Detailed information for compound 1449269

Basic information

Technical information
  • TDR Targets ID: 1449269
  • Name: MLS000729215
  • MW: 446.858 | Formula: C20H13ClF2N4O2S
  • H donors: 1 H acceptors: 2 LogP: 3.84 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(c(c1)F)NC(=O)Cn1c2ccc(cc2c2c1c(=O)n1c(n2)SCC1)F
  • InChi: 1S/C20H13ClF2N4O2S/c21-10-1-3-14(13(23)7-10)24-16(28)9-27-15-4-2-11(22)8-12(15)17-18(27)19(29)26-5-6-30-20(26)25-17/h1-4,7-8H,5-6,9H2,(H,24,28)
  • InChiKey: UMGSTDLFURZSIZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4-chloro-2-fluorophenyl)-2-(9-fluoro-5-oxo-2,3-dihydro[1,3]thiazolo[3',2':1,2]pyrimido[5,4-b]indol-6(5H)-yl)acetamide
  • SMR000307493
  • A3665/0155361

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Bacillus subtilis 4'-phosphopantetheinyl transferase ffp Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens l(3)mbt-like 1 (Drosophila) Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis L aminoadipate semialdehyde Get druggable targets OG5_129301 All targets in OG5_129301
Schistosoma mansoni hypothetical protein Get druggable targets OG5_130415 All targets in OG5_130415
Schistosoma japonicum Lethal(3)malignant brain tumor-like 3 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Onchocerca volvulus Get druggable targets OG5_129301 All targets in OG5_129301
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma japonicum expressed protein Get druggable targets OG5_129301 All targets in OG5_129301
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase Get druggable targets OG5_129301 All targets in OG5_129301
Cryptosporidium hominis proteinx0005 Get druggable targets OG5_129301 All targets in OG5_129301
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129301 All targets in OG5_129301
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Echinococcus granulosus endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma japonicum ko:K00142 aminoadipate-semialdehyde dehydrogenase [EC1.2.1.31], putative Get druggable targets OG5_129301 All targets in OG5_129301
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase Get druggable targets OG5_129301 All targets in OG5_129301
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma japonicum Lethal(3)malignant brain tumor-like 4 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Cryptosporidium parvum phosphopantetheinyl transferase Get druggable targets OG5_129301 All targets in OG5_129301
Echinococcus multilocularis endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Echinococcus granulosus L aminoadipate semialdehyde Get druggable targets OG5_129301 All targets in OG5_129301
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Candida albicans aminoadipate-semialdehyde dehydrogenase small subunit 4'-phosphopantetheinyl transferase ffp   224 aa 183 aa 27.3 %
Trichomonas vaginalis conserved hypothetical protein 4'-phosphopantetheinyl transferase ffp   224 aa 197 aa 22.3 %
Candida albicans aminoadipate-semialdehyde dehydrogenase small subunit 4'-phosphopantetheinyl transferase ffp   224 aa 183 aa 27.3 %
Entamoeba histolytica hypothetical protein 4'-phosphopantetheinyl transferase ffp   224 aa 198 aa 28.3 %
Onchocerca volvulus 4'-phosphopantetheinyl transferase ffp   224 aa 186 aa 26.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0369 0.0891
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0369 0.0881
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0082 0.1056 0.1048
Onchocerca volvulus 0.0023 0.0186 0.0272
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0066 0.0818 0.1274
Entamoeba histolytica PH domain containing protein kinase, putative 0.0142 0.1969 0.4754
Mycobacterium tuberculosis Putative conserved ATPase 0.0017 0.0086 0.0012
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0019 0.001
Brugia malayi Protein kinase domain containing protein 0.0087 0.1136 0.1776
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0016
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0121 0.0155
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0014 0.0049 0.1101
Echinococcus multilocularis Diacylglycerol kinase theta 0.0076 0.097 0.0962
Mycobacterium ulcerans hypothetical protein 0.0157 0.2179 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0092 0.0131
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.4141 1
Loa Loa (eye worm) TK/ALK protein kinase 0.0016 0.0073 0.0102
Schistosoma mansoni alpha glucosidase 0.0036 0.0369 0.0361
Leishmania major hypothetical protein, conserved 0.0209 0.297 0.3962
Schistosoma mansoni alpha-glucosidase 0.0138 0.1902 0.1895
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0013 0.0035 0.0084
Loa Loa (eye worm) raf kinase 0.0076 0.097 0.1514
Schistosoma mansoni rotamase 0.0033 0.0328 0.032
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0.022 0.1592
Entamoeba histolytica diacylglycerol kinase, putative 0.0076 0.097 0.2343
Schistosoma mansoni importin beta-1 0.0028 0.0261 0.0253
Onchocerca volvulus 0.0016 0.0073 0.0095
Brugia malayi F/Y-rich N-terminus family protein 0.0023 0.018 0.0269
Schistosoma mansoni 6-phosphofructokinase 0.0107 0.1437 0.143
Schistosoma mansoni flap endonuclease-1 0.0023 0.0183 0.0175
Echinococcus multilocularis polycomb protein SCMH1 0.0058 0.0698 0.069
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0414 0.0406
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0019 0.0006
Loa Loa (eye worm) troponin T 0.0062 0.0769 0.1198
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0369 0.0881
Schistosoma mansoni cercarial elastase (S01 family) 0.0012 0.0013 0.0004
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0076 0.097 0.0962
Echinococcus granulosus transitional endoplasmic reticulum atpase 0.0028 0.0253 0.024
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0019 0.0016
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0723 0.1125
Trypanosoma brucei hypothetical protein, conserved 0.0209 0.297 0.3962
Loa Loa (eye worm) hypothetical protein 0.0196 0.2763 0.4337
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0019 0.0006
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0376 0.0497
Toxoplasma gondii calcium binding egf domain-containing protein 0.0027 0.0246 0.183
Giardia lamblia DINP protein human, muc B family 0.0019 0.0121 0.0086
Mycobacterium tuberculosis Conserved hypothetical protein 0.0157 0.2179 1
Onchocerca volvulus 0.01 0.1339 0.2089
Trichomonas vaginalis AGC family protein kinase 0.0087 0.1136 0.2737
Echinococcus multilocularis glycoprotein Antigen 5 0.0012 0.0013 0.0004
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0186 0.0797
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0007
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0028 0.0259 0.6806
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0087 0.1136 0.1776
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0369 0.0881
Plasmodium falciparum plasmepsin II 0.0017 0.0092 0.2259
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0141 0.1942 0.2588
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0269 0.7076
Schistosoma mansoni diacylglycerol kinase theta 0.0076 0.097 0.0962
Schistosoma mansoni serine/threonine protein kinase 0.0087 0.1136 0.1129
Echinococcus granulosus bloom syndrome protein 0.0021 0.0151 0.0138
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0095 0.1262 0.1255
Loa Loa (eye worm) hypothetical protein 0.0076 0.097 0.1514
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0287 0.4137 0.4132
Echinococcus multilocularis troponin i 0.0105 0.1409 0.1402
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0097 0.2416
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0186 0.0279
Loa Loa (eye worm) hypothetical protein 0.0023 0.0186 0.0279
Toxoplasma gondii diacylglycerol kinase, putative 0.0076 0.097 0.8474
Echinococcus multilocularis expressed protein 0.0033 0.0328 0.032
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.7227 0.7225
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0087 0.1136 0.1125
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0019 0.0016
Schistosoma mansoni hypothetical protein 0.0015 0.0057 0.0048
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.0381 0.092
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0019 0.0016
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0012 0.0013 0.0004
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0141 0.1939 0.8854
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0032 0.0317 0.0765
Brugia malayi Variant SH3 domain containing protein 0.0076 0.097 0.1514
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0266 0.0253
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0381 0.0369
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0186 0.0448
Entamoeba histolytica hypothetical protein 0.0023 0.0181 0.0436
Brugia malayi Troponin I 0.0105 0.1409 0.2205
Schistosoma mansoni atypical protein kinase C 0.0401 0.5834 0.5831
Schistosoma mansoni troponin t invertebrate 0.013 0.1787 0.178
Onchocerca volvulus Arrow homolog 0.003 0.0286 0.043
Schistosoma mansoni cercarial elastase (S01 family) 0.0012 0.0013 0.0004
Entamoeba histolytica Flap nuclease, putative 0.0026 0.022 0.0531
Schistosoma mansoni cercarial elastase (S01 family) 0.0012 0.0013 0.0004
Brugia malayi Protein kinase domain containing protein 0.0087 0.1136 0.1776
Echinococcus multilocularis serine:threonine protein kinase 38 0.0087 0.1136 0.1129
Onchocerca volvulus 0.003 0.0287 0.0432
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0076 0.097 0.0962
Brugia malayi Trypsin family protein 0.0012 0.0013 0.0007
Giardia lamblia Fructose-bisphosphate aldolase 0.0288 0.4141 1
Schistosoma mansoni hypothetical protein 0.0016 0.0073 0.0065
Brugia malayi phosphofructokinase 0.0107 0.1437 0.2249
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0019 0.0016
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0113 0.0101
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0599 0.0794
Echinococcus multilocularis MAM 0.0016 0.0073 0.0065
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0121 0.0155
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0007
Loa Loa (eye worm) hypothetical protein 0.0019 0.0121 0.0176
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0307 0.4427 0.6957
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0087 0.1136 0.1776
Loa Loa (eye worm) hypothetical protein 0.0036 0.0376 0.0579
Loa Loa (eye worm) hypothetical protein 0.0016 0.0073 0.0102
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0024 0.0197 0.0851
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0028 0.0259 0.9419
Schistosoma mansoni protein kinase C mu 0.0198 0.2802 0.2796
Echinococcus multilocularis musashi 0.0027 0.0234 0.0225
Brugia malayi Protein kinase domain containing protein 0.0091 0.1197 0.1871
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0058 0.0698 0.069
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0013 0.0033 0.002
Echinococcus granulosus lysosomal alpha glucosidase 0.016 0.2236 0.2226
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0181 0.0427
Plasmodium falciparum cell division cycle protein 48 homologue, putative 0.0026 0.0231 0.6056
Schistosoma mansoni hypothetical protein 0.0012 0.0013 0.0004
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.1262 0.3041
Schistosoma mansoni cercarial elastase (S01 family) 0.0012 0.0013 0.0004
Loa Loa (eye worm) hypothetical protein 0.0017 0.0097 0.014
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0121 0.0155
Schistosoma mansoni intermediate filament proteins 0.0027 0.0234 0.0225
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.1437 0.3464
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0266 0.0257
Leishmania major mitochondrial DNA polymerase beta 0.0297 0.4285 0.5719
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0094 0.1243 0.1231
Schistosoma mansoni unc-13 (munc13) 0.0084 0.1095 0.1087
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0019 0.0016
Echinococcus multilocularis protein kinase c eta type 0.0076 0.097 0.0962
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0266 0.2013
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0029 0.0269 0.0386
Brugia malayi RhoGEF domain containing protein 0.0076 0.097 0.1514
Brugia malayi Kringle domain containing protein 0.0036 0.0376 0.0579
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0303 0.437 0.6867
Trichomonas vaginalis AGC family protein kinase 0.0091 0.1197 0.2883
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.1437 0.3471
Echinococcus multilocularis dna polymerase eta 0.0019 0.0121 0.0112
Loa Loa (eye worm) hypothetical protein 0.0036 0.0381 0.0586
Brugia malayi C1-like domain containing protein 0.0198 0.2802 0.4399
Brugia malayi Bromodomain containing protein 0.0038 0.04 0.0617
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0024 0.0197 0.0466
Echinococcus granulosus RNA directed DNA polymerase 0.0116 0.1579 0.1568
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0019 0.0016
Trichomonas vaginalis rotamase, putative 0.0032 0.0317 0.0755
Schistosoma mansoni hypothetical protein 0.0082 0.1056 0.1048
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0016
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0019 0.001
Schistosoma mansoni hypothetical protein 0.0016 0.0073 0.0065
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0186 0.0797
Loa Loa (eye worm) runx1 0.0055 0.0655 0.1017
Loa Loa (eye worm) DOMON domain-containing protein 0.0015 0.0057 0.0076
Brugia malayi protein kinase C3,putative 0.03 0.433 0.6803
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0328 0.0783
Schistosoma mansoni cell polarity protein 0.0016 0.008 0.0072
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0266 0.0405
Schistosoma mansoni 6-phosphofructokinase 0.0107 0.1437 0.143
Plasmodium falciparum plasmepsin V 0.0017 0.0092 0.2259
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0186 0.0797
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0116 0.1579 0.1571
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0151 0.0142
Echinococcus granulosus Rac GTPase activating protein 1 0.0076 0.097 0.0958
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0369 0.0881
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0082 0.1056 0.1044
Loa Loa (eye worm) hypothetical protein 0.0058 0.0698 0.1086
Onchocerca volvulus 0.0027 0.0234 0.0348
Schistosoma mansoni serine/threonine kinase 0.0087 0.1136 0.1129
Echinococcus multilocularis microtubule associated protein 2 0.0679 1 1
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0107 0.1437 0.1915
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0017 0.0092 0.0131
Loa Loa (eye worm) trypsin family protein 0.0012 0.0013 0.0007
Schistosoma mansoni hypothetical protein 0.0082 0.1056 0.1048
Onchocerca volvulus Troponin T, skeletal muscle homolog 0.0062 0.0769 0.1192
Entamoeba histolytica cdc48-like protein, putative 0.0026 0.0231 0.0559
Brugia malayi Ras association domain family 1 isoform A 0.0076 0.097 0.1514
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0121 0.0112
Schistosoma mansoni bromodomain containing protein 0.0064 0.0798 0.079
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0017 0.0092 0.0414
Trichomonas vaginalis AGC family protein kinase 0.0091 0.1197 0.2883
Brugia malayi RhoGAP domain containing protein 0.0076 0.097 0.1514
Loa Loa (eye worm) hypothetical protein 0.008 0.103 0.1609
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0121 0.0155
Loa Loa (eye worm) hypothetical protein 0.0105 0.1409 0.2205
Trichomonas vaginalis AGC family protein kinase 0.0091 0.1197 0.2883
Loa Loa (eye worm) hypothetical protein 0.0017 0.0097 0.014
Schistosoma mansoni memapsin-2 (A01 family) 0.0425 0.619 0.6186
Schistosoma mansoni serine/threonine protein kinase 0.0287 0.4137 0.4132
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0198 0.2802 0.4399
Brugia malayi valosin containing protein 0.0016 0.0081 0.0113
Trypanosoma cruzi squalene monooxygenase, putative 0.0511 0.7488 1
Schistosoma mansoni serine/threonine protein kinase 0.0087 0.1136 0.1129
Brugia malayi hypothetical protein 0.0017 0.0092 0.0131
Toxoplasma gondii aspartyl protease ASP3 0.0017 0.0092 0.0414
Brugia malayi PHD-finger family protein 0.0029 0.0266 0.0405
Schistosoma mansoni serine/threonine protein kinase 0.0307 0.4427 0.4423
Entamoeba histolytica serine/threonine protein kinase, putative 0.0095 0.1262 0.3048
Plasmodium falciparum phd finger protein, putative 0.0029 0.0266 0.6992
Loa Loa (eye worm) hypothetical protein 0.0016 0.008 0.0113
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0019 0.0016
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0121 0.0155
Echinococcus multilocularis peregrin 0.0031 0.0301 0.0292
Loa Loa (eye worm) hypothetical protein 0.0436 0.636 1
Brugia malayi Partitioning defective-6 homolog alpha 0.0016 0.008 0.0113
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.1262 0.1255
Brugia malayi aspartic protease BmAsp-2, identical 0.0017 0.0092 0.0131
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0198 0.2802 0.4399
Schistosoma mansoni zinc finger protein 0.0021 0.0154 0.0146
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0317 0.0417
Trypanosoma brucei polo-like protein kinase 0.0095 0.1262 0.1681
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0092 0.0083
Loa Loa (eye worm) hypothetical protein 0.0023 0.0186 0.0279
Onchocerca volvulus 0.0017 0.0092 0.0124
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0019 0.001
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0017 0.0092 0.0414
Echinococcus granulosus serine:threonine protein kinase N2 0.0138 0.1908 0.1898
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0121 0.0155
Brugia malayi CXXC zinc finger family protein 0.0035 0.0355 0.0546
Loa Loa (eye worm) hypothetical protein 0.0076 0.097 0.1514
Echinococcus granulosus protein kinase C gamma type 0.0212 0.3003 0.2994
Brugia malayi Glycosyl hydrolases family 31 protein 0.016 0.2236 0.3507
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.016 0.2236 0.3507
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0019 0.001
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0013 0.0033 0.0024
Schistosoma mansoni cercarial elastase (S01 family) 0.0012 0.0013 0.0004
Loa Loa (eye worm) 6-phosphofructokinase 0.0107 0.1437 0.2249
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0121 0.0112
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0035 0.0074
Brugia malayi hypothetical protein 0.0016 0.0073 0.0102
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0087 0.1136 0.1129
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0036 0.0381 0.0729
Echinococcus multilocularis laminin 0.0027 0.0246 0.0237
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0198 0.019
Onchocerca volvulus Putative cubilin 0.0013 0.0034 0.0033
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.1942 0.2588
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0186 0.0242
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.0381 0.0503
Brugia malayi mbt repeat family protein 0.0058 0.0698 0.1086
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0269 0.064
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.1262 0.3041
Trypanosoma brucei squalene monooxygenase, putative 0.0511 0.7488 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0097 0.0068
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0269 0.0452
Brugia malayi serine/threonine-protein kinase plk-2 0.0095 0.1262 0.1974
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0269 0.7076
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0019 0.0006
Schistosoma mansoni cercarial elastase (S01 family) 0.0012 0.0013 0.0004
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0019 0.001
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0381 0.0373
Entamoeba histolytica protein kinase, putative 0.0091 0.1197 0.289
Loa Loa (eye worm) hypothetical protein 0.0076 0.097 0.1514
Brugia malayi Importin beta-1 subunit 0.0028 0.0261 0.0398
Plasmodium falciparum plasmepsin X 0.0017 0.0092 0.2259
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0369 0.0891
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0019 0.0016
Onchocerca volvulus 0.0436 0.636 1
Echinococcus multilocularis lamin 0.0027 0.0234 0.0225
Brugia malayi Pre-SET motif family protein 0.0206 0.2913 0.4573
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0414 0.0406
Trypanosoma cruzi ISWI complex protein 0.0015 0.0062 0.0077
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0019 0.001
Echinococcus granulosus flap endonuclease 1 0.0026 0.022 0.0207
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0019 0.001
Toxoplasma gondii aspartyl protease 0.0017 0.0092 0.0414
Brugia malayi Protein kinase domain containing protein 0.0036 0.0376 0.0579
Toxoplasma gondii aspartyl protease ASP1 0.0017 0.0092 0.0414
Echinococcus multilocularis raf serine:threonine protein kinase 0.0076 0.097 0.0962
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0019 0.001
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0121 0.0155
Leishmania major DNA polymerase kappa, putative 0.0019 0.0121 0.0155
Echinococcus granulosus expressed protein 0.0033 0.0328 0.0316
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0085 0.0076
Trichomonas vaginalis AGC family protein kinase 0.0091 0.1197 0.2883
Loa Loa (eye worm) RasGEF domain-containing protein 0.0076 0.097 0.1514
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0035 0.0074
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0151 0.0354
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.003 0.0286 0.0437
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0087 0.1136 0.1776
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0007
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0121 0.0108
Brugia malayi 6-phosphofructokinase 0.0107 0.1437 0.2249
Brugia malayi MH2 domain containing protein 0.0144 0.1994 0.3125
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0088 0.0079
Schistosoma mansoni cpg binding protein 0.0035 0.0355 0.0347
Echinococcus granulosus protein kinase c eta type 0.0076 0.097 0.0958
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0121 0.0155
Schistosoma mansoni serine/threonine protein kinase 0.0087 0.1136 0.1129
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0127 0.1742 0.273
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.022 0.0521
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.1437 0.3464
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0186 0.0242
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0019 0.0016
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0087 0.1136 0.1129
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0019 0.0016
Brugia malayi Muscle positioning protein 4 0.0025 0.0213 0.0322
Leishmania major phospholipase c-like protein 0.0012 0.0009 0.0007
Onchocerca volvulus Serine\/threonine kinase homolog 0.0095 0.1262 0.1968
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0113 0.0146
Onchocerca volvulus 0.0272 0.3902 0.6127
Echinococcus granulosus N chimaerin 0.0076 0.097 0.0958
Loa Loa (eye worm) hypothetical protein 0.0192 0.2712 0.4257
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0028 0.0259 0.6806
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0033 0.0328 0.0503
Mycobacterium ulcerans 6-phosphofructokinase 0.0107 0.1437 0.6575
Leishmania major phosphopantetheinyl transferase-like protein 0.0028 0.0259 0.034
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0088 0.0075
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0019 0.001
Schistosoma mansoni microtubule-associated protein tau 0.0679 1 1
Echinococcus granulosus serine:threonine protein kinase N2 0.0087 0.1136 0.1125
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0141 0.1939 0.8891
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0269 0.7076
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0019 0.001
Echinococcus granulosus citrate lyase subunit beta protein 0.0024 0.0197 0.0185
Plasmodium vivax importin-beta 2, putative 0.0028 0.0261 0.6864
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0369 0.0361
Loa Loa (eye worm) hypothetical protein 0.003 0.0287 0.0438
Echinococcus multilocularis cpg binding protein 0.0039 0.0413 0.0405
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.026 0.0247
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0369 0.0881
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0366 0.0357
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0018 0.0112 0.2828
Brugia malayi jmjC domain containing protein 0.0039 0.0414 0.0638
Echinococcus multilocularis protein kinase c iota type 0.0385 0.5591 0.5587
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0019 0.0016
Onchocerca volvulus 0.0015 0.0057 0.0069
Loa Loa (eye worm) hypothetical protein 0.0047 0.0539 0.0834
Loa Loa (eye worm) STE/STE11/MEKK2 protein kinase 0.0019 0.0119 0.0174
Echinococcus multilocularis lysosomal alpha glucosidase 0.016 0.2236 0.2229
Onchocerca volvulus 0.0015 0.0057 0.0069
Loa Loa (eye worm) hypothetical protein 0.0016 0.0073 0.0102
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.4141 1
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0381 0.0369
Trypanosoma cruzi hypothetical protein, conserved 0.0209 0.297 0.3962
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.022 0.0288
Leishmania major DNA polymerase eta, putative 0.0019 0.0121 0.0155
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0113 0.0274
Plasmodium falciparum importin beta, putative 0.0028 0.0261 0.6864
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0113 0.0145
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0381 0.0373
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0381 0.0373
Trypanosoma cruzi PB1 domain containing protein, putative 0.0016 0.008 0.0101
Echinococcus multilocularis partitioning defective protein 6 0.0016 0.008 0.0072
Echinococcus granulosus unc 13 munc13 0.0084 0.1095 0.1083
Schistosoma mansoni myelin transcription factor 1 myt1 0.0066 0.0818 0.081
Loa Loa (eye worm) PAR-6 protein 0.0016 0.008 0.0113
Echinococcus granulosus protein TFG 0.0016 0.008 0.0067
Mycobacterium ulcerans hypothetical protein 0.0024 0.0197 0.0851
Brugia malayi hypothetical protein 0.0017 0.0092 0.0131
Echinococcus granulosus laminin 0.0027 0.0246 0.0233
Brugia malayi nuclear receptor NHR-88 0.0012 0.0019 0.0016
Trypanosoma brucei glucosidase, putative 0.0036 0.0369 0.0487
Trypanosoma brucei Valosin-containing protein 0.0026 0.0231 0.0303
Loa Loa (eye worm) aspartyl protease 6 0.0017 0.0092 0.0131
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0035 0.0074
Trypanosoma brucei hypothetical protein, conserved 0.0028 0.0259 0.034
Loa Loa (eye worm) hypothetical protein 0.0017 0.0092 0.0131
Brugia malayi PHD-finger family protein 0.0013 0.0034 0.0041
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0539 0.053
Loa Loa (eye worm) hypothetical protein 0.02 0.2824 0.4432
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.0019
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0369 0.0881
Schistosoma mansoni protein kinase C mu 0.0076 0.097 0.0962
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0019 0.0016
Mycobacterium leprae conserved hypothetical protein 0.0028 0.0259 0.0418
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0113 0.2852
Echinococcus granulosus protein kinase c epsilon type 0.0307 0.4427 0.442
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0113 0.0464
Loa Loa (eye worm) 6-phosphofructokinase 0.0107 0.1437 0.2249
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0087 0.1136 0.1125
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0092 0.0083
Trypanosoma cruzi PB1 domain containing protein, putative 0.0016 0.008 0.0101
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0287 0.2211
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0121 0.0291
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0462 0.0611
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0019 0.001
Brugia malayi diacylglycerol kinase 0.0076 0.097 0.1514
Schistosoma mansoni cercarial elastase (S01 family) 0.0012 0.0013 0.0004
Loa Loa (eye worm) hypothetical protein 0.0028 0.0261 0.0398
Onchocerca volvulus 0.02 0.2824 0.4429
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.1994 0.3125
Schistosoma mansoni lozenge 0.0055 0.0655 0.0647
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0028 0.0259 0.195
Brugia malayi Pepsin A precursor 0.0017 0.0092 0.0131
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0287 0.0279
Echinococcus granulosus tissue type plasminogen activator 0.0036 0.0376 0.0364
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0082 0.1056 0.1048
Echinococcus multilocularis serine threonine protein kinase 0.0212 0.3003 0.2997
Echinococcus granulosus lamin dm0 0.0027 0.0234 0.0221
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0019 0.001
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0019 0.0016
Brugia malayi Hr1 repeat family protein 0.0087 0.1136 0.1776
Entamoeba histolytica transitional endoplasmic reticulum ATPase, putative 0.0026 0.0231 0.0559
Brugia malayi Protein kinase domain containing protein 0.0019 0.0119 0.0174
Schistosoma mansoni hypothetical protein 0.0015 0.0062 0.0053
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0261 0.0343
Echinococcus granulosus 6 phosphofructokinase 0.0107 0.1437 0.1426
Schistosoma mansoni hypothetical protein 0.0105 0.1409 0.1402
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0088 0.0079
Trichomonas vaginalis AGC family protein kinase 0.0087 0.1136 0.2737
Brugia malayi hypothetical protein 0.0062 0.0769 0.1198
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0097 0.2416
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0266 0.2013
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0181 0.0427
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0266 0.0257
Loa Loa (eye worm) hypothetical protein 0.0017 0.0097 0.014
Brugia malayi hypothetical protein 0.0012 0.0013 0.0007
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.4141 1
Entamoeba histolytica protein kinase, putative 0.0091 0.1197 0.289
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0019 0.001
Onchocerca volvulus 0.0084 0.1095 0.1704
Loa Loa (eye worm) hypothetical protein 0.0025 0.0213 0.0322
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0066 0.0818 0.0806
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.4141 1
Onchocerca volvulus Alhambra homolog 0.0029 0.0266 0.0398
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0047 0.0539 0.053
Echinococcus granulosus lysine specific demethylase 5A 0.0039 0.0414 0.0401
Echinococcus multilocularis 6 phosphofructokinase 0.0107 0.1437 0.143
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0013 0.0035 0.0034
Trypanosoma brucei unspecified product 0.0019 0.0121 0.0155
Echinococcus granulosus lamin 0.0027 0.0234 0.0221
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0369 0.0567
Onchocerca volvulus 0.0017 0.0092 0.0124
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0019 0.001
Loa Loa (eye worm) mbt repeat family protein 0.0058 0.0698 0.1086
Echinococcus multilocularis histone acetyltransferase MYST2 0.0066 0.0818 0.081
Schistosoma mansoni cathepsin D (A01 family) 0.0017 0.0092 0.0083
Echinococcus granulosus histone lysine methyltransferase setb 0.0047 0.0539 0.0526
Toxoplasma gondii exonuclease III APE 0.0019 0.0113 0.0615
Brugia malayi aspartic protease BmAsp-1, identical 0.0017 0.0092 0.0131
Echinococcus granulosus zinc finger protein 0.0021 0.0154 0.0142
Brugia malayi Pleckstrin Homology Domain 0.008 0.103 0.1609
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0381 0.0911
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.1994 0.3125
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0186 0.0448
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0049 0.0064
Loa Loa (eye worm) hypothetical protein 0.0013 0.0034 0.004
Entamoeba histolytica hypothetical protein, conserved 0.0016 0.008 0.0194
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0121 0.0155
Loa Loa (eye worm) apoptosis regulator protein 0.0082 0.1056 0.1649
Echinococcus granulosus SAM and MBT domain containing protein 0.0058 0.0698 0.0686
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0028 0.0259 0.195
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.022 0.0288
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0462 0.0611
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0113 0.0264
Schistosoma mansoni serine/threonine protein kinase 0.0078 0.1009 0.1001
Schistosoma mansoni hypothetical protein 0.0076 0.097 0.0962
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0019 0.0006
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0027 0.0246 0.0374
Brugia malayi ecdysteroid receptor 0.0012 0.0019 0.0016
Loa Loa (eye worm) hypothetical protein 0.0017 0.0092 0.0131
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0012 0.0013 0.0004
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0151 0.0224
Brugia malayi Troponin family protein 0.0105 0.1409 0.2205
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0016
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0317 0.0417
Entamoeba histolytica protein kinase, putative 0.0087 0.1136 0.2744
Loa Loa (eye worm) hypothetical protein 0.0359 0.5202 0.8177
Schistosoma mansoni lamin 0.0027 0.0234 0.0225
Brugia malayi hypothetical protein 0.0436 0.636 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0028 0.002
Trichomonas vaginalis rotamase, putative 0.0033 0.0328 0.0783
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0019 0.001
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0539 0.053
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0122 0.1669 0.2614
Echinococcus multilocularis enteropeptidase 0.0012 0.0013 0.0004
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0369 0.2959
Echinococcus multilocularis citrate lyase subunit beta protein 0.0024 0.0197 0.0189
Brugia malayi vesicle-fusing ATPase 0.0016 0.0081 0.0113
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0028 0.0259 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0019 0.0122 0.0113
Brugia malayi Protein kinase c protein 2 0.0203 0.2876 0.4515
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.1262 0.3041
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0186 0.0489
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0082 0.1056 0.1044
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0012 0.0013 0.0004
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0007
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.4141 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0016
Leishmania major hypothetical protein, conserved 0.0036 0.0376 0.0497
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.022 0.0333
Echinococcus granulosus protein kinase c iota type 0.0385 0.5591 0.5585
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0095 0.1262 0.1251
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0017 0.0094 0.0086
Echinococcus multilocularis zinc finger protein 0.0021 0.0154 0.0146
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0012 0.0013 0.0004
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0186 0.0489
Onchocerca volvulus 0.0019 0.0119 0.0168
Echinococcus multilocularis transitional endoplasmic reticulum atpase 0.0028 0.0253 0.0244
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0381 0.0369
Trypanosoma cruzi squalene monooxygenase, putative 0.0511 0.7488 1
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0197 0.0258
Entamoeba histolytica hypothetical protein 0.0028 0.0259 0.0625
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0019 0.0006
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0181 0.0236
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0121 0.0176
Echinococcus multilocularis Mastin 0.0012 0.0013 0.0004
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0019 0.0016
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0261 0.0343
Loa Loa (eye worm) hypothetical protein 0.0017 0.0087 0.0124
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0381 0.0503
Echinococcus multilocularis snurportin 1 0.0303 0.437 0.4365
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0121 0.0497
Loa Loa (eye worm) hypothetical protein 0.003 0.0286 0.0437
Schistosoma mansoni serine/threonine protein kinase 0.0287 0.4137 0.4132
Brugia malayi Trypsin family protein 0.0012 0.0013 0.0007
Schistosoma mansoni diacylglycerol kinase theta 0.0076 0.097 0.0962
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0113 0.0146
Trypanosoma brucei ISWI complex protein 0.0015 0.0062 0.0077
Brugia malayi Protein kinase domain containing protein 0.0078 0.1009 0.1575
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0369 0.0487
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0121 0.0155
Trypanosoma cruzi polo-like protein kinase, putative 0.0095 0.1262 0.1681
Schistosoma mansoni ap endonuclease 0.0019 0.0113 0.0105
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0269 1
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0269 0.2042
Echinococcus granulosus dna polymerase kappa 0.0019 0.0121 0.0108
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.003 0.0287 0.0279
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.1262 0.3041
Brugia malayi jmjC domain containing protein 0.0094 0.1243 0.1943
Loa Loa (eye worm) PHD-finger family protein 0.002 0.014 0.0207
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0019 0.0016
Toxoplasma gondii transitional endoplasmic reticulum ATPase, putative 0.0017 0.0086 0.036
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0269 0.064
Loa Loa (eye worm) troponin I 0.0105 0.1409 0.2205
Brugia malayi mbt repeat family protein 0.0058 0.0698 0.1086
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0028 0.0259 0.0839
Echinococcus granulosus oncosphere protein Tso22e 0.013 0.1787 0.1777
Echinococcus granulosus dna polymerase eta 0.0019 0.0121 0.0108
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0381 0.0911
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0019 0.001
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0269 0.064
Leishmania major glycosyl hydrolase-like protein 0.0013 0.0035 0.0041
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0366 0.0353
Plasmodium falciparum plasmepsin III 0.0017 0.0092 0.2259
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0078 0.1009 0.1001
Loa Loa (eye worm) hypothetical protein 0.0038 0.0401 0.0619
Schistosoma mansoni troponin I 0.0105 0.1409 0.1402
Schistosoma mansoni vav2 0.008 0.103 0.1023
Treponema pallidum fructose-bisphosphate aldolase 0.0288 0.4141 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0297 0.4285 0.5719
Brugia malayi Trypsin family protein 0.0012 0.0013 0.0007
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0698 0.069
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0269 0.064
Toxoplasma gondii calcium binding egf domain-containing protein 0.0027 0.0246 0.183
Loa Loa (eye worm) hypothetical protein 0.0272 0.3902 0.613
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0028 0.0259 0.1136
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0269 0.2042
Brugia malayi intermediate filament protein 0.0027 0.0234 0.0354
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0369 0.0567
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0007
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0317 0.4573 0.7187
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0013 0.0035 0.0041
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0269 0.064
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0369 0.0487
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0016
Trypanosoma cruzi polo-like protein kinase, putative 0.0095 0.1262 0.1681
Giardia lamblia Flap structure-specific endonuclease 0.0026 0.022 0.0331
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0019 0.0016
Loa Loa (eye worm) hypothetical protein 0.0027 0.0246 0.0374
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0261 0.197
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0369 0.0356
Loa Loa (eye worm) hypothetical protein 0.0082 0.1056 0.1649
Loa Loa (eye worm) hypothetical protein 0.0016 0.0073 0.0102
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0035 0.0074
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0019 0.0016
Schistosoma mansoni troponin I 0.0105 0.1409 0.1402
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0121 0.0176
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0121 0.0155
Onchocerca volvulus 0.0016 0.008 0.0106
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0186 0.0242
Plasmodium falciparum plasmepsin VIII, putative 0.0017 0.0092 0.2259
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0186 0.0797
Loa Loa (eye worm) AGC/AKT protein kinase 0.0091 0.1197 0.1871
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0024 0.0197 0.0851
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0092 0.0083
Loa Loa (eye worm) hypothetical protein 0.004 0.0436 0.0674
Loa Loa (eye worm) hypothetical protein 0.0272 0.3902 0.613
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0121 0.0281
Toxoplasma gondii hypothetical protein 0.0048 0.0554 0.4656
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.022 0.0288
Brugia malayi steroid hormone receptor 0.0012 0.0019 0.0016
Trypanosoma brucei unspecified product 0.0013 0.0032 0.0038
Toxoplasma gondii cell division protein CDC48CY 0.0028 0.0253 0.1894
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0261 0.0253
Giardia lamblia Kinase, PLK 0.0095 0.1262 0.2901
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0121 0.0155
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0012 0.0013 0.0004
Echinococcus multilocularis N chimaerin 0.0076 0.097 0.0962
Loa Loa (eye worm) hypothetical protein 0.0044 0.0494 0.0764
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0381 0.0911
Echinococcus multilocularis serine:threonine protein kinase N2 0.0223 0.3169 0.3163
Schistosoma mansoni hypothetical protein 0.0494 0.7227 0.7225
Schistosoma mansoni DNA polymerase eta 0.0019 0.0121 0.0112
Brugia malayi Variant SH3 domain containing protein 0.0012 0.0021 0.002
Mycobacterium ulcerans ATPase 0.0017 0.0086 0.0335
Echinococcus multilocularis myotubularin protein 13 0.008 0.103 0.1023
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0121 0.0155
Giardia lamblia PHD finger protein 15 0.0029 0.0266 0.0444
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0369 0.0487
Plasmodium falciparum plasmepsin IV 0.0017 0.0092 0.2259
Schistosoma mansoni cell division control protein 48 aaa family protein 0.0028 0.0253 0.0244
Echinococcus granulosus histone acetyltransferase MYST2 0.0066 0.0818 0.0806
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0019 0.0006
Trichomonas vaginalis AGC family protein kinase 0.0091 0.1197 0.2883
Brugia malayi Pre-SET motif family protein 0.003 0.0287 0.0439
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0028 0.0259 0.0361
Loa Loa (eye worm) hypothetical protein 0.0013 0.0028 0.0031
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0121 0.0155
Schistosoma mansoni egf-like domain protein 0.0027 0.0246 0.0237
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0017 0.0092 0.0211
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0012 0.0013 0.0005
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0113 0.0069
Brugia malayi Bromodomain containing protein 0.0076 0.0971 0.1515
Trypanosoma cruzi hypothetical protein, conserved 0.0209 0.297 0.3962
Schistosoma mansoni serine/threonine protein kinase 0.0078 0.1009 0.1001
Leishmania major hypothetical protein, conserved 0.0015 0.0062 0.0077
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0032 0.0317 0.0417
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0019 0.0016
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0092 0.0083
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.1262 0.3041
Echinococcus granulosus importin subunit beta 1 0.0028 0.0261 0.0248
Loa Loa (eye worm) hypothetical protein 0.007 0.0878 0.1369
Toxoplasma gondii peptidylprolyl isomerase 0.0032 0.0317 0.248
Loa Loa (eye worm) hypothetical protein 0.0017 0.0097 0.014
Brugia malayi p70 ribosomal S6 kinase beta 0.0087 0.1136 0.1776
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0092 0.0083
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0019 0.0016
Echinococcus granulosus Diacylglycerol kinase theta 0.0076 0.097 0.0958
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0092 0.0083
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.1437 0.3471
Onchocerca volvulus 0.0027 0.0234 0.0348
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0234 0.0354
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0092 0.0083
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0266 0.6992
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0121 0.0497
Loa Loa (eye worm) hypothetical protein 0.0023 0.0186 0.0279
Brugia malayi Trypsin-like protease protein 5 0.0012 0.0013 0.0007
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0121 0.0112
Echinococcus granulosus NDR protein kinase 0.0087 0.1136 0.1125
Loa Loa (eye worm) hypothetical protein 0.0347 0.5036 0.7915
Brugia malayi Bromodomain containing protein 0.0031 0.0301 0.046
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0269 0.0649
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0369 0.0881
Echinococcus multilocularis tissue type plasminogen activator 0.0036 0.0376 0.0368
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0197 0.0258
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0381 0.0373
Brugia malayi Flap endonuclease-1 0.0026 0.022 0.0333
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0078 0.1009 0.0998
Toxoplasma gondii cell division protein CDC48AP 0.0017 0.0086 0.036
Loa Loa (eye worm) hypothetical protein 0.0017 0.0097 0.014
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0186 0.0448
Brugia malayi nuclear hormone receptor 0.0012 0.0019 0.0016
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0121 0.0155
Schistosoma mansoni hypothetical protein 0.0354 0.5132 0.5128
Leishmania major ATP-dependent phosphofructokinase 0.0107 0.1437 0.1915
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0287 0.0279
Loa Loa (eye worm) hypothetical protein 0.012 0.163 0.2552
Echinococcus multilocularis Tolloid protein 1 0.003 0.0287 0.0279
Loa Loa (eye worm) hypothetical protein 0.0015 0.0057 0.0076
Trichomonas vaginalis maltase-glucoamylase, putative 0.0013 0.0035 0.0074
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0269 0.064
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0381 0.0503
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0028 0.0015
Brugia malayi Troponin T 0.0062 0.0769 0.1198
Brugia malayi Troponin T 0.0062 0.0769 0.1198
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0024 0.0197 0.0851
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0012 0.0021 0.002
Plasmodium falciparum plasmepsin IX 0.0017 0.0092 0.2259
Entamoeba histolytica protein kinase, putative 0.0087 0.1136 0.2744
Onchocerca volvulus 0.0016 0.0073 0.0095
Loa Loa (eye worm) hypothetical protein 0.0084 0.1095 0.171
Schistosoma mansoni troponin I 0.0105 0.1409 0.1402
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0381 0.0373
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0088 0.0079
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0019 0.001
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0007
Echinococcus multilocularis unc 13 (munc13) 0.0084 0.1095 0.1087
Brugia malayi Eukaryotic aspartyl protease family protein 0.0017 0.0092 0.0131
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0369 0.0881
Echinococcus granulosus snurportin 1 0.0303 0.437 0.4363
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0186 0.0797
Mycobacterium ulcerans hypothetical protein 0.0024 0.0197 0.0851
Loa Loa (eye worm) AGC/NDR protein kinase 0.0087 0.1136 0.1776
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0017 0.0092 0.0083
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.01 0.1339 0.1331
Entamoeba histolytica hypothetical protein 0.0076 0.097 0.2343
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0019 0.001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0019 0.0016
Plasmodium vivax aspartyl protease, putative 0.0017 0.0092 0.2259
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0017 0.0092 0.0131
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0061 0.0745 0.0737
Echinococcus multilocularis RNA directed DNA polymerase 0.0116 0.1579 0.1571
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0141 0.1939 1
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0033 0.0328 0.0503
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0076 0.097 0.0958
Loa Loa (eye worm) bone morphogenetic protein 1b 0.003 0.0287 0.0438
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0019 0.001
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0186 0.0797
Echinococcus granulosus raf serine:threonine protein kinase 0.0076 0.097 0.0958
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.1437 0.3464
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0107 0.1437 0.3287
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0121 0.0155
Schistosoma mansoni cell division control protein 48 aaa family protein 0.0026 0.0231 0.0223
Schistosoma mansoni cercarial elastase (S01 family) 0.0012 0.0013 0.0004
Loa Loa (eye worm) hypothetical protein 0.0049 0.0573 0.0888
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0075 0.0953 0.0946
Schistosoma mansoni hypothetical protein 0.0303 0.437 0.4365
Plasmodium vivax aspartyl proteinase, putative 0.0017 0.0092 0.2259
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0007
Loa Loa (eye worm) hypothetical protein 0.0116 0.1579 0.2472
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0082 0.1056 0.1048
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0288 0.4141 1
Brugia malayi 6-phosphofructokinase 0.0107 0.1437 0.2249
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0297 0.4285 0.5719
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0076 0.097 0.1514
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.056 0.1343
Echinococcus multilocularis lysosomal alpha glucosidase 0.016 0.2236 0.2229
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0058 0.0698 0.108
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0032 0.0317 0.0417
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0287 0.0279
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0121 0.0155
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0019 0.0016
Entamoeba histolytica calcium-binding protein, putative 0.0012 0.0009 0.0023
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0107 0.1437 0.1915
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0092 0.0083
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.2913 0.4573
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0094 0.1243 0.1235
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.0414 0.0638
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0019 0.001
Trichomonas vaginalis AGC family protein kinase 0.0091 0.1197 0.2883
Onchocerca volvulus 0.0093 0.1224 0.1909
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.1262 0.3041
Loa Loa (eye worm) hypothetical protein 0.0013 0.0035 0.0041
Loa Loa (eye worm) hypothetical protein 0.0076 0.097 0.1514
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0076 0.097 0.1514
Onchocerca volvulus 0.0015 0.0057 0.0069
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.0019
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0121 0.0155
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.4141 1
Schistosoma mansoni unc-13 (munc13) 0.0084 0.1095 0.1087
Echinococcus granulosus MAM 0.0016 0.0073 0.0061
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.4141 1
Schistosoma mansoni cpg binding protein 0.0039 0.0413 0.0405
Schistosoma mansoni alpha-glucosidase 0.0138 0.1902 0.1895
Entamoeba histolytica recQ family helicase, putative 0.0011 0.0004 0.001
Onchocerca volvulus 0.0196 0.2763 0.4333
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0084 0.1095 0.1083
Schistosoma mansoni coup transcription factor 0.0012 0.0019 0.001
Brugia malayi RNA, U transporter 1 0.0081 0.1044 0.163
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0019 0.0006
Plasmodium falciparum plasmepsin I 0.0017 0.0092 0.2259
Loa Loa (eye worm) MBCTL1 0.0066 0.0818 0.1274
Trichomonas vaginalis AGC family protein kinase 0.0091 0.1197 0.2883
Toxoplasma gondii kringle domain-containing protein 0.0036 0.0376 0.3029
Onchocerca volvulus Troponin I homolog 0.0105 0.1409 0.22
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0019 0.001
Plasmodium vivax plasmepsin V, putative 0.0017 0.0092 0.2259
Echinococcus multilocularis L aminoadipate semialdehyde 0.01 0.1339 0.1331
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.01 0.1339 0.2094
Onchocerca volvulus 0.0058 0.0698 0.108
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.1942 0.2588
Schistosoma mansoni hypothetical protein 0.002 0.014 0.0132
Echinococcus granulosus dnaJ subfamily B 0.0494 0.7227 0.7224
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0234 0.0354
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.056 0.1343
Plasmodium vivax aspartyl protease, putative 0.0017 0.0092 0.2259
Loa Loa (eye worm) troponin 0.0062 0.0769 0.1198
Schistosoma mansoni hypothetical protein 0.0029 0.0266 0.0257
Trichomonas vaginalis spermatogenesis associated factor, putative 0.0028 0.0253 0.0601
Echinococcus granulosus myotubularin protein 13 0.008 0.103 0.1019
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0356 0.0348
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0012 0.0013 0.0004
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0198 0.019
Echinococcus granulosus jumonji domain containing protein 0.004 0.0434 0.0422
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0012 0.0013 0.0004
Trypanosoma brucei unspecified product 0.0013 0.0032 0.0038
Plasmodium vivax cell division cycle protein 48 homologue, putative 0.0026 0.0231 0.6056
Schistosoma mansoni cathepsin D (A01 family) 0.0017 0.0092 0.0083
Schistosoma mansoni hypothetical protein 0.0036 0.0376 0.0368
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0012 0.0013 0.0007
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0061 0.0745 0.0733
Onchocerca volvulus Troponin T, skeletal muscle homolog 0.013 0.1787 0.2796
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0186 0.0279
Echinococcus granulosus troponin i 0.0105 0.1409 0.1398
Trypanosoma brucei PB1 domain containing protein, putative 0.0016 0.008 0.0101
Loa Loa (eye worm) hypothetical protein 0.0016 0.0081 0.0113
Onchocerca volvulus Transitional endoplasmic reticulum ATPase homolog 0.0028 0.0253 0.0378
Loa Loa (eye worm) hypothetical protein 0.0029 0.0266 0.0405
Loa Loa (eye worm) hypothetical protein 0.0027 0.0246 0.0374
Echinococcus multilocularis transmembrane protease serine 3 0.0012 0.0013 0.0004
Trichomonas vaginalis set domain proteins, putative 0.0234 0.3336 0.8055
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0016
Onchocerca volvulus 0.0035 0.0355 0.054
Schistosoma mansoni hypothetical protein 0.0012 0.0013 0.0004
Loa Loa (eye worm) TK/ROR protein kinase 0.0036 0.0376 0.0579
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0035 0.0074
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0113 0.0264
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0019 0.0006
Brugia malayi SEA domain containing protein 0.0015 0.0057 0.0076
Loa Loa (eye worm) AGC/PKN protein kinase 0.0087 0.1136 0.1776
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0231 0.3289 0.328
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0019 0.0016
Onchocerca volvulus Protein TFG homolog 0.0016 0.008 0.0106
Brugia malayi PHD-finger family protein 0.0026 0.0233 0.0353
Schistosoma mansoni cercarial elastase (S01 family) 0.0012 0.0013 0.0004
Schistosoma mansoni cpg binding protein 0.0039 0.0413 0.0405
Plasmodium vivax SET domain protein, putative 0.003 0.0287 0.7579
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0012 0.0013 0.0004
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0035 0.0074
Plasmodium vivax plasmepsin IV, putative 0.0017 0.0092 0.2259
Plasmodium vivax aspartyl protease, putative 0.0017 0.0092 0.2259
Schistosoma mansoni apoptosis regulator bax 0.0082 0.1056 0.1048
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0066 0.0818 0.081
Trichomonas vaginalis AGC family protein kinase 0.0091 0.1197 0.2883
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0234 0.0354
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0121 0.0155
Loa Loa (eye worm) hypothetical protein 0.0105 0.1409 0.2205
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0269 0.2042
Trichomonas vaginalis AGC family protein kinase 0.0087 0.1136 0.2737
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0019 0.0016
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0036 0.0376 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0032 0.0038
Schistosoma mansoni cercarial elastase (S01 family) 0.0012 0.0013 0.0004
Onchocerca volvulus 0.0015 0.0057 0.0069
Schistosoma mansoni cercarial elastase (S01 family) 0.0012 0.0013 0.0004
Brugia malayi diacylglycerol kinase 0.0076 0.097 0.1514
Echinococcus granulosus L aminoadipate semialdehyde 0.01 0.1339 0.1328
Schistosoma mansoni serine/threonine protein kinase 0.0076 0.097 0.0962
Echinococcus granulosus polycomb protein SCMH1 0.0058 0.0698 0.0686
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0013 0.0035 0.0041
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0087 0.1136 0.1129
Brugia malayi Protein kinase domain containing protein 0.0016 0.0073 0.0102
Echinococcus multilocularis Protein lozenge 0.0055 0.0655 0.0647
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0381 0.0503
Echinococcus multilocularis protein kinase c epsilon type 0.0307 0.4427 0.4423
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0269 0.7076
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0084 0.1097 0.2642
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0121 0.0179
Echinococcus multilocularis SAM and MBT domain containing protein 0.0058 0.0698 0.069
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0113 0.0165
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.003 0.0286 0.0437
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.4141 1
Plasmodium falciparum plasmepsin VI 0.0017 0.0092 0.2259
Onchocerca volvulus 0.0025 0.0213 0.0315
Schistosoma mansoni jumonji domain containing protein 0.0075 0.0954 0.0946
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0032 0.0038
Onchocerca volvulus 0.012 0.163 0.2547
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0269 1
Echinococcus granulosus peregrin 0.0031 0.0301 0.0288
Loa Loa (eye worm) hypothetical protein 0.0026 0.0226 0.0343
Schistosoma mansoni rac gtpase activating protein 0.0076 0.097 0.0962
Mycobacterium ulcerans hypothetical protein 0.0023 0.0186 0.0797
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0121 0.0155
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0019 0.0016
Loa Loa (eye worm) hypothetical protein 0.0436 0.636 1
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.1437 0.3471
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0369 0.0881
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0698 0.069
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0016
Brugia malayi Glycosyl hydrolases family 31 protein 0.0013 0.0035 0.0041
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0032 0.0038
Loa Loa (eye worm) hypothetical protein 0.0066 0.0818 0.1274
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0113 0.0146
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0076 0.097 0.1514
Loa Loa (eye worm) RecQ helicase 0.0021 0.0151 0.0224
Echinococcus multilocularis oncosphere protein tso22e oncosphere protein tso22d oncosphere protein tso22c oncosphere protein tso22b oncosphere protein tso22 0.013 0.1787 0.178
Trypanosoma brucei glycosyl hydrolase-like protein 0.0013 0.0035 0.0041
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0082 0.1056 0.1649
Leishmania major importin beta-1 subunit, putative 0.0023 0.0181 0.0236
Schistosoma mansoni troponin I 0.0105 0.1409 0.1402
Loa Loa (eye worm) hypothetical protein 0.0033 0.0327 0.0501
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.1437 0.3464
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0016
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0434 0.0426
Onchocerca volvulus 0.0036 0.0376 0.0573
Schistosoma mansoni hypothetical protein 0.0082 0.1056 0.1048
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0049 0.0064
Brugia malayi Troponin T 0.0062 0.0769 0.1198
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0092 0.0083
Trypanosoma cruzi Valosin-containing protein, putative 0.0026 0.0231 0.0303
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0019 0.001
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0121 0.0176
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0035 0.0074
Loa Loa (eye worm) hypothetical protein 0.0076 0.097 0.1514
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0015 0.0054 0.0045
Echinococcus granulosus intermediate filament protein 0.0027 0.0234 0.0221
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0198 0.0185
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0095 0.1262 0.1681
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0113 0.2852
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0113 0.0146
Loa Loa (eye worm) hypothetical protein 0.0062 0.0769 0.1198
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.022 0.5747
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0097 0.039
Leishmania major Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog 0.0026 0.0231 0.0303
Loa Loa (eye worm) vesicle-fusing ATPase 0.0016 0.0081 0.0113
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0107 0.1437 0.7138
Plasmodium vivax aspartyl proteinase, putative 0.0017 0.0092 0.2259
Plasmodium falciparum plasmepsin VII 0.0017 0.0092 0.2259
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0084 0.1095 0.1087
Trypanosoma cruzi ISWI complex protein 0.0015 0.0062 0.0077
Mycobacterium tuberculosis Conserved protein 0.0024 0.0197 0.0545
Echinococcus granulosus Protein kinase C brain isozyme 0.0287 0.4137 0.4129
Schistosoma mansoni protein kinase C 0.0084 0.1095 0.1087
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0107 0.1437 0.646
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0019 0.0006
Plasmodium falciparum cysteine repeat modular protein 1 0.0036 0.0376 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0113 0.0105
Loa Loa (eye worm) hypothetical protein 0.01 0.1339 0.2094
Loa Loa (eye worm) hypothetical protein 0.0027 0.0234 0.0354
Brugia malayi Fibulin-1 precursor 0.0027 0.0246 0.0374
Onchocerca volvulus 0.0012 0.0019 0.001
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0087 0.1136 0.1776
Loa Loa (eye worm) hypothetical protein 0.0272 0.3902 0.613
Schistosoma mansoni ap endonuclease 0.0019 0.0113 0.0105
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0462 0.0611
Brugia malayi protein kinase C II. 0.0307 0.4427 0.6957
Schistosoma mansoni serine/threonine protein kinase 0.0087 0.1136 0.1129
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0355 0.0546
Brugia malayi Calcium binding EGF domain containing protein 0.0013 0.0034 0.004
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0462 0.0611
Echinococcus multilocularis fibrillin 1 0.0027 0.0246 0.0237
Loa Loa (eye worm) hypothetical protein 0.012 0.163 0.2552
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0097 0.0139
Echinococcus multilocularis protein TFG 0.0016 0.008 0.0072
Trypanosoma brucei rac serine-threonine kinase, putative 0.0091 0.1197 0.1593
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0019 0.001
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0186 0.0797
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0087 0.1136 0.1125
Leishmania major hypothetical protein, conserved 0.0016 0.008 0.0101
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0297 0.4285 0.5719
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0024 0.0197 0.0545
Schistosoma mansoni zinc finger protein 0.0015 0.0062 0.0053
Schistosoma mansoni kinase 0.005 0.0578 0.057
Loa Loa (eye worm) hypothetical protein 0.0076 0.097 0.1514
Echinococcus granulosus Tolloid protein 1 0.003 0.0287 0.0274
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.1262 0.3041
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0121 0.0112
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0019 0.001
Brugia malayi Trypsin family protein 0.0012 0.0013 0.0007
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0231 0.3289 0.3283
Entamoeba histolytica diacylglycerol kinase, putative 0.0076 0.097 0.2343
Loa Loa (eye worm) histone methyltransferase 0.0012 0.0013 0.0007
Loa Loa (eye worm) phosphofructokinase 0.0107 0.1437 0.2249
Loa Loa (eye worm) zinc finger protein 0.0016 0.008 0.0113
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0269 0.064
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0197 0.0258
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0028 0.0259 0.1136
Leishmania major squalene monooxygenase-like protein 0.0511 0.7488 1
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0095 0.1262 0.1974
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0186 0.0279
Toxoplasma gondii AGC kinase 0.0087 0.1136 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0288 0.4141 1
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0381 0.0586
Loa Loa (eye worm) hypothetical protein 0.0013 0.0034 0.0041
Echinococcus multilocularis serine:threonine protein kinase N2 0.0087 0.1136 0.1129
Toxoplasma gondii histone lysine methyltransferase SET1 0.0069 0.0871 0.7562
Schistosoma mansoni lamin 0.0027 0.0234 0.0225
Onchocerca volvulus 0.0234 0.3336 0.5236
Echinococcus granulosus cpg binding protein 0.0039 0.0413 0.0401
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0121 0.0281
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0113 0.0165
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0151 0.0354
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0017 0.0092 0.0079
Echinococcus multilocularis Rac GTPase activating protein 1 0.0076 0.097 0.0962
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0121 0.0179
Plasmodium falciparum flap endonuclease 1 0.0026 0.022 0.5747
Echinococcus multilocularis lamin dm0 0.0027 0.0234 0.0225
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0181 0.0427
Brugia malayi RhoGAP domain containing protein 0.0076 0.097 0.1514
Echinococcus multilocularis flap endonuclease 1 0.0026 0.022 0.0212
Brugia malayi Calcium binding EGF domain containing protein 0.0027 0.0246 0.0374
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0076 0.097 0.0962

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.7079 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) = 1.5849 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.5481 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 21.1923 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.1093 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference
Potency (functional) 67.4555 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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