Detailed information for compound 1448638

Basic information

Technical information
  • TDR Targets ID: 1448638
  • Name: 1-[(2-fluorophenyl)methyl]-2-[(4-methoxypheny l)methyl]benzimidazole
  • MW: 346.397 | Formula: C22H19FN2O
  • H donors: 0 H acceptors: 1 LogP: 5.06 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)Cc1nc2c(n1Cc1ccccc1F)cccc2
  • InChi: 1S/C22H19FN2O/c1-26-18-12-10-16(11-13-18)14-22-24-20-8-4-5-9-21(20)25(22)15-17-6-2-3-7-19(17)23/h2-13H,14-15H2,1H3
  • InChiKey: UDIVYHXEHAJWAG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(2-fluorobenzyl)-2-(4-methoxybenzyl)benzimidazole
  • ZINC00572402
  • STK189775
  • D011-4306
  • NCGC00114736-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens ubiquitin specific peptidase 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis cathepsin L 0.0313 0.341 0.341
Brugia malayi cathepsin F-like cysteine proteinase 0.0112 0.0869 0.1217
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0607 0.7138 1
Entamoeba histolytica cysteine protease, putative 0.0313 0.341 0.4778
Echinococcus multilocularis cathepsin L cysteine protease 0.0607 0.7138 0.7138
Brugia malayi Cathepsin L-like precursor 0.0406 0.4596 0.6439
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0607 0.7138 1
Leishmania major cathepsin L-like protease 0.0607 0.7138 1
Giardia lamblia Cathepsin L precursor 0.0112 0.0869 0.5
Echinococcus multilocularis cysteine protease 0.0607 0.7138 0.7138
Brugia malayi Papain family cysteine protease containing protein 0.0112 0.0869 0.1217
Giardia lamblia Encystation-specific protease 0.0112 0.0869 0.5
Entamoeba histolytica cysteine protease, putative 0.0112 0.0869 0.1217
Loa Loa (eye worm) hypothetical protein 0.0286 0.3065 0.412
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0607 0.7138 1
Entamoeba histolytica cysteine protease, putative 0.0607 0.7138 1
Brugia malayi cathepsin L precursor 0.0112 0.0869 0.1217
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0313 0.341 0.4054
Schistosoma mansoni cathepsin S (C01 family) 0.0112 0.0869 0.0869
Trypanosoma cruzi cysteine peptidase, putative 0.0607 0.7138 1
Giardia lamblia Cathepsin L precursor 0.0112 0.0869 0.5
Onchocerca volvulus 0.0607 0.7138 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0607 0.7138 1
Echinococcus multilocularis cathepsin L 0.0112 0.0869 0.0869
Giardia lamblia Cathepsin L precursor 0.0112 0.0869 0.5
Trypanosoma cruzi cruzipain precursor, putative 0.0607 0.7138 1
Schistosoma mansoni microtubule-associated protein tau 0.0833 1 1
Brugia malayi Papain family cysteine protease containing protein 0.0313 0.341 0.4778
Leishmania major cathepsin L-like protease 0.0607 0.7138 1
Entamoeba histolytica cysteine proteinase, putative 0.0607 0.7138 1
Echinococcus granulosus biogenic amine 5HT receptor 0.012 0.0966 0.0966
Leishmania major cathepsin L-like protease 0.0607 0.7138 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0313 0.341 0.4054
Giardia lamblia Cathepsin B precursor 0.0112 0.0869 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0406 0.4596 0.5946
Entamoeba histolytica cysteine proteinase, putative 0.0313 0.341 0.4778
Schistosoma mansoni cathepsin F (C01 family) 0.0406 0.4596 0.4596
Brugia malayi Papain family cysteine protease containing protein 0.0112 0.0869 0.1217
Onchocerca volvulus 0.0607 0.7138 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0313 0.341 0.4054
Entamoeba histolytica cysteine protease, putative 0.0112 0.0869 0.1217
Brugia malayi cathepsin B-like cysteine proteinase 0.0112 0.0869 0.1217
Loa Loa (eye worm) fibroinase 0.0607 0.7138 1
Onchocerca volvulus 0.0607 0.7138 1
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.3065 0.3065
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.3065 0.3065
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0112 0.0869 0.0869
Entamoeba histolytica cysteine protease, putative 0.0313 0.341 0.4778
Loa Loa (eye worm) hypothetical protein 0.0112 0.0869 0.0948
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0112 0.0869 0.0869
Giardia lamblia Cathepsin B precursor 0.0112 0.0869 0.5
Leishmania major cathepsin L-like protease 0.0607 0.7138 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0406 0.4596 0.5946
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0607 0.7138 1
Giardia lamblia Cysteine protease 0.0112 0.0869 0.5
Echinococcus granulosus cathepsin L cysteine proteinase 0.0607 0.7138 0.7138
Entamoeba histolytica cysteine proteinase, putative 0.0607 0.7138 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0607 0.7138 1
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.1275 0.1535
Plasmodium vivax vivapain-2 0.0607 0.7138 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0607 0.7138 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.0869 0.0948
Brugia malayi Cathepsin L-like precursor 0.0201 0.1991 0.279
Trypanosoma cruzi cysteine peptidase, putative 0.0607 0.7138 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0607 0.7138 1
Loa Loa (eye worm) hypothetical protein 0.0406 0.4596 0.633
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0112 0.0869 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0607 0.7138 1
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0112 0.0869 0.1217
Trypanosoma cruzi cysteine peptidase, putative 0.0201 0.1991 0.1791
Loa Loa (eye worm) cysteine protease 0.0607 0.7138 1
Onchocerca volvulus 0.0607 0.7138 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0607 0.7138 0.7138
Echinococcus multilocularis cathepsin b 0.0112 0.0869 0.0869
Echinococcus granulosus cysteine protease 0.0313 0.341 0.341
Echinococcus granulosus cathepsin L cysteine protease 0.0313 0.341 0.341
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0607 0.7138 1
Brugia malayi MH2 domain containing protein 0.0144 0.1275 0.1787
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0187 0.0262
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0112 0.0869 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0607 0.7138 1
Schistosoma mansoni cathepsin C 0.0112 0.0869 0.0869
Loa Loa (eye worm) hypothetical protein 0.0112 0.0869 0.0948
Loa Loa (eye worm) hypothetical protein 0.0406 0.4596 0.633
Giardia lamblia Cathepsin B precursor 0.0112 0.0869 0.5
Brugia malayi Cathepsin L-like precursor 0.0607 0.7138 1
Brugia malayi cathepsin L-like cysteine proteinase 0.0112 0.0869 0.1217
Entamoeba histolytica cysteine protease, putative 0.0112 0.0869 0.1217
Onchocerca volvulus Cathepsin L homolog 0.0607 0.7138 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0607 0.7138 1
Giardia lamblia Cathepsin L precursor 0.0112 0.0869 0.5
Echinococcus granulosus cathepsin L 0.0313 0.341 0.341
Entamoeba histolytica cysteine proteinase, putative 0.0313 0.341 0.4778
Giardia lamblia Cathepsin L-like protease 0.0112 0.0869 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0607 0.7138 1
Entamoeba histolytica cysteine protease, putative 0.0313 0.341 0.4778
Giardia lamblia Cathepsin B precursor 0.0112 0.0869 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0607 0.7138 1
Plasmodium vivax unspecified product 0.0313 0.341 0.4054
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0112 0.0869 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0607 0.7138 1
Loa Loa (eye worm) cathepsin B 0.0112 0.0869 0.0948
Plasmodium vivax unspecified product 0.0201 0.1991 0.1791
Brugia malayi cathepsin Z-like cysteine proteinase 0.0112 0.0869 0.1217
Entamoeba histolytica cysteine protease, putative 0.0313 0.341 0.4778
Plasmodium falciparum cysteine proteinase falcipain 1 0.0313 0.341 0.4054
Giardia lamblia Cathepsin L-like protease 0.0112 0.0869 0.5
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0112 0.0869 0.0869
Trypanosoma cruzi cysteine peptidase, putative 0.0607 0.7138 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0313 0.341 0.341
Echinococcus granulosus cathepsin b 0.0112 0.0869 0.0869
Plasmodium vivax vivapain-3 0.0313 0.341 0.4054
Giardia lamblia Cathepsin B precursor 0.0112 0.0869 0.5
Echinococcus granulosus cathepsin l1 0.0406 0.4596 0.4596
Brugia malayi Cathepsin L-like precursor 0.0607 0.7138 1
Leishmania major cathepsin L-like protease 0.0607 0.7138 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0201 0.1991 0.279
Plasmodium falciparum cysteine proteinase falcipain 3 0.0607 0.7138 1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0112 0.0869 0.0869
Loa Loa (eye worm) hypothetical protein 0.0112 0.0869 0.0948
Echinococcus granulosus cathepsin l1 0.0607 0.7138 0.7138
Leishmania major cathepsin L-like protease 0.0607 0.7138 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0607 0.7138 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.0112 0.0869 0.1217
Toxoplasma gondii cathepsin CPL 0.0607 0.7138 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0201 0.1991 0.2569
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0607 0.7138 1
Entamoeba histolytica cysteine protease, putative 0.0313 0.341 0.4778
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0212 0.0297
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0112 0.0869 0.0869
Giardia lamblia Cathepsin B precursor 0.0112 0.0869 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0607 0.7138 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0112 0.0869 0.0869
Brugia malayi Cathepsin L-like cysteine proteinase 0.0406 0.4596 0.6439
Onchocerca volvulus 0.0607 0.7138 1
Plasmodium vivax vivapain-1 0.0313 0.341 0.4054
Entamoeba histolytica cysteine proteinase 2 0.0313 0.341 0.4778
Echinococcus granulosus cathepsin b 0.0112 0.0869 0.0869
Brugia malayi Cathepsin L-like precursor 0.0607 0.7138 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.1275 0.1535
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0112 0.0869 0.0869
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0607 0.7138 1
Loa Loa (eye worm) ctsf protein 0.0607 0.7138 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0607 0.7138 1
Entamoeba histolytica cysteine proteinase, putative 0.0313 0.341 0.4778
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0607 0.7138 1
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0201 0.1991 0.279
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0112 0.0869 0.0869
Onchocerca volvulus 0.0607 0.7138 1
Giardia lamblia Cathepsin B precursor 0.0112 0.0869 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0607 0.7138 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0607 0.7138 1
Entamoeba histolytica cysteine protease, putative 0.0313 0.341 0.4778
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0112 0.0869 0.1217
Entamoeba histolytica hypothetical protein 0.0112 0.0869 0.1217
Brugia malayi Papain family cysteine protease containing protein 0.0112 0.0869 0.1217
Brugia malayi hypothetical protein 0.0286 0.3065 0.4294
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0607 0.7138 1
Onchocerca volvulus 0.0406 0.4596 0.6343
Trypanosoma cruzi cysteine proteinase, putative 0.0313 0.341 0.4054
Leishmania major cathepsin L-like protease 0.0607 0.7138 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.0869 0.0948
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0607 0.7138 1
Loa Loa (eye worm) hypothetical protein 0.012 0.0966 0.1088
Loa Loa (eye worm) hypothetical protein 0.0201 0.1991 0.2569
Entamoeba histolytica cysteine protease, putative 0.0112 0.0869 0.1217
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0607 0.7138 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0607 0.7138 1
Entamoeba histolytica cysteine proteinase 1, putative 0.0313 0.341 0.4778
Entamoeba histolytica cysteine protease, putative 0.0112 0.0869 0.1217
Schistosoma mansoni survival motor neuron protein 0.0058 0.0187 0.0187
Entamoeba histolytica cysteine proteinase, putative 0.0406 0.4596 0.6439
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0607 0.7138 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0607 0.7138 1
Onchocerca volvulus 0.0607 0.7138 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0212 0.0297
Echinococcus multilocularis cysteine protease 0.0607 0.7138 0.7138
Giardia lamblia Cysteine protease 0.0112 0.0869 0.5
Onchocerca volvulus Cathepsin F homolog 0.0607 0.7138 1
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0112 0.0869 0.5
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0112 0.0869 0.0948
Loa Loa (eye worm) hypothetical protein 0.0201 0.1991 0.2569
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0112 0.0869 0.0869
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0112 0.0869 0.0869
Echinococcus multilocularis serotonin receptor 0.012 0.0966 0.0966
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0112 0.0869 0.0869
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0607 0.7138 1
Loa Loa (eye worm) hypothetical protein 0.012 0.0966 0.1088
Schistosoma mansoni cathepsin F (C01 family) 0.0607 0.7138 0.7138
Entamoeba histolytica cysteine protease, putative 0.0313 0.341 0.4778
Brugia malayi Cathepsin L-like precursor 0.0607 0.7138 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0607 0.7138 1
Entamoeba histolytica cysteine protease, putative 0.0313 0.341 0.4778
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0607 0.7138 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0607 0.7138 1
Giardia lamblia Cysteine protease 0.0112 0.0869 0.5
Giardia lamblia Cathepsin B precursor 0.0112 0.0869 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0406 0.4596 0.5946
Echinococcus granulosus cathepsin l cysteine peptidase 0.0607 0.7138 0.7138
Entamoeba histolytica cysteine protease, putative 0.0313 0.341 0.4778
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0313 0.341 0.341
Trypanosoma cruzi cysteine peptidase, putative 0.0313 0.341 0.4054
Onchocerca volvulus Cathepsin L homolog 0.0607 0.7138 1
Trypanosoma cruzi cysteine peptidase, putative 0.0607 0.7138 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0607 0.7138 1
Entamoeba histolytica cysteine protease, putative 0.0313 0.341 0.4778
Brugia malayi Cathepsin L-like precursor 0.0607 0.7138 1
Loa Loa (eye worm) hypothetical protein 0.0406 0.4596 0.633
Schistosoma mansoni hypothetical protein 0.0058 0.0187 0.0187
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0313 0.341 0.4054
Schistosoma mansoni cathepsin s 0.0201 0.1991 0.1991
Onchocerca volvulus 0.0112 0.0869 0.098
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0607 0.7138 1
Trypanosoma cruzi cruzipain precursor, putative 0.0201 0.1991 0.1791
Schistosoma mansoni cathepsin F (C01 family) 0.0607 0.7138 0.7138
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0607 0.7138 1
Giardia lamblia Cathepsin L precursor 0.0112 0.0869 0.5
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0607 0.7138 0.7138
Loa Loa (eye worm) hypothetical protein 0.0201 0.1991 0.2569
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0112 0.0869 0.0869
Trypanosoma cruzi cysteine proteinase, putative 0.0313 0.341 0.4054
Leishmania major cysteine peptidase A (CPA) 0.0607 0.7138 1
Giardia lamblia Hypothetical protein 0.0112 0.0869 0.5
Echinococcus multilocularis cathepsin L cysteine protease 0.0607 0.7138 0.7138
Brugia malayi fibroinase precursor 0.0112 0.0869 0.1217
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0607 0.7138 1
Loa Loa (eye worm) hypothetical protein 0.0607 0.7138 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0112 0.0869 0.0869
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0313 0.341 0.4054
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0112 0.0869 0.0948
Loa Loa (eye worm) hypothetical protein 0.0112 0.0869 0.0948
Brugia malayi Cathepsin L-like precursor 0.0406 0.4596 0.6439
Trypanosoma cruzi cysteine protease, putative 0.0313 0.341 0.4054
Brugia malayi Cathepsin L-like precursor 0.0607 0.7138 1
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0112 0.0869 0.0948
Entamoeba histolytica cysteine protease, putative 0.0313 0.341 0.4778
Echinococcus multilocularis cathepsin b 0.0112 0.0869 0.0869
Echinococcus multilocularis microtubule associated protein 2 0.0833 1 1
Giardia lamblia Hypothetical protein 0.0112 0.0869 0.5
Giardia lamblia Cysteine protease 0.0112 0.0869 0.5
Onchocerca volvulus Cathepsin L homolog 0.0112 0.0869 0.098
Brugia malayi Papain family cysteine protease containing protein 0.0607 0.7138 1
Brugia malayi cathepsin L-like precursor 0.0406 0.4596 0.6439
Entamoeba histolytica cysteine protease, putative 0.0313 0.341 0.4778
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0607 0.7138 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0313 0.341 0.341
Loa Loa (eye worm) hypothetical protein 0.0112 0.0869 0.0948
Echinococcus granulosus cathepsin L 0.0112 0.0869 0.0869
Echinococcus multilocularis serotonin receptor 0.012 0.0966 0.0966
Entamoeba histolytica cysteine proteinase, putative 0.0313 0.341 0.4778
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0112 0.0869 0.1217
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0607 0.7138 1
Leishmania major cathepsin L-like protease 0.0607 0.7138 1
Brugia malayi Papain family cysteine protease containing protein 0.0313 0.341 0.4778
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0112 0.0869 0.0869
Entamoeba histolytica cysteine protease, putative 0.0112 0.0869 0.1217
Plasmodium vivax vivapain-2 0.0607 0.7138 1
Schistosoma mansoni cathepsin B (C01 family) 0.0112 0.0869 0.0869
Giardia lamblia Cathepsin L precursor 0.0112 0.0869 0.5
Schistosoma mansoni biogenic amine (5HT) receptor 0.012 0.0966 0.0966
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0607 0.7138 1
Entamoeba histolytica cysteine protease, putative 0.0313 0.341 0.4778

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.5849 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.6234 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 7.9433 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 18.3564 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 30.1313 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Permissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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