Detailed information for compound 1448937

Basic information

Technical information
  • TDR Targets ID: 1448937
  • Name: 2-[(3-phenyl-1,2,4-oxadiazol-5-yl)methylsulfa nyl]-1,3-benzoxazole
  • MW: 309.342 | Formula: C16H11N3O2S
  • H donors: 0 H acceptors: 3 LogP: 4.02 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: c1ccc(cc1)c1noc(n1)CSc1nc2c(o1)cccc2
  • InChi: 1S/C16H11N3O2S/c1-2-6-11(7-3-1)15-18-14(21-19-15)10-22-16-17-12-8-4-5-9-13(12)20-16/h1-9H,10H2
  • InChiKey: VZXANSUMSNOENL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[(3-phenyl-1,2,4-oxadiazol-5-yl)methylthio]-1,3-benzoxazole
  • ZINC00094117
  • 2-{[(3-phenyl-1,2,4-oxadiazol-5-yl)methyl]thio}-1,3-benzoxazole
  • MLS000085182
  • SMR000019722
  • EU-0081199
  • IDI1_003085
  • ChemDiv2_004370

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi nuclear receptor NHR-88 0.0117 1 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.446 0.446
Brugia malayi nuclear hormone receptor 0.0055 0.3795 0.3795
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0062 0.446 0.4369
Loa Loa (eye worm) hypothetical protein 0.0055 0.3795 0.3795
Schistosoma mansoni thyroid hormone receptor 0.0117 1 1
Onchocerca volvulus 0.0117 1 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.016 0.016
Schistosoma mansoni nuclear receptor nhr-48 0.0055 0.3795 0.3694
Brugia malayi Nuclear hormone receptor E75 0.0055 0.3795 0.3795
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0117 1 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0117 1 1
Loa Loa (eye worm) hypothetical protein 0.0117 1 1
Brugia malayi nuclear receptor NHR-88 0.0055 0.3795 0.3795
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0117 1 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.4277 0.4277
Schistosoma mansoni nuclear hormone receptor 0.0055 0.3795 0.3694
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0062 0.446 0.446
Echinococcus multilocularis ecdysone induced protein 78C 0.0117 1 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0117 1 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0117 1 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.3795 0.3795
Loa Loa (eye worm) hypothetical protein 0.0117 1 1
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0055 0.3795 0.3694
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0117 1 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.4277 0.4277
Brugia malayi intermediate filament protein 0.0033 0.1513 0.1513
Loa Loa (eye worm) hypothetical protein 0.0055 0.3795 0.3795
Loa Loa (eye worm) hypothetical protein 0.0055 0.3795 0.3795
Brugia malayi ecdysone receptor 0.0055 0.3795 0.3795
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0117 1 1
Loa Loa (eye worm) DR-78 0.0055 0.3795 0.3795
Brugia malayi nuclear hormone receptor family member odr-7 0.0055 0.3795 0.3795
Echinococcus multilocularis nuclear receptor nhr 48 0.0055 0.3795 0.3694
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.016 0.016
Brugia malayi hypothetical protein 0.0055 0.3795 0.3795
Loa Loa (eye worm) hypothetical protein 0.0117 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0117 1 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.3795 0.3795
Onchocerca volvulus 0.0055 0.3795 0.2689
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0117 1 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0117 1 1
Echinococcus granulosus lamin 0.0033 0.1513 0.1374
Brugia malayi Nuclear hormone receptor-like 1 0.0062 0.446 0.446
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0055 0.3795 0.3694
Brugia malayi conserved hypotetical protein 0.0055 0.3795 0.3795
Loa Loa (eye worm) hypothetical protein 0.0117 1 1
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0055 0.3795 0.3694
Loa Loa (eye worm) hypothetical protein 0.0117 1 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0062 0.446 0.4369
Brugia malayi nuclear hormone receptor 0.0117 1 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0117 1 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.3795 0.3795
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0117 1 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.3795 0.3795
Echinococcus granulosus Nuclear hormone receptor HR96 0.0055 0.3795 0.3694
Schistosoma mansoni hypothetical protein 0.0041 0.2372 0.2247
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0055 0.3795 0.2689
Onchocerca volvulus Bile acid receptor homolog 0.0117 1 1
Schistosoma mansoni coup transcription factor 0.0117 1 1
Schistosoma mansoni lamin 0.0033 0.1513 0.1374
Echinococcus granulosus intermediate filament protein 0.0033 0.1513 0.1374
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0117 1 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.446 0.446
Loa Loa (eye worm) hypothetical protein 0.0062 0.446 0.446
Loa Loa (eye worm) hypothetical protein 0.0033 0.1513 0.1513
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0117 1 1
Schistosoma mansoni thyroid hormone receptor 0.0117 1 1
Schistosoma mansoni nuclear receptor 0.0055 0.3795 0.3694
Brugia malayi nuclear receptor RXR 0.0062 0.446 0.446
Echinococcus multilocularis FTZ F1 alpha 0.0117 1 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0062 0.446 0.4369
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0117 1 1
Brugia malayi Nuclear hormone receptor-like 1 0.0117 1 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0117 1 1
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.2372 0.2372
Onchocerca volvulus Protein ultraspiracle homolog 0.0117 1 1
Loa Loa (eye worm) hypothetical protein 0.0117 1 1
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.1513 0.1513
Loa Loa (eye worm) hypothetical protein 0.0055 0.3795 0.3795
Loa Loa (eye worm) hypothetical protein 0.0055 0.3795 0.3795
Brugia malayi Latrophilin receptor protein 2 0.0019 0.016 0.016
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0117 1 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.1453 0.1453
Schistosoma mansoni nuclear hormone receptor 0.0117 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0117 1 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.2372 0.2372
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0117 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0117 1 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0117 1 1
Loa Loa (eye worm) steroid hormone receptor 0.0117 1 1
Schistosoma mansoni intermediate filament proteins 0.0033 0.1513 0.1374
Loa Loa (eye worm) hypothetical protein 0.0055 0.3795 0.3795
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0117 1 1
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0055 0.3795 0.3694
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0062 0.446 0.4369
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0117 1 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0117 1 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0117 1 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0055 0.3795 0.3694
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0055 0.3795 0.3694
Brugia malayi nuclear receptor NHR-67 0.0055 0.3795 0.3795
Loa Loa (eye worm) intermediate filament protein 0.0033 0.1513 0.1513
Brugia malayi nuclear receptor RXR 0.0055 0.3795 0.3795
Schistosoma mansoni retinoic acid receptor RXR 0.0117 1 1
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0055 0.3795 0.3795
Echinococcus granulosus thyroid hormone receptor alpha 0.0055 0.3795 0.3694
Schistosoma mansoni steroid hormone receptor ad4bp 0.0117 1 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.3795 0.3795
Schistosoma mansoni zinc finger protein 0.0055 0.3795 0.3694
Brugia malayi tailless protein 0.0055 0.3795 0.3795
Echinococcus granulosus FTZ F1 alpha 0.0117 1 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0117 1 1
Onchocerca volvulus 0.0055 0.3795 0.2689
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0055 0.3795 0.3795
Brugia malayi nuclear hormone receptor family member nhr-6 0.0055 0.3795 0.3795
Brugia malayi Nuclear hormone receptor E75 0.0055 0.3795 0.3795
Echinococcus multilocularis lamin 0.0033 0.1513 0.1374
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0117 1 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.4277 0.4277
Loa Loa (eye worm) hypothetical protein 0.006 0.4277 0.4277
Loa Loa (eye worm) hypothetical protein 0.0117 1 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0117 1 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0117 1 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.3795 0.3795
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0117 1 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0055 0.3795 0.3694
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0117 1 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0055 0.3795 0.2689
Brugia malayi orphan nuclear receptor NR2E1 0.0055 0.3795 0.3795
Echinococcus granulosus ecdysone induced protein 78C 0.0117 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0117 1 1
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0055 0.3795 0.3694
Schistosoma mansoni nuclear receptor 0.0055 0.3795 0.3694
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0117 1 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.446 0.446
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0117 1 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.3795 0.3795
Loa Loa (eye worm) hypothetical protein 0.0062 0.446 0.446
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.016 0.016
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0117 1 1
Brugia malayi steroid hormone receptor 0.0117 1 1
Echinococcus granulosus lamin dm0 0.0033 0.1513 0.1374
Echinococcus multilocularis lamin dm0 0.0033 0.1513 0.1374
Loa Loa (eye worm) nuclear hormone receptor 0.0055 0.3795 0.3795
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0117 1 1
Schistosoma mansoni lamin 0.0033 0.1513 0.1374
Loa Loa (eye worm) nuclear receptor NHR-67 0.0055 0.3795 0.3795
Brugia malayi Nuclear hormone receptor-like 1 0.0062 0.446 0.446
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0117 1 1
Echinococcus multilocularis musashi 0.0033 0.1513 0.1374
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0117 1 1
Brugia malayi hypothetical protein 0.0055 0.3795 0.3795
Brugia malayi hypothetical protein 0.0062 0.446 0.446
Echinococcus granulosus nuclear receptor nhr 48 0.0055 0.3795 0.3694
Brugia malayi hypothetical protein 0.0062 0.446 0.446
Schistosoma mansoni nuclear hormone receptor 0.0055 0.3795 0.3694
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.1513 0.1513
Brugia malayi photoreceptor-specific nuclear receptor 0.0117 1 1
Loa Loa (eye worm) hypothetical protein 0.0117 1 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0055 0.3795 0.3694
Echinococcus granulosus Nuclear hormone receptor HR96 0.0055 0.3795 0.3694
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0117 1 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0117 1 1
Schistosoma mansoni RAR-like nuclear receptor 0.0117 1 1
Brugia malayi Steroid receptor seven-up type 2 0.0117 1 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0117 1 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 69.31 uM PubChem BioAssay. Dose ResponseConfirmation of SKN-1 Inhibitor hits in a fluorescence ratio assay - Set 2. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) = 75.75 uM PubChem BioAssay. Dose Response Confirmation of SKN-1 Inhibitor hits in a fluorescence ratio assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 37.933 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) 75.6863 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 125.8925 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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