0177 0.7839 0.7839
Leishmania major heat shock protein 83-1 0.0039 0.1335 0.1612
Schistosoma mansoni hypothetical protein 0.0019 0.0421 0.0421
Leishmania major heat shock protein 83-1 0.0039 0.1335 0.1612
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0033 0.1073 0.1073
Trypanosoma cruzi Aminopeptidase M1, putative 0.0012 0.0085 0.0107
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0012 0.0085 0.0107
Trichomonas vaginalis fk506 binding protein, putative 0.0039 0.1376 0.1756
Echinococcus multilocularis agrin 0.0023 0.0587 0.0587
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.045 0.0573
Leishmania major heat shock protein 83-1 0.0039 0.1335 0.1612
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0018 0.0366 0.0466
Wolbachia endosymbiont of Brugia malayi parvulin-like peptidyl-prolyl isomerase, PPID 0.0012 0.0103 0.075
Trypanosoma brucei unspecified product 0.0041 0.1444 0.1841
Leishmania major heat shock protein 83-1 0.0039 0.1335 0.1612
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.004 0.1418 0.1691
Loa Loa (eye worm) hypothetical protein 0.0033 0.1078 0.1077
Trypanosoma brucei DNA polymerase kappa, putative 0.0049 0.1811 0.2309
Schistosoma mansoni protein phosphatase-2b 0.005 0.1857 0.1857
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0033 0.1073 0.1073
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0025 0.07 0.5085
Brugia malayi nuclear hormone receptor 0.0016 0.0257 0.0306
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0023 0.0587 0.2248
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.1021 0.1303
Loa Loa (eye worm) hypothetical protein 0.0033 0.1073 0.1072
Brugia malayi Nuclear hormone receptor E75 0.0016 0.0257 0.0306
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0033 0.1073 0.1072
Trypanosoma brucei heat shock protein, putative 0.0039 0.1335 0.1702
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.1456 0.1736
Entamoeba histolytica heat shock protein 90, putative 0.0039 0.1335 0.1688
Giardia lamblia Grp94/Hsp90 0.0031 0.0967 0.0375
Leishmania major cytochrome p450-like protein 0.0029 0.0896 0.1046
Mycobacterium tuberculosis Probable trigger factor (TF) protein Tig 0.0039 0.1376 1
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0012 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0016 0.0257 0.0256
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0177 0.7839 1
Trypanosoma brucei heat shock protein, putative 0.0039 0.1335 0.1702
Brugia malayi secreted modular calcium-binding protein 1 0.0023 0.0587 0.0699
Schistosoma mansoni agrin 0.0023 0.0587 0.0587
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.1661 0.2119
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0033 0.1073 0.128
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0053 0.2026 0.2026
Toxoplasma gondii heat shock protein 90, putative 0.0039 0.1335 0.5121
Trypanosoma brucei heat shock protein 90, putative 0.0039 0.1335 0.1702
Leishmania major heat shock protein 83-1 0.0039 0.1335 0.1612
Trichomonas vaginalis fk506-binding protein, putative 0.0039 0.1376 0.1756
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.1153 0.1152
Loa Loa (eye worm) peptidase family M1 containing protein 0.0012 0.0085 0.0084
Brugia malayi tailless protein 0.0016 0.0257 0.0306
Trypanosoma cruzi DNA polymerase kappa, putative 0.0049 0.1811 0.2309
Mycobacterium ulcerans DNA polymerase IV 0.0049 0.1811 0.231
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0177 0.7839 1
Onchocerca volvulus 0.0033 0.1078 0.1197
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0033 0.1073 0.128
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.1335 0.1702
Echinococcus multilocularis dna polymerase kappa 0.0049 0.1811 0.1811
Leishmania major fk506-binding protein 1-like protein 0.0177 0.7839 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0049 0.1811 0.2309
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0177 0.7839 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0033 0.1073 0.128
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.115 0.1467
Loa Loa (eye worm) sodium-independent organic anion transporter 0.0033 0.1078 0.1077
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0053 0.2026 0.2562
Brugia malayi ImpB/MucB/SamB family protein 0.0017 0.0333 0.0396
Brugia malayi nuclear receptor RXR 0.0017 0.0345 0.041
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0012 0.0085 0.0107
Loa Loa (eye worm) hypothetical protein 0.006 0.2348 0.2347
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0033 0.1073 0.1073
Loa Loa (eye worm) hypothetical protein 0.0023 0.0587 0.0586
Trypanosoma cruzi Heat shock protein 83, putative 0.0039 0.1335 0.1702
Loa Loa (eye worm) hypothetical protein 0.0033 0.1078 0.1077
Loa Loa (eye worm) hypothetical protein 0.0017 0.0345 0.0344
Leishmania major heat shock protein 83-1 0.0039 0.1335 0.1612
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0023 0.0587 0.0699
Loa Loa (eye worm) hypothetical protein 0.0033 0.1073 0.1072
Loa Loa (eye worm) hypothetical protein 0.0017 0.0345 0.0344
Entamoeba histolytica heat shock protein 90, putative 0.0039 0.1335 0.1688
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0023 0.0587 0.2248
Brugia malayi nuclear receptor NHR-88 0.0033 0.1073 0.128
Loa Loa (eye worm) hypothetical protein 0.0016 0.0257 0.0256
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0039 0.1373 0.1661
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0012 0.0085 0.0085
Trichomonas vaginalis PIKK family atypical protein kinase 0.001 0.0001 0.0002
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0179 0.7904 0.7904
Trypanosoma cruzi heat shock protein 90, putative 0.0023 0.0595 0.0758
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.1515 0.1933
Entamoeba histolytica Ser/Thr protein phosphatase, putative 0.005 0.1857 0.2348
Loa Loa (eye worm) hypothetical protein 0.0023 0.0587 0.0586
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.0366 0.0366
Leishmania major heat shock protein 83-1 0.0039 0.1335 0.1612
Onchocerca volvulus Protein ultraspiracle homolog 0.0033 0.1073 0.1191
Loa Loa (eye worm) hypothetical protein 0.0016 0.0257 0.0256
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.1515 0.1933
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0366 0.0467
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0016 0.0257 0.0257
Trypanosoma brucei heat shock protein 90, putative 0.0039 0.1335 0.1702
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0179 0.7904 0.7904
Toxoplasma gondii aminopeptidase N, putative 0.0012 0.0085 0.0323
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.0012 0.0103 0.0392
Brugia malayi ecdysone receptor 0.0016 0.0257 0.0306
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.1021 0.1303
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.045 0.0573
Loa Loa (eye worm) agrin synaptic family protein 0.0023 0.0587 0.0586
Treponema pallidum heat shock protein 90 0.0031 0.0967 0.1234
Echinococcus multilocularis heat shock protein 90 0.0039 0.1335 0.1335
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0033 0.1073 0.1072
Schistosoma mansoni hypothetical protein 0.0041 0.1456 0.1456
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein 0.0039 0.1376 0.5279
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0366 0.0436
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.001 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0016 0.0257 0.0256
Echinococcus granulosus heat shock protein 90 0.0039 0.1335 0.1335
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0031 0.0967 0.7028
Trypanosoma brucei macrophage infectivity potentiator, precursor, putative 0.0138 0.5969 0.7614
Trypanosoma brucei FKBP-type peptidylprolyl cis-trans isomerase, putative 0.0039 0.1376 0.1754
Schistosoma mansoni nuclear hormone receptor 0.0016 0.0257 0.0257
Brugia malayi nuclear hormone receptor 0.0033 0.1073 0.128
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0022 0.0566 0.0721
Loa Loa (eye worm) hypothetical protein 0.0033 0.1073 0.1072
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0012 0.0085 0.0107
Loa Loa (eye worm) hypothetical protein 0.0011 0.0038 0.0037
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0177 0.7839 0.9355
Toxoplasma gondii protease inhibitor PI2 0.0023 0.0587 0.2248
Loa Loa (eye worm) hypothetical protein 0.0033 0.1073 0.1072
Toxoplasma gondii Hsp90 domain-containing protein 0.0016 0.0269 0.1028
Entamoeba histolytica Ser/Thr protein phosphatase, putative 0.005 0.1857 0.2348
Echinococcus granulosus Nuclear hormone receptor HR96 0.0016 0.0257 0.0257
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0033 0.1073 0.1073
Brugia malayi hypothetical protein 0.0016 0.0257 0.0306
Schistosoma mansoni hypothetical protein 0.0019 0.0421 0.0421
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0023 0.0587 0.0699
Echinococcus multilocularis aminopeptidase N 0.0012 0.0085 0.0085
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.1515 0.1933
Brugia malayi Cytochrome P450 family protein 0.0029 0.0896 0.1068
Onchocerca volvulus 0.0182 0.8074 0.9632
Loa Loa (eye worm) hypothetical protein 0.0033 0.1078 0.1077
Echinococcus granulosus expressed protein 0.004 0.1418 0.1418
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.1204 0.1536
Trichomonas vaginalis heat shock protein, putative 0.0039 0.1335 0.1703
Leishmania major heat shock protein 83-1 0.0039 0.1335 0.1612
Brugia malayi photoreceptor-specific nuclear receptor 0.0033 0.1073 0.128
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0033 0.1073 0.1073
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.0366 0.0366
Loa Loa (eye worm) FKBP5 protein 0.0177 0.7839 0.7838
Trypanosoma cruzi FKBP-type peptidylprolyl cis-trans isomerase, putative 0.0039 0.1376 0.1754
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0877 0.1119
Onchocerca volvulus 0.0033 0.1078 0.1197
Leishmania major heat shock protein 83-1 0.0039 0.1335 0.1612
Echinococcus multilocularis FK506 binding protein 8, 38 kDa 0.0041 0.1441 0.1441
Echinococcus multilocularis splicing factor 3b subunit 3 0.0033 0.1078 0.1078
Trichomonas vaginalis rotamase, putative 0.004 0.1418 0.1809
Trichomonas vaginalis conserved hypothetical protein 0.004 0.1418 0.1809
Brugia malayi sodium-independent organic anion transporter family protein 0.0033 0.1078 0.1285
Loa Loa (eye worm) hypothetical protein 0.0189 0.8379 0.8379
Brugia malayi Nuclear hormone receptor E75 0.0016 0.0257 0.0306
Trypanosoma cruzi serine/threonine protein phosphatase, putative 0.005 0.1857 0.2367
Mycobacterium ulcerans aminopeptidase N PepN 0.0012 0.0085 0.0109
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.045 0.0573
Echinococcus multilocularis Solute carrier organic anion transporter family 0.0033 0.1078 0.1078
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0345 0.041
Brugia malayi CXXC zinc finger family protein 0.0035 0.1153 0.1375
Brugia malayi polk-prov protein 0.0037 0.1256 0.1498
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0177 0.7839 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0085 0.0084
Brugia malayi steroid hormone receptor 0.0033 0.1073 0.128
Schistosoma mansoni endoplasmin 0.0039 0.1335 0.1335
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0177 0.7839 0.7838
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0053 0.2026 0.2562
Leishmania major serine/threonine protein phosphatase 2B catalytic subunit A2, putative 0.005 0.1857 0.2285
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.1335 0.1702
Loa Loa (eye worm) hypothetical protein 0.0039 0.1376 0.1375
Echinococcus multilocularis GPCR, family 2 0.0019 0.0421 0.0421
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0017 0.0345 0.0344
Echinococcus multilocularis dna polymerase eta 0.0017 0.0333 0.0333
Brugia malayi Cytochrome P450 family protein 0.0029 0.0896 0.1068
Loa Loa (eye worm) hypothetical protein 0.0138 0.5991 0.5991
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0029 0.0896 0.1143
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0031 0.0031
Trypanosoma brucei cytochrome P450, putative 0.0029 0.0896 0.1142
Leishmania major heat shock protein 83-1 0.0039 0.1335 0.1612
Brugia malayi Hsp90 protein 0.0016 0.0269 0.032
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0033 0.1073 0.1073
Schistosoma mansoni coup transcription factor 0.0033 0.1073 0.1073
Plasmodium vivax heat shock protein, putative 0.0016 0.0269 0.0237
Leishmania major serine/threonine protein phosphatase, putative 0.005 0.1857 0.2285
Loa Loa (eye worm) hypothetical protein 0.0033 0.1078 0.1077
Trypanosoma brucei aminopeptidase, putative 0.0012 0.0085 0.0107
Trypanosoma cruzi target of rapamycin kinase 3 0.0042 0.1517 0.1934
Schistosoma mansoni endoplasmin 0.0039 0.1335 0.1335
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0039 0.1373 0.1751
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0012 0.0085 0.0085
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0177 0.7839 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0257 0.0256
Brugia malayi hypothetical protein 0.0033 0.1078 0.1285
Echinococcus multilocularis cpg binding protein 0.0037 0.1246 0.1246
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0023 0.0587 0.2248
Leishmania major heat shock protein 83-1 0.0039 0.1335 0.1612
Loa Loa (eye worm) hypothetical protein 0.0012 0.0085 0.0084
Echinococcus multilocularis expressed protein 0.004 0.1418 0.1418
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0138 0.5969 0.7552
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0011 0.0055 0.0207
Brugia malayi nuclear receptor NHR-88 0.0016 0.0257 0.0306
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0016 0.0257 0.0257
Trypanosoma brucei Heat shock protein 83, putative 0.0039 0.1335 0.1702
Schistosoma mansoni thyroid hormone receptor 0.0033 0.1073 0.1073
Trypanosoma brucei DNA polymerase kappa, putative 0.0025 0.07 0.0891
Plasmodium falciparum heat shock protein 90 0.0039 0.1335 0.1612
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0177 0.7839 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0016 0.0257 0.0208
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0033 0.1073 0.1073
Toxoplasma gondii protein phosphatase 2B catalytic subunit, calcineurin family phosphatse superfamily protein 0.005 0.1857 0.7124
Trypanosoma cruzi macrophage infectivity potentiator, precursor, putative 0.0138 0.5969 0.7614
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0033 0.1073 0.128
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0012 0.0085 0.0109
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0033 0.1073 0.1073
Echinococcus granulosus serine:threonine protein kinase SMG1 0.001 0.0001 0.0001
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0016 0.0257 0.0257
Loa Loa (eye worm) hypothetical protein 0.0033 0.1078 0.1077
Loa Loa (eye worm) nuclear receptor NHR-67 0.0016 0.0257 0.0256
Loa Loa (eye worm) hypothetical protein 0.0016 0.0257 0.0256
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0033 0.1073 0.1072
Trypanosoma cruzi heat shock protein, putative 0.0016 0.0269 0.0342
Schistosoma mansoni heat shock protein 0.0016 0.0269 0.0269
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-13 0.0138 0.5969 0.5968
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.1256 0.1601
Trypanosoma cruzi DNA polymerase kappa, putative 0.0049 0.1811 0.2309
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0018 0.0366 0.0466
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0016 0.0257 0.0257
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0017 0.0333 0.0333
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.004 0.1418 0.1417
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0012 0.0085 0.0085
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0177 0.7839 0.9355
Trypanosoma brucei heat shock protein, putative 0.0039 0.1335 0.1702
Schistosoma mansoni hypothetical protein 0.0201 0.8944 0.8944
Schistosoma mansoni heat shock protein 0.0039 0.1335 0.1335
Plasmodium falciparum splicing factor 3B subunit 3, putative 0.0033 0.1078 0.128
Loa Loa (eye worm) DR-78 0.0016 0.0257 0.0256
Echinococcus granulosus splicing factor 3b subunit 3 0.0033 0.1078 0.1078
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0012 0.0085 0.0085
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.1515 0.1933
Trichomonas vaginalis endoplasmin, putative 0.0024 0.0637 0.0812
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0042 0.1517 0.1847
Loa Loa (eye worm) endoplasmin 0.0039 0.1335 0.1334
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0033 0.1073 0.128
Schistosoma mansoni organic anion transporter 0.0033 0.1078 0.1078
Schistosoma mansoni nuclear receptor nhr-48 0.0016 0.0257 0.0257
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0033 0.1073 0.1072
Loa Loa (eye worm) aminopeptidase N 0.0012 0.0085 0.0084
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0033 0.1073 0.1072
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0033 0.1073 0.1073
Trypanosoma brucei Aminopeptidase M1, putative 0.0012 0.0085 0.0107
Echinococcus granulosus organic anion transporting polypeptide 30B 0.0033 0.1078 0.1078
Echinococcus multilocularis heat shock protein 0.0039 0.1335 0.1335
Entamoeba histolytica calcineurin catalytic subunit A, putative 0.005 0.1857 0.2348
Trypanosoma brucei DNA polymerase kappa, putative 0.0049 0.1811 0.2309
Brugia malayi heat shock protein 90 0.0039 0.1335 0.1592
Loa Loa (eye worm) hypothetical protein 0.0016 0.0257 0.0256
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-33 0.0039 0.1376 0.1375
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0139 0.6056 0.6056
Trypanosoma brucei DNA polymerase IV, putative 0.0049 0.1811 0.2309
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0031 0.0967 0.7028
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0016 0.0269 0.0269
Schistosoma mansoni cpg binding protein 0.0037 0.1246 0.1246
Brugia malayi nuclear receptor RXR 0.0016 0.0257 0.0306
Toxoplasma gondii target of rapamycin (TOR), putative 0.004 0.1386 0.5317
Trichomonas vaginalis spliceosomal protein sap, putative 0.0033 0.1078 0.1375
Schistosoma mansoni nuclear receptor 0.0016 0.0257 0.0257
Toxoplasma gondii heat shock protein 75, putative 0.0016 0.0269 0.1028

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.9953 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.1623 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.6234 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.5733 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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