Detailed information for compound 1447674

Basic information

Technical information
  • TDR Targets ID: 1447674
  • Name: [2-[(2-ethoxyphenyl)amino]pyridin-3-yl]-pyrro lidin-1-ylmethanone
  • MW: 311.378 | Formula: C18H21N3O2
  • H donors: 1 H acceptors: 2 LogP: 3.56 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccccc1Nc1ncccc1C(=O)N1CCCC1
  • InChi: 1S/C18H21N3O2/c1-2-23-16-10-4-3-9-15(16)20-17-14(8-7-11-19-17)18(22)21-12-5-6-13-21/h3-4,7-11H,2,5-6,12-13H2,1H3,(H,19,20)
  • InChiKey: JKIPRDZLHILGLX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [2-[(2-ethoxyphenyl)amino]-3-pyridyl]-pyrrolidin-1-yl-methanone
  • [2-[(2-ethoxyphenyl)amino]-3-pyridyl]-1-pyrrolidinylmethanone
  • [2-[(2-ethoxyphenyl)amino]pyridin-3-yl]-pyrrolidin-1-yl-methanone
  • [2-(2-Ethoxy-phenylamino)-pyridin-3-yl]-pyrrolidin-1-yl-methanone
  • MLS000073063
  • SMR000003785

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens thyroid stimulating hormone receptor Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens bromodomain adjacent to zinc finger domain, 2B Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K01549 ATP synthase [EC3.6.3.14], putative Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus granulosus bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma japonicum Cleft lip and palate transmembrane protein 1-like protein, putative Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Brugia malayi Bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0206 0.0206
Echinococcus multilocularis lamin 0.0033 0.0936 0.0936
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0206 0.0206
Schistosoma mansoni zinc finger protein 0.0018 0.0431 0.0631
Onchocerca volvulus 0.0033 0.0936 0.0773
Brugia malayi TAR-binding protein 0.0064 0.2063 0.2063
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0206 0.0206
Brugia malayi ecdysteroid receptor 0.0012 0.0206 0.0206
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0206 0.0206
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0206 0.0206
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0206 0.0302
Schistosoma mansoni smad 0.001 0.0121 0.0177
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0206 0.0302
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0206 0.0302
Loa Loa (eye worm) hypothetical protein 0.0033 0.0936 0.0936
Trichomonas vaginalis set domain proteins, putative 0.0276 0.9644 1
Schistosoma mansoni tar DNA-binding protein 0.0064 0.2063 0.3019
Schistosoma mansoni lamin 0.0033 0.0936 0.1369
Echinococcus granulosus intermediate filament protein 0.0033 0.0936 0.0936
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0206 0.0206
Echinococcus granulosus TGF beta signal transducer SmadC 0.001 0.0121 0.0121
Echinococcus granulosus tar DNA binding protein 0.0064 0.2063 0.2063
Brugia malayi PHD-finger family protein 0.003 0.0847 0.0847
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.0553 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.0553 0.0553
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.0553 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0206 0.0206
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0936 0.0936
Loa Loa (eye worm) hypothetical protein 0.0286 1 1
Schistosoma mansoni hypothetical protein 0.0197 0.6833 1
Brugia malayi Pre-SET motif family protein 0.0035 0.1013 0.1013
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.2063 0.2063
Schistosoma mansoni survival motor neuron protein 0.0058 0.1856 0.2716
Brugia malayi MH2 domain containing protein 0.001 0.0121 0.0121
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0206 0.0206
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0206 0.0302
Treponema pallidum exodeoxyribonuclease (exoA) 0.0022 0.0553 0.5
Schistosoma mansoni ap endonuclease 0.0022 0.0553 0.0809
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0394 0.0394
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0206 0.0206
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1748 0.2558
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0035 0.1013 0.1013
Mycobacterium tuberculosis Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) 0.0178 0.6139 1
Echinococcus granulosus lamin dm0 0.0033 0.0936 0.0936
Loa Loa (eye worm) hypothetical protein 0.0012 0.0206 0.0206
Echinococcus multilocularis mothers against decapentaplegic 5 0.001 0.0121 0.0121
Loa Loa (eye worm) hypothetical protein 0.0049 0.1532 0.1532
Schistosoma mansoni zinc finger protein 0.0024 0.0616 0.0901
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0553 0.5
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0936 0.0936
Loa Loa (eye worm) hypothetical protein 0.0015 0.0311 0.0311
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.1269 0.1269
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0021 0.0507 0.0507
Echinococcus multilocularis Smad4 0.001 0.0121 0.0121
Loa Loa (eye worm) hypothetical protein 0.0052 0.1614 0.1614
Echinococcus granulosus lamin 0.0033 0.0936 0.0936
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0035 0.1013 0.1483
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0744 0.1089
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0206 0.0206
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0016 0.0332 0.0332
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0022 0.0553 0.5
Schistosoma mansoni tar DNA-binding protein 0.0064 0.2063 0.3019
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0206 0.0206
Schistosoma mansoni tar DNA-binding protein 0.0064 0.2063 0.3019
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0206 0.0302
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0206 0.0302
Schistosoma mansoni Smad4 0.001 0.0121 0.0177
Echinococcus granulosus histone lysine methyltransferase setb 0.0055 0.1751 0.1751
Loa Loa (eye worm) hypothetical protein 0.0012 0.0206 0.0206
Onchocerca volvulus 0.0035 0.1013 0.0855
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0206 0.0206
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0242 0.8445 0.8445
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0206 0.0206
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0016 0.0332 0.0332
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0206 0.0206
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0206 0.0206
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1748 0.2558
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0035 0.1013 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0206 0.0206
Loa Loa (eye worm) Smad1 0.001 0.0121 0.0121
Schistosoma mansoni lamin 0.0033 0.0936 0.1369
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.1856 0.1856
Brugia malayi MH1 domain containing protein 0.001 0.0121 0.0121
Echinococcus granulosus methyl CpG binding domain protein 2 0.0021 0.0507 0.0507
Brugia malayi Bromodomain containing protein 0.0046 0.1426 0.1426
Loa Loa (eye worm) hypothetical protein 0.0032 0.0914 0.0914
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0206 0.0206
Brugia malayi Smad1 0.001 0.0121 0.0121
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0206 0.0206
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.1324 0.1324
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0022 0.0553 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 0.0206 0.0206
Echinococcus multilocularis tar DNA binding protein 0.0064 0.2063 0.2063
Brugia malayi nuclear hormone receptor 0.0012 0.0206 0.0206
Echinococcus multilocularis zinc finger protein 0.0024 0.0616 0.0616
Schistosoma mansoni bromodomain containing protein 0.0076 0.2507 0.3669
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.4934 0.4934
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0206 0.0206
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0206 0.0206
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0206 0.0302
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0206 0.0302
Schistosoma mansoni hypothetical protein 0.0197 0.6833 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.0553 0.0553
Loa Loa (eye worm) hypothetical protein 0.0046 0.1429 0.1429
Schistosoma mansoni smad1 5 8 and 0.001 0.0121 0.0177
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.0553 0.0553
Echinococcus multilocularis musashi 0.0033 0.0936 0.0936
Schistosoma mansoni hypothetical protein 0.0018 0.0431 0.0631
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0206 0.0206
Brugia malayi RNA binding protein 0.0064 0.2063 0.2063
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0206 0.0206
Loa Loa (eye worm) hypothetical protein 0.0012 0.0206 0.0206
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0206 0.0206
Schistosoma mansoni smad1 5 8 and 0.001 0.0121 0.0177
Echinococcus granulosus mothers against decapentaplegic 5 0.001 0.0121 0.0121
Brugia malayi hypothetical protein 0.0042 0.1269 0.1269
Echinococcus multilocularis TGF beta signal transducer SmadC 0.001 0.0121 0.0121
Entamoeba histolytica hypothetical protein 0.0042 0.1269 1
Loa Loa (eye worm) MH1 domain-containing protein 0.001 0.0121 0.0121
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0744 0.0744
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1748 0.1748
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.1269 0.1269
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0206 0.0302
Schistosoma mansoni ap endonuclease 0.0022 0.0553 0.0809
Brugia malayi MH1 domain containing protein 0.001 0.0121 0.0121
Echinococcus multilocularis lamin dm0 0.0033 0.0936 0.0936
Loa Loa (eye worm) hypothetical protein 0.0015 0.0311 0.0311
Schistosoma mansoni smad1 5 8 and 0.001 0.0121 0.0177
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1748 0.1748
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0206 0.0206
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0206 0.0206
Schistosoma mansoni TGF-beta signal transducer Smad2 0.001 0.0121 0.0177
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0206 0.0206
Schistosoma mansoni tar DNA-binding protein 0.0064 0.2063 0.3019
Brugia malayi follicle stimulating hormone receptor 0.028 0.979 0.979
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.1324 0.1324
Schistosoma mansoni coup transcription factor 0.0012 0.0206 0.0302
Echinococcus multilocularis smad 0.001 0.0121 0.0121
Schistosoma mansoni hypothetical protein 0.0042 0.1269 0.1857
Schistosoma mansoni tar DNA-binding protein 0.0064 0.2063 0.3019
Onchocerca volvulus 0.0058 0.1856 0.1748
Loa Loa (eye worm) follicle stimulating hormone receptor 0.028 0.979 0.979
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1748 0.2558
Brugia malayi MH2 domain containing protein 0.0144 0.4934 0.4934
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0206 0.0206
Echinococcus granulosus zinc finger protein 0.0024 0.0616 0.0616
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0206 0.0302
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1748 0.1748
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0206 0.0206
Brugia malayi nuclear receptor NHR-88 0.0012 0.0206 0.0206
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.1748 0.1748
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0206 0.0206
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0206 0.0206
Entamoeba histolytica hypothetical protein 0.0042 0.1269 1
Schistosoma mansoni intermediate filament proteins 0.0033 0.0936 0.1369
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0662 0.0662
Onchocerca volvulus 0.0276 0.9644 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.1748 0.1748
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0533 0.0533
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0206 0.0206
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0206 0.0206
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0206 0.0206
Echinococcus multilocularis survival motor neuron protein 1 0.0286 1 1
Brugia malayi MH2 domain containing protein 0.001 0.0121 0.0121
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.2352 0.2352
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0206 0.0206
Loa Loa (eye worm) hypothetical protein 0.0012 0.0206 0.0206
Schistosoma mansoni hypothetical protein 0.0058 0.1856 0.2716
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1748 0.1748
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0206 0.0206
Entamoeba histolytica hypothetical protein 0.0042 0.1269 1
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0744 0.0744
Loa Loa (eye worm) RNA binding protein 0.0064 0.2063 0.2063
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0206 0.0302
Loa Loa (eye worm) MH2 domain-containing protein 0.001 0.0121 0.0121
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.0553 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0206 0.0206
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0206 0.0206
Echinococcus multilocularis geminin 0.0197 0.6833 0.6833
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0206 0.0302
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0055 0.1751 0.1751
Brugia malayi intermediate filament protein 0.0033 0.0936 0.0936
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0055 0.1751 0.2563
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0055 0.1751 0.2563
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.4934 0.4934
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.0553 0.0553
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0507 0.0742
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0206 0.0206
Schistosoma mansoni hypothetical protein 0.0025 0.0662 0.0968
Echinococcus granulosus geminin 0.0197 0.6833 0.6833
Brugia malayi Bromodomain containing protein 0.0091 0.3014 0.3014
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0507 0.0742
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.2352 0.2352
Loa Loa (eye worm) hypothetical protein 0.0012 0.0206 0.0206
Echinococcus granulosus survival motor neuron protein 1 0.0286 1 1
Loa Loa (eye worm) TAR-binding protein 0.0064 0.2063 0.2063
Loa Loa (eye worm) hypothetical protein 0.0012 0.0206 0.0206
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0394 0.0394
Loa Loa (eye worm) hypothetical protein 0.0055 0.1751 0.1751
Entamoeba histolytica hypothetical protein 0.0042 0.1269 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0332 0.0332
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.1269 0.1857
Brugia malayi Pre-SET motif family protein 0.0242 0.8445 0.8445
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0206 0.0206
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.1013 0.1483
Brugia malayi steroid hormone receptor 0.0012 0.0206 0.0206
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0206 0.0206
Echinococcus granulosus Smad4 0.001 0.0121 0.0121
Mycobacterium ulcerans epoxide hydrolase EphA 0.0178 0.6139 1
Echinococcus granulosus smad 0.001 0.0121 0.0121
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0206 0.0206
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0968 0.0968
Loa Loa (eye worm) hypothetical protein 0.0085 0.2829 0.2829
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.2063 0.2063
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0206 0.0206
Onchocerca volvulus 0.0033 0.0936 0.0773
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0936 0.0936
Loa Loa (eye worm) hypothetical protein 0.0012 0.0206 0.0206
Plasmodium vivax SET domain protein, putative 0.0035 0.1013 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0022 0.0553 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.7079 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 0.8913 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1.9953 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1.9953 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.9811 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 8.2753 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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