Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Peripheral-type benzodiazepine receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Peripheral-type benzodiazepine receptor | 169 aa | 156 aa | 25.6 % | |
Echinococcus granulosus | vacuolar h atpase | Peripheral-type benzodiazepine receptor | 169 aa | 137 aa | 25.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0163 | 0.101 | 0.5 |
Mycobacterium ulcerans | tryptophan-rich sensory protein | 0.0322 | 0.2447 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0322 | 0.2447 | 1 |
Trypanosoma cruzi | thymidine kinase, putative | 0.1041 | 0.8937 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0163 | 0.101 | 0.1094 |
Trichomonas vaginalis | thymidine kinase, putative | 0.1041 | 0.8937 | 1 |
Onchocerca volvulus | 0.0322 | 0.2447 | 1 | |
Trypanosoma brucei | thymidine kinase | 0.1041 | 0.8937 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0134 | 0.0749 | 0.3063 |
Trichomonas vaginalis | thymidine kinase, putative | 0.1041 | 0.8937 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0322 | 0.2447 | 1 |
Leishmania major | thymidine kinase, putative | 0.1041 | 0.8937 | 1 |
Echinococcus multilocularis | translocator protein | 0.0322 | 0.2447 | 1 |
Schistosoma mansoni | peripheral-type benzodiazepine receptor | 0.0322 | 0.2447 | 1 |
Echinococcus granulosus | thymidine kinase | 0.024 | 0.1706 | 0.6021 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0116 | 0.0585 | 1 |
Schistosoma mansoni | thymidine kinase | 0.024 | 0.1706 | 0.6972 |
Echinococcus multilocularis | thymidine kinase | 0.024 | 0.1706 | 0.6021 |
Echinococcus granulosus | thymidine kinase | 0.024 | 0.1706 | 0.6021 |
Onchocerca volvulus | 0.0322 | 0.2447 | 1 | |
Trichomonas vaginalis | thymidine kinase, putative | 0.1041 | 0.8937 | 1 |
Onchocerca volvulus | 0.0322 | 0.2447 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0124 | 0.066 | 0.2696 |
Trypanosoma cruzi | thymidine kinase, putative | 0.1041 | 0.8937 | 1 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0124 | 0.066 | 0.0403 |
Echinococcus granulosus | translocator protein | 0.0322 | 0.2447 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0322 | 0.2447 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0134 | 0.0749 | 0.3063 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0116 | 0.0585 | 0.5 |
Echinococcus multilocularis | thymidine kinase | 0.024 | 0.1706 | 0.6021 |
Brugia malayi | thymidylate synthase | 0.0116 | 0.0585 | 0.2272 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0163 | 0.101 | 0.5 |
Echinococcus granulosus | Thymidine kinase 2 mitochondrial | 0.024 | 0.1706 | 0.6021 |
Onchocerca volvulus | 0.0322 | 0.2447 | 1 | |
Echinococcus multilocularis | transfer RNA-Ile | 0.024 | 0.1706 | 0.6021 |
Loa Loa (eye worm) | hypothetical protein | 0.0322 | 0.2447 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0134 | 0.0749 | 0.0885 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0116 | 0.0585 | 0.2389 |
Brugia malayi | TspO/MBR family protein | 0.0322 | 0.2447 | 1 |
Brugia malayi | hypothetical protein | 0.013 | 0.0714 | 0.2808 |
Entamoeba histolytica | thymidine kinase, putative | 0.1041 | 0.8937 | 0.5 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0124 | 0.066 | 0.0403 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0163 | 0.101 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = -8.19 | In vitro binding affinity (pIC50) was tested against peripheral benzodiazepine receptor (PBR) in rat. | ChEMBL. | 9288173 |
IC50 (binding) | = 6.4 nM | In vitro displacement of [3H]-PK11195 from the peripheral benzodiazepine receptor (PBR) in rat cortex | ChEMBL. | 9288173 |
IC50 (binding) | = 6.4 nM | Test in vitro, for potential ability to displace [3H]-1 from PBR in rat brain cortex | ChEMBL. | 11312914 |
IC50 (binding) | = 6.4 nM | In vitro displacement of [3H]-PK11195 from the peripheral benzodiazepine receptor (PBR) in rat cortex | ChEMBL. | 9288173 |
IC50 (binding) | = 6.4 nM | Test in vitro, for potential ability to displace [3H]-1 from PBR in rat brain cortex | ChEMBL. | 11312914 |
Log IC50 (binding) | = 8.19 | In vitro binding affinity (pIC50) was tested against peripheral benzodiazepine receptor (PBR) in rat. | ChEMBL. | 9288173 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.