TDR Targets

Basic information

Technical information

TDR Targets ID: 1446569
Name: N-[(2-chlorophenyl)methyl]-3-[1-[2-[(3-ethylp henyl)amino]-2-oxoethyl]-2,4-dioxothieno[3,2- d]pyrimidin-3-yl]propanamide
MW: 525.019 | Formula: C26H25ClN4O4S
H donors: 2 H acceptors: 4 LogP: 3.89 Rotable bonds: 11
Rule of 5 violations (Lipinski): 2
SMILES: CCc1cccc(c1)NC(=O)Cn1c(=O)n(CCC(=O)NCc2ccccc2Cl)c(=O)c2c1ccs2
InChi: 1S/C26H25ClN4O4S/c1-2-17-6-5-8-19(14-17)29-23(33)16-31-21-11-13-36-24(21)25(34)30(26(31)35)12-10-22(32)28-15-18-7-3-4-9-20(18)27/h3-9,11,13-14H,2,10,12,15-16H2,1H3,(H,28,32)(H,29,33)
InChiKey: DDLVNSWCCSNDHR-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[(2-chlorophenyl)methyl]-3-[1-[2-[(3-ethylphenyl)amino]-2-oxo-ethyl]-2,4-dioxo-thieno[3,2-d]pyrimidin-3-yl]propanamide
N-[(2-chlorophenyl)methyl]-3-[1-[2-[(3-ethylphenyl)amino]-2-oxoethyl]-2,4-dioxo-3-thieno[3,2-d]pyrimidinyl]propanamide
N-(2-chlorobenzyl)-3-[1-[2-[(3-ethylphenyl)amino]-2-keto-ethyl]-2,4-diketo-thieno[3,2-d]pyrimidin-3-yl]propionamide
C241-2059
NCGC00105944-01

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	microtubule-associated protein tau	Starlite/ChEMBL	No references
Homo sapiens	ubiquitin specific peptidase 1	Starlite/ChEMBL	No references
Homo sapiens	tumor protein p53	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	microtubule-associated protein tau	Get druggable targets OG5_133504	All targets in OG5_133504
Echinococcus multilocularis	microtubule associated protein 2	Get druggable targets OG5_133504	All targets in OG5_133504
Echinococcus multilocularis	tumor protein p63	Get druggable targets OG5_140038	All targets in OG5_140038
Schistosoma japonicum	ko:K04380 microtubule-associated protein tau, putative	Get druggable targets OG5_133504	All targets in OG5_133504
Echinococcus granulosus	tumor protein p63	Get druggable targets OG5_140038	All targets in OG5_140038
Echinococcus granulosus	microtubule associated protein 2	Get druggable targets OG5_133504	All targets in OG5_133504

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0262	0.07	0.07
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0262	0.07	0.07
Loa Loa (eye worm)	steroid hormone receptor	0.0262	0.07	0.0727
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.163	0.4822	0.8591
Schistosoma mansoni	retinoic acid receptor RXR	0.0262	0.07	0.1226
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0284	0.0294
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0138	0.0328	0.0561
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0123	0.0284	0.0284
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0262	0.07	0.0727
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0098	0.0207	0.0401
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0123	0.0284	0.0294
Echinococcus granulosus	microtubule associated protein 2	0.0833	0.2423	0.501
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0262	0.07	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0098	0.0207	0.0401
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0284	0.0294
Echinococcus granulosus	FTZ F1 alpha	0.0262	0.07	0.1427
Schistosoma mansoni	hypothetical protein	0.0038	0.0025	0.0019
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0262	0.07	0.1226
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0262	0.07	0.0727
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0262	0.07	0.1226
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0025	0.0026
Onchocerca volvulus	Protein ultraspiracle homolog	0.0262	0.07	1
Loa Loa (eye worm)	hypothetical protein	0.0138	0.0328	0.0341
Schistosoma mansoni	nuclear hormone receptor	0.0123	0.0284	0.0482
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0123	0.0284	0.0561
Brugia malayi	nuclear receptor NHR-88	0.0262	0.07	0.07
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0262	0.07	0.1427
Brugia malayi	Nuclear hormone receptor E75	0.0123	0.0284	0.0284
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0123	0.0284	0.3155
Echinococcus granulosus	tumor protein p63	0.0408	0.1141	0.2344
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0262	0.07	0.07
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.3225	0.9628	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0055	0.0077	0.0077
Echinococcus granulosus	thyroid hormone receptor alpha	0.0123	0.0284	0.0561
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0262	0.07	0.1427
Brugia malayi	nuclear receptor RXR	0.0138	0.0328	0.0328
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0262	0.07	0.1226
Schistosoma mansoni	thyroid hormone receptor	0.1891	0.561	1
Loa Loa (eye worm)	hypothetical protein	0.0262	0.07	0.0727
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0284	0.0294
Brugia malayi	hypothetical protein	0.0138	0.0328	0.0328
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0098	0.0207	0.0344
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, putative	0.0033	0.0012	0.5
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0262	0.07	0.07
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0262	0.07	0.1226
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0262	0.07	0.07
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0123	0.0284	0.0284
Brugia malayi	nuclear receptor NHR-67	0.0123	0.0284	0.0284
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0262	0.07	0.1427
Loa Loa (eye worm)	hypothetical protein	0.0262	0.07	0.0727
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0284	0.0294
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0055	0.0077	0.0077
Onchocerca volvulus		0.0123	0.0284	0.3155
Loa Loa (eye worm)	Pin1-type peptidyl-prolyl cis-trans isomerase	0.0034	0.0014	0.0015
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0138	0.0328	0.0561
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0262	0.07	0.1226
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0123	0.0284	0.0294
Brugia malayi	nuclear hormone receptor	0.0123	0.0284	0.0284
Toxoplasma gondii	peptidylprolyl isomerase	0.0033	0.0012	0.5
Loa Loa (eye worm)	nuclear hormone receptor	0.0123	0.0284	0.0294
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0262	0.07	0.1226
Echinococcus granulosus	nuclear receptor nhr 48	0.0123	0.0284	0.0561
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0284	0.0294
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0123	0.0284	0.0561
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0262	0.07	0.1226
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0098	0.0207	0.0344
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0098	0.0207	0.0344
Brugia malayi	Nuclear hormone receptor E75	0.0123	0.0284	0.0284
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.163	0.4822	1
Loa Loa (eye worm)	hypothetical protein	0.0138	0.0328	0.0341
Loa Loa (eye worm)	hypothetical protein	0.0262	0.07	0.0727
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0138	0.0328	0.0653
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0262	0.07	0.1427
Loa Loa (eye worm)	hypothetical protein	0.321	0.9584	0.9954
Schistosoma mansoni	hypothetical protein	0.163	0.4822	0.8591
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0262	0.07	0.1427
Brugia malayi	nuclear hormone receptor	0.0262	0.07	0.07
Loa Loa (eye worm)	hypothetical protein	0.0138	0.0328	0.0341
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0262	0.07	0.07
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0123	0.0284	0.3155
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0262	0.07	0.07
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0262	0.07	0.1427
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0284	0.0294
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0262	0.07	0.07
Loa Loa (eye worm)	hypothetical protein	0.0138	0.0328	0.0341
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0284	0.0294
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0033	0.0012	1
Brugia malayi	hypothetical protein	0.0123	0.0284	0.0284
Brugia malayi	Nuclear hormone receptor-like 1	0.3225	0.9628	0.9628
Brugia malayi	ecdysteroid receptor	0.0262	0.07	0.07
Trichomonas vaginalis	rotamase, putative	0.0034	0.0014	1
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase/rotamase, putative	0.0033	0.0012	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0098	0.0207	0.0344
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0262	0.07	0.07
Loa Loa (eye worm)	hypothetical protein	0.0262	0.07	0.0727
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0014	1
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0033	0.0012	1
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0262	0.07	0.1226
Loa Loa (eye worm)	cytochrome P450 family protein	0.0031	0.0006	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0077	0.008
Echinococcus multilocularis	ecdysone induced protein 78C	0.0262	0.07	0.1226
Echinococcus multilocularis	FTZ F1 alpha	0.0262	0.07	0.1226
Brugia malayi	steroid hormone receptor	0.0262	0.07	0.07
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0262	0.07	0.07
Schistosoma mansoni	nuclear receptor	0.0123	0.0284	0.0482
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0123	0.0284	0.0482
Schistosoma mansoni	nuclear receptor nhr-48	0.0123	0.0284	0.0482
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0123	0.0284	0.0482
Brugia malayi	orphan nuclear receptor NR2E1	0.0123	0.0284	0.0284
Schistosoma mansoni	RAR-like nuclear receptor	0.0262	0.07	0.1226
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0284	0.0294
Schistosoma mansoni	microtubule-associated protein tau	0.0833	0.2423	0.4304
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0262	0.07	0.0727
Loa Loa (eye worm)	hypothetical protein	0.006	0.0092	0.0095
Schistosoma mansoni	nuclear receptor	0.0123	0.0284	0.0482
Schistosoma mansoni	coup transcription factor	0.0262	0.07	0.1226
Loa Loa (eye worm)	hypothetical protein	0.0262	0.07	0.0727
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0262	0.07	0.0727
Schistosoma mansoni	thyroid hormone receptor	0.1891	0.561	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0262	0.07	0.1226
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0055	0.0077	0.008
Brugia malayi	hypothetical protein	0.0123	0.0284	0.0284
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0262	0.07	0.0727
Brugia malayi	hypothetical protein	0.0138	0.0328	0.0328
Loa Loa (eye worm)	DR-78	0.0123	0.0284	0.0294
Onchocerca volvulus		0.0123	0.0284	0.3155
Brugia malayi	latrophilin 2 splice variant baaae	0.0038	0.0025	0.0025
Echinococcus multilocularis	tumor protein p63	0.0408	0.1141	0.2014
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0098	0.0207	0.0207
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0262	0.07	0.07
Brugia malayi	photoreceptor-specific nuclear receptor	0.0262	0.07	0.07
Brugia malayi	nuclear receptor NHR-88	0.0123	0.0284	0.0284
Loa Loa (eye worm)	hypothetical protein	0.0138	0.0328	0.0341
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0262	0.07	0.1226
Echinococcus multilocularis	thyroid hormone receptor alpha	0.1891	0.561	1
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0262	0.07	0.1226
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0098	0.0207	0.0215
Loa Loa (eye worm)	hypothetical protein	0.0262	0.07	0.0727
Echinococcus multilocularis	microtubule associated protein 2	0.0833	0.2423	0.4304
Loa Loa (eye worm)	hypothetical protein	0.0262	0.07	0.0727
Onchocerca volvulus	Bile acid receptor homolog	0.0262	0.07	1
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0123	0.0284	0.0482
Schistosoma mansoni	cellular tumor antigen P53	0.006	0.0092	0.0139
Brugia malayi	Nuclear hormone receptor-like 1	0.3225	0.9628	0.9628
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0123	0.0284	0.0482
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0123	0.0284	0.0482
Loa Loa (eye worm)	hypothetical protein	0.0262	0.07	0.0727
Schistosoma mansoni	nuclear hormone receptor	0.0262	0.07	0.1226
Brugia malayi	nuclear receptor RXR	0.0123	0.0284	0.0284
Brugia malayi	conserved hypotetical protein	0.0123	0.0284	0.0284
Echinococcus granulosus	ecdysone induced protein 78C	0.0262	0.07	0.1427
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0284	0.0294
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0284	0.0294
Brugia malayi	nuclear hormone receptor family member odr-7	0.0123	0.0284	0.0284
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0029	0	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0262	0.07	0.0727
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0098	0.0207	0.0344
Brugia malayi	tailless protein	0.0123	0.0284	0.0284
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0262	0.07	0.1427
Echinococcus multilocularis	nuclear receptor nhr 48	0.0123	0.0284	0.0482
Schistosoma mansoni	zinc finger protein	0.0123	0.0284	0.0482
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0262	0.07	0.1226
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0123	0.0284	0.0561
Brugia malayi	ecdysone receptor	0.0123	0.0284	0.0284
Schistosoma mansoni	nuclear hormone receptor	0.0123	0.0284	0.0482
Brugia malayi	Steroid receptor seven-up type 2	0.0262	0.07	0.07
Onchocerca volvulus		0.0262	0.07	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0262	0.07	0.07
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0123	0.0284	0.0482
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0123	0.0284	0.0561
Brugia malayi	Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1	0.0034	0.0014	0.0014
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0123	0.0284	0.0482
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0284	0.0294
Leishmania major	peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative	0.0033	0.0012	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0262	0.07	0.0727
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0138	0.0328	0.0561
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0262	0.07	0.07
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0262	0.07	0.1226
Brugia malayi	Cytochrome P450 family protein	0.0031	0.0006	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0284	0.0294

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (binding)	= 12.5893 um	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ]	ChEMBL.	No reference
Potency (functional)	= 12.5893 um	PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	15.8489 uM	PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 25.1189 um	PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Nonpermissive Temperature. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	26.1216 uM	PUBCHEM_BIOASSAY: Acumen qHTS Assay for Inhibitors of the mTORC1 Signaling Pathway in MEF (Tsc2-/-, p53-/-) Cells: Sytravon. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2660, AID2666, AID2667, AID2668, AID2681, AID504465]	ChEMBL.	No reference
Potency (functional)	= 31.6228 um	PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Permissive Temperature. (Class of assay: confirmatory) [Related pubchem assays: 902 ]	ChEMBL.	No reference
Potency (functional)	= 39.8107 um	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1595518

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1446569