Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | TATA binding protein associated factor | 0.0026 | 0.0155 | 0.0354 |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.0026 | 0.0155 | 0.084 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0026 | 0.0155 | 0.084 |
Brugia malayi | hypothetical protein | 0.0026 | 0.0155 | 0.0354 |
Echinococcus multilocularis | aminopeptidase N | 0.0026 | 0.0155 | 0.0034 |
Toxoplasma gondii | aminopeptidase N protein | 0.0026 | 0.0155 | 0.084 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0026 | 0.0155 | 0.0034 |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0026 | 0.0155 | 0.084 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0112 | 0.1945 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0027 | 0.0174 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0101 | 0.171 | 0.8342 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0029 | 0.0218 | 0.2399 |
Toxoplasma gondii | thioredoxin reductase | 0.0044 | 0.0526 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0044 | 0.0526 | 0.0411 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0026 | 0.0155 | 0.0034 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.0497 | 1 | 1 |
Trypanosoma cruzi | puromycin-sensitive aminopeptidase-like protein, putative | 0.0026 | 0.0155 | 0.084 |
Echinococcus granulosus | aminopeptidase N | 0.0026 | 0.0155 | 0.0034 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.0026 | 0.0155 | 0.084 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0026 | 0.0155 | 0.0034 |
Brugia malayi | Peptidase family M1 containing protein | 0.0026 | 0.0155 | 0.0354 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0053 | 0.072 | 0.0606 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0026 | 0.0155 | 0.0034 |
Schistosoma mansoni | importin beta-1 | 0.0034 | 0.0307 | 0.0188 |
Loa Loa (eye worm) | glutathione reductase | 0.0044 | 0.0526 | 0.0411 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0026 | 0.0155 | 0.0034 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0026 | 0.0155 | 0.084 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0044 | 0.0526 | 1 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0034 | 0.0307 | 0.4584 |
Brugia malayi | hypothetical protein | 0.0229 | 0.4383 | 1 |
Toxoplasma gondii | aminopeptidase n, putative | 0.0026 | 0.0155 | 0.084 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0026 | 0.0155 | 0.0034 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0045 | 0.0539 | 0.0423 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.072 | 0.0606 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0307 | 0.0188 |
Mycobacterium tuberculosis | Probable reductase | 0.0101 | 0.171 | 0.8342 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0026 | 0.0155 | 0.6461 |
Loa Loa (eye worm) | aminopeptidase N | 0.0026 | 0.0155 | 0.0034 |
Echinococcus multilocularis | Peptidase M1, membrane alanine aminopeptidase, N terminal | 0.0026 | 0.0155 | 0.0034 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.072 | 0.0606 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0034 | 0.0307 | 0.4584 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0045 | 0.0539 | 0.0423 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0218 | 0.0099 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0029 | 0.0218 | 0.2399 |
Trypanosoma brucei | aminopeptidase, putative | 0.0026 | 0.0155 | 0.084 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0026 | 0.0155 | 0.0034 |
Plasmodium vivax | M1-family alanyl aminopeptidase, putative | 0.0026 | 0.0155 | 0.084 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0112 | 0.1945 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0155 | 0.0034 |
Giardia lamblia | GTP-binding nuclear protein RAN/TC4 | 0.0025 | 0.0121 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.072 | 0.0606 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0155 | 0.0034 |
Plasmodium vivax | glutathione reductase, putative | 0.0044 | 0.0526 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0155 | 0.0034 |
Trypanosoma brucei | trypanothione reductase | 0.0044 | 0.0526 | 1 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0026 | 0.0155 | 0.084 |
Brugia malayi | Peptidase family M1 containing protein | 0.0026 | 0.0155 | 0.0354 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0029 | 0.0218 | 0.2399 |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.0026 | 0.0155 | 0.5 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0026 | 0.0155 | 0.0034 |
Entamoeba histolytica | aminopeptidase, putative | 0.0026 | 0.0155 | 0.6461 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0029 | 0.0218 | 0.2399 |
Leishmania major | trypanothione reductase | 0.0044 | 0.0526 | 1 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | 0.0497 | 1 | 1 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0026 | 0.0155 | 0.084 |
Brugia malayi | RNA, U transporter 1 | 0.0096 | 0.1605 | 0.3663 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.072 | 0.0606 |
Leishmania major | importin beta-1 subunit, putative | 0.0027 | 0.0174 | 0.13 |
Schistosoma mansoni | aminopeptidase A (M01 family) | 0.0026 | 0.0155 | 0.0034 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0026 | 0.0155 | 0.084 |
Brugia malayi | hypothetical protein | 0.0026 | 0.0155 | 0.0354 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0029 | 0.0218 | 0.2399 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0101 | 0.171 | 0.8342 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0101 | 0.171 | 0.8342 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0044 | 0.0526 | 1 |
Trypanosoma cruzi | metallo-peptidase, Clan MA(E) Family M1 | 0.0026 | 0.0155 | 0.084 |
Loa Loa (eye worm) | TATA binding protein associated factor | 0.0026 | 0.0155 | 0.0034 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0026 | 0.0155 | 0.084 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0026 | 0.0155 | 0.0034 |
Brugia malayi | hypothetical protein | 0.0029 | 0.0218 | 0.0498 |
Onchocerca volvulus | Phospholipase A2 homolog | 0.0198 | 0.3745 | 1 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0027 | 0.0174 | 1 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0026 | 0.0155 | 0.084 |
Trypanosoma cruzi | puromycin-sensitive aminopeptidase-like protein, putative | 0.0026 | 0.0155 | 0.084 |
Schistosoma mansoni | cytosol alanyl aminopeptidase (M01 family) | 0.0026 | 0.0155 | 0.0034 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0101 | 0.171 | 0.8342 |
Plasmodium vivax | M1-family alanyl aminopeptidase, putative | 0.0026 | 0.0155 | 0.084 |
Brugia malayi | GTP-binding nuclear protein RAN/TC4 | 0.0025 | 0.0121 | 0.0276 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0027 | 0.0174 | 1 |
Schistosoma mansoni | Tata binding protein associated factor (M01 family) | 0.0026 | 0.0155 | 0.0034 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0026 | 0.0155 | 0.0034 |
Brugia malayi | Phospholipase A2 family protein | 0.0198 | 0.3745 | 0.8546 |
Echinococcus granulosus | snurportin 1 | 0.036 | 0.7121 | 0.7085 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.036 | 0.7121 | 0.7085 |
Schistosoma mansoni | hypothetical protein | 0.036 | 0.7121 | 0.7085 |
Loa Loa (eye worm) | hypothetical protein | 0.0198 | 0.3745 | 0.3669 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0026 | 0.0155 | 0.0034 |
Plasmodium falciparum | thioredoxin reductase | 0.0044 | 0.0526 | 1 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0026 | 0.0155 | 0.084 |
Leishmania major | puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0026 | 0.0155 | 0.084 |
Plasmodium falciparum | importin beta, putative | 0.0034 | 0.0307 | 0.4584 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0027 | 0.0174 | 0.13 |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.0026 | 0.0155 | 0.5 |
Plasmodium vivax | importin-beta 2, putative | 0.0034 | 0.0307 | 0.4584 |
Trichomonas vaginalis | importin beta-1, putative | 0.0027 | 0.0174 | 1 |
Toxoplasma gondii | aminopeptidase N, putative | 0.0026 | 0.0155 | 0.084 |
Plasmodium falciparum | M1-family alanyl aminopeptidase | 0.0026 | 0.0155 | 0.084 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0034 | 0.0307 | 0.0188 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0101 | 0.171 | 0.8342 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.072 | 0.0606 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.072 | 0.0606 |
Plasmodium falciparum | glutathione reductase | 0.0044 | 0.0526 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0029 | 0.0218 | 0.2399 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0026 | 0.0155 | 0.0034 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0026 | 0.0155 | 0.6461 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0112 | 0.1945 | 1 |
Onchocerca volvulus | Phospholipase A2 homolog | 0.0198 | 0.3745 | 1 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0112 | 0.1945 | 1 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0026 | 0.0155 | 0.6461 |
Leishmania major | hypothetical protein, conserved | 0.0029 | 0.0218 | 0.2399 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0029 | 0.0218 | 0.2399 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.072 | 0.0606 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0026 | 0.0155 | 0.0034 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0053 | 0.072 | 0.1642 |
Plasmodium falciparum | M1-family alanyl aminopeptidase, putative | 0.0026 | 0.0155 | 0.084 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.0497 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0198 | 0.3745 | 0.3669 |
Brugia malayi | Thioredoxin reductase | 0.0044 | 0.0526 | 0.1201 |
Brugia malayi | Importin beta-1 subunit | 0.0034 | 0.0307 | 0.07 |
Brugia malayi | Peptidase family M1 containing protein | 0.0026 | 0.0155 | 0.0354 |
Echinococcus multilocularis | snurportin 1 | 0.036 | 0.7121 | 0.7085 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0034 | 0.0307 | 0.4584 |
Echinococcus granulosus | importin subunit beta 1 | 0.0034 | 0.0307 | 0.0188 |
Brugia malayi | glutathione reductase | 0.0044 | 0.0526 | 0.1201 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 20.7865 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 23.0999 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (binding) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.