Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | RAB9A, member RAS oncogene family | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | ras-related protein Rab-5B | RAB9A, member RAS oncogene family | 201 aa | 165 aa | 30.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | acetylcholinesterase | 0.0226 | 0.6078 | 0.6002 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0226 | 0.6078 | 0.6002 |
Brugia malayi | Carboxylesterase family protein | 0.0226 | 0.6078 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0226 | 0.6078 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0226 | 0.6078 | 0.6002 |
Echinococcus granulosus | neuroligin | 0.0038 | 0.0344 | 0.0155 |
Loa Loa (eye worm) | carboxylesterase | 0.0038 | 0.0344 | 0.0155 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0344 | 0.0155 |
Schistosoma mansoni | acetylcholinesterase | 0.0038 | 0.0344 | 0.0155 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0226 | 0.6078 | 0.6002 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0033 | 0.0192 | 0.5 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0038 | 0.0344 | 0.0155 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0038 | 0.0344 | 0.0155 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0355 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0038 | 0.0344 | 0.0259 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0344 | 0.0155 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0038 | 0.0344 | 0.0155 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0344 | 0.0155 |
Entamoeba histolytica | hypothetical protein | 0.0027 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0344 | 0.0155 |
Onchocerca volvulus | 0.0038 | 0.0344 | 0.5 | |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0027 | 0 | 0.5 |
Brugia malayi | RNA, U transporter 1 | 0.0095 | 0.2061 | 0.3175 |
Echinococcus multilocularis | neuroligin | 0.0038 | 0.0344 | 0.0155 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0344 | 0.0155 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0038 | 0.0344 | 0.0155 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0038 | 0.0344 | 0.0155 |
Schistosoma mansoni | hypothetical protein | 0.0355 | 1 | 1 |
Plasmodium falciparum | importin beta, putative | 0.0033 | 0.0192 | 0.5 |
Brugia malayi | hypothetical protein | 0.0038 | 0.0344 | 0.0259 |
Brugia malayi | Carboxylesterase family protein | 0.0038 | 0.0344 | 0.0259 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0226 | 0.6078 | 0.6002 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0038 | 0.0344 | 0.0155 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0038 | 0.0344 | 0.0155 |
Echinococcus granulosus | carboxylesterase 5A | 0.0226 | 0.6078 | 0.6002 |
Echinococcus multilocularis | snurportin 1 | 0.0355 | 1 | 1 |
Onchocerca volvulus | 0.0038 | 0.0344 | 0.5 | |
Brugia malayi | Carboxylesterase family protein | 0.0038 | 0.0344 | 0.0259 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0038 | 0.0344 | 0.0155 |
Plasmodium vivax | importin-beta 2, putative | 0.0033 | 0.0192 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0038 | 0.0344 | 0.0259 |
Echinococcus granulosus | acetylcholinesterase | 0.0226 | 0.6078 | 0.6002 |
Echinococcus granulosus | acetylcholinesterase | 0.0226 | 0.6078 | 0.6002 |
Onchocerca volvulus | 0.0038 | 0.0344 | 0.5 | |
Loa Loa (eye worm) | carboxylesterase | 0.0226 | 0.6078 | 0.6002 |
Leishmania major | importin beta-1 subunit, putative | 0.0027 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 0.6078 | 0.6002 |
Schistosoma mansoni | gliotactin | 0.0038 | 0.0344 | 0.0155 |
Onchocerca volvulus | 0.0038 | 0.0344 | 0.5 | |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0033 | 0.0192 | 0.5 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0033 | 0.0192 | 0.5 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0038 | 0.0344 | 0.5 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0038 | 0.0344 | 0.0155 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0344 | 0.0155 |
Loa Loa (eye worm) | carboxylesterase | 0.0038 | 0.0344 | 0.0155 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0038 | 0.0344 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0038 | 0.0344 | 0.0155 |
Onchocerca volvulus | 0.0038 | 0.0344 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0344 | 0.0155 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0038 | 0.0344 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0038 | 0.0344 | 0.5 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0038 | 0.0344 | 1 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0038 | 0.0344 | 0.0155 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0038 | 0.0344 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 0.6078 | 0.6002 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 4.4668 um | PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.