Detailed information for compound 1448760

Basic information

Technical information
  • TDR Targets ID: 1448760
  • Name: 3-[5-[(4-fluorophenyl)methylsulfanyl]-4-(fura n-2-ylmethyl)-1,2,4-triazol-3-yl]pyridine
  • MW: 366.412 | Formula: C19H15FN4OS
  • H donors: 0 H acceptors: 3 LogP: 3.15 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)CSc1nnc(n1Cc1ccco1)c1cccnc1
  • InChi: 1S/C19H15FN4OS/c20-16-7-5-14(6-8-16)13-26-19-23-22-18(15-3-1-9-21-11-15)24(19)12-17-4-2-10-25-17/h1-11H,12-13H2
  • InChiKey: BEAYBBLBCCHMOC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[5-[(4-fluorophenyl)methylsulfanyl]-4-(2-furylmethyl)-1,2,4-triazol-3-yl]pyridine
  • 3-[5-[(4-fluorophenyl)methylthio]-4-(2-furylmethyl)-1,2,4-triazol-3-yl]pyridine
  • 3-[5-[(4-fluorobenzyl)thio]-4-(2-furylmethyl)-1,2,4-triazol-3-yl]pyridine
  • MLS000082412
  • ST5085144
  • ZINC04313109
  • SMR000043430

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens parathyroid hormone 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K04588 secretin receptor, putative Get druggable targets OG5_139196 All targets in OG5_139196
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) tubulin beta chain 0.043 1 1
Leishmania major beta tubulin 0.043 1 1
Echinococcus granulosus tubulin alpha chain 0.0181 0.2986 0.2986
Schistosoma mansoni alpha tubulin 0.0181 0.2986 0.2986
Mycobacterium ulcerans cell division protein FtsZ 0.0075 0 0.5
Plasmodium vivax tubulin gamma chain, putative 0.0173 0.2759 0.2759
Plasmodium vivax tubulin beta chain, putative 0.043 1 1
Leishmania major alpha tubulin 0.0181 0.2986 0.2986
Trypanosoma cruzi epsilon tubulin, putative 0.0173 0.2759 0.2759
Leishmania major beta tubulin 0.043 1 1
Loa Loa (eye worm) hypothetical protein 0.0106 0.0869 0.0869
Trichomonas vaginalis tubulin beta chain, putative 0.0098 0.0642 0.0642
Echinococcus multilocularis tubulin alpha chain 0.0181 0.2986 0.2986
Trypanosoma brucei epsilon tubulin 0.0173 0.2759 0.2759
Echinococcus multilocularis tubulin, beta 4A class IVa 0.043 1 1
Echinococcus multilocularis tubulin alpha 3 chain 0.0181 0.2986 0.2986
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0173 0.2759 0.2759
Echinococcus granulosus tubulin alpha 3 chain 0.0181 0.2986 0.2986
Leishmania major beta tubulin 0.043 1 1
Entamoeba histolytica tubulin family protein 0.043 1 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.043 1 1
Echinococcus granulosus Tubulin alpha 1 chain 0.0181 0.2986 0.2986
Leishmania major beta tubulin 0.043 1 1
Mycobacterium tuberculosis Cell division protein FtsZ 0.0075 0 0.5
Plasmodium falciparum tubulin epsilon chain, putative 0.0173 0.2759 0.2759
Trichomonas vaginalis tubulin alpha chain, putative 0.0173 0.2759 0.2759
Plasmodium vivax tubulin alpha chain, putative 0.0181 0.2986 0.2986
Plasmodium falciparum alpha tubulin 1 0.0181 0.2986 0.2986
Echinococcus granulosus tubulin subunit TubB 0.0181 0.2986 0.2986
Toxoplasma gondii beta-tubulin, putative 0.043 1 1
Schistosoma mansoni tubulin subunit beta 0.043 1 1
Toxoplasma gondii alpha tubulin TUBA1 0.0181 0.2986 0.2986
Leishmania major beta tubulin 0.043 1 1
Leishmania major beta tubulin 0.043 1 1
Toxoplasma gondii beta-1 tubulin, putative 0.043 1 1
Echinococcus multilocularis tubulin alpha 3 chain 0.0181 0.2986 0.2986
Echinococcus multilocularis tubulin gamma 1 chain 0.0173 0.2759 0.2759
Echinococcus multilocularis Tubulin beta 2C chain 0.043 1 1
Trichomonas vaginalis tubulin, putative 0.0098 0.0642 0.0642
Trypanosoma brucei beta tubulin 0.0173 0.2759 0.2759
Trypanosoma brucei alpha tubulin, putative 0.0098 0.0642 0.0642
Toxoplasma gondii beta tubulin 0.043 1 1
Loa Loa (eye worm) tubulin alpha chain 0.0181 0.2986 0.2986
Schistosoma mansoni tubulin subunit alpha 0.0181 0.2986 0.2986
Echinococcus multilocularis tubulin subunit TubB 0.0181 0.2986 0.2986
Trichomonas vaginalis tubulin beta chain, putative 0.0181 0.2986 0.2986
Echinococcus multilocularis Tubulin beta 2C chain 0.043 1 1
Echinococcus multilocularis Tubulin alpha 1 chain 0.0181 0.2986 0.2986
Trichomonas vaginalis tubulin epsilon chain, putative 0.0181 0.2986 0.2986
Leishmania major alpha tubulin 0.0181 0.2986 0.2986
Loa Loa (eye worm) tubulin alpha 2 0.0106 0.0869 0.0869
Echinococcus granulosus Tubulin beta 2C chain 0.043 1 1
Giardia lamblia Alpha-tubulin 0.0181 0.2986 0.2986
Leishmania major beta tubulin 0.043 1 1
Trypanosoma cruzi beta tubulin, putative 0.043 1 1
Leishmania major beta tubulin 0.043 1 1
Schistosoma mansoni tubulin subunit epsilon 0.0173 0.2759 0.2759
Leishmania major alpha tubulin 0.0181 0.2986 0.2986
Echinococcus multilocularis tubulin alpha chain 0.0181 0.2986 0.2986
Loa Loa (eye worm) tubulin alpha-2 chain 0.0181 0.2986 0.2986
Trypanosoma brucei alpha tubulin 0.0181 0.2986 0.2986
Echinococcus multilocularis beta tubulin 0.043 1 1
Loa Loa (eye worm) beta-tubulin 0.043 1 1
Trichomonas vaginalis tubulin gamma chain, putative 0.0173 0.2759 0.2759
Echinococcus multilocularis Tubulin beta 2C chain 0.043 1 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0098 0.0642 0.0642
Echinococcus multilocularis Tubulin beta 2C chain 0.043 1 1
Schistosoma mansoni tubulin subunit beta 0.043 1 1
Echinococcus multilocularis tubulin alpha chain 0.0181 0.2986 0.2986
Loa Loa (eye worm) tubulin beta-4 chain 0.043 1 1
Leishmania major alpha tubulin 0.0181 0.2986 0.2986
Trichomonas vaginalis tubulin beta chain, putative 0.043 1 1
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0083 0.0228 0.0228
Schistosoma mansoni alpha tubulin 0.0181 0.2986 0.2986
Loa Loa (eye worm) tubulin gamma chain 0.0173 0.2759 0.2759
Leishmania major beta tubulin 0.043 1 1
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0098 0.0642 0.0642
Trichomonas vaginalis tubulin, putative 0.0098 0.0642 0.0642
Echinococcus granulosus tubulin alpha chain 0.0181 0.2986 0.2986
Echinococcus multilocularis tubulin beta 1 chain 0.043 1 1
Brugia malayi latrophilin 2 splice variant baaae 0.0082 0.0205 0.0205
Loa Loa (eye worm) BEN-1 protein 0.043 1 1
Trypanosoma brucei beta tubulin 0.043 1 1
Trypanosoma cruzi tubulin gamma chain 0.0173 0.2759 0.2759
Brugia malayi Calcitonin receptor-like protein seb-1 0.012 0.1279 0.1279
Giardia lamblia Beta tubulin 0.043 1 1
Trypanosoma brucei epsilon tubulin 0.0173 0.2759 0.2759
Trypanosoma brucei epsilon tubulin 0.0173 0.2759 0.2759
Brugia malayi Tubulin gamma chain 0.0173 0.2759 0.2759
Giardia lamblia Beta tubulin 0.043 1 1
Loa Loa (eye worm) tubulin beta-2A chain 0.043 1 1
Leishmania major alpha tubulin 0.0181 0.2986 0.2986
Plasmodium falciparum alpha tubulin 2 0.0181 0.2986 0.2986
Loa Loa (eye worm) hypothetical protein 0.0082 0.0205 0.0205
Echinococcus granulosus Tubulin alpha 1 chain 0.0181 0.2986 0.2986
Plasmodium falciparum tubulin gamma chain 0.0173 0.2759 0.2759
Trypanosoma brucei alpha tubulin 0.0181 0.2986 0.2986
Echinococcus multilocularis hypothetical protein 0.0181 0.2986 0.2986
Echinococcus granulosus tubulin subunit beta 0.043 1 1
Leishmania major gamma-tubulin 0.0173 0.2759 0.2759
Schistosoma mansoni tubulin subunit beta 0.043 1 1
Leishmania major beta tubulin 0.043 1 1
Echinococcus granulosus Tubulin beta 2C chain 0.043 1 1
Brugia malayi beta-tubulin, identical 0.043 1 1
Leishmania major beta tubulin 0.043 1 1
Loa Loa (eye worm) tubulin beta-1 chain 0.043 1 1
Giardia lamblia Gamma tubulin 0.0173 0.2759 0.2759
Trypanosoma brucei tubulin gamma chain 0.0173 0.2759 0.2759
Entamoeba histolytica tubulin alpha-1 chain 0.0181 0.2986 0.0314
Trypanosoma brucei beta tubulin 0.043 1 1
Trypanosoma cruzi alpha tubulin, putative 0.0181 0.2986 0.2986
Trichomonas vaginalis tubulin beta chain, putative 0.0181 0.2986 0.2986
Trichomonas vaginalis tubulin alpha chain, putative 0.0098 0.0642 0.0642
Echinococcus multilocularis tubulin alpha chain 0.0181 0.2986 0.2986
Leishmania major beta tubulin 0.043 1 1
Schistosoma mansoni hypothetical protein 0.0082 0.0205 0.0205
Echinococcus multilocularis tubulin epsilon chain 0.0173 0.2759 0.2759
Loa Loa (eye worm) tubulin alpha-3 chain 0.0083 0.0228 0.0228
Echinococcus granulosus alpha tubulin 0.0181 0.2986 0.2986
Echinococcus multilocularis peroxisome assembly protein 26 0.0181 0.2986 0.2986
Schistosoma mansoni tubulin subunit beta 0.043 1 1
Leishmania major beta tubulin 0.043 1 1
Entamoeba histolytica tubulin family protein 0.043 1 1
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0181 0.2986 0.2986
Brugia malayi Tubulin alpha-2 chain 0.0181 0.2986 0.2986
Leishmania major alpha tubulin 0.0181 0.2986 0.2986
Echinococcus multilocularis beta tubulin 0.043 1 1
Loa Loa (eye worm) tubulin alpha 2 0.0106 0.0869 0.0869
Schistosoma mansoni tubulin subunit gamma 0.0173 0.2759 0.2759
Echinococcus granulosus tubulin beta 4A class IVa 0.043 1 1
Brugia malayi tubulin alpha chain - mouse 0.0181 0.2986 0.2986
Echinococcus multilocularis Tubulin beta 2C chain 0.043 1 1
Trichomonas vaginalis tubulin gamma chain, putative 0.0173 0.2759 0.2759
Treponema pallidum cell division protein FtsZ 0.0075 0 0.5
Leishmania major beta tubulin 0.043 1 1
Trichomonas vaginalis tubulin alpha chain, putative 0.043 1 1
Leishmania major beta tubulin 0.043 1 1
Brugia malayi Tubulin beta chain 0.0098 0.0642 0.0642
Trichomonas vaginalis tubulin alpha chain, putative 0.0098 0.0642 0.0642
Echinococcus granulosus tubulin alpha 3 chain 0.0181 0.2986 0.2986
Leishmania major beta tubulin 0.043 1 1
Echinococcus multilocularis tubulin alpha 1C chain 0.0181 0.2986 0.2986
Leishmania major alpha tubulin 0.0181 0.2986 0.2986
Echinococcus granulosus tubulin alpha 1C chain 0.0181 0.2986 0.2986
Plasmodium falciparum tubulin beta chain 0.043 1 1
Trypanosoma brucei alpha tubulin 0.0181 0.2986 0.2986
Brugia malayi tubulin alpha-2 chain 0.0181 0.2986 0.2986
Trichomonas vaginalis tubulin beta chain, putative 0.0181 0.2986 0.2986
Trichomonas vaginalis tubulin beta chain, putative 0.0181 0.2986 0.2986
Echinococcus granulosus peroxisome assembly protein 26 0.0181 0.2986 0.2986
Leishmania major beta tubulin 0.043 1 1
Mycobacterium leprae cell division protein FtsZ 0.0075 0 0.5
Trichomonas vaginalis tubulin epsilon chain, putative 0.0181 0.2986 0.2986
Schistosoma mansoni tubulin subunit beta 0.043 1 1
Trypanosoma brucei beta tubulin 0.043 1 1
Echinococcus multilocularis tubulin alpha 1C chain 0.0181 0.2986 0.2986
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0075 0 0.5
Giardia lamblia Alpha-tubulin 0.0181 0.2986 0.2986
Echinococcus granulosus tubulin gamma 1 chain 0.0173 0.2759 0.2759
Onchocerca volvulus 0.0098 0.0642 0.5
Trichomonas vaginalis tubulin epsilon chain, putative 0.043 1 1
Echinococcus granulosus tubulin alpha chain 0.0181 0.2986 0.2986
Echinococcus granulosus Tubulin alpha 1 chain 0.0181 0.2986 0.2986
Echinococcus granulosus Tubulin beta 2C chain 0.043 1 1
Echinococcus granulosus tubulin alpha chain 0.0181 0.2986 0.2986
Echinococcus multilocularis tubulin subunit beta 0.043 1 1
Loa Loa (eye worm) hypothetical protein 0.0181 0.2986 0.2986
Schistosoma mansoni tubulin subunit alpha 0.0181 0.2986 0.2986
Echinococcus granulosus Tubulin beta 2C chain 0.043 1 1
Toxoplasma gondii alpha-tubulin I, putative 0.0181 0.2986 0.2986
Echinococcus multilocularis Tubulin alpha 1 chain 0.0181 0.2986 0.2986
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.012 0.1279 0.1279
Brugia malayi alpha-tubulin 0.0181 0.2986 0.2986
Loa Loa (eye worm) hypothetical protein 0.012 0.1279 0.1279
Trypanosoma brucei beta tubulin 0.043 1 1
Brugia malayi Tubulin alpha-2 chain 0.0181 0.2986 0.2986
Trichomonas vaginalis tubulin, putative 0.043 1 1
Loa Loa (eye worm) hypothetical protein 0.0083 0.0228 0.0228
Leishmania major epsilon tubulin, putative 0.0173 0.2759 0.2759
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0106 0.0869 0.0869
Loa Loa (eye worm) alpha-tubulin 0.0181 0.2986 0.2986
Loa Loa (eye worm) BEN-1 protein 0.043 1 1
Echinococcus granulosus tubulin beta 1 chain 0.043 1 1
Trichomonas vaginalis tubulin beta chain, putative 0.0181 0.2986 0.2986
Schistosoma mansoni alpha tubulin 0.0181 0.2986 0.2986
Trichomonas vaginalis tubulin beta chain, putative 0.0181 0.2986 0.2986
Trypanosoma brucei alpha tubulin 0.0181 0.2986 0.2986
Plasmodium vivax tubulin alpha chain, putative 0.0181 0.2986 0.2986
Echinococcus granulosus beta tubulin 0.043 1 1
Echinococcus granulosus tubulin alpha 1C chain 0.0181 0.2986 0.2986
Echinococcus granulosus tubulin epsilon chain 0.0173 0.2759 0.2759
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0106 0.0869 0.0869
Echinococcus multilocularis tubulin alpha chain 0.0181 0.2986 0.2986
Trypanosoma cruzi epsilon tubulin, putative 0.0173 0.2759 0.2759
Echinococcus granulosus tubulin alpha 0.0173 0.2759 0.2759
Echinococcus multilocularis tubulin alpha 0.0173 0.2759 0.2759
Plasmodium vivax tubulin epsilon chain, putative 0.0173 0.2759 0.2759
Echinococcus multilocularis Tubulin alpha 1 chain 0.0181 0.2986 0.2986
Leishmania major alpha tubulin 0.0181 0.2986 0.2986
Leishmania major alpha tubulin 0.0181 0.2986 0.2986
Loa Loa (eye worm) pigment dispersing factor receptor c 0.012 0.1279 0.1279
Leishmania major beta tubulin 0.043 1 1
Loa Loa (eye worm) tubulin alpha chain 0.0181 0.2986 0.2986
Echinococcus granulosus Tubulin beta 2C chain 0.043 1 1
Schistosoma mansoni tubulin subunit alpha 0.0181 0.2986 0.2986
Leishmania major alpha tubulin 0.0181 0.2986 0.2986
Leishmania major alpha tubulin 0.0181 0.2986 0.2986
Brugia malayi Tubulin alpha chain 0.0181 0.2986 0.2986
Loa Loa (eye worm) alpha-tubulin 0.0181 0.2986 0.2986
Leishmania major alpha tubulin 0.0181 0.2986 0.2986
Entamoeba histolytica tubulin alpha chain, putative 0.0181 0.2986 0.0314
Giardia lamblia Beta tubulin 0.043 1 1
Trichomonas vaginalis tubulin gamma chain, putative 0.043 1 1
Echinococcus granulosus beta tubulin 0.043 1 1
Echinococcus granulosus tubulin alpha chain 0.0181 0.2986 0.2986
Schistosoma mansoni tubulin subunit beta 0.043 1 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.5012 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.1623 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.5113 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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