Detailed information for compound 1446982

Basic information

Technical information
  • TDR Targets ID: 1446982
  • Name: (E)-2-(1,3-dithiolan-2-ylidene)-5-furan-2-yl- 3-oxopent-4-enoic acid
  • MW: 282.335 | Formula: C12H10O4S2
  • H donors: 1 H acceptors: 3 LogP: 2.67 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)C(=C1SCCS1)C(=O)/C=C/c1ccco1
  • InChi: 1S/C12H10O4S2/c13-9(4-3-8-2-1-5-16-8)10(11(14)15)12-17-6-7-18-12/h1-5H,6-7H2,(H,14,15)/b4-3+
  • InChiKey: HKHAYBJVVCMCFI-ONEGZZNKSA-N  


Substructure search Similarity search

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Synonyms

  • 2-(1,3-dithiolan-2-ylidene)-5-furan-2-yl-3-oxopent-4-enoic acid
  • (E)-2-(1,3-dithiolan-2-ylidene)-5-(2-furyl)-3-oxo-pent-4-enoic acid
  • 2-(1,3-dithiolan-2-ylidene)-5-(2-furyl)-3-oxo-pent-4-enoic acid
  • (E)-2-(1,3-dithiolan-2-ylidene)-5-(2-furyl)-3-oxopent-4-enoic acid
  • 2-(1,3-dithiolan-2-ylidene)-5-(2-furyl)-3-oxopent-4-enoic acid
  • (E)-2-(1,3-dithiolan-2-ylidene)-5-(2-furyl)-3-keto-pent-4-enoic acid
  • 2-(1,3-dithiolan-2-ylidene)-5-(2-furyl)-3-keto-pent-4-enoic acid
  • (E)-2-(1,3-dithiolan-2-ylidene)-5-furan-2-yl-3-oxo-pent-4-enoic acid
  • 2-(1,3-dithiolan-2-ylidene)-5-furan-2-yl-3-oxo-pent-4-enoic acid
  • SMR000161795
  • 2-(1,3-dithiolan-2-ylidene)-5-(2-furyl)-3-oxo-4-pentenoic acid
  • ST036850
  • MLS000540779

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens peptidylprolyl cis/trans isomerase, NIMA-interacting 1 Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), eta Starlite/ChEMBL No references
Homo sapiens Werner syndrome, RecQ helicase-like Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens tyrosyl-DNA phosphodiesterase 1 Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references
Homo sapiens snurportin 1 No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania mexicana tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Neospora caninum peptidyl-prolyl cis-trans isomerase NIMA- interacting 1, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma congolense peptidyl-prolyl cis-trans isomerase/rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma congolense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Toxoplasma gondii peptidylprolyl isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Babesia bovis peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium parvum DinB/family X-type DNA polymerase Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana Get druggable targets OG5_128521 All targets in OG5_128521
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni rotamase Get druggable targets OG5_128367 All targets in OG5_128367
Candida albicans peptidylprolyl cis/trans isomerase isolated by functional complementation of S. cerevisiae ESS1 (YJR017C) which interacts with t Get druggable targets OG5_128367 All targets in OG5_128367
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans peptidylprolyl cis/trans isomerase isolated by functional complementation of S. cerevisiae ESS1 (YJR017C) which interacts with t Get druggable targets OG5_128367 All targets in OG5_128367
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania braziliensis tyrosyl-DNA phosphodiesterase, putative;with=GeneDB:LinJ33_V3.3210 Get druggable targets OG5_129037 All targets in OG5_129037
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma mansoni tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma mansoni DNA polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis expressed protein Get druggable targets OG5_128367 All targets in OG5_128367
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania mexicana peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_129037 All targets in OG5_129037
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
Trypanosoma brucei gambiense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus expressed protein Get druggable targets OG5_128367 All targets in OG5_128367
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus granulosus transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania infantum peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania infantum tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum Pc21g17280 protein, related Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Schistosoma japonicum ko:K09578 peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, putative Get druggable targets OG5_128367 All targets in OG5_128367
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Leishmania donovani peptidyl-prolyl cis-trans isomerase/rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein Get druggable targets OG5_129037 All targets in OG5_129037
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative Get druggable targets OG5_129037 All targets in OG5_129037
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 Get druggable targets OG5_128367 All targets in OG5_128367
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum tyrosyl-DNA phodphodiesterase 1 (tdp1) Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K01113 phosphodiesterase/alkaline phosphatase D [EC3.1.4.1], putative Get druggable targets OG5_129037 All targets in OG5_129037
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Leishmania major peptidyl-prolyl cis-trans isomerase, putative peptidylprolyl cis/trans isomerase, NIMA-interacting 1 163 aa 133 aa 27.8 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0101 0.106 0.1623
Toxoplasma gondii preprocathepsin c precursor, putative 0.0101 0.106 0.1623
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0146 0.021
Leishmania major hypothetical protein, conserved 0.003 0.0205 0.0301
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0101 0.106 0.1607
Brugia malayi RNA, U transporter 1 0.0099 0.1041 0.1594
Plasmodium vivax unspecified product 0.018 0.2031 0.3123
Schistosoma mansoni cathepsin F (C01 family) 0.0545 0.6482 0.6482
Echinococcus granulosus cathepsin L 0.0101 0.106 0.106
Entamoeba histolytica cysteine protease, putative 0.0281 0.3258 0.5009
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0101 0.106 0.106
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0101 0.106 0.1607
Loa Loa (eye worm) hypothetical protein 0.0062 0.0596 0.0905
Schistosoma mansoni hypothetical protein 0.0049 0.0433 0.0433
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0146 0.0146
Entamoeba histolytica cysteine proteinase, putative 0.0545 0.6482 1
Brugia malayi Cathepsin L-like precursor 0.0545 0.6482 1
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0101 0.106 1
Entamoeba histolytica cysteine protease, putative 0.0281 0.3258 0.5009
Trypanosoma brucei DNA polymerase eta, putative 0.0077 0.0777 0.1186
Brugia malayi beta-lactamase family protein 0.0043 0.0364 0.0547
Mycobacterium tuberculosis Conserved hypothetical protein 0.0047 0.0402 0.0134
Loa Loa (eye worm) hypothetical protein 0.0365 0.4284 0.6604
Brugia malayi Papain family cysteine protease containing protein 0.0101 0.106 0.1623
Trypanosoma cruzi DNA polymerase eta, putative 0.0077 0.0777 0.1186
Trypanosoma brucei unspecified product 0.0032 0.0226 0.0333
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0456 0.0456
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0728 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0545 0.6482 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0101 0.106 0.106
Onchocerca volvulus 0.0545 0.6482 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0365 0.4284 0.6604
Leishmania major GTP-binding protein, putative 0.0026 0.0146 0.021
Giardia lamblia Cathepsin B precursor 0.0101 0.106 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0101 0.106 0.1623
Entamoeba histolytica cysteine protease, putative 0.0281 0.3258 0.5009
Echinococcus granulosus cathepsin L 0.0281 0.3258 0.3258
Echinococcus multilocularis cathepsin L 0.0101 0.106 0.106
Loa Loa (eye worm) hypothetical protein 0.0043 0.0364 0.0547
Echinococcus multilocularis dna polymerase kappa 0.0047 0.0402 0.0402
Schistosoma mansoni importin beta-1 0.0035 0.0258 0.0258
Giardia lamblia Cathepsin B precursor 0.0101 0.106 1
Loa Loa (eye worm) fibroinase 0.0545 0.6482 1
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0022 0.0019
Schistosoma mansoni cathepsin C 0.0101 0.106 0.106
Brugia malayi CHE-14 protein 0.0051 0.0456 0.0689
Giardia lamblia Hypothetical protein 0.0101 0.106 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.0402 0.0606
Loa Loa (eye worm) hypothetical protein 0.0101 0.106 0.1623
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0281 0.3258 0.3258
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0281 0.3258 0.5009
Onchocerca volvulus 0.0545 0.6482 1
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0101 0.106 0.1623
Entamoeba histolytica hypothetical protein 0.0028 0.0178 0.0241
Schistosoma mansoni rotamase 0.004 0.0326 0.0326
Trypanosoma cruzi cysteine proteinase, putative 0.0281 0.3258 0.5019
Entamoeba histolytica cysteine protease, putative 0.0281 0.3258 0.5009
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0545 0.6482 1
Leishmania major cathepsin L-like protease 0.0545 0.6482 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0545 0.6482 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0545 0.6482 0.6482
Entamoeba histolytica cysteine protease, putative 0.0101 0.106 0.1607
Loa Loa (eye worm) hypothetical protein 0.018 0.2031 0.3123
Loa Loa (eye worm) hypothetical protein 0.0101 0.106 0.1623
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0146 0.021
Schistosoma mansoni cathepsin B (C01 family) 0.0101 0.106 0.106
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0728 0.0728
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0402 0.0606
Brugia malayi beta-lactamase 0.0043 0.0364 0.0547
Giardia lamblia Cathepsin L-like protease 0.0101 0.106 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0146 0.021
Schistosoma mansoni cathepsin F (C01 family) 0.0365 0.4284 0.4284
Schistosoma mansoni hypothetical protein 0.0049 0.0433 0.0433
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0364 0.0364
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0545 0.6482 1
Loa Loa (eye worm) hypothetical protein 0.018 0.2031 0.3123
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0101 0.106 0.1623
Giardia lamblia Cathepsin L precursor 0.0101 0.106 1
Echinococcus multilocularis cysteine protease 0.0545 0.6482 0.6482
Echinococcus granulosus transcription factor Dp 1 0.0046 0.0396 0.0396
Entamoeba histolytica cysteine proteinase, putative 0.0545 0.6482 1
Plasmodium falciparum serine repeat antigen 1 0.0101 0.106 0.1623
Trypanosoma cruzi cysteine peptidase, putative 0.0545 0.6482 1
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.1906 0.1906
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0101 0.106 0.1623
Echinococcus multilocularis protein dispatched 1 0.0058 0.0544 0.0544
Trypanosoma cruzi cysteine peptidase, putative 0.0281 0.3258 0.5019
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0101 0.106 0.106
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0545 0.6482 1
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0456 0.0456
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0101 0.106 0.1607
Trypanosoma cruzi DNA polymerase eta, putative 0.0045 0.0385 0.058
Giardia lamblia Cysteine protease 0.0101 0.106 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0545 0.6482 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0545 0.6482 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0101 0.106 0.106
Trichomonas vaginalis esterase, putative 0.0043 0.0364 0.0529
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0365 0.4284 0.6597
Giardia lamblia Cathepsin L precursor 0.0101 0.106 1
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.008 0.0806 0.123
Loa Loa (eye worm) hypothetical protein 0.0051 0.0456 0.0689
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0101 0.106 0.1607
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0456 0.0456
Loa Loa (eye worm) cathepsin B 0.0101 0.106 0.1623
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0545 0.6482 1
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0101 0.106 0.106
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0728 0.1274
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.1906 0.1906
Brugia malayi Importin beta-1 subunit 0.0035 0.0258 0.0384
Brugia malayi cathepsin L precursor 0.0101 0.106 0.1623
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0101 0.106 0.106
Entamoeba histolytica cysteine proteinase, putative 0.0365 0.4284 0.6597
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0101 0.106 0.1607
Mycobacterium ulcerans beta-lactamase 0.0043 0.0364 0.4929
Mycobacterium ulcerans lipase LipD 0.0043 0.0364 0.4929
Plasmodium falciparum serine repeat antigen 9 0.0101 0.106 0.1623
Echinococcus multilocularis cathepsin L cysteine protease 0.0545 0.6482 0.6482
Schistosoma mansoni hypothetical protein 0.0049 0.0433 0.0433
Entamoeba histolytica cysteine proteinase, putative 0.0281 0.3258 0.5009
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0101 0.106 0.1607
Echinococcus granulosus dna polymerase kappa 0.0047 0.0402 0.0402
Echinococcus granulosus cathepsin l1 0.0365 0.4284 0.4284
Entamoeba histolytica cysteine proteinase 1, putative 0.0281 0.3258 0.5009
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.008 0.0806 0.123
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0101 0.106 0.1607
Brugia malayi Cathepsin L-like precursor 0.0365 0.4284 0.6604
Brugia malayi hypothetical protein 0.002 0.0073 0.0098
Brugia malayi hypothetical protein 0.003 0.0205 0.0301
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0545 0.6482 1
Brugia malayi Cathepsin L-like precursor 0.0545 0.6482 1
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.1284 0.1953
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0364 0.0547
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0364 0.5
Schistosoma mansoni DNA polymerase IV / kappa 0.0014 0.001 0.001
Entamoeba histolytica cysteine protease, putative 0.0281 0.3258 0.5009
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0101 0.106 0.1623
Schistosoma mansoni blooms syndrome DNA helicase 0.0023 0.0113 0.0113
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0545 0.6482 0.6482
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0364 0.0547
Loa Loa (eye worm) hypothetical protein 0.0043 0.0364 0.0547
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0101 0.106 0.106
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0101 0.106 0.1623
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0545 0.6482 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0545 0.6482 1
Schistosoma mansoni hypothetical protein 0.0372 0.4368 0.4368
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0545 0.6482 1
Onchocerca volvulus 0.0101 0.106 0.1138
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0545 0.6482 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0545 0.6482 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0402 0.0606
Schistosoma mansoni hypothetical protein 0.0049 0.0433 0.0433
Giardia lamblia Cathepsin L precursor 0.0101 0.106 1
Giardia lamblia Cathepsin B precursor 0.0101 0.106 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0047 0.0402 0.0606
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0101 0.106 0.106
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0101 0.106 0.1607
Brugia malayi beta-lactamase family protein 0.0043 0.0364 0.0547
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0364 0.0547
Brugia malayi fibroinase precursor 0.0101 0.106 0.1623
Plasmodium vivax vivapain-1 0.0281 0.3258 0.5019
Loa Loa (eye worm) hypothetical protein 0.0101 0.106 0.1623
Plasmodium falciparum serine repeat antigen 3 0.0101 0.106 0.1623
Leishmania major cathepsin L-like protease 0.0545 0.6482 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0728 0.0728
Leishmania major cathepsin L-like protease 0.0545 0.6482 1
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0281 0.3258 0.5019
Brugia malayi Papain family cysteine protease containing protein 0.0281 0.3258 0.5019
Echinococcus multilocularis dna polymerase eta 0.0077 0.0777 0.0777
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0101 0.106 0.1607
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.002 0.0073 0.0097
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0101 0.106 0.106
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0039 0.0314 0.047
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0226 0.0333
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0101 0.106 0.1623
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0364 0.0547
Brugia malayi Papain family cysteine protease containing protein 0.0281 0.3258 0.5019
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0101 0.106 0.1623
Brugia malayi ImpB/MucB/SamB family protein 0.0077 0.0777 0.1186
Plasmodium falciparum serine repeat antigen 8 0.0101 0.106 0.1623
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0045 0.0385 0.058
Giardia lamblia Cathepsin B precursor 0.0101 0.106 1
Echinococcus granulosus cathepsin b 0.0101 0.106 0.106
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0728 0.1109
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0402 0.0606
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0456 0.0689
Echinococcus multilocularis cathepsin b 0.0101 0.106 0.106
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0545 0.6482 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0047 0.0402 0.0402
Entamoeba histolytica Ran family GTPase 0.0026 0.0146 0.0192
Plasmodium falciparum importin beta, putative 0.0035 0.0258 0.0384
Schistosoma mansoni cathepsin F (C01 family) 0.0545 0.6482 0.6482
Onchocerca volvulus Cathepsin L homolog 0.0545 0.6482 1
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.008 0.0806 0.123
Onchocerca volvulus Cathepsin L homolog 0.0101 0.106 0.1138
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0364 0.0529
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0101 0.106 0.1623
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0205 0.0301
Toxoplasma gondii peptidylprolyl isomerase 0.0039 0.0314 0.047
Leishmania major cathepsin L-like protease 0.0545 0.6482 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0281 0.3258 0.3258
Brugia malayi Papain family cysteine protease containing protein 0.0101 0.106 0.1623
Onchocerca volvulus 0.0365 0.4284 0.6407
Entamoeba histolytica hypothetical protein 0.0101 0.106 0.1607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0545 0.6482 1
Entamoeba histolytica cysteine protease, putative 0.0281 0.3258 0.5009
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0364 0.0547
Schistosoma mansoni microtubule-associated protein tau 0.0833 1 1
Echinococcus granulosus cathepsin l1 0.0545 0.6482 0.6482
Trichomonas vaginalis conserved hypothetical protein 0.0101 0.106 0.1607
Loa Loa (eye worm) hypothetical protein 0.0545 0.6482 1
Echinococcus multilocularis cathepsin b 0.0101 0.106 0.106
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0205 0.0301
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.0402 0.0606
Plasmodium vivax importin-beta 2, putative 0.0035 0.0258 0.0384
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0226 0.0333
Trypanosoma brucei unspecified product 0.0047 0.0402 0.0606
Giardia lamblia DINP protein human, muc B family 0.0047 0.0402 0.3733
Mycobacterium ulcerans hypothetical protein 0.0043 0.0364 0.4929
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0364 0.4929
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0101 0.106 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0402 0.0606
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0545 0.6482 1
Schistosoma mansoni cathepsin S (C01 family) 0.0101 0.106 0.106
Schistosoma mansoni patched 1 0.0051 0.0456 0.0456
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0545 0.6482 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0545 0.6482 1
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0364 0.0529
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.0402 0.0606
Onchocerca volvulus 0.0545 0.6482 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0101 0.106 0.1623
Echinococcus multilocularis cathepsin L 0.0281 0.3258 0.3258
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0101 0.106 0.1607
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0178 0.0241
Entamoeba histolytica cysteine protease, putative 0.0101 0.106 0.1607
Giardia lamblia Encystation-specific protease 0.0101 0.106 1
Plasmodium falciparum serine repeat antigen 4 0.0101 0.106 0.1623
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0728 0.1109
Entamoeba histolytica cysteine protease, putative 0.0281 0.3258 0.5009
Brugia malayi Cathepsin L-like precursor 0.0365 0.4284 0.6604
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0146 0.021
Entamoeba histolytica cysteine proteinase, putative 0.0281 0.3258 0.5009
Brugia malayi Papain family cysteine protease containing protein 0.0545 0.6482 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0364 0.0547
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0205 0.0301
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0039 0.0314 0.047
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0205 0.0301
Loa Loa (eye worm) hypothetical protein 0.0043 0.0364 0.0547
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0047 0.0402 0.0606
Trypanosoma cruzi major cysteine proteinase, putative 0.0101 0.106 0.1623
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0545 0.6482 1
Loa Loa (eye worm) hypothetical protein 0.0101 0.106 0.1623
Giardia lamblia Cathepsin B precursor 0.0101 0.106 1
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.008 0.0806 0.1213
Giardia lamblia Cathepsin L precursor 0.0101 0.106 1
Giardia lamblia Cathepsin B precursor 0.0101 0.106 1
Plasmodium vivax vivapain-3 0.0281 0.3258 0.5019
Echinococcus multilocularis microtubule associated protein 2 0.0833 1 1
Leishmania major DNA polymerase eta, putative 0.0045 0.0385 0.058
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0402 0.0606
Leishmania major cathepsin L-like protease 0.0545 0.6482 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0806 0.123
Giardia lamblia Cysteine protease 0.0101 0.106 1
Loa Loa (eye worm) hypothetical protein 0.0365 0.4284 0.6604
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0101 0.106 0.106
Giardia lamblia Cathepsin B precursor 0.0101 0.106 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0258 0.0384
Trypanosoma brucei cysteine peptidase C (CPC) 0.0101 0.106 0.1623
Plasmodium falciparum cysteine proteinase falcipain 1 0.0281 0.3258 0.5019
Entamoeba histolytica cysteine protease, putative 0.0281 0.3258 0.5009
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0178 0.0241
Trypanosoma cruzi major cysteine proteinase, putative 0.0101 0.106 0.1623
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0101 0.106 1
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0039 0.0314 0.0451
Echinococcus granulosus cysteine protease 0.0281 0.3258 0.3258
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0226 0.0333
Toxoplasma gondii cathepsin CPL 0.0545 0.6482 1
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.1284 0.1284
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0146 0.021
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0101 0.106 0.106
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0101 0.106 0.1607
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0101 0.106 0.1623
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0039 0.0314 0.047
Entamoeba histolytica cysteine protease, putative 0.0101 0.106 0.1607
Trichomonas vaginalis DNA helicase recq1, putative 0.0029 0.0187 0.0255
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0205 0.0301
Mycobacterium ulcerans DNA polymerase IV 0.0047 0.0402 0.5461
Entamoeba histolytica cysteine protease, putative 0.0101 0.106 0.1607
Toxoplasma gondii cathepsin CPC2 0.0101 0.106 0.1623
Trypanosoma cruzi cysteine peptidase, putative 0.0545 0.6482 1
Trichomonas vaginalis ran, putative 0.0026 0.0146 0.0192
Entamoeba histolytica cysteine proteinase, putative 0.0281 0.3258 0.5009
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0101 0.106 0.1623
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0545 0.6482 1
Trypanosoma brucei DNA polymerase IV, putative 0.0047 0.0402 0.0606
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0047 0.0402 0.0402
Onchocerca volvulus 0.0545 0.6482 1
Brugia malayi Cathepsin L-like cysteine proteinase 0.0365 0.4284 0.6604
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0101 0.106 0.1607
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.004 0.0326 0.0488
Echinococcus granulosus expressed protein 0.004 0.0326 0.0326
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0326 0.0469
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0022 0.0019
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.1306 0.1306
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0101 0.106 0.106
Entamoeba histolytica cysteine protease, putative 0.0281 0.3258 0.5009
Brugia malayi cathepsin L-like cysteine proteinase 0.0101 0.106 0.1623
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0101 0.106 0.1623
Plasmodium falciparum cysteine proteinase falcipain 3 0.0545 0.6482 1
Onchocerca volvulus Cathepsin L homolog 0.0545 0.6482 1
Leishmania major cathepsin L-like protease 0.0545 0.6482 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0728 0.0728
Echinococcus granulosus cathepsin b 0.0101 0.106 0.106
Trypanosoma cruzi cruzipain precursor, putative 0.0545 0.6482 1
Entamoeba histolytica cysteine protease, putative 0.0281 0.3258 0.5009
Entamoeba histolytica cysteine protease, putative 0.0281 0.3258 0.5009
Plasmodium vivax vivapain-2 0.0545 0.6482 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0545 0.6482 1
Plasmodium vivax unspecified product 0.0281 0.3258 0.5019
Loa Loa (eye worm) hypothetical protein 0.0365 0.4284 0.6604
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0101 0.106 0.1607
Giardia lamblia Hypothetical protein 0.0101 0.106 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0364 0.0364
Onchocerca volvulus 0.0545 0.6482 1
Schistosoma mansoni DNA polymerase eta 0.0077 0.0777 0.0777
Brugia malayi cathepsin Z-like cysteine proteinase 0.0101 0.106 0.1623
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0728 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0258 0.0384
Schistosoma mansoni terminal deoxycytidyl transferase 0.0047 0.0402 0.0402
Echinococcus multilocularis cysteine protease 0.0545 0.6482 0.6482
Trichomonas vaginalis rotamase, putative 0.004 0.0326 0.0469
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0545 0.6482 1
Loa Loa (eye worm) RecQ helicase 0.0029 0.0187 0.0274
Echinococcus multilocularis expressed conserved protein 0.0112 0.1196 0.1196
Trypanosoma brucei DNA polymerase IV, putative 0.0047 0.0402 0.0606
Loa Loa (eye worm) hypothetical protein 0.0146 0.1614 0.2478
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0178 0.0241
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.008 0.0806 0.0806
Leishmania major importin beta-1 subunit, putative 0.0028 0.0178 0.026
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.1284 0.1968
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0545 0.6482 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0281 0.3258 0.3258
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0101 0.106 0.1623
Schistosoma mansoni cathepsin s 0.018 0.2031 0.2031
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0101 0.106 0.1623
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0101 0.106 0.1607
Echinococcus granulosus expressed conserved protein 0.0112 0.1196 0.1196
Brugia malayi ImpB/MucB/SamB family protein 0.0047 0.0402 0.0606
Plasmodium vivax unspecified product 0.0101 0.106 0.1623
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0545 0.6482 1
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0101 0.106 0.1607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0101 0.106 0.106
Trichomonas vaginalis DNA polymerase eta, putative 0.0047 0.0402 0.0588
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0101 0.106 0.1607
Onchocerca volvulus 0.0545 0.6482 1
Brugia malayi Cathepsin L-like precursor 0.0545 0.6482 1
Entamoeba histolytica cysteine protease, putative 0.0101 0.106 0.1607
Entamoeba histolytica cysteine proteinase, putative 0.0281 0.3258 0.5009
Brugia malayi Cathepsin L-like precursor 0.0545 0.6482 1
Loa Loa (eye worm) hypothetical protein 0.0101 0.106 0.1623
Schistosoma mansoni ran 0.0026 0.0146 0.0146
Loa Loa (eye worm) papain family cysteine protease containing protein 0.018 0.2031 0.3123
Loa Loa (eye worm) cysteine protease 0.0545 0.6482 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0101 0.106 0.1607
Mycobacterium leprae Probable lipase LipE 0.0043 0.0364 0.5
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0205 0.0301
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0047 0.0402 0.0588
Trypanosoma cruzi cruzipain precursor, putative 0.018 0.2031 0.3123
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0545 0.6482 0.6482
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0101 0.106 0.1623
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0545 0.6482 1
Trichomonas vaginalis rotamase, putative 0.0039 0.0314 0.0451
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0545 0.6482 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0281 0.3258 0.5019
Echinococcus multilocularis expressed protein 0.004 0.0326 0.0326
Trypanosoma cruzi cysteine peptidase, putative 0.018 0.2031 0.3123
Brugia malayi Papain family cysteine protease containing protein 0.0101 0.106 0.1623
Echinococcus multilocularis snurportin 1 0.0372 0.4368 0.4368
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0545 0.6482 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0365 0.4284 0.6597
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.008 0.0806 0.0806
Echinococcus granulosus importin subunit beta 1 0.0035 0.0258 0.0258
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0364 0.0529
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0364 0.0547
Plasmodium falciparum serine repeat antigen 6 0.0101 0.106 0.1623
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0047 0.0402 0.0402
Brugia malayi cathepsin F-like cysteine proteinase 0.018 0.2031 0.3123
Loa Loa (eye worm) hypothetical protein 0.003 0.0205 0.0301
Plasmodium falciparum serine repeat antigen 2 0.0101 0.106 0.1623
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0101 0.106 0.1623
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0806 0.123
Onchocerca volvulus 0.0545 0.6482 1
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0146 0.021
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0039 0.0314 0.047
Trypanosoma brucei unspecified product 0.0032 0.0226 0.0333
Loa Loa (eye worm) hypothetical protein 0.0119 0.1284 0.1968
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.1284 0.1284
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0402 0.0606
Trypanosoma cruzi cysteine proteinase, putative 0.0281 0.3258 0.5019
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0545 0.6482 1
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0146 0.021
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0364 0.0529
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0281 0.3258 0.5009
Echinococcus granulosus dna polymerase eta 0.0077 0.0777 0.0777
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0545 0.6482 1
Schistosoma mansoni ran 0.0026 0.0146 0.0146
Brugia malayi cathepsin L-like precursor 0.0365 0.4284 0.6604
Loa Loa (eye worm) hypothetical protein 0.0101 0.106 0.1623
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0364 0.4929
Giardia lamblia Cathepsin L precursor 0.0101 0.106 1
Trichomonas vaginalis DNA helicase recq, putative 0.0029 0.0187 0.0255
Echinococcus granulosus cathepsin L cysteine protease 0.0281 0.3258 0.3258
Giardia lamblia Cathepsin B precursor 0.0101 0.106 1
Entamoeba histolytica cysteine protease, putative 0.0545 0.6482 1
Trypanosoma brucei DNA polymerase IV, putative 0.0047 0.0402 0.0606
Onchocerca volvulus Cathepsin F homolog 0.0545 0.6482 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0101 0.106 0.1623
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0146 0.021
Plasmodium vivax vivapain-2 0.0545 0.6482 1
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0146 0.1296
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0364 0.0364
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0101 0.106 0.1607
Toxoplasma gondii ABC1 family protein 0.0043 0.0364 0.0547
Loa Loa (eye worm) hypothetical protein 0.0043 0.0364 0.0547
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0101 0.106 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0545 0.6482 1
Giardia lamblia Cysteine protease 0.0101 0.106 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0101 0.106 0.106
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.0402 0.0606
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0545 0.6482 1
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0025 0.0144 0.0207
Toxoplasma gondii cathepsin CPC1 0.0101 0.106 0.1623
Leishmania major cathepsin L-like protease 0.0545 0.6482 1
Echinococcus granulosus snurportin 1 0.0372 0.4368 0.4368
Brugia malayi cathepsin B-like cysteine proteinase 0.0101 0.106 0.1623
Echinococcus granulosus cathepsin l cysteine peptidase 0.0545 0.6482 0.6482
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0402 0.0606
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0545 0.6482 1
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0022 0.0019
Loa Loa (eye worm) hypothetical protein 0.0043 0.0364 0.0547
Toxoplasma gondii cathepsin B 0.0101 0.106 0.1623
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.008 0.0806 0.0806
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0402 0.0606
Entamoeba histolytica cysteine proteinase 2 0.0281 0.3258 0.5009
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0402 0.0606
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0545 0.6482 1
Plasmodium falciparum serine repeat antigen 5 0.0101 0.106 0.1623
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0364 0.0529
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0258 0.0258
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0806 0.123
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0545 0.6482 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0545 0.6482 1
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0101 0.106 0.1623
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0456 0.0671
Brugia malayi cathepsin Z-like cysteine proteinase 0.0101 0.106 0.1623
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0728 1
Entamoeba histolytica cysteine protease, putative 0.0281 0.3258 0.5009
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0545 0.6482 1
Giardia lamblia Cathepsin L precursor 0.0101 0.106 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0258 0.0384
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0728 0.0728
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.018 0.2031 0.3123
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0101 0.106 0.1623
Trypanosoma cruzi cysteine peptidase, putative 0.0545 0.6482 1
Echinococcus multilocularis protein patched 0.0051 0.0456 0.0456
Entamoeba histolytica deoxycytidyl transferase, putative 0.0047 0.0402 0.0588
Loa Loa (eye worm) ctsf protein 0.0545 0.6482 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0364 0.0364
Giardia lamblia Cysteine protease 0.0101 0.106 1
Entamoeba histolytica cysteine protease, putative 0.0101 0.106 0.1607
Echinococcus multilocularis cathepsin L cysteine protease 0.0545 0.6482 0.6482
Brugia malayi Cathepsin L-like precursor 0.0545 0.6482 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0545 0.6482 1
Leishmania major DNA polymerase eta, putative 0.0077 0.0777 0.1186
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0101 0.106 0.1607
Echinococcus multilocularis transcription factor Dp 1 0.0046 0.0396 0.0396
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0178 0.026
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.3222 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.0777 0.1186
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0101 0.106 0.1607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0545 0.6482 1
Trypanosoma cruzi cysteine protease, putative 0.0281 0.3258 0.5019
Loa Loa (eye worm) hypothetical protein 0.018 0.2031 0.3123
Plasmodium falciparum serine repeat antigen 7 0.0101 0.106 0.1623
Plasmodium vivax serine-repeat antigen (SERA) 0.0101 0.106 0.1623
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0545 0.6482 1
Echinococcus multilocularis bloom syndrome protein 0.0029 0.0187 0.0187
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0205 0.0301
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0146 0.0146
Leishmania major cathepsin L-like protease 0.0545 0.6482 1
Loa Loa (eye worm) beta-lactamase 0.0043 0.0364 0.0547
Echinococcus granulosus bloom syndrome protein 0.0029 0.0187 0.0187
Brugia malayi Cathepsin L-like precursor 0.0545 0.6482 1
Mycobacterium ulcerans DNA polymerase IV 0.0047 0.0402 0.5461
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0402 0.0606
Brugia malayi Cathepsin L-like precursor 0.018 0.2031 0.3123
Giardia lamblia Cathepsin L-like protease 0.0101 0.106 1
Leishmania major cysteine peptidase A (CPA) 0.0545 0.6482 1
Leishmania major hypothetical protein, conserved 0.0043 0.0364 0.0547
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.004 0.0326 0.0488
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.007 0.0092
Plasmodium vivax serine-repeat antigen (SERA) 0.0101 0.106 0.1623
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0281 0.3258 0.5019
Brugia malayi Bloom's syndrome protein homolog 0.0029 0.0187 0.0274
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0047 0.0402 0.0134
Trichomonas vaginalis conserved hypothetical protein 0.0101 0.106 0.1607
Leishmania major DNA polymerase kappa, putative 0.0047 0.0402 0.0606
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.4368 0.6734
Loa Loa (eye worm) hypothetical protein 0.0101 0.106 0.1623
Trypanosoma cruzi cysteine peptidase, putative 0.0545 0.6482 1
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0258 0.0384
Entamoeba histolytica cysteine protease, putative 0.0281 0.3258 0.5009

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 21.884 um PUBCHEM_BIOASSAY: Fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of myeloid cell leukemia sequence 1 (MCL1) interactions with BIM-BH3 peptide. (Class of assay: confirmatory) [Related pubchem assays: 2090 (Summary AID.), 2057 (Screening assay (MCL1 inhibitors).), 2168 (Screening assay (MCL1 inhibitors).)] ChEMBL. No reference
IC50 (binding) > 108.803 um PUBCHEM_BIOASSAY: Counterscreen for inhibitors of MCL1: fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of BCL2-related protein, long isoform (BCLXL). (Class of assay: confirmatory) [Related pubchem assays: 2129 (Screening assay (BCLXL inhibitors).), 2057 (Screening assay (MCL-1 inhibitors).), 2144 (Summary AID.), 2166 (Screening assay (BCLXL inhibitors).)] ChEMBL. No reference
Potency (functional) = 0.631 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1.7783 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 3.9811 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 8.1995 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 8.9125 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 13.3714 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.1014 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 15.8489 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (binding) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (binding) 28.1838 uM PUBCHEM_BIOASSAY: qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1484, AID504370, AID504374, AID504375] ChEMBL. No reference
Potency (functional) 29.9349 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) [Related pubchem assays: 1379 ] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: Confirmation qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1) - Round 2 Cherry Picks. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2367, AID593, AID594] ChEMBL. No reference
Potency (functional) 37.933 uM PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of T. brucei phosphofructokinase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488768, AID492961] ChEMBL. No reference
Potency (functional) 37.933 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1). (Class of assay: confirmatory) [Related pubchem assays: 594 (Rhodamine region spectral profiling screen), 593 (Fluorescein region spectral profiling screen), 2367 (Probe Development Summary for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1)), 2353 (qHTS Validation Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1))] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] ChEMBL. No reference
Potency (functional) 47.7548 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Eta: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 53.2326 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Iota: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: Confirmation Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485290, AID485312, AID504464, AID504474] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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