Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bos taurus | Synaptic vesicular amine transporter | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | Synaptic vesicular amine transporter, putative | Get druggable targets OG5_129780 | All targets in OG5_129780 |
Echinococcus granulosus | synaptic vesicular amine transporter | Get druggable targets OG5_129780 | All targets in OG5_129780 |
Brugia malayi | Abnormal catecholamine distribution protein 1 | Get druggable targets OG5_129780 | All targets in OG5_129780 |
Echinococcus multilocularis | synaptic vesicular amine transporter | Get druggable targets OG5_129780 | All targets in OG5_129780 |
Schistosoma japonicum | Synaptic vesicular amine transporter, putative | Get druggable targets OG5_129780 | All targets in OG5_129780 |
Schistosoma mansoni | vesicular amine transporter | Get druggable targets OG5_129780 | All targets in OG5_129780 |
Loa Loa (eye worm) | abnormal catecholamine distribution protein 1 | Get druggable targets OG5_129780 | All targets in OG5_129780 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | vesicular acetylcholine transporter | Synaptic vesicular amine transporter | 517 aa | 520 aa | 36.2 % |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | Synaptic vesicular amine transporter | 517 aa | 477 aa | 38.4 % |
Brugia malayi | vesicular acetylcholine transporter unc-17 | Synaptic vesicular amine transporter | 517 aa | 517 aa | 36.8 % |
Onchocerca volvulus | Synaptic vesicular amine transporter | 517 aa | 476 aa | 38.4 % | |
Onchocerca volvulus | Synaptic vesicular amine transporter | 517 aa | 435 aa | 51.7 % | |
Schistosoma japonicum | ko:K08155 MFS transporter, DHA1 family, solute carrier family 18 (vesicular, putative | Synaptic vesicular amine transporter | 517 aa | 534 aa | 36.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | sterol regulatory element binding protein | 0.1365 | 0.3683 | 0.3683 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.3314 | 1 | 0.5 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.1555 | 0.43 | 1 |
Echinococcus multilocularis | protein patched | 0.1365 | 0.3683 | 0.3683 |
Echinococcus multilocularis | protein dispatched 1 | 0.1365 | 0.3683 | 0.3683 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.3314 | 1 | 0.5 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.1365 | 0.3683 | 0.3683 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.1365 | 0.3683 | 0.3683 |
Loa Loa (eye worm) | hypothetical protein | 0.3314 | 1 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.3314 | 1 | 0.5 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.1365 | 0.3683 | 0.3683 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.3314 | 1 | 1 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.1365 | 0.3683 | 0.3683 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.1555 | 0.43 | 1 |
Schistosoma mansoni | patched 1 | 0.1365 | 0.3683 | 0.3683 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.1365 | 0.3683 | 0.3683 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.3314 | 1 | 0.5 |
Echinococcus granulosus | Protein patched homolog 1 | 0.1365 | 0.3683 | 0.3683 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.1555 | 0.43 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1365 | 0.3683 | 0.3683 |
Brugia malayi | CHE-14 protein | 0.1365 | 0.3683 | 0.3683 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.3314 | 1 | 0.5 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.3314 | 1 | 1 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.1555 | 0.43 | 0.5 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.3314 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 16.7 uM | Inhibitory constant for dopamine uptake into resealed bovine chromaffin granule ghosts through the vesicular monoamine transporter | ChEMBL. | 12801224 |
Ki (binding) | = 16.7 uM | Inhibitory constant for dopamine uptake into resealed bovine chromaffin granule ghosts through the vesicular monoamine transporter | ChEMBL. | 12801224 |
Ratio (binding) | = 1.4 | Km DA/Ki ratio was determined by different ghost preparations | ChEMBL. | 12801224 |
Ratio (binding) | = 1.4 | Km DA/Ki ratio was determined by different ghost preparations | ChEMBL. | 12801224 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.