Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | tyrosyl-DNA phosphodiesterase 1 | Starlite/ChEMBL | No references |
Homo sapiens | chromobox homolog 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | retinoic acid receptor RXR | 0.0314 | 0.659 | 0.6129 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0323 | 0.0241 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0314 | 0.659 | 0.6129 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0459 | 1 | 1 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0302 | 0.6312 | 0.5813 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0266 | 0.5458 | 0.4844 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0047 | 0.0323 | 0.2714 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0266 | 0.5458 | 0.4844 |
Trichomonas vaginalis | chromobox protein, putative | 0.0084 | 0.1191 | 1 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0459 | 1 | 0.5 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0051 | 0.0407 | 1 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0459 | 1 | 1 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0459 | 1 | 1 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0459 | 1 | 0.5 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0459 | 1 | 0.5 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0084 | 0.1191 | 0.1117 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0459 | 1 | 0.5 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0459 | 1 | 0.5 |
Trichomonas vaginalis | chromobox protein, putative | 0.0051 | 0.0407 | 0.3419 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0047 | 0.0323 | 0.7399 |
Trichomonas vaginalis | chromobox protein, putative | 0.0084 | 0.1191 | 1 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0459 | 1 | 1 |
Brugia malayi | Heterochromatin protein 1 | 0.0084 | 0.1191 | 0.0897 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0047 | 0.0323 | 0.2714 |
Trichomonas vaginalis | chromobox protein, putative | 0.0051 | 0.0407 | 0.3419 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.6964 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (binding) | = 19.9526 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay; Stimulation with EGF. (Class of assay: confirmatory) [Related pubchem assays: 995 ] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.