Detailed information for compound 1447905

Basic information

Technical information
  • TDR Targets ID: 1447905
  • Name: N-[[4-(difluoromethoxy)-3-methoxyphenyl]methy l]-N-methylthieno[3,2-e]pyrimidin-4-amine
  • MW: 351.371 | Formula: C16H15F2N3O2S
  • H donors: 0 H acceptors: 2 LogP: 4.4 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(ccc1OC(F)F)CN(c1ncnc2c1ccs2)C
  • InChi: 1S/C16H15F2N3O2S/c1-21(14-11-5-6-24-15(11)20-9-19-14)8-10-3-4-12(23-16(17)18)13(7-10)22-2/h3-7,9,16H,8H2,1-2H3
  • InChiKey: FJXBWQOEUKRXJG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[[4-(difluoromethoxy)-3-methoxy-phenyl]methyl]-N-methyl-thieno[3,2-e]pyrimidin-4-amine
  • N-[[4-(difluoromethoxy)-3-methoxyphenyl]methyl]-N-methyl-4-thieno[3,2-e]pyrimidinamine
  • [4-(difluoromethoxy)-3-methoxy-benzyl]-methyl-thieno[3,2-e]pyrimidin-4-yl-amine
  • ZINC07814414
  • T5506492

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens snurportin 1 No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens parathyroid hormone 1 receptor Starlite/ChEMBL No references
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K04588 secretin receptor, putative Get druggable targets OG5_139196 All targets in OG5_139196
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni thyroid hormone receptor 0.2098 0.5577 1
Brugia malayi nuclear receptor NHR-88 0.0137 0.021 0.021
Echinococcus multilocularis snurportin 1 0.0372 0.0853 0.1461
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.029 0.063 0.0654
Loa Loa (eye worm) hypothetical protein 0.0153 0.0255 0.0265
Loa Loa (eye worm) hypothetical protein 0.029 0.063 0.0654
Loa Loa (eye worm) hypothetical protein 0.0137 0.021 0.0218
Schistosoma mansoni nuclear receptor nhr-48 0.0137 0.021 0.0299
Echinococcus multilocularis ecdysone induced protein 78C 0.029 0.063 0.1057
Brugia malayi Nuclear hormone receptor family member nhr-19 0.029 0.063 0.063
Loa Loa (eye worm) hypothetical protein 0.0137 0.021 0.0218
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.029 0.063 0.063
Brugia malayi ecdysone receptor 0.0137 0.021 0.021
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.029 0.063 0.1235
Brugia malayi Nuclear hormone receptor family member nhr-31 0.029 0.063 0.063
Brugia malayi Nuclear hormone receptor family member nhr-25 0.029 0.063 0.063
Echinococcus granulosus retinoic acid receptor rxr beta a 0.029 0.063 0.1235
Loa Loa (eye worm) RNA binding protein 0.0076 0.0045 0.0046
Loa Loa (eye worm) hypothetical protein 0.0137 0.021 0.0218
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.029 0.063 0.1057
Schistosoma mansoni nuclear receptor 0.0137 0.021 0.0299
Schistosoma mansoni nuclear hormone receptor 0.029 0.063 0.1057
Schistosoma mansoni zinc finger protein 0.0137 0.021 0.0299
Loa Loa (eye worm) hypothetical protein 0.029 0.063 0.0654
Brugia malayi hypothetical protein 0.0137 0.021 0.021
Brugia malayi Nuclear hormone receptor family member nhr-1 0.029 0.063 0.063
Brugia malayi nuclear hormone receptor family member odr-7 0.0137 0.021 0.021
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.029 0.063 0.063
Loa Loa (eye worm) hypothetical protein 0.029 0.063 0.0654
Brugia malayi nuclear hormone receptor family member nhr-6 0.0137 0.021 0.021
Schistosoma mansoni hypothetical protein 0.1807 0.4783 0.8564
Brugia malayi Steroid receptor seven-up type 2 0.029 0.063 0.063
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.029 0.063 0.1235
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.029 0.063 1
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0045 0.0045
Schistosoma mansoni hypothetical protein 0.0372 0.0853 0.1461
Schistosoma mansoni nuclear hormone receptor 0.0137 0.021 0.0299
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.029 0.063 0.1057
Brugia malayi RNA binding protein 0.0076 0.0045 0.0045
Echinococcus granulosus nuclear receptor 2DBD gamma 0.029 0.063 0.1235
Schistosoma mansoni retinoic acid receptor RXR 0.029 0.063 0.1057
Brugia malayi Nuclear hormone receptor family member nhr-25 0.029 0.063 0.063
Brugia malayi Nuclear hormone receptor-like 1 0.3576 0.9625 0.9625
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0137 0.021 0.0299
Loa Loa (eye worm) hypothetical protein 0.0153 0.0255 0.0265
Schistosoma mansoni Tr4/Tr2 (homologue) 0.029 0.063 0.1057
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0153 0.0255 0.038
Loa Loa (eye worm) nuclear hormone receptor 0.0137 0.021 0.0218
Loa Loa (eye worm) hypothetical protein 0.0137 0.021 0.0218
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0137 0.021 0.021
Echinococcus granulosus thyroid hormone receptor alpha 0.0137 0.021 0.0349
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.029 0.063 0.1235
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0137 0.021 0.0299
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0137 0.021 0.0299
Echinococcus multilocularis nuclear receptor nhr 48 0.0137 0.021 0.0299
Brugia malayi Nuclear hormone receptor-like 1 0.3576 0.9625 0.9625
Brugia malayi Nuclear hormone receptor E75 0.0137 0.021 0.021
Brugia malayi nuclear hormone receptor 0.0137 0.021 0.021
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0153 0.0255 0.0444
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.3576 0.9625 1
Loa Loa (eye worm) hypothetical protein 0.0137 0.021 0.0218
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.029 0.063 0.0654
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.1807 0.4783 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.0853 0.0886
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.029 0.063 0.1057
Loa Loa (eye worm) hypothetical protein 0.0153 0.0255 0.0265
Brugia malayi Nuclear hormone receptor family member nhr-49 0.029 0.063 0.063
Loa Loa (eye worm) hypothetical protein 0.0153 0.0255 0.0265
Loa Loa (eye worm) hypothetical protein 0.0137 0.021 0.0218
Brugia malayi nuclear receptor NHR-88 0.029 0.063 0.063
Loa Loa (eye worm) hypothetical protein 0.0137 0.021 0.0218
Loa Loa (eye worm) hypothetical protein 0.0137 0.021 0.0218
Echinococcus granulosus nuclear receptor 2DBD gamma 0.029 0.063 0.1235
Schistosoma mansoni nuclear hormone receptor 0.0137 0.021 0.0299
Brugia malayi hypothetical protein 0.0137 0.021 0.021
Loa Loa (eye worm) hypothetical protein 0.0153 0.0255 0.0265
Loa Loa (eye worm) hypothetical protein 0.029 0.063 0.0654
Echinococcus multilocularis FTZ F1 alpha 0.029 0.063 0.1057
Echinococcus granulosus Nuclear hormone receptor HR96 0.0137 0.021 0.0349
Brugia malayi hypothetical protein 0.0153 0.0255 0.0255
Brugia malayi orphan nuclear receptor NR2E1 0.0137 0.021 0.021
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0137 0.021 0.0299
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.029 0.063 0.1057
Brugia malayi Nuclear hormone receptor family member nhr-14 0.029 0.063 0.063
Brugia malayi Nuclear hormone receptor family member nhr-3 0.029 0.063 0.063
Echinococcus granulosus Nuclear hormone receptor HR96 0.0137 0.021 0.0349
Schistosoma mansoni coup transcription factor 0.029 0.063 0.1057
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.029 0.063 0.0654
Loa Loa (eye worm) hypothetical protein 0.0137 0.021 0.0218
Onchocerca volvulus Bile acid receptor homolog 0.029 0.063 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0137 0.021 0.0299
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.029 0.063 0.0654
Brugia malayi RNA, U transporter 1 0.0099 0.0106 0.0106
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0137 0.021 0.0349
Echinococcus granulosus snurportin 1 0.0372 0.0853 0.1706
Loa Loa (eye worm) hypothetical protein 0.356 0.958 0.9953
Brugia malayi ecdysteroid receptor 0.029 0.063 0.063
Brugia malayi Nuclear hormone receptor family member nhr-41 0.029 0.063 0.063
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.1807 0.4783 0.8564
Brugia malayi TAR-binding protein 0.0076 0.0045 0.0045
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.029 0.063 0.1057
Brugia malayi photoreceptor-specific nuclear receptor 0.029 0.063 0.063
Schistosoma mansoni RAR-like nuclear receptor 0.029 0.063 0.1057
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.029 0.063 0.0654
Echinococcus granulosus ecdysone induced protein 78C 0.029 0.063 0.1235
Brugia malayi nuclear receptor RXR 0.0137 0.021 0.021
Schistosoma mansoni nuclear receptor 0.0137 0.021 0.0299
Brugia malayi nuclear receptor NHR-67 0.0137 0.021 0.021
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.029 0.063 0.1057
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.2516 0.4467
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0045 0.0046
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0045 0.0046
Brugia malayi Nuclear hormone receptor family member nhr-19 0.029 0.063 0.063
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.029 0.063 0.1057
Loa Loa (eye worm) steroid hormone receptor 0.029 0.063 0.0654
Brugia malayi steroid hormone receptor 0.029 0.063 0.063
Loa Loa (eye worm) hypothetical protein 0.029 0.063 0.0654
Loa Loa (eye worm) hypothetical protein 0.029 0.063 0.0654
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0137 0.021 0.0218
Schistosoma mansoni steroid hormone receptor ad4bp 0.029 0.063 0.1057
Echinococcus granulosus nuclear receptor nhr 48 0.0137 0.021 0.0349
Loa Loa (eye worm) hypothetical protein 0.029 0.063 0.0654
Schistosoma mansoni retinoid-x-receptor (RXR) 0.029 0.063 0.1057
Loa Loa (eye worm) hypothetical protein 0.0137 0.021 0.0218
Loa Loa (eye worm) hypothetical protein 0.029 0.063 0.0654
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.029 0.063 0.0654
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0137 0.021 0.0349
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.029 0.063 0.1235
Brugia malayi conserved hypotetical protein 0.0137 0.021 0.021
Brugia malayi nuclear hormone receptor 0.029 0.063 0.063
Echinococcus granulosus FTZ F1 alpha 0.029 0.063 0.1235
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.029 0.063 0.0654
Loa Loa (eye worm) hypothetical protein 0.0137 0.021 0.0218
Brugia malayi hypothetical protein 0.0153 0.0255 0.0255
Echinococcus multilocularis thyroid hormone receptor alpha 0.2098 0.5577 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.029 0.063 0.1057
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.029 0.063 0.1057
Brugia malayi Nuclear hormone receptor family member nhr-40 0.029 0.063 0.063
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0137 0.021 0.0299
Schistosoma mansoni thyroid hormone receptor 0.2098 0.5577 1
Loa Loa (eye worm) hypothetical protein 0.0137 0.021 0.0218
Brugia malayi nuclear receptor RXR 0.0153 0.0255 0.0255
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0153 0.0255 0.038
Loa Loa (eye worm) DR-78 0.0137 0.021 0.0218
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0137 0.021 0.0299
Onchocerca volvulus 0.029 0.063 1
Loa Loa (eye worm) nuclear receptor NHR-67 0.0137 0.021 0.0218
Brugia malayi Nuclear hormone receptor E75 0.0137 0.021 0.021
Onchocerca volvulus Protein ultraspiracle homolog 0.029 0.063 1
Brugia malayi tailless protein 0.0137 0.021 0.021
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.029 0.063 0.1057
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0153 0.0255 0.038

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.1623 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.1995 uM PubChem BioAssay. Nrf2 qHTS screen for inhibitors: Nrf2 A549 ARE-Fluc Confirmation Assay for Hit Validation. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 9.2 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.99 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 17.7828 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 70.7946 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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