Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0029 | 0.0053 | 0.0075 |
Brugia malayi | hypothetical protein | 0.0174 | 0.706 | 0.818 |
Brugia malayi | Muscleblind-like protein | 0.0148 | 0.5796 | 0.6705 |
Echinococcus multilocularis | CD36 class B scavenger receptor | 0.0174 | 0.706 | 1 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0029 | 0.0053 | 0.5 |
Echinococcus multilocularis | CD36 class B scavenger receptor | 0.0174 | 0.706 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.1014 | 0.1122 |
Brugia malayi | CD36 family protein | 0.0174 | 0.706 | 0.818 |
Echinococcus granulosus | acetylcholinesterase | 0.0134 | 0.5154 | 0.7301 |
Echinococcus multilocularis | CD36 class B scavenger receptor | 0.0174 | 0.706 | 1 |
Schistosoma mansoni | scavenger receptor class B type-2 (sr-B2) | 0.0174 | 0.706 | 1 |
Echinococcus multilocularis | lysosome membrane protein 2 | 0.0174 | 0.706 | 1 |
Trichomonas vaginalis | set domain proteins, putative | 0.0234 | 1 | 0.5 |
Brugia malayi | hypothetical protein | 0.0174 | 0.706 | 0.818 |
Echinococcus granulosus | acetylcholinesterase | 0.0134 | 0.5154 | 0.7301 |
Brugia malayi | Carboxylesterase family protein | 0.0134 | 0.5154 | 0.5956 |
Brugia malayi | Carboxylesterase family protein | 0.0134 | 0.5154 | 0.5956 |
Echinococcus multilocularis | acetylcholinesterase | 0.0134 | 0.5154 | 0.728 |
Schistosoma mansoni | cd36 antigen | 0.0174 | 0.706 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.1014 | 0.1122 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0134 | 0.5154 | 0.5956 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.5796 | 0.6705 |
Echinococcus multilocularis | muscleblind protein | 0.0148 | 0.5796 | 0.8196 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 0.706 | 0.818 |
Schistosoma mansoni | CD36-like class B scavenger receptor | 0.0174 | 0.706 | 1 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0148 | 0.5796 | 0.8196 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1014 | 0.1122 |
Schistosoma mansoni | CD36-like class B scavenger receptor | 0.0174 | 0.706 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 0.706 | 0.818 |
Echinococcus multilocularis | CD36 class B scavenger receptor | 0.0174 | 0.706 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.1014 | 0.1122 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.5154 | 0.5956 |
Echinococcus multilocularis | acetylcholinesterase | 0.0134 | 0.5154 | 0.728 |
Echinococcus granulosus | CD36 class B scavenger receptor | 0.0174 | 0.706 | 1 |
Echinococcus granulosus | CD36 class B scavenger receptor | 0.0174 | 0.706 | 1 |
Echinococcus granulosus | lysosome membrane protein 2 | 0.0174 | 0.706 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0134 | 0.5154 | 0.728 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 0.706 | 0.818 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0256 | 0.0237 |
Echinococcus granulosus | CD36 class B scavenger receptor | 0.0174 | 0.706 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0206 | 0.8618 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0256 | 0.029 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.5154 | 0.5956 |
Plasmodium vivax | SET domain protein, putative | 0.0029 | 0.0053 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.5796 | 0.6705 |
Echinococcus multilocularis | CD36 class B scavenger receptor | 0.0174 | 0.706 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 0.706 | 0.818 |
Echinococcus granulosus | CD36 class B scavenger receptor | 0.0174 | 0.706 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 0.706 | 0.818 |
Echinococcus granulosus | CD36 class B scavenger receptor | 0.0174 | 0.706 | 1 |
Onchocerca volvulus | Lysosome membrane protein 2 homolog | 0.0174 | 0.706 | 0.7044 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0206 | 0.8618 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 0.706 | 0.818 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0134 | 0.5154 | 0.728 |
Echinococcus granulosus | carboxylesterase 5A | 0.0134 | 0.5154 | 0.7301 |
Loa Loa (eye worm) | carboxylesterase | 0.0134 | 0.5154 | 0.5956 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.0256 | 0.0237 |
Echinococcus granulosus | muscleblind protein | 0.0148 | 0.5796 | 0.821 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 2.7 uM | Cytotoxicity against mouse leukemia (P388) cell line | ChEMBL. | 15109664 |
IC50 (functional) | = 2.7 uM | Cytotoxicity against mouse leukemia (P388) cell line | ChEMBL. | 15109664 |
IC50 (functional) | = 2.8 uM | Cytotoxicity against human cervix carcinoma (HeLa) cell line | ChEMBL. | 15109664 |
IC50 (functional) | = 2.8 uM | Cytotoxicity against human cervix carcinoma (HeLa) cell line | ChEMBL. | 15109664 |
IC50 (functional) | = 11 uM | Inhibitory activity of the compound against rat fibroblast (3Y1) cell line | ChEMBL. | 15109664 |
IC50 (binding) | = 80 uM | Inhibitory activity against histone deacetylase (HDAC) | ChEMBL. | 15109664 |
IC50 (binding) | = 80 uM | Inhibitory activity against histone deacetylase (HDAC) | ChEMBL. | 15109664 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 15109664 | |
Homo sapiens | ChEMBL23 | 15109664 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.