Detailed information for compound 1447570

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 290.311 | Formula: C16H18O5
  • H donors: 1 H acceptors: 2 LogP: 1.71 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCO[C@@H]1c2c(ccc3c2oc(=O)cc3)OC([C@H]1O)(C)C
  • InChi: 1S/C16H18O5/c1-4-19-14-12-10(21-16(2,3)15(14)18)7-5-9-6-8-11(17)20-13(9)12/h5-8,14-15,18H,4H2,1-3H3/t14-,15+/m1/s1
  • InChiKey: UCLKQWHJVUDTFJ-CABCVRRESA-N  

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba Get druggable targets OG5_131639 All targets in OG5_131639
Candida albicans fructose-bisphosphate aldolase Get druggable targets OG5_131639 All targets in OG5_131639
Mycobacterium ulcerans fructose-bisphosphate aldolase Get druggable targets OG5_131639 All targets in OG5_131639
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba Get druggable targets OG5_131639 All targets in OG5_131639
Candida albicans fructose-bisphosphate aldolase Get druggable targets OG5_131639 All targets in OG5_131639

By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Echinococcus multilocularis chromobox protein 1 0.0068 0.0075 0.0068
Trichomonas vaginalis D-aminoacylase, putative 0.0221 0.039 0.3385
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0046 0.003 0.0341
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0068 0.0075 0.129
Trypanosoma cruzi aminopeptidase, putative 0.026 0.047 0.8073
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0065 0.1117
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0039 0.0015 0.0101
Loa Loa (eye worm) peptidase family M1 containing protein 0.026 0.047 0.0459
Onchocerca volvulus 0.0116 0.0174 0.2374
Echinococcus granulosus peregrin 0.0135 0.0213 0.0211
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0014 0.0002
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0172 0.029 0.2488
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0047 0.0033 0.003
Brugia malayi Calcitonin receptor-like protein seb-1 0.0729 0.1436 0.3132
Schistosoma mansoni thyroid hormone receptor 0.0162 0.0269 0.0269
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0056 0.0051 0.4895
Schistosoma mansoni smad 0.0062 0.0062 0.0062
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0636 0.1244 0.1234
Echinococcus granulosus dnaJ subfamily B 0.1252 0.2515 0.2513
Echinococcus granulosus puromycin sensitive aminopeptidase 0.026 0.047 0.0467
Brugia malayi Bromodomain containing protein 0.0135 0.0213 0.0445
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0141 0.0226 0.0223
Loa Loa (eye worm) hypothetical protein 0.0221 0.039 0.0379
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0447 0.0857 0.2943
Trichomonas vaginalis penicillin-binding protein, putative 0.0221 0.039 0.3385
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.026 0.047 0.047
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0044 0.0026 0.0447
Giardia lamblia Fructose-bisphosphate aldolase 0.0172 0.029 1
Loa Loa (eye worm) nuclear factor I 0.0076 0.0092 0.0081
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0068 0.0075 0.129
Brugia malayi Smad1 0.0138 0.0219 0.0458
Schistosoma mansoni ran 0.0044 0.0025 0.0025
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0141 0.0226 0.0218
Brugia malayi hypothetical protein 0.026 0.047 0.1009
Schistosoma mansoni ran 0.0044 0.0025 0.0025
Leishmania major trypanothione reductase 0.0196 0.0339 0.5828
Schistosoma mansoni hypothetical protein 0.0039 0.0015 0.0015
Mycobacterium ulcerans esterase/lipase LipP 0.0221 0.039 0.2339
Entamoeba histolytica aminopeptidase, putative 0.026 0.047 0.5715
Echinococcus granulosus JmjC domain containing protein 4 0.0038 0.0014 0.0011
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0056 0.0051 0.0885
Trypanosoma cruzi aminopeptidase, putative 0.026 0.047 0.8073
Schistosoma mansoni ferritin 0.0045 0.0028 0.0028
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0047 0.0033 0.0025
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0044 0.0025 0.0325
Brugia malayi hypothetical protein 0.0421 0.0803 0.1741
Onchocerca volvulus 0.026 0.047 0.6751
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.0007 0.0007
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.026 0.047 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0056 0.0051 0.0877
Brugia malayi latrophilin 2 splice variant baaae 0.0498 0.0961 0.2089
Plasmodium vivax ataxin-2 like protein, putative 0.0106 0.0152 0.3091
Brugia malayi Peptidase family M1 containing protein 0.026 0.047 0.1009
Echinococcus multilocularis aminopeptidase N 0.026 0.047 0.0463
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0142 0.0227 0.4721
Loa Loa (eye worm) hypothetical protein 0.006 0.0058 0.0046
Onchocerca volvulus 0.026 0.047 0.6751
Plasmodium falciparum phd finger protein, putative 0.0119 0.018 0.3633
Loa Loa (eye worm) MH2 domain-containing protein 0.2024 0.4103 0.4096
Loa Loa (eye worm) thioredoxin reductase 0.0196 0.0339 0.0328
Schistosoma mansoni smad1 5 8 and 0.0138 0.0219 0.0219
Loa Loa (eye worm) hypothetical protein 0.0072 0.0083 0.0071
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0074 0.0088 0.008
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0221 0.039 0.0835
Echinococcus granulosus cpg binding protein 0.0127 0.0196 0.0193
Giardia lamblia PHD finger protein 15 0.0119 0.018 0.5824
Echinococcus multilocularis muscleblind protein 1 0.015 0.0244 0.0237
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0048 0.0035 0.02
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.026 0.047 0.4095
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0221 0.039 0.1287
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0038 0.0014 0.0241
Onchocerca volvulus 0.0221 0.039 0.5576
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.008 0.0099 0.0092
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0221 0.039 0.039
Plasmodium falciparum glutathione reductase 0.0068 0.0075 0.134
Mycobacterium leprae conserved hypothetical protein 0.0221 0.039 0.2339
Loa Loa (eye worm) hypothetical protein 0.0319 0.0592 0.0581
Echinococcus granulosus GTP binding nuclear protein Ran 0.0044 0.0025 0.0023
Schistosoma mansoni jumonji/arid domain-containing protein 0.0154 0.0253 0.0253
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0149 0.0241 0.4145
Echinococcus multilocularis beta LACTamase domain containing family member 0.0221 0.039 0.0383
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0729 0.1436 0.3132
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0068 0.0075 0.0167
Trichomonas vaginalis mercuric reductase, putative 0.0068 0.0075 0.0563
Brugia malayi Pre-SET motif family protein 0.024 0.0429 0.0919
Loa Loa (eye worm) leukotriene A4 hydrolase 0.4887 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0065 0.1117
Brugia malayi PHD-finger family protein 0.0069 0.0078 0.0148
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0172 0.029 0.2488
Loa Loa (eye worm) RNA binding protein 0.0266 0.0484 0.0473
Brugia malayi CXXC zinc finger family protein 0.0116 0.0174 0.0359
Echinococcus multilocularis cpg binding protein 0.0127 0.0196 0.0188
Plasmodium vivax thioredoxin reductase, putative 0.0196 0.0339 0.7156
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0231 0.041 0.0408
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0068 0.0075 0.134
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0068 0.0075 0.129
Schistosoma mansoni glutaminase 0.058 0.113 0.113
Loa Loa (eye worm) latrophilin receptor protein 2 0.0231 0.041 0.0399
Echinococcus granulosus jumonji domain containing protein 0.0165 0.0275 0.0273
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0068 0.0075 0.0304
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.026 0.047 0.0463
Treponema pallidum exodeoxyribonuclease (exoA) 0.0056 0.0051 0.088
Loa Loa (eye worm) hypothetical protein 0.0162 0.0268 0.0257
Plasmodium vivax glutathione reductase, putative 0.0196 0.0339 0.7156
Schistosoma mansoni gabp alpha 0.0074 0.0088 0.0088
Echinococcus multilocularis smad 0.0138 0.0219 0.0212
Plasmodium falciparum ataxin-2 like protein, putative 0.0106 0.0152 0.3036
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0088 0.0117 0.0106
Toxoplasma gondii HEAT repeat-containing protein 0.006 0.0058 0.103
Brugia malayi Importin beta-1 subunit 0.006 0.0058 0.0104
Loa Loa (eye worm) hypothetical protein 0.0063 0.0066 0.0054
Plasmodium falciparum histone acetyltransferase GCN5 0.0126 0.0194 0.3943
Loa Loa (eye worm) hypothetical protein 0.0038 0.0014 0.0002
Schistosoma mansoni hypothetical protein 0.0636 0.1244 0.1244
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0068 0.0075 0.0142
Trypanosoma cruzi major cysteine proteinase, putative 0.005 0.0037 0.0639
Brugia malayi beta-lactamase 0.0221 0.039 0.0835
Toxoplasma gondii exonuclease III APE 0.0056 0.0051 0.0885
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0065 0.1117
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.026 0.047 0.4095
Echinococcus multilocularis microtubule associated protein 2 0.2239 0.4547 0.4543
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0068 0.0075 0.129
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0072 0.0083 0.0083
Loa Loa (eye worm) aminopeptidase N 0.026 0.047 0.0459
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0026 0.0447
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0172 0.029 0.2488
Brugia malayi glutathione reductase 0.0196 0.0339 0.0722
Trichomonas vaginalis ran, putative 0.0044 0.0025 0.0118
Brugia malayi MH2 domain containing protein 0.0138 0.0219 0.0458
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0056 0.0051 0.0082
Echinococcus multilocularis lysine specific demethylase 5A 0.0144 0.0231 0.0224
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0376 0.071 0.1537
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0068 0.0075 0.129
Brugia malayi hypothetical protein 0.026 0.047 0.1009
Loa Loa (eye worm) jmjC domain-containing protein 0.0245 0.044 0.0429
Echinococcus granulosus tar DNA binding protein 0.0266 0.0484 0.0481
Entamoeba histolytica hypothetical protein 0.0421 0.0803 1
Schistosoma mansoni protein phosphatase 2C 0.0038 0.0014 0.0014
Schistosoma mansoni ap endonuclease 0.0056 0.0051 0.0051
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0056 0.0051 0.0048
Plasmodium vivax JmjC domain containing protein 0.0038 0.0014 0.0079
Brugia malayi jmjC domain containing protein 0.0154 0.0253 0.0532
Brugia malayi Peptidase family M1 containing protein 0.026 0.047 0.1009
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.4887 1 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0068 0.0075 0.0073
Schistosoma mansoni cpg binding protein 0.0127 0.0196 0.0196
Loa Loa (eye worm) MH2 domain-containing protein 0.0062 0.0062 0.005
Echinococcus multilocularis musashi 0.0165 0.0275 0.0267
Mycobacterium tuberculosis Conserved hypothetical protein 0.0165 0.0276 0.088
Brugia malayi exodeoxyribonuclease III family protein 0.0056 0.0051 0.0089
Schistosoma mansoni Smad4 0.0138 0.0219 0.0219
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0038 0.0014 0.0079
Echinococcus granulosus puromycin sensitive aminopeptidase 0.026 0.047 0.0467
Mycobacterium tuberculosis Probable lipase LipE 0.0221 0.039 0.1287
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.026 0.047 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0068 0.0075 0.1409
Echinococcus granulosus mothers against decapentaplegic 5 0.0138 0.0219 0.0217
Giardia lamblia NADH oxidase lateral transfer candidate 0.0068 0.0075 0.1879
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0072 0.0083 0.0075
Onchocerca volvulus 0.0165 0.0275 0.3863
Schistosoma mansoni jumonji domain containing protein 0.0038 0.0014 0.0014
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0065 0.1117
Trichomonas vaginalis set domain proteins, putative 0.0273 0.0496 0.4333
Toxoplasma gondii PHD-finger domain-containing protein 0.0119 0.018 0.3683
Brugia malayi MH1 domain containing protein 0.0076 0.0092 0.018
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0119 0.018 0.018
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0056 0.0051 0.0877
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0068 0.0075 0.1409
Leishmania major GTP-binding protein, putative 0.0044 0.0025 0.0435
Brugia malayi jmjC domain containing protein 0.0038 0.0014 0.0008
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0172 0.029 0.3406
Treponema pallidum fructose-bisphosphate aldolase 0.0172 0.029 1
Schistosoma mansoni ferritin light chain 0.0045 0.0028 0.0028
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.026 0.047 0.0463
Echinococcus multilocularis lysine specific demethylase 6a 0.0038 0.0014 0.0007
Echinococcus multilocularis JmjC domain containing protein 4 0.0038 0.0014 0.0007
Brugia malayi beta-lactamase family protein 0.0221 0.039 0.0835
Loa Loa (eye worm) hypothetical protein 0.0231 0.041 0.0399
Brugia malayi PHD-finger family protein 0.0119 0.018 0.0372
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0044 0.0026 0.0447
Schistosoma mansoni jumonji/arid domain-containing protein 0.0154 0.0253 0.0253
Echinococcus granulosus mothers against decapentaplegic 6 0.0062 0.0062 0.0059
Brugia malayi hypothetical protein 0.2247 0.4562 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0065 0.1117
Trypanosoma cruzi PAB1-binding protein , putative 0.0106 0.0152 0.2619
Loa Loa (eye worm) hypothetical protein 0.0221 0.039 0.0379
Loa Loa (eye worm) hypothetical protein 0.0221 0.039 0.0379
Schistosoma mansoni ets-related 0.0225 0.0398 0.0398
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0376 0.071 0.0708
Trypanosoma cruzi trypanothione reductase, putative 0.0068 0.0075 0.129
Mycobacterium tuberculosis Conserved protein 0.0221 0.039 0.1287
Toxoplasma gondii aminopeptidase N, putative 0.026 0.047 1
Brugia malayi RNA, U transporter 1 0.0169 0.0284 0.0601
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0138 0.0219 0.0219
Echinococcus granulosus histone lysine methyltransferase setb 0.0072 0.0083 0.008
Schistosoma mansoni hypothetical protein 0.0231 0.041 0.041
Onchocerca volvulus 0.0221 0.039 0.5576
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0039 0.0015 0.0258
Echinococcus multilocularis mothers against decapentaplegic 2 0.0062 0.0062 0.0055
Brugia malayi hypothetical protein 0.0147 0.0238 0.0499
Loa Loa (eye worm) hypothetical protein 0.0221 0.039 0.0379
Toxoplasma gondii histone lysine methyltransferase SET1 0.0237 0.0424 0.9001
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0068 0.0075 0.129
Echinococcus granulosus cytoplasmic intermediate filament protein 0.008 0.0099 0.0096
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0068 0.0075 0.129
Trichomonas vaginalis D-aminoacylase, putative 0.0221 0.039 0.3385
Echinococcus multilocularis thyroid hormone receptor alpha 0.0162 0.0269 0.0261
Schistosoma mansoni hypothetical protein 0.0047 0.0033 0.0033
Schistosoma mansoni hypothetical protein 0.0231 0.041 0.041
Echinococcus granulosus lamin 0.0165 0.0275 0.0272
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0797 0.1577 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0014 0.0002
Brugia malayi jmjC domain containing protein 0.0038 0.0014 0.0008
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0231 0.041 0.0403
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.026 0.047 0.8073
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0068 0.0075 0.0304
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0056 0.0051 0.0812
Loa Loa (eye worm) hypothetical protein 0.0147 0.0238 0.0226
Leishmania major cathepsin L-like protease 0.0063 0.0065 0.1117
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0131 0.0205 0.0203
Loa Loa (eye worm) transcription factor SMAD2 0.2024 0.4103 0.4096
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0314 0.0582 1
Plasmodium falciparum glutathione reductase 0.0196 0.0339 0.7133
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0172 0.029 0.2488
Entamoeba histolytica hypothetical protein 0.0421 0.0803 1
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0044 0.0025 0.0248
Echinococcus multilocularis thioredoxin glutathione reductase 0.0196 0.0339 0.0332
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0068 0.0075 0.129
Mycobacterium leprae Probable lipase LipE 0.0221 0.039 0.2339
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0056 0.0051 0.0331
Mycobacterium tuberculosis Probable reductase 0.0447 0.0857 0.2943
Echinococcus multilocularis dnaJ subfamily B 0.1252 0.2515 0.2509
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0497 0.096 0.3308
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0038 0.0014 0.0241
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0231 0.041 0.0403
Echinococcus multilocularis zinc finger protein 0.0058 0.0055 0.0048
Schistosoma mansoni aminopeptidase A (M01 family) 0.026 0.047 0.047
Echinococcus multilocularis expressed protein 0.0045 0.0028 0.0021
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0065 0.1117
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0074 0.0088 0.0085
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.026 0.047 0.8073
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0389 0.0736 0.0734
Echinococcus granulosus microtubule associated protein 2 0.2239 0.4547 0.4545
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.024 0.0429 0.0418
Mycobacterium ulcerans hypothetical protein 0.0165 0.0276 0.1599
Schistosoma mansoni ferritin 0.0045 0.0028 0.0028
Brugia malayi Heterochromatin protein 1 0.0068 0.0075 0.0142
Loa Loa (eye worm) hypothetical protein 0.0062 0.0062 0.005
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0729 0.1436 0.1426
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0231 0.041 0.0408
Trichomonas vaginalis D-aminoacylase, putative 0.0221 0.039 0.3385
Schistosoma mansoni hypothetical protein 0.0131 0.0205 0.0205
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0065 0.1117
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0014 0.0002
Loa Loa (eye worm) hypothetical protein 0.0079 0.0098 0.0086
Brugia malayi mothers against decapentaplegic homolog 3 0.0062 0.0062 0.0113
Echinococcus granulosus GPCR family 2 0.0231 0.041 0.0408
Trypanosoma brucei importin beta-1 subunit, putative 0.006 0.0058 0.0992
Echinococcus granulosus histone acetyltransferase KAT2B 0.0142 0.0227 0.0225
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0068 0.0075 0.129
Loa Loa (eye worm) hypothetical protein 0.0106 0.0153 0.0142
Brugia malayi RNA recognition motif domain containing protein 0.0266 0.0484 0.104
Trichomonas vaginalis importin beta-1, putative 0.0048 0.0035 0.02
Mycobacterium tuberculosis Conserved protein 0.0221 0.039 0.1287
Echinococcus granulosus importin subunit beta 1 0.006 0.0058 0.0055
Echinococcus multilocularis jumonji domain containing 1A 0.0038 0.0014 0.0007
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0026 0.0447
Schistosoma mansoni thyroid hormone receptor 0.0162 0.0269 0.0269
Echinococcus multilocularis jumonji domain containing protein 0.0165 0.0275 0.0268
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0068 0.0075 0.129
Mycobacterium ulcerans aminopeptidase N PepN 0.026 0.047 0.2851
Loa Loa (eye worm) hypothetical protein 0.0038 0.0014 0.0002
Toxoplasma gondii aminopeptidase n, putative 0.026 0.047 1
Schistosoma mansoni smad1 5 8 and 0.0138 0.0219 0.0219
Schistosoma mansoni tar DNA-binding protein 0.0266 0.0484 0.0484
Mycobacterium tuberculosis Conserved protein 0.0221 0.039 0.1287
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0044 0.0025 0.0435
Schistosoma mansoni microtubule-associated protein tau 0.2239 0.4547 0.4547
Echinococcus granulosus lysine specific demethylase 5A 0.0154 0.0253 0.025
Trypanosoma brucei hypothetical protein, conserved 0.0221 0.039 0.6709
Schistosoma mansoni hypothetical protein 0.0231 0.041 0.041
Loa Loa (eye worm) hypothetical protein 0.0038 0.0014 0.0002
Echinococcus granulosus mothers against decapentaplegic 2 0.0062 0.0062 0.0059
Plasmodium falciparum M1-family alanyl aminopeptidase 0.026 0.047 1
Echinococcus multilocularis muscleblind protein 0.015 0.0244 0.0237
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0068 0.0075 0.5
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0221 0.039 0.039
Mycobacterium tuberculosis Possible penicillin-binding protein 0.1412 0.2844 1
Brugia malayi beta-lactamase family protein 0.0221 0.039 0.0835
Echinococcus granulosus TGF beta signal transducer SmadC 0.0138 0.0219 0.0217
Trichomonas vaginalis glutaminase, putative 0.058 0.113 1
Onchocerca volvulus 0.0147 0.0238 0.3316
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.3412 0.6962 0.696
Schistosoma mansoni smad 0.0138 0.0219 0.0219
Brugia malayi MH1 domain containing protein 0.0138 0.0219 0.0458
Schistosoma mansoni smad1 5 8 and 0.0138 0.0219 0.0219
Echinococcus granulosus beta LACTamase domain containing family member 0.0221 0.039 0.0388
Brugia malayi hypothetical protein 0.0068 0.0075 0.0143
Loa Loa (eye worm) hypothetical protein 0.015 0.0244 0.0233
Brugia malayi jmjC domain containing protein 0.0038 0.0014 0.0008
Brugia malayi MH2 domain containing protein 0.2024 0.4103 0.8991
Schistosoma mansoni tar DNA-binding protein 0.0266 0.0484 0.0484
Onchocerca volvulus 0.0165 0.0275 0.3863
Plasmodium falciparum thioredoxin reductase 0.0196 0.0339 0.7133
Loa Loa (eye worm) MH1 domain-containing protein 0.0062 0.0062 0.005
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0053 0.0044 0.0037
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0065 0.1117
Schistosoma mansoni tar DNA-binding protein 0.0266 0.0484 0.0484
Schistosoma mansoni hypothetical protein 0.069 0.1357 0.1357
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.005 0.0038 0.0061
Schistosoma mansoni ap endonuclease 0.0056 0.0051 0.0051
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.026 0.047 0.8073
Echinococcus multilocularis GPCR, family 2 0.0231 0.041 0.0403
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0056 0.0051 0.0971
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0068 0.0075 1
Schistosoma mansoni cellular tumor antigen P53 0.0319 0.0592 0.0592
Brugia malayi MH1 domain containing protein 0.0076 0.0092 0.018
Schistosoma mansoni jumonji domain containing protein 0.0309 0.0571 0.0571
Brugia malayi Ets-domain containing protein 0.0074 0.0088 0.017
Brugia malayi Bromodomain containing protein 0.009 0.0121 0.0243
Schistosoma mansoni hypothetical protein 0.0498 0.0961 0.0961
Echinococcus multilocularis PHD finger protein rhinoceros 0.0119 0.018 0.0172
Trichomonas vaginalis bromodomain-containing protein, putative 0.0142 0.0227 0.1925
Loa Loa (eye worm) hypothetical protein 0.0095 0.0131 0.012
Echinococcus granulosus geminin 0.069 0.1357 0.1355
Leishmania major importin beta-1 subunit, putative 0.0048 0.0035 0.0593
Loa Loa (eye worm) hypothetical protein 0.0049 0.0037 0.0025
Echinococcus granulosus tumor protein p63 0.218 0.4426 0.4425
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.026 0.047 0.8073
Brugia malayi MH2 domain containing protein 0.0138 0.0219 0.0458
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.026 0.047 1
Trypanosoma brucei aminopeptidase, putative 0.026 0.047 0.8073
Schistosoma mansoni ferritin light chain 0.0045 0.0028 0.0028
Echinococcus multilocularis phd:f box containing protein 0.0038 0.0014 0.0007
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0072 0.0083 0.0083
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0172 0.029 0.2488
Echinococcus granulosus muscleblind protein 0.015 0.0244 0.0242
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0068 0.0075 0.0304
Loa Loa (eye worm) hypothetical protein 0.0076 0.0092 0.0081
Toxoplasma gondii aminopeptidase N protein 0.026 0.047 1
Loa Loa (eye worm) bromodomain containing protein 0.0048 0.0034 0.0022
Loa Loa (eye worm) PHD-finger family protein 0.0119 0.018 0.0168
Brugia malayi MH2 domain containing protein 0.0062 0.0062 0.0113
Toxoplasma gondii PHD-finger domain-containing protein 0.0119 0.018 0.3683
Schistosoma mansoni lamin 0.0165 0.0275 0.0275
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0497 0.096 0.3308
Brugia malayi F/Y-rich N-terminus family protein 0.0079 0.0099 0.0194
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.026 0.047 0.0463
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0049 0.0036 0.0028
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0376 0.071 0.0708
Echinococcus granulosus PHD finger protein rhinoceros 0.0119 0.018 0.0177
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0048 0.0033 0.0033
Echinococcus multilocularis ferritin 0.0045 0.0028 0.0021
Schistosoma mansoni hypothetical protein 0.0421 0.0803 0.0803
Loa Loa (eye worm) hypothetical protein 0.0498 0.0961 0.0951
Trypanosoma brucei Aminopeptidase M1, putative 0.026 0.047 0.8073
Trypanosoma brucei Aminopeptidase M1, putative 0.026 0.047 0.8073
Schistosoma mansoni lamin 0.0165 0.0275 0.0275
Leishmania major hypothetical protein, conserved 0.0221 0.039 0.6709
Mycobacterium ulcerans glutaminase 0.058 0.113 0.711
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0421 0.0803 0.0796
Loa Loa (eye worm) beta-lactamase 0.0221 0.039 0.0379
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.026 0.047 0.0463
Loa Loa (eye worm) hypothetical protein 0.008 0.0099 0.0087
Toxoplasma gondii PHD-finger domain-containing protein 0.0039 0.0015 0.0101
Loa Loa (eye worm) hypothetical protein 0.0366 0.0689 0.0679
Schistosoma mansoni phosphatidylserine receptor 0.0038 0.0014 0.0014
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0044 0.0025 0.0014
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0069 0.0077 0.0077
Echinococcus multilocularis geminin 0.069 0.1357 0.135
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0056 0.0051 0.0877
Echinococcus multilocularis mothers against decapentaplegic 6 0.0062 0.0062 0.0055
Trichomonas vaginalis ap endonuclease, putative 0.0056 0.0051 0.0348
Entamoeba histolytica hypothetical protein 0.0421 0.0803 1
Toxoplasma gondii NADPH-glutathione reductase 0.0068 0.0075 0.1409
Loa Loa (eye worm) hypothetical protein 0.015 0.0244 0.0233
Mycobacterium ulcerans hypothetical protein 0.0221 0.039 0.2339
Echinococcus granulosus puromycin sensitive aminopeptidase 0.026 0.047 0.0467
Leishmania major hypothetical protein, conserved 0.0106 0.0152 0.2619
Brugia malayi MH1 domain containing protein 0.0138 0.0219 0.0458
Schistosoma mansoni apoferritin-2 0.0045 0.0028 0.0028
Echinococcus granulosus fetal alzheimer antigen falz 0.0053 0.0044 0.0042
Onchocerca volvulus 0.0273 0.0496 0.7144
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0068 0.0075 0.129
Loa Loa (eye worm) acetyltransferase 0.0471 0.0905 0.0894
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0048 0.0035 0.02
Brugia malayi glutaminase DH11.1 0.058 0.113 0.2459
Loa Loa (eye worm) MH2 domain-containing protein 0.0138 0.0219 0.0208
Echinococcus multilocularis tumor protein p63 0.218 0.4426 0.4422
Trypanosoma cruzi cruzipain precursor, putative 0.0063 0.0065 0.1117
Echinococcus granulosus aminopeptidase N 0.026 0.047 0.0467
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.026 0.047 0.8073
Entamoeba histolytica acetyltransferase, GNAT family 0.0126 0.0194 0.2165
Echinococcus multilocularis lamin 0.0165 0.0275 0.0267
Echinococcus granulosus jumonji domain containing 1A 0.0038 0.0014 0.0011
Brugia malayi TAR-binding protein 0.0266 0.0484 0.104
Toxoplasma gondii hypothetical protein 0.0051 0.0039 0.0632
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0054 0.0046 0.0789
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0196 0.0339 0.1105
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0068 0.0075 0.134
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0149 0.0241 0.4145
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0068 0.0075 0.129
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.026 0.047 0.8073
Echinococcus granulosus ferritin 0.0045 0.0028 0.0025
Trypanosoma cruzi importin beta-1 subunit, putative 0.0048 0.0035 0.0593
Schistosoma mansoni ferritin 0.0045 0.0028 0.0028
Onchocerca volvulus 0.026 0.047 0.6751
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0447 0.0857 0.2943
Schistosoma mansoni cpg binding protein 0.0116 0.0174 0.0174
Mycobacterium ulcerans aminopeptidase N PepN 0.026 0.047 0.2851
Onchocerca volvulus 0.0048 0.0033 0.0291
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0056 0.0051 0.0149
Brugia malayi chromobox protein homolog 3 0.0038 0.0014 0.0007
Trichomonas vaginalis chromobox protein, putative 0.0041 0.002 0.0067
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0389 0.0736 0.0729
Trichomonas vaginalis glutathione reductase, putative 0.0068 0.0075 0.0563
Loa Loa (eye worm) CXXC zinc finger family protein 0.0116 0.0174 0.0163
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0049 0.0036 0.0033
Echinococcus multilocularis tar DNA binding protein 0.0266 0.0484 0.0476
Schistosoma mansoni tar DNA-binding protein 0.0266 0.0484 0.0484
Brugia malayi AF-10 protein 0.0039 0.0015 0.001
Echinococcus granulosus histone acetyltransferase KAT2B 0.0453 0.0868 0.0865
Mycobacterium tuberculosis Probable dehydrogenase 0.0447 0.0857 0.2943
Loa Loa (eye worm) hypothetical protein 0.0077 0.0093 0.0081
Echinococcus granulosus puromycin sensitive aminopeptidase 0.026 0.047 0.0467
Onchocerca volvulus 0.0319 0.0592 0.8566
Loa Loa (eye worm) fli-1 protein 0.0225 0.0398 0.0387
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.0007 0.0007
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0172 0.029 0.3406
Leishmania major mitochondrial DNA polymerase beta 0.0314 0.0582 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0221 0.039 0.0379
Loa Loa (eye worm) hypothetical protein 0.0221 0.039 0.0379
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0068 0.0075 0.129
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0037 0.0012 0.0009
Brugia malayi Fli-1 protein 0.0225 0.0398 0.0853
Plasmodium falciparum ataxin-2 like protein, putative 0.0106 0.0152 0.3036
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0014 0.0013
Brugia malayi Bromodomain containing protein 0.0173 0.029 0.0615
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0376 0.071 0.071
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0037 0.001 0.0003
Trichomonas vaginalis ferritin, putative 0.0045 0.0028 0.0141
Mycobacterium tuberculosis Probable esterase LipL 0.0221 0.039 0.1287
Loa Loa (eye worm) hypothetical protein 0.0221 0.039 0.0379
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0039 0.0015 0.0258
Echinococcus multilocularis chromobox protein 1 0.0068 0.0075 0.0068
Plasmodium falciparum thioredoxin reductase 0.0068 0.0075 0.134
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.0075 0.0064
Schistosoma mansoni Smad4 0.0062 0.0062 0.0062
Echinococcus granulosus chromobox protein 1 0.0068 0.0075 0.0073
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0314 0.0582 1
Echinococcus granulosus intermediate filament protein 0.0165 0.0275 0.0272
Schistosoma mansoni hypothetical protein 0.0043 0.0023 0.0023
Brugia malayi TATA binding protein associated factor 0.026 0.047 0.1009
Schistosoma mansoni bromodomain containing protein 0.0148 0.0241 0.0241
Loa Loa (eye worm) hypothetical protein 0.0204 0.0354 0.0343
Trichomonas vaginalis penicillin-binding protein, putative 0.0221 0.039 0.3385
Entamoeba histolytica hypothetical protein 0.0048 0.0035 0.0118
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0074 0.0088 0.0076
Loa Loa (eye worm) hypothetical protein 0.026 0.047 0.0459
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.026 0.047 0.8073
Trypanosoma cruzi Aminopeptidase M1, putative 0.026 0.047 0.8073
Echinococcus multilocularis lamin dm0 0.0165 0.0275 0.0267
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0231 0.041 0.0878
Brugia malayi intermediate filament protein 0.0165 0.0275 0.0581
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.005 0.0038 0.0061
Brugia malayi RNA binding protein 0.0266 0.0484 0.104
Schistosoma mansoni chromobox protein 0.0068 0.0075 0.0075
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0172 0.029 0.2488
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.001 0.001
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.026 0.047 0.0463
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0447 0.0857 0.5349
Loa Loa (eye worm) Smad1 0.0138 0.0219 0.0208
Brugia malayi acetyltransferase, GNAT family protein 0.0471 0.0905 0.1964
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0065 0.1117
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0058 0.0054 0.0923
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0014 0.0013
Loa Loa (eye worm) MH1 domain-containing protein 0.0138 0.0219 0.0208
Loa Loa (eye worm) PHD-finger family protein 0.0043 0.0023 0.0011
Echinococcus granulosus methyl CpG binding domain protein 2 0.0035 0.0007 0.0005
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0447 0.0857 0.2943
Giardia lamblia Histone acetyltransferase GCN5 0.0126 0.0194 0.6358
Schistosoma mansoni hypothetical protein 0.0119 0.018 0.018
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0068 0.0075 0.1409
Schistosoma mansoni transcription factor LCR-F1 0.0421 0.0803 0.0803
Schistosoma mansoni chromobox protein 0.0068 0.0075 0.0075
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0068 0.0075 1
Schistosoma mansoni apoferritin-2 0.0045 0.0028 0.0028
Echinococcus multilocularis mothers against decapentaplegic 5 0.0138 0.0219 0.0212
Onchocerca volvulus Alhambra homolog 0.0119 0.018 0.2456
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.026 0.047 0.8073
Echinococcus multilocularis Smad4 0.0138 0.0219 0.0212
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0376 0.071 0.071
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0044 0.0025 0.0018
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.026 0.047 0.8073
Trypanosoma brucei importin beta-1 subunit, putative 0.006 0.0058 0.0992
Treponema pallidum NADH oxidase 0.0068 0.0075 0.1797
Brugia malayi Muscleblind-like protein 0.015 0.0244 0.0514
Leishmania major cathepsin L-like protease 0.0063 0.0065 0.1117
Trichomonas vaginalis esterase, putative 0.0221 0.039 0.3385
Trypanosoma cruzi trypanothione reductase, putative 0.0196 0.0339 0.5828
Loa Loa (eye worm) hypothetical protein 0.0119 0.018 0.0168
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0138 0.0219 0.0212
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0038 0.0014 0.0079
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0065 0.1117
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.026 0.047 0.0463
Brugia malayi N-terminal motif family protein 0.0366 0.0689 0.1492
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0142 0.0227 0.1925
Loa Loa (eye worm) hypothetical protein 0.0146 0.0235 0.0224
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0056 0.0051 0.0039
Echinococcus granulosus expressed protein 0.0045 0.0028 0.0025
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.002 0.0088
Echinococcus granulosus puromycin sensitive aminopeptidase 0.026 0.047 0.0467
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0376 0.071 0.0703
Echinococcus granulosus zinc finger protein 0.0058 0.0055 0.0053
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0266 0.0484 0.0473
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.026 0.047 0.047
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0314 0.0582 1
Trypanosoma cruzi hypothetical protein, conserved 0.0221 0.039 0.6709
Leishmania major hypothetical protein, conserved 0.0038 0.0014 0.0241
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0447 0.0857 0.2943
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0037 0.0012 0.0004
Loa Loa (eye worm) TAR-binding protein 0.0266 0.0484 0.0473
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0172 0.029 0.2488
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0797 0.1577 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0196 0.0339 0.0337
Loa Loa (eye worm) hypothetical protein 0.026 0.047 0.0459
Toxoplasma gondii ABC1 family protein 0.0221 0.039 0.8272
Loa Loa (eye worm) glutaminase 2 0.058 0.113 0.1119
Mycobacterium ulcerans beta-lactamase 0.0221 0.039 0.2339
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0471 0.0905 0.0905
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0221 0.039 0.1287
Entamoeba histolytica hypothetical protein 0.0421 0.0803 1
Loa Loa (eye worm) glutaminase 0.058 0.113 0.1119
Brugia malayi Latrophilin receptor protein 2 0.0231 0.041 0.0878
Plasmodium vivax hypothetical protein, conserved 0.0046 0.003 0.0418
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0165 0.0275 0.0263
Schistosoma mansoni hypothetical protein 0.069 0.1357 0.1357
Loa Loa (eye worm) hypothetical protein 0.0077 0.0093 0.0081
Loa Loa (eye worm) hypothetical protein 0.026 0.047 0.0459
Onchocerca volvulus 0.0221 0.039 0.5576
Brugia malayi Peptidase family M1 containing protein 0.026 0.047 0.1009
Toxoplasma gondii thioredoxin reductase 0.0196 0.0339 0.7156
Echinococcus granulosus lamin dm0 0.0165 0.0275 0.0272
Mycobacterium tuberculosis Probable oxidoreductase 0.0497 0.096 0.3308
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.026 0.047 0.4095
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0075 0.0564
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0038 0.0014 0.0014
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0044 0.0025 0.0435
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0068 0.0075 0.129
Schistosoma mansoni intermediate filament proteins 0.0165 0.0275 0.0275
Echinococcus granulosus GA binding protein alpha chain 0.0074 0.0088 0.0085
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0366 0.0689 1
Leishmania major cathepsin L-like protease 0.0063 0.0065 0.1117
Plasmodium vivax hypothetical protein, conserved 0.0119 0.018 0.3683
Brugia malayi hypothetical protein 0.0106 0.0152 0.0312
Trypanosoma brucei PAB1-binding protein , putative 0.0106 0.0152 0.2619
Schistosoma mansoni hypothetical protein 0.0231 0.041 0.041
Loa Loa (eye worm) hypothetical protein 0.0729 0.1436 0.1426
Echinococcus granulosus lysine specific demethylase 6a 0.0038 0.0014 0.0011
Mycobacterium tuberculosis Probable hydrolase 0.0221 0.039 0.1287
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.026 0.047 0.047
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0221 0.039 0.1287
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0062 0.0062 0.0716
Mycobacterium ulcerans lipase LipD 0.0221 0.039 0.2339
Schistosoma mansoni Smad4 0.0062 0.0062 0.0062
Echinococcus granulosus snurportin 1 0.0636 0.1244 0.1242
Plasmodium falciparum importin beta, putative 0.006 0.0058 0.0959
Plasmodium vivax hypothetical protein, conserved 0.0221 0.039 0.8272
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0044 0.0025 0.0033
Loa Loa (eye worm) jmjC domain-containing protein 0.0154 0.0253 0.0241
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0797 0.1577 0.5502
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0075 0.0564
Brugia malayi Intermediate filament tail domain containing protein 0.0165 0.0275 0.0581
Brugia malayi Thioredoxin reductase 0.0196 0.0339 0.0722
Brugia malayi jmjC domain containing protein 0.0389 0.0736 0.1594
Loa Loa (eye worm) glutathione reductase 0.0196 0.0339 0.0328
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0044 0.0025 0.0325
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0056 0.0051 0.0044
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0038 0.0014 0.0241
Echinococcus granulosus puromycin sensitive aminopeptidase 0.026 0.047 0.0467
Loa Loa (eye worm) hypothetical protein 0.0165 0.0275 0.0263
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0221 0.039 0.2339
Echinococcus granulosus Smad4 0.0138 0.0219 0.0217
Trichomonas vaginalis chromobox protein, putative 0.0041 0.002 0.0067
Mycobacterium tuberculosis Probable lipase LipD 0.0221 0.039 0.1287
Trypanosoma brucei trypanothione reductase 0.0196 0.0339 0.5828
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0065 0.1117
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0065 0.1117
Schistosoma mansoni zinc finger protein 0.0058 0.0055 0.0055
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0068 0.0075 0.0068
Trichomonas vaginalis ap endonuclease, putative 0.0056 0.0051 0.0348
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0497 0.096 0.6012
Echinococcus multilocularis snurportin 1 0.0636 0.1244 0.1238
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0172 0.029 0.2488
Schistosoma mansoni tar DNA-binding protein 0.0266 0.0484 0.0484
Echinococcus multilocularis importin subunit beta 1 0.006 0.0058 0.005
Schistosoma mansoni phd/f-box containing protein 0.0038 0.0014 0.0014
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0056 0.0051 0.0877
Brugia malayi PHD-finger family protein 0.0049 0.0037 0.0058
Loa Loa (eye worm) TATA binding protein associated factor 0.026 0.047 0.0459
Brugia malayi jmjC domain containing protein 0.0038 0.0014 0.0008
Schistosoma mansoni hypothetical protein 0.1252 0.2515 0.2515
Echinococcus multilocularis peregrin 0.0135 0.0213 0.0206
Plasmodium vivax importin-beta 2, putative 0.006 0.0058 0.103
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0068 0.0075 0.129
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.026 0.047 0.8073
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0068 0.0075 0.129
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0131 0.0205 0.0198
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0376 0.071 0.071
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0149 0.0241 0.4145
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0065 0.1117
Schistosoma mansoni importin beta-1 0.006 0.0058 0.0058
Echinococcus multilocularis leukotriene A 4 hydrolase 0.4887 1 1
Loa Loa (eye worm) hypothetical protein 0.0106 0.0152 0.0141
Brugia malayi cytoplasmic intermediate filament protein 0.0088 0.0117 0.0234
Echinococcus granulosus smad 0.0138 0.0219 0.0217
Trypanosoma cruzi PAB1-binding protein , putative 0.0106 0.0152 0.2619
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0044 0.0025 0.0435
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0421 0.0803 0.0801
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0142 0.0227 0.4721
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0247 0.0444 0.0444
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0068 0.0075 0.0075
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0471 0.0905 0.0898
Schistosoma mansoni ferritin 0.0045 0.0028 0.0028
Echinococcus granulosus phd:f box containing protein 0.0038 0.0014 0.0011
Loa Loa (eye worm) intermediate filament protein 0.0165 0.0275 0.0263
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0376 0.071 0.0703
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0053 0.0044 0.0044
Trypanosoma cruzi hypothetical protein, conserved 0.0221 0.039 0.6709
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0065 0.1117
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0142 0.0227 0.4721
Brugia malayi Ets-domain containing protein 0.0074 0.0088 0.017
Echinococcus granulosus chromobox protein 1 0.0068 0.0075 0.0073
Echinococcus multilocularis GA binding protein alpha chain 0.0074 0.0088 0.008
Schistosoma mansoni cpg binding protein 0.0127 0.0196 0.0196
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0376 0.071 0.0699
Toxoplasma gondii LsmAD domain-containing protein 0.0106 0.0152 0.3091

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 1.11 uM PubChem BioAssay. Fluorescence-based biochemical high throughput dose response assay for inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberculosis. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 16.5113 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.