Detailed information for compound 1448157

Basic information

Technical information
  • TDR Targets ID: 1448157
  • Name: 1-[(4-nitrophenyl)methyl]-4-[3-(trifluorometh yl)phenyl]triazole
  • MW: 348.279 | Formula: C16H11F3N4O2
  • H donors: 0 H acceptors: 4 LogP: 3.66 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-][N+](=O)c1ccc(cc1)Cn1nnc(c1)c1cccc(c1)C(F)(F)F
  • InChi: 1S/C16H11F3N4O2/c17-16(18,19)13-3-1-2-12(8-13)15-10-22(21-20-15)9-11-4-6-14(7-5-11)23(24)25/h1-8,10H,9H2
  • InChiKey: LCXDAMWDAXTPPB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(4-nitrobenzyl)-4-[3-(trifluoromethyl)phenyl]triazole
  • 1-[(4-nitrophenyl)methyl]-4-[3-(trifluoromethyl)phenyl]-1,2,3-triazole

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens K(lysine) acetyltransferase 2A Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium yoelii histone acetyltransferase GCN5-related Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum ko:K06062 p300/CBP-associated factor, putative Get druggable targets OG5_127781 All targets in OG5_127781
Giardia lamblia Histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis bromodomain-containing protein, putative Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium knowlesi histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium falciparum histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum hypothetical protein Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Cryptosporidium parvum GCN5 like acetylase + bromodomain Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Entamoeba histolytica acetyltransferase, GNAT family Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii histone lysine acetyltransferase GCN5-B Get druggable targets OG5_127781 All targets in OG5_127781
Theileria parva histone acetyltransferase Gcn5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Cryptosporidium hominis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Babesia bovis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum Bromodomain containing protein, related Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Plasmodium berghei histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi acetyltransferase, GNAT family protein Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii histone lysine acetyltransferase GCN5-A Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Plasmodium vivax histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.0328 0.5
Echinococcus granulosus ecdysone induced protein 78C 0.0054 0.0361 0.0361
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0054 0.0361 0.0361
Loa Loa (eye worm) hypothetical protein 0.0029 0.0039 0.0039
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.1501 0.1501
Loa Loa (eye worm) acetyltransferase 0.0175 0.1891 0.1891
Echinococcus multilocularis transcription factor Dp 1 0.0472 0.5652 0.5652
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0054 0.0361 0.0361
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0054 0.0361 0.0361
Schistosoma mansoni thyroid hormone receptor 0.0054 0.0361 0.0361
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0054 0.0361 0.0361
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0054 0.0361 0.0361
Loa Loa (eye worm) hypothetical protein 0.0054 0.0361 0.0361
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0816 1 1
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0816 1 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0054 0.0361 0.0361
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0054 0.0361 0.0361
Brugia malayi ecdysteroid receptor 0.0054 0.0361 0.0361
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.0328 0.5
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0029 0.0039 0.0039
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0645 0.0645
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0729 0.8899 0.8899
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0054 0.0361 0.0361
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0816 1 0.5
Brugia malayi acetyltransferase, GNAT family protein 0.0175 0.1891 0.1891
Loa Loa (eye worm) hypothetical protein 0.0054 0.0361 0.0361
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0645 0.0645
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0054 0.0361 0.0361
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0645 0.0645
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0054 0.0361 0.0361
Loa Loa (eye worm) hypothetical protein 0.0054 0.0361 0.0361
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0054 0.0361 0.0361
Brugia malayi Nuclear hormone receptor-like 1 0.0029 0.0039 0.0039
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0054 0.0361 0.0361
Echinococcus multilocularis FTZ F1 alpha 0.0054 0.0361 0.0361
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0029 0.0039 0.0039
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0645 0.0645
Brugia malayi hypothetical protein 0.0029 0.0039 0.0039
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0054 0.0361 0.0361
Schistosoma mansoni thyroid hormone receptor 0.0054 0.0361 0.0361
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0054 0.0361 0.0361
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.0274 0.5
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0054 0.0361 0.0361
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0054 0.0361 0.0361
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0054 0.0361 0.0361
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 0.1891 0.1891
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 0.1891 0.1891
Brugia malayi RNA binding protein 0.0076 0.0645 0.0645
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0054 0.0361 0.0361
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0054 0.0361 0.0361
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0645 0.0645
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0054 0.0361 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0645 0.0645
Schistosoma mansoni retinoic acid receptor RXR 0.0758 0.926 0.926
Loa Loa (eye worm) RNA binding protein 0.0076 0.0645 0.0645
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0054 0.0361 0.0361
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0816 1 0.5
Brugia malayi MH2 domain containing protein 0.0144 0.1501 0.1501
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.0328 0.0328
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0816 1 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0054 0.0361 0.0361
Echinococcus granulosus transcription factor Dp 1 0.0472 0.5652 0.5652
Onchocerca volvulus 0.0054 0.0361 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0054 0.0361 0.0361
Brugia malayi Nuclear hormone receptor-like 1 0.0054 0.0361 0.0361
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0054 0.0361 0.0361
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0054 0.0361 0.0361
Brugia malayi nuclear hormone receptor 0.0054 0.0361 0.0361
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0816 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0029 0.0039 0.0039
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0054 0.0361 0.0361
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0054 0.0361 0.0361
Loa Loa (eye worm) hypothetical protein 0.0054 0.0361 0.0361
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.0328 0.5
Loa Loa (eye worm) hypothetical protein 0.0029 0.0039 0.0039
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0645 0.0645
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.0274 0.5
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0054 0.0361 0.0361
Brugia malayi photoreceptor-specific nuclear receptor 0.0054 0.0361 0.0361
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0054 0.0361 0.0361
Loa Loa (eye worm) hypothetical protein 0.0029 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0029 0.0039 0.0039
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0816 1 1
Loa Loa (eye worm) steroid hormone receptor 0.0054 0.0361 0.0361
Loa Loa (eye worm) hypothetical protein 0.0054 0.0361 0.0361
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.1829 0.1829
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0054 0.0361 0.0361
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0054 0.0361 0.0361
Schistosoma mansoni RAR-like nuclear receptor 0.0054 0.0361 0.0361
Brugia malayi TAR-binding protein 0.0076 0.0645 0.0645
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.0328 0.5
Brugia malayi Nuclear hormone receptor-like 1 0.0029 0.0039 0.0039
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0029 0.0039 0.0039
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0054 0.0361 0.0361
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.1501 0.1501
Schistosoma mansoni nuclear hormone receptor 0.0054 0.0361 0.0361
Brugia malayi hypothetical protein 0.0029 0.0039 0.0039
Brugia malayi nuclear receptor NHR-88 0.0054 0.0361 0.0361
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0054 0.0361 0.0361
Echinococcus granulosus tar DNA binding protein 0.0076 0.0645 0.0645
Brugia malayi nuclear receptor RXR 0.0029 0.0039 0.0039
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.0328 0.5
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0816 1 0.5
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0054 0.0361 0.0361
Echinococcus multilocularis thyroid hormone receptor alpha 0.0054 0.0361 0.0361
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0029 0.0039 0.0039
Brugia malayi steroid hormone receptor 0.0054 0.0361 0.0361
Onchocerca volvulus Bile acid receptor homolog 0.0054 0.0361 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0361 0.0361
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0054 0.0361 0.0361
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0054 0.0361 0.0361
Onchocerca volvulus Protein ultraspiracle homolog 0.0054 0.0361 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0054 0.0361 0.0361
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0054 0.0361 0.0361
Brugia malayi Steroid receptor seven-up type 2 0.0054 0.0361 0.0361
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0054 0.0361 0.0361
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0645 0.0645
Loa Loa (eye worm) hypothetical protein 0.0054 0.0361 0.0361
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0054 0.0361 0.0361
Schistosoma mansoni coup transcription factor 0.0054 0.0361 0.0361
Echinococcus granulosus FTZ F1 alpha 0.0054 0.0361 0.0361
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0029 0.0039 0.0039
Schistosoma mansoni steroid hormone receptor ad4bp 0.0054 0.0361 0.0361
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0645 0.0645
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0816 1 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0361 0.0361
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0758 0.926 0.926

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.8526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 2.8184 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 4.4668 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.1093 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 31.6228 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (binding) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] ChEMBL. No reference
Potency (functional) 100 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 112.2018 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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