Detailed information for compound 1449288

Basic information

Technical information
  • TDR Targets ID: 1449288
  • Name: N-[1-[5-methyl-1-(2-methylphenyl)pyrazol-4-yl ]ethyl]furan-2-carboxamide
  • MW: 309.362 | Formula: C18H19N3O2
  • H donors: 1 H acceptors: 2 LogP: 3.23 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccco1)NC(c1cnn(c1C)c1ccccc1C)C
  • InChi: 1S/C18H19N3O2/c1-12-7-4-5-8-16(12)21-14(3)15(11-19-21)13(2)20-18(22)17-9-6-10-23-17/h4-11,13H,1-3H3,(H,20,22)
  • InChiKey: UEWJOEMDOWKUKN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[1-[5-methyl-1-(2-methylphenyl)-4-pyrazolyl]ethyl]-2-furancarboxamide
  • N-[1-[5-methyl-1-(2-methylphenyl)pyrazol-4-yl]ethyl]-2-furamide
  • SMR000317163
  • MLS000734985
  • N-{1-[5-methyl-1-(2-methylphenyl)-1H-pyrazol-4-yl]ethyl}-2-furamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lamin A/C Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus ryanodine receptor 44f 0.0052 0.005 0.0067
Echinococcus multilocularis hyperpolarization activated cyclic 0.0052 0.005 0.0067
Trypanosoma brucei heat shock protein, putative 0.0063 0.0077 0.123
Schistosoma mansoni myosin xvIII 0.0334 0.069 0.069
Loa Loa (eye worm) hypothetical protein 0.0306 0.0626 0.2051
Trypanosoma cruzi heat shock protein 85, putative 0.0063 0.0077 1
Trypanosoma cruzi Heat shock protein 83, putative 0.0063 0.0077 1
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0052 0.005 0.4906
Onchocerca volvulus 0.0089 0.0134 0.115
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0052 0.005 0.0127
Brugia malayi hypothetical protein 0.0334 0.069 0.185
Trypanosoma brucei heat shock protein, putative 0.0063 0.0077 0.123
Onchocerca volvulus 0.0334 0.069 0.6194
Brugia malayi solute carrier family 40, member 1 0.0407 0.0855 0.2292
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0047 0.0039 0.0052
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0334 0.069 0.069
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0318 0.5957
Loa Loa (eye worm) hypothetical protein 0.0052 0.005 0.0155
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0334 0.069 0.069
Loa Loa (eye worm) hypothetical protein 0.0052 0.005 0.0155
Loa Loa (eye worm) hypothetical protein 0.0052 0.005 0.0155
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0052 0.005 0.005
Onchocerca volvulus 0.0334 0.069 0.6194
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0306 0.0626 0.0828
Onchocerca volvulus 0.006 0.0069 0.0561
Brugia malayi neuropeptide F receptor 0.0334 0.069 0.185
Schistosoma mansoni transient receptor potential channel 4 0.0052 0.005 0.005
Echinococcus granulosus hypothetical protein 0.0052 0.005 0.0067
Onchocerca volvulus 0.0334 0.069 0.6194
Schistosoma mansoni opsin-like receptor 0.0334 0.069 0.069
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0306 0.0626 0.0828
Loa Loa (eye worm) hypothetical protein 0.0052 0.005 0.0155
Schistosoma mansoni glutamate receptor AMPA 0.0031 0.0003 0.0003
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0052 0.005 0.0127
Onchocerca volvulus 0.0334 0.069 0.6194
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0306 0.0626 0.1676
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0306 0.0626 0.0828
Loa Loa (eye worm) hypothetical protein 0.0052 0.005 0.0155
Loa Loa (eye worm) hypothetical protein 0.0306 0.0626 0.2051
Leishmania major heat shock protein 83-1 0.0063 0.0077 1
Echinococcus granulosus sodium leak channel non selective protein 0.0052 0.005 0.0067
Echinococcus multilocularis glutamate receptor 2 0.0031 0.0003 0.0004
Giardia lamblia Grp94/Hsp90 0.0051 0.0048 0.3533
Loa Loa (eye worm) K+ channel tetramerisation domain-containing protein 0.006 0.0069 0.0216
Trypanosoma brucei heat shock protein 90, putative 0.0063 0.0077 0.123
Schistosoma mansoni amine GPCR 0.0334 0.069 0.069
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.016 0.0296 0.0963
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0334 0.069 0.069
Trichomonas vaginalis cyclins, putative 0.0043 0.0032 0.0585
Schistosoma mansoni vesicular amine transporter 0.0111 0.0186 0.0186
Onchocerca volvulus 0.0429 0.0906 0.8147
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0334 0.069 0.0913
Brugia malayi mKIAA0176 protein 0.006 0.0069 0.0177
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0334 0.069 0.0913
Echinococcus multilocularis G protein coupled receptor 139 0.3365 0.7561 1
Echinococcus multilocularis fmrfamide receptor 0.0334 0.069 0.0913
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0052 0.005 0.0127
Brugia malayi glutaminase DH11.1 0.0265 0.0534 0.1427
Schistosoma mansoni tyrosine kinase 0.0086 0.0128 0.0128
Echinococcus granulosus neuropeptide receptor 0.0334 0.069 0.0913
Echinococcus granulosus hyperpolarization activated cyclic 0.0052 0.005 0.0067
Loa Loa (eye worm) TK/INSR protein kinase 0.0051 0.0049 0.0151
Echinococcus granulosus rhodopsin orphan GPCR 0.0334 0.069 0.0913
Loa Loa (eye worm) hypothetical protein 0.0334 0.069 0.2264
Schistosoma mansoni lamin 0.0033 0.0007 0.0007
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0334 0.069 0.069
Loa Loa (eye worm) hypothetical protein 0.0052 0.005 0.0155
Echinococcus granulosus endoplasmin 0.0051 0.0048 0.0063
Schistosoma mansoni neurotransmitter gated ion channel 0.0141 0.0253 0.0253
Trypanosoma brucei heat shock protein, putative 0.0063 0.0077 0.123
Brugia malayi ion channel NompC 0.0052 0.005 0.0127
Leishmania major heat shock protein 83-1 0.0063 0.0077 1
Echinococcus granulosus heat shock protein 0.0063 0.0077 0.0102
Loa Loa (eye worm) hypothetical protein 0.0334 0.069 0.2264
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0086 0.0128 0.0169
Loa Loa (eye worm) hypothetical protein 0.0089 0.0134 0.0431
Loa Loa (eye worm) TYRA-2 protein 0.0334 0.069 0.2264
Leishmania major heat shock protein 83-1 0.0063 0.0077 1
Schistosoma mansoni hypothetical protein 0.0342 0.0709 0.0709
Brugia malayi excitatory GABA receptor EXP-1A 0.0306 0.0626 0.1676
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0052 0.005 0.005
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0052 0.005 0.0067
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0052 0.005 0.0067
Brugia malayi K+ channel tetramerisation domain containing protein 0.006 0.0069 0.0177
Loa Loa (eye worm) hypothetical protein 0.0334 0.069 0.2264
Onchocerca volvulus 0.0165 0.0306 0.2713
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0519 0.111 0.3647
Echinococcus multilocularis neuropeptide s receptor 0.0334 0.069 0.0913
Echinococcus granulosus transient receptor potential cation channel 0.0052 0.005 0.0067
Schistosoma mansoni tyrosine kinase 0.0086 0.0128 0.0128
Loa Loa (eye worm) hypothetical protein 0.0306 0.0626 0.2051
Loa Loa (eye worm) hypothetical protein 0.0334 0.069 0.2264
Brugia malayi K+ channel tetramerisation domain containing protein 0.006 0.0069 0.0177
Echinococcus granulosus neuropeptides capa receptor 0.0334 0.069 0.0913
Echinococcus multilocularis Protein lozenge 0.0054 0.0055 0.0073
Brugia malayi latrophilin 2 splice variant baaae 0.0342 0.0709 0.1899
Loa Loa (eye worm) solute carrier family 6 member 4 0.0089 0.0134 0.0431
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0334 0.069 0.0913
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0047 0.0039 0.0052
Chlamydia trachomatis glutamine binding protein 0.0079 0.0113 0.5
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0306 0.0626 0.0828
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0306 0.0626 0.0828
Loa Loa (eye worm) hypothetical protein 0.0334 0.069 0.2264
Schistosoma mansoni neuropeptide receptor 0.0334 0.069 0.069
Onchocerca volvulus 0.0141 0.0253 0.2227
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0334 0.069 0.0913
Trichomonas vaginalis cyclins, putative 0.0043 0.0032 0.0585
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0052 0.005 0.0932
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0052 0.005 0.0155
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0334 0.069 0.0913
Echinococcus granulosus BTB:POZ domain containing protein KCTD16 0.006 0.0069 0.0091
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.05 0.1068 0.2866
Toxoplasma gondii hypothetical protein 0.0052 0.005 0.4906
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0052 0.005 0.005
Schistosoma mansoni endoplasmin 0.0063 0.0077 0.0077
Schistosoma mansoni nAChR subunit 0.0306 0.0626 0.0626
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0052 0.005 0.0127
Leishmania major heat shock protein 83-1 0.0063 0.0077 1
Brugia malayi Cyclin, N-terminal domain containing protein 0.0043 0.0032 0.0077
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0334 0.069 0.069
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0306 0.0626 0.0828
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0052 0.005 0.0067
Trypanosoma cruzi btb/poz domain containing protein, putative 0.006 0.0069 0.8617
Echinococcus granulosus neuropeptides capa receptor 0.0334 0.069 0.0913
Entamoeba histolytica hypothetical protein 0.0165 0.0306 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0334 0.069 0.0913
Onchocerca volvulus 0.004 0.0025 0.0158
Loa Loa (eye worm) hypothetical protein 0.0306 0.0626 0.2051
Trypanosoma cruzi heat shock protein 85, putative 0.0063 0.0077 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.005 0.0155
Echinococcus multilocularis heat shock protein 90 0.0051 0.0048 0.0063
Loa Loa (eye worm) hypothetical protein 0.0165 0.0306 0.0999
Loa Loa (eye worm) runx1 0.0054 0.0055 0.0171
Trypanosoma cruzi heat shock protein 85, putative 0.0051 0.0048 0.503
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0047 0.0041 0.3045
Echinococcus multilocularis transfer RNA-Gly 0.0111 0.0186 0.0246
Loa Loa (eye worm) hypothetical protein 0.0141 0.0253 0.0822
Brugia malayi cation channel family protein 0.0052 0.005 0.0127
Echinococcus granulosus nmda type glutamate receptor 0.011 0.0183 0.0242
Trichomonas vaginalis cyclin B, putative 0.0043 0.0032 0.0585
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0165 0.0306 0.0306
Echinococcus granulosus alpha 1A adrenergic receptor 0.0334 0.069 0.0913
Echinococcus multilocularis lamin 0.0033 0.0007 0.0009
Brugia malayi intermediate filament protein 0.0033 0.0007 0.001
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0306 0.0626 0.1676
Loa Loa (eye worm) hypothetical protein 0.0429 0.0906 0.2974
Loa Loa (eye worm) hypothetical protein 0.0052 0.005 0.0155
Onchocerca volvulus 0.0334 0.069 0.6194
Loa Loa (eye worm) hypothetical protein 0.0334 0.069 0.2264
Loa Loa (eye worm) hypothetical protein 0.0334 0.069 0.2264
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0051 0.0048 0.4422
Onchocerca volvulus 0.0334 0.069 0.6194
Echinococcus multilocularis g-protein coupled receptor 0.0334 0.069 0.0913
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0047 0.0041 0.0123
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0052 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0334 0.069 0.2264
Brugia malayi Tachykinin-like peptides receptor 99D 0.0334 0.069 0.185
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0052 0.005 0.0932
Loa Loa (eye worm) hypothetical protein 0.0429 0.0906 0.2974
Schistosoma mansoni voltage-gated potassium channel 0.006 0.0069 0.0069
Loa Loa (eye worm) hypothetical protein 0.004 0.0025 0.007
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0306 0.0626 0.0828
Echinococcus granulosus g protein coupled receptor 0.0334 0.069 0.0913
Schistosoma mansoni biogenic amine receptor 0.0334 0.069 0.069
Loa Loa (eye worm) serotonin transporter b 0.0089 0.0134 0.0431
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.137 0.3038 0.8171
Loa Loa (eye worm) hypothetical protein 0.0306 0.0626 0.2051
Trypanosoma brucei potassium voltage-gated channel, putative 0.006 0.0069 0.1009
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0334 0.069 0.2264
Onchocerca volvulus 0.0141 0.0253 0.2227
Loa Loa (eye worm) hypothetical protein 0.0306 0.0626 0.2051
Echinococcus granulosus transient receptor potential cation channel 0.0052 0.005 0.0067
Schistosoma mansoni voltage-gated potassium channel 0.0111 0.0186 0.0186
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0052 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0165 0.0306 0.0999
Brugia malayi G-protein coupled receptor 0.0334 0.069 0.185
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0306 0.0626 0.0626
Trichomonas vaginalis heat shock protein, putative 0.0039 0.0022 0.0391
Schistosoma mansoni biogenic amine (5HT) receptor 0.0334 0.069 0.069
Loa Loa (eye worm) hypothetical protein 0.0052 0.005 0.0155
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0306 0.0626 0.1676
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0306 0.0626 0.2051
Brugia malayi hypothetical protein 0.0141 0.0253 0.0672
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0519 0.111 0.1468
Onchocerca volvulus 0.0334 0.069 0.6194
Schistosoma mansoni nAChR subunit 0.0306 0.0626 0.0626
Brugia malayi larval opioid receptor 0.0334 0.069 0.185
Onchocerca volvulus Neuropeptide F receptor homolog 0.0334 0.069 0.6194
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0334 0.069 0.0913
Brugia malayi olfactory channel protein osm-9 0.0052 0.005 0.0127
Echinococcus granulosus potassium large conductance calcium activated 0.0052 0.005 0.0067
Echinococcus multilocularis allatostatin A receptor 0.0334 0.069 0.0913
Loa Loa (eye worm) hypothetical protein 0.0334 0.069 0.2264
Schistosoma mansoni neuropeptide F-like receptor 0.0334 0.069 0.069
Schistosoma mansoni endoplasmin 0.0063 0.0077 0.0077
Brugia malayi heat shock protein 90 0.0063 0.0077 0.0199
Schistosoma mansoni hypothetical protein 0.0158 0.0292 0.0292
Loa Loa (eye worm) hypothetical protein 0.0141 0.0253 0.0822
Schistosoma mansoni voltage-gated potassium channel 0.006 0.0069 0.0069
Schistosoma mansoni hypothetical protein 0.0334 0.069 0.069
Loa Loa (eye worm) GABA receptor subunit 0.0165 0.0306 0.0999
Echinococcus multilocularis potassium voltage gated channel protein 0.137 0.3038 0.4018
Loa Loa (eye worm) ACC-1 protein 0.0306 0.0626 0.2051
Leishmania major hypothetical protein, conserved 0.006 0.0069 0.8449
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0067 0.0067
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0449 0.0951 0.0951
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0141 0.0253 0.0334
Loa Loa (eye worm) G-protein coupled receptor 0.0334 0.069 0.2264
Echinococcus multilocularis transient receptor potential cation channel 0.0052 0.005 0.0067
Trypanosoma brucei heat shock protein, putative 0.0063 0.0077 0.123
Loa Loa (eye worm) hypothetical protein 0.0052 0.005 0.0155
Schistosoma mansoni nAChR subunit 0.0306 0.0626 0.0626
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0141 0.0253 0.0822
Schistosoma mansoni hypothetical protein 0.004 0.0025 0.0025
Schistosoma mansoni ryanodine receptor related 0.0052 0.005 0.005
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0334 0.069 0.069
Onchocerca volvulus 0.0334 0.069 0.6194
Loa Loa (eye worm) voltage-dependent calcium channel 0.0052 0.005 0.0155
Leishmania major heat shock protein 83-1 0.0063 0.0077 1
Schistosoma mansoni tyrosine kinase 0.0051 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0141 0.0253 0.0822
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0334 0.069 0.185
Schistosoma mansoni opsin-like receptor 0.0334 0.069 0.069
Echinococcus multilocularis dro:myosuppressin receptor 0.0334 0.069 0.0913
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0053 0.5367
Schistosoma mansoni tyrosine kinase 0.0085 0.0126 0.0126
Brugia malayi Protein kinase domain containing protein 0.0041 0.0027 0.0063
Onchocerca volvulus Glucosylceramidase homolog 0.017 0.0318 0.2819
Schistosoma mansoni voltage-gated potassium channel 0.0052 0.005 0.005
Brugia malayi Kringle domain containing protein 0.004 0.0025 0.0057
Echinococcus granulosus calcium activated potassium channel 0.0052 0.005 0.0067
Toxoplasma gondii transporter, cation channel family protein 0.0052 0.005 0.4906
Schistosoma mansoni voltage-gated potassium channel 0.0052 0.005 0.005
Onchocerca volvulus 0.0334 0.069 0.6194
Echinococcus multilocularis short transient receptor potential channel 6 0.0052 0.005 0.0067
Brugia malayi hypothetical protein 0.0334 0.069 0.185
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0079 0.0113 0.0259
Schistosoma mansoni biogenic amine (5HT) receptor 0.0334 0.069 0.069
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0052 0.005 0.005
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0141 0.0253 0.0334
Schistosoma mansoni sodium/chloride dependent transporter 0.0089 0.0134 0.0134
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0052 0.005 0.0067
Brugia malayi follicle stimulating hormone receptor 0.0781 0.1703 0.4575
Echinococcus multilocularis g protein coupled receptor 0.0334 0.069 0.0913
Plasmodium vivax kelch protein K13, putative 0.006 0.0069 0.8449
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0031 0.0003 0.0004
Trypanosoma cruzi potassium voltage-gated channel 0.006 0.0069 0.8617
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0141 0.0253 0.0672
Brugia malayi Endoplasmin precursor 0.0063 0.0077 0.0199
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0158 0.0292 0.0387
Echinococcus granulosus glutamate NMDA receptor subunit 0.026 0.0523 0.0692
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0318 0.5957
Echinococcus multilocularis short transient receptor potential channel 6 0.0052 0.005 0.0067
Brugia malayi ORL1-like opioid receptor 0.0334 0.069 0.185
Trichomonas vaginalis heat shock protein, putative 0.0051 0.0048 0.0885
Echinococcus granulosus voltage gated potassium channel 0.0052 0.005 0.0067
Brugia malayi G protein-coupled receptor 0.0334 0.069 0.185
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0334 0.069 0.069
Loa Loa (eye worm) hypothetical protein 0.0158 0.0292 0.0952
Brugia malayi Melatonin receptor type 1A 0.0334 0.069 0.185
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0158 0.0292 0.0387
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0052 0.005 0.0127
Loa Loa (eye worm) hypothetical protein 0.0141 0.0253 0.0822
Echinococcus granulosus short transient receptor potential channel 6 0.0052 0.005 0.0067
Schistosoma mansoni nAChR subunit 0.0306 0.0626 0.0626
Loa Loa (eye worm) hypothetical protein 0.0052 0.005 0.0155
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0052 0.005 0.005
Echinococcus multilocularis orexin receptor type 2 0.0334 0.069 0.0913
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0079 0.0113 0.5
Onchocerca volvulus 0.006 0.0069 0.0561
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0031 0.0003 0.0004
Echinococcus granulosus short transient receptor potential channel 6 0.0052 0.005 0.0067
Mycobacterium ulcerans 3-dehydroquinate dehydratase 0.1153 0.2546 1
Loa Loa (eye worm) TK/ROR protein kinase 0.0041 0.0027 0.0077
Schistosoma mansoni cathepsin D (A01 family) 0.014 0.025 0.025
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0306 0.0626 0.2051
Echinococcus multilocularis somatostatin receptor 0.0334 0.069 0.0913
Schistosoma mansoni hypothetical protein 0.0158 0.0292 0.0292
Schistosoma mansoni voltage-gated potassium channel 0.0052 0.005 0.005
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0007 0.001
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0052 0.005 0.005
Echinococcus multilocularis rhodopsin orphan GPCR 0.0334 0.069 0.0913
Echinococcus granulosus GPCR family 2 0.0158 0.0292 0.0387
Echinococcus multilocularis two pore calcium channel protein 2 0.0052 0.005 0.0067
Brugia malayi Dopamine receptor protein 1 0.0334 0.069 0.185
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0111 0.0186 0.0246
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0334 0.069 0.069
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0052 0.005 0.005
Echinococcus multilocularis GPCR, family 2 0.0158 0.0292 0.0387
Echinococcus multilocularis nmda type glutamate receptor 0.011 0.0183 0.0242
Brugia malayi cation channel family protein 0.0052 0.005 0.0127
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0111 0.0186 0.0246
Schistosoma mansoni transient receptor potential channel 0.0052 0.005 0.005
Trypanosoma brucei btb/poz domain containing protein, putative 0.006 0.0069 0.1009
Echinococcus multilocularis calcium activated potassium channel 0.0052 0.005 0.0067
Echinococcus granulosus rhodopsin orphan GPCR 0.0334 0.069 0.0913
Loa Loa (eye worm) hypothetical protein 0.0334 0.069 0.2264
Onchocerca volvulus 0.0334 0.069 0.6194
Echinococcus granulosus g protein coupled receptor 0.0334 0.069 0.0913
Loa Loa (eye worm) hypothetical protein 0.05 0.1068 0.3507
Schistosoma mansoni neuropeptide receptor 0.0334 0.069 0.069
Onchocerca volvulus 0.0449 0.0951 0.8559
Echinococcus multilocularis glycine receptor subunit beta 0.0306 0.0626 0.0828
Brugia malayi Dopamine receptor protein 2 0.0334 0.069 0.185
Loa Loa (eye worm) hypothetical protein 0.0334 0.069 0.2264
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0306 0.0626 0.0828
Loa Loa (eye worm) hypothetical protein 0.0334 0.069 0.2264
Plasmodium vivax K+ channel tetramerisation domain containing protein 0.006 0.0069 0.8449
Echinococcus granulosus tachykinin peptides receptor 99D 0.0334 0.069 0.0913
Leishmania major heat shock protein 83-1 0.0063 0.0077 1
Schistosoma mansoni opsin-like receptor 0.0334 0.069 0.069
Onchocerca volvulus Putative nachr subunit 0.0519 0.111 1
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0052 0.005 0.0504
Trichomonas vaginalis cyclins, putative 0.0043 0.0032 0.0585
Brugia malayi G protein-coupled receptor F59B2.13 0.0334 0.069 0.185
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0306 0.0626 0.0828
Loa Loa (eye worm) hypothetical protein 0.0047 0.0041 0.0123
Echinococcus multilocularis neuropeptides capa receptor 0.0334 0.069 0.0913
Echinococcus granulosus neuropeptide Y receptor 0.0334 0.069 0.0913
Echinococcus granulosus serotonin receptor 0.0334 0.069 0.0913
Schistosoma mansoni tyrosine kinase 0.016 0.0296 0.0296
Schistosoma mansoni intermediate filament proteins 0.0033 0.0007 0.0007
Echinococcus multilocularis cyclin B 0.0043 0.0032 0.0042
Echinococcus multilocularis sodium channel protein 0.0052 0.005 0.0067
Brugia malayi Latrophilin receptor protein 2 0.0158 0.0292 0.0778
Schistosoma mansoni amine GPCR 0.0334 0.069 0.069
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0306 0.0626 0.1676
Echinococcus granulosus dro:myosuppressin receptor 0.0334 0.069 0.0913
Echinococcus granulosus voltage dependent calcium channel 0.0052 0.005 0.0067
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0334 0.069 0.2264
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.052 0.9741
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0052 0.005 0.0067
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0052 0.005 0.005
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0165 0.0306 0.0816
Onchocerca volvulus 0.0334 0.069 0.6194
Plasmodium falciparum plasmepsin II 0.0047 0.0041 0.3431
Toxoplasma gondii aspartyl protease ASP1 0.0047 0.0041 0.3045
Schistosoma mansoni heat shock protein 0.0063 0.0077 0.0077
Leishmania major heat shock protein 83-1 0.0063 0.0077 1
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0519 0.111 0.1468
Echinococcus multilocularis rhodopsin orphan GPCR 0.0334 0.069 0.0913
Schistosoma mansoni glutamate receptor NMDA 0.026 0.0523 0.0523
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0306 0.0626 0.2051
Schistosoma mansoni hypothetical protein 0.0052 0.005 0.005
Echinococcus multilocularis heat shock protein 90 0.0063 0.0077 0.0102
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0306 0.0626 0.0626
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0334 0.069 0.0913
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0007 0.0013
Echinococcus multilocularis potassium large conductance calcium activated 0.0052 0.005 0.0067
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0334 0.069 0.0913
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0052 0.005 0.005
Onchocerca volvulus 0.0334 0.069 0.6194
Echinococcus granulosus glycine receptor subunit beta 0.0306 0.0626 0.0828
Echinococcus multilocularis transient receptor potential cation channel 0.0052 0.005 0.0067
Schistosoma mansoni amine GPCR 0.0334 0.069 0.069
Schistosoma mansoni hypothetical protein 0.0334 0.069 0.069
Schistosoma mansoni neurotransmitter gated ion channel 0.0165 0.0306 0.0306
Loa Loa (eye worm) hypothetical protein 0.0334 0.069 0.2264
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0043 0.0032 0.1376
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0158 0.0292 0.0778
Entamoeba histolytica heat shock protein 90, putative 0.0063 0.0077 0.1649
Echinococcus multilocularis transient receptor potential cation channel 0.0052 0.005 0.0067
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0334 0.069 0.185
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0334 0.069 0.069
Plasmodium vivax aspartyl proteinase, putative 0.0047 0.0041 0.3045
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0047 0.0039 0.0052
Echinococcus granulosus voltage gated hydrogen channel 1 0.0052 0.005 0.0067
Echinococcus granulosus biogenic amine 5HT receptor 0.0334 0.069 0.0913
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0047 0.0039 0.0052
Echinococcus multilocularis BTB:POZ domain containing protein 0.006 0.0069 0.0091
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0141 0.0253 0.0334
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0052 0.005 0.005
Echinococcus granulosus tm gpcr rhodopsin 0.0334 0.069 0.0913
Loa Loa (eye worm) hypothetical protein 0.0052 0.005 0.0155
Echinococcus multilocularis neuropeptide receptor A26 0.0334 0.069 0.0913
Echinococcus granulosus rhodopsin orphan GPCR 0.0334 0.069 0.0913
Loa Loa (eye worm) hypothetical protein 0.0141 0.0253 0.0822
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0306 0.0626 0.1676
Loa Loa (eye worm) hypothetical protein 0.006 0.0069 0.0216
Schistosoma mansoni potassium channel tetramerization domain-containing 0.006 0.0069 0.0069
Echinococcus granulosus tm gpcr rhodopsin 0.0334 0.069 0.0913
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0052 0.005 0.0067
Loa Loa (eye worm) hypothetical protein 0.0141 0.0253 0.0822
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0158 0.0292 0.0387
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0306 0.0626 0.0626
Echinococcus multilocularis sex peptide receptor 0.0334 0.069 0.0913
Echinococcus granulosus sex peptide receptor 0.0334 0.069 0.0913
Loa Loa (eye worm) hypothetical protein 0.0449 0.0951 0.3123
Onchocerca volvulus 0.0449 0.0951 0.8559
Brugia malayi hypothetical protein 0.0141 0.0253 0.0672
Loa Loa (eye worm) melatonin receptor type 1A 0.0334 0.069 0.2264
Echinococcus multilocularis BTB:POZ domain containing protein KCTD16 0.006 0.0069 0.0091
Onchocerca volvulus 0.0306 0.0626 0.5609
Loa Loa (eye worm) hypothetical protein 0.0165 0.0306 0.0999
Plasmodium falciparum plasmepsin IV 0.0047 0.0041 0.3431
Loa Loa (eye worm) hypothetical protein 0.0141 0.0253 0.0822
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0052 0.005 0.0504
Echinococcus multilocularis neuropeptide Y receptor 0.0334 0.069 0.0913
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0052 0.005 0.0067
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0165 0.0306 0.0816
Toxoplasma gondii heat shock protein 90, putative 0.0063 0.0077 1
Loa Loa (eye worm) voltage-gated potassium channel 0.0111 0.0186 0.0602
Echinococcus granulosus glutamate receptor subunit protein glur 0.0031 0.0003 0.0004
Echinococcus multilocularis transient receptor potential cation channel 0.0052 0.005 0.0067
Leishmania major heat shock protein 83-1 0.0063 0.0077 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0306 0.0626 0.1676
Schistosoma mansoni voltage-gated potassium channel 0.0111 0.0186 0.0186
Schistosoma mansoni neuropeptide receptor 0.3365 0.7561 0.7561
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0519 0.111 0.1468
Schistosoma mansoni glutaminase 0.0265 0.0534 0.0534
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0052 0.005 0.0067
Leishmania major cyclin 0.0043 0.0032 0.1376
Echinococcus multilocularis dnaJ subfamily B 0.0396 0.0831 0.11
Schistosoma mansoni neurotransmitter gated ion channel 0.0141 0.0253 0.0253
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0052 0.005 0.0127
Schistosoma mansoni voltage-gated potassium channel 0.0052 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0334 0.069 0.2264
Trypanosoma cruzi btb/poz domain containing protein, putative 0.006 0.0069 0.8617
Leishmania major hypothetical protein, conserved 0.006 0.0069 0.8449
Schistosoma mansoni glutamate receptor kainate 0.0031 0.0003 0.0003
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0111 0.0186 0.0492
Echinococcus multilocularis endoplasmin 0.0051 0.0048 0.0063
Echinococcus granulosus rhodopsin orphan GPCR 0.0334 0.069 0.0913
Schistosoma mansoni voltage-gated potassium channel 0.0111 0.0186 0.0186
Echinococcus granulosus potassium voltage gated channel protein 0.0111 0.0186 0.0246
Plasmodium falciparum cysteine repeat modular protein 1 0.004 0.0025 0.0555
Trypanosoma brucei btb/poz domain containing protein, putative 0.006 0.0069 0.1009
Echinococcus multilocularis glycine receptor subunit beta 0.0306 0.0626 0.0828
Brugia malayi neuropeptide F receptor 0.0334 0.069 0.185
Loa Loa (eye worm) hypothetical protein 0.0306 0.0626 0.2051
Echinococcus multilocularis transient receptor potential cation channel 0.0052 0.005 0.0067
Schistosoma mansoni heat shock protein 0.0063 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0352 0.073 0.2395
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0052 0.005 0.005
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0051 0.0048 0.5
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0052 0.005 0.0067
Leishmania major heat shock protein 83-1 0.0063 0.0077 1
Loa Loa (eye worm) ACC-1 protein 0.0306 0.0626 0.2051
Echinococcus multilocularis rhodopsin orphan GPCR 0.0334 0.069 0.0913
Leishmania major hypothetical protein, conserved 0.0052 0.005 0.4906
Brugia malayi hypothetical protein 0.0052 0.005 0.0127
Brugia malayi hypothetical protein 0.0141 0.0253 0.0672
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.052 0.9741
Loa Loa (eye worm) hypothetical protein 0.0165 0.0306 0.0999
Schistosoma mansoni alpha-1 adrenergic receptor 0.0334 0.069 0.069
Schistosoma mansoni voltage-gated potassium channel 0.137 0.3038 0.3038
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0052 0.005 0.0067
Echinococcus granulosus heat shock protein 90 0.0051 0.0048 0.0063
Loa Loa (eye worm) hypothetical protein 0.0141 0.0253 0.0822
Echinococcus multilocularis potassium voltage gated channel protein 0.0111 0.0186 0.0246
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0141 0.0253 0.0672
Loa Loa (eye worm) hypothetical protein 0.0342 0.0709 0.2324
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0079 0.0113 0.0259
Trichomonas vaginalis endoplasmin, putative 0.0039 0.0022 0.0391
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.011 0.0183 0.0242
Trichomonas vaginalis glutaminase, putative 0.0265 0.0534 1
Brugia malayi Transient-receptor-potential like protein 0.0052 0.005 0.0127
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0141 0.0253 0.0672
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0781 0.1703 0.5599
Trichomonas vaginalis cyclin B, putative 0.0043 0.0032 0.0585
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0306 0.0626 0.0828
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0334 0.069 0.0913
Loa Loa (eye worm) hypothetical protein 0.0052 0.005 0.0155
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0306 0.0626 0.1676
Schistosoma mansoni neuropeptide F-like receptor 0.0334 0.069 0.069
Trypanosoma cruzi heat shock protein 90, putative 0.0051 0.0048 0.503
Trichomonas vaginalis heat shock protein, putative 0.0051 0.0048 0.0885
Trichomonas vaginalis heat shock protein, putative 0.0063 0.0077 0.1434
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.006 0.0069 0.0069
Loa Loa (eye worm) potassium channel tetramerisation domain containing 3 0.006 0.0069 0.0216
Loa Loa (eye worm) hypothetical protein 0.0052 0.005 0.0155
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0052 0.005 0.0067
Leishmania major heat shock protein 83-1 0.0063 0.0077 1
Brugia malayi hypothetical protein 0.0334 0.069 0.185
Schistosoma mansoni biogenic amine receptor 0.0334 0.069 0.069
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0047 0.0039 0.0052
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.026 0.0523 0.0692
Loa Loa (eye worm) hypothetical protein 0.0043 0.0032 0.0094
Leishmania major heat shock protein 83-1 0.0063 0.0077 1
Echinococcus multilocularis voltage gated potassium channel 0.0111 0.0186 0.0246
Treponema pallidum sodium- and chloride- dependent transporter 0.0089 0.0134 1
Echinococcus granulosus neuropeptide Y receptor 0.0334 0.069 0.0913
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0449 0.0951 0.0951
Echinococcus granulosus insulin receptor 0.0051 0.0049 0.0065
Trypanosoma brucei heat shock protein, putative 0.0063 0.0077 0.123
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0334 0.069 0.6194
Brugia malayi Protein kinase domain containing protein 0.0051 0.0049 0.0123
Loa Loa (eye worm) hypothetical protein 0.0306 0.0626 0.2051
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0052 0.005 0.0127
Echinococcus granulosus potassium voltage gated channel protein 0.0052 0.005 0.0067
Loa Loa (eye worm) hypothetical protein 0.0141 0.0253 0.0822
Entamoeba histolytica heat shock protein 90, putative 0.0063 0.0077 0.1649
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0141 0.0253 0.0334
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0052 0.005 0.0067
Echinococcus granulosus g protein coupled receptor 0.0334 0.069 0.0913
Schistosoma mansoni tyrosine kinase 0.0085 0.0126 0.0126
Loa Loa (eye worm) ion channel NompC 0.0052 0.005 0.0155
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0306 0.0626 0.1676
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0052 0.005 0.0067
Loa Loa (eye worm) hypothetical protein 0.0306 0.0626 0.2051
Echinococcus granulosus lamin dm0 0.0033 0.0007 0.0009
Onchocerca volvulus 0.0306 0.0626 0.5609
Loa Loa (eye worm) hypothetical protein 0.0449 0.0951 0.3123
Schistosoma mansoni nAChR subunit 0.0306 0.0626 0.0626
Loa Loa (eye worm) hypothetical protein 0.0306 0.0626 0.2051
Loa Loa (eye worm) hypothetical protein 0.0141 0.0253 0.0822
Brugia malayi putative neuropeptide receptor NPR1 0.0334 0.069 0.185
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0334 0.069 0.069
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0111 0.0186 0.0246
Loa Loa (eye worm) hypothetical protein 0.0306 0.0626 0.2051
Schistosoma mansoni voltage-gated potassium channel 0.0111 0.0186 0.0186
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0141 0.0253 0.0822
Echinococcus granulosus glycine receptor subunit alpha 1 0.0306 0.0626 0.0828
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0052 0.005 0.0067
Brugia malayi Dopamine receptor 0.0334 0.069 0.185
Schistosoma mansoni glutamate receptor kainate 0.0031 0.0003 0.0003
Trypanosoma cruzi cyclin, putative 0.0043 0.0032 0.2315
Echinococcus multilocularis potassium voltage gated channel protein 0.0111 0.0186 0.0246
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0052 0.005 0.005
Echinococcus granulosus somatostatin receptor 0.0334 0.069 0.0913
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0334 0.069 0.0913
Echinococcus multilocularis rhodopsin orphan GPCR 0.0334 0.069 0.0913
Loa Loa (eye worm) hypothetical protein 0.0141 0.0253 0.0822
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0052 0.005 0.0067
Echinococcus multilocularis rhodopsin orphan GPCR 0.0334 0.069 0.0913
Brugia malayi Cation transporter family protein 0.0306 0.0626 0.1676
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0025 0.1089
Loa Loa (eye worm) norepinephrine transporter 0.0089 0.0134 0.0431
Loa Loa (eye worm) hypothetical protein 0.0334 0.069 0.2264
Brugia malayi Cyclic-nucleotide gated cation channel 0.0052 0.005 0.0127
Loa Loa (eye worm) Kv4.2 voltage-gated potassium channel 0.006 0.0069 0.0216
Loa Loa (eye worm) heat shock protein 90 0.0063 0.0077 0.0243
Echinococcus multilocularis rhodopsin orphan GPCR 0.0334 0.069 0.0913
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0047 0.0039 0.0052
Brugia malayi hypothetical protein 0.0334 0.069 0.185
Schistosoma mansoni voltage-gated potassium channel 0.137 0.3038 0.3038
Mycobacterium tuberculosis 3-dehydroquinate dehydratase AroD (AROQ) (3-dehydroquinase) (type II dhqase) 0.1153 0.2546 1
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0089 0.0134 0.0134
Echinococcus multilocularis nAChR subunit 0.0165 0.0306 0.0405
Echinococcus granulosus transient receptor potential cation channel 0.0052 0.005 0.0067
Echinococcus multilocularis nAChR subunit 0.0306 0.0626 0.0828
Echinococcus multilocularis conserved hypothetical protein 0.0052 0.005 0.0067
Schistosoma mansoni cyclin B 0.0043 0.0032 0.0032
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0334 0.069 0.069
Loa Loa (eye worm) K+ channel tetramerisation domain-containing protein 0.006 0.0069 0.0216
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0158 0.0292 0.0387
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0031 0.0003 0.0004
Brugia malayi Cation transporter family protein 0.0449 0.0951 0.2552
Loa Loa (eye worm) endoplasmin 0.0063 0.0077 0.0243
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0259 0.052 0.1701
Schistosoma mansoni glutamate receptor NMDA 0.0047 0.0039 0.0039
Schistosoma mansoni transient receptor potential channel 0.0052 0.005 0.005
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0334 0.069 0.0913
Loa Loa (eye worm) pigment dispersing factor receptor c 0.1237 0.2738 0.901
Trypanosoma cruzi cyclin, putative 0.0043 0.0032 0.2315
Onchocerca volvulus 0.006 0.0069 0.0561
Echinococcus multilocularis heat shock protein 0.0063 0.0077 0.0102
Echinococcus granulosus nAChR subunit 0.0165 0.0306 0.0405
Loa Loa (eye worm) hypothetical protein 0.0334 0.069 0.2264
Echinococcus multilocularis 0.0049 0.0045 0.006
Loa Loa (eye worm) K+ channel tetramerisation domain-containing protein 0.006 0.0069 0.0216
Schistosoma mansoni cathepsin D (A01 family) 0.014 0.025 0.025
Echinococcus granulosus transient receptor potential gamma protein 0.0052 0.005 0.0067
Loa Loa (eye worm) hypothetical protein 0.0334 0.069 0.2264
Leishmania major heat shock protein 83-1 0.0063 0.0077 1
Echinococcus multilocularis neuropeptides capa receptor 0.0334 0.069 0.0913
Plasmodium falciparum plasmepsin VI 0.0047 0.0041 0.3431
Trichomonas vaginalis cyclin A, putative 0.0043 0.0032 0.0585
Echinococcus granulosus rhodopsin orphan GPCR 0.0334 0.069 0.0913
Echinococcus granulosus TRP transient receptor potential channel 0.0052 0.005 0.0067
Onchocerca volvulus 0.006 0.0069 0.0561
Echinococcus granulosus transient receptor potential cation channel 0.0052 0.005 0.0067
Schistosoma mansoni nAChR subunit 0.0306 0.0626 0.0626
Onchocerca volvulus 0.0334 0.069 0.6194
Echinococcus multilocularis voltage dependent calcium channel 0.0052 0.005 0.0067
Loa Loa (eye worm) hypothetical protein 0.0334 0.069 0.2264
Echinococcus multilocularis ryanodine receptor 44f 0.0052 0.005 0.0067
Echinococcus granulosus transient receptor potential cation channel 0.0052 0.005 0.0067
Loa Loa (eye worm) hypothetical protein 0.0306 0.0626 0.2051
Schistosoma mansoni edp1-related 0.006 0.0069 0.0069
Schistosoma mansoni voltage-gated potassium channel 0.0052 0.005 0.005
Brugia malayi Serotonin receptor 0.0334 0.069 0.185
Trypanosoma brucei RNA helicase, putative 0.0206 0.04 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0334 0.069 0.0913
Echinococcus granulosus BTB:POZ domain containing protein 0.006 0.0069 0.0091
Echinococcus granulosus transient receptor potential cation channel 0.0052 0.005 0.0067
Echinococcus multilocularis neuropeptide FF receptor 2 0.0334 0.069 0.0913
Schistosoma mansoni tyrosine kinase 0.0085 0.0126 0.0126
Plasmodium falciparum plasmepsin I 0.0047 0.0041 0.3431
Loa Loa (eye worm) neuropeptide F receptor 0.0334 0.069 0.2264
Echinococcus granulosus shaker cognate 0.0111 0.0186 0.0246
Echinococcus granulosus nAChR subunit 0.0306 0.0626 0.0828
Plasmodium falciparum heat shock protein 90 0.0063 0.0077 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0334 0.069 0.069
Plasmodium vivax endoplasmin, putative 0.0063 0.0077 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0334 0.069 0.0913
Leishmania major heat shock protein 83-1 0.0063 0.0077 1
Schistosoma mansoni amine GPCR 0.0334 0.069 0.069
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0051 0.0048 0.0063
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0334 0.069 0.0913
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0047 0.0041 0.0054
Trypanosoma brucei heat shock protein, putative 0.0063 0.0077 0.123
Echinococcus multilocularis voltage dependent calcium channel 0.0052 0.005 0.0067
Plasmodium vivax plasmepsin IV, putative 0.0047 0.0041 0.3045
Echinococcus granulosus 7TM GPCR rhodopsin 0.0334 0.069 0.0913
Echinococcus multilocularis transient receptor potential gamma protein 0.0052 0.005 0.0067
Brugia malayi Serotonin receptor 0.0334 0.069 0.185
Loa Loa (eye worm) hypothetical protein 0.0165 0.0306 0.0999
Toxoplasma gondii K+ channel tetramerisation domain-containing protein 0.006 0.0069 0.8449
Loa Loa (eye worm) hypothetical protein 0.0334 0.069 0.2264
Brugia malayi Angiotensin-converting enzyme family protein 0.016 0.0296 0.0787
Loa Loa (eye worm) hypothetical protein 0.0334 0.069 0.2264
Echinococcus multilocularis shaker cognate 0.0111 0.0186 0.0246
Loa Loa (eye worm) hypothetical protein 0.0334 0.069 0.2264
Echinococcus granulosus potassium voltage gated channel protein 0.0111 0.0186 0.0246
Echinococcus granulosus 7tm_1 domain containing protein 0.0334 0.069 0.0913
Echinococcus multilocularis musashi 0.0033 0.0007 0.0009
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0052 0.005 0.0067
Echinococcus multilocularis NMDA receptor 0.0031 0.0003 0.0004
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0334 0.069 0.069
Brugia malayi Protein kinase domain containing protein 0.0352 0.073 0.1957
Toxoplasma gondii kelch repeat and K+ channel tetramerisation domain containing protein 0.006 0.0069 0.8449
Schistosoma mansoni nAChR subunit 0.0306 0.0626 0.0626
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0334 0.069 0.069
Plasmodium vivax heat shock protein 86, putative 0.0063 0.0077 1
Echinococcus granulosus intermediate filament protein 0.0033 0.0007 0.0009
Schistosoma mansoni 60S ribosomal protein L21 0.0052 0.005 0.005
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0052 0.005 0.0067
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0306 0.0626 0.1676
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0052 0.005 0.005
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0047 0.0039 0.0052
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0052 0.005 0.0392
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0318 0.5957
Loa Loa (eye worm) hypothetical protein 0.137 0.3038 1
Schistosoma mansoni glutamate receptor kainate 0.0031 0.0003 0.0003
Echinococcus multilocularis serotonin transporter 0.0089 0.0134 0.0177
Brugia malayi K+ channel tetramerisation domain containing protein 0.006 0.0069 0.0177
Schistosoma mansoni hypothetical protein 0.0158 0.0292 0.0292
Loa Loa (eye worm) hypothetical protein 0.0334 0.069 0.2264
Echinococcus multilocularis glutamate receptor 2 0.0047 0.0039 0.0052
Loa Loa (eye worm) G-protein coupled receptor 0.0334 0.069 0.2264
Brugia malayi Furin-like cysteine rich region family protein 0.016 0.0296 0.0787
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0052 0.005 0.0067
Loa Loa (eye worm) potassium channel tetramerisation domain containing 5 0.006 0.0069 0.0216
Brugia malayi sulfakinin receptor protein 0.0334 0.069 0.185
Brugia malayi hypothetical protein 0.0334 0.069 0.185
Echinococcus multilocularis potassium voltage gated channel protein 0.0052 0.005 0.0067
Loa Loa (eye worm) hypothetical protein 0.0052 0.005 0.0155
Schistosoma mansoni two-pore calcium channel 0.0052 0.005 0.005
Echinococcus multilocularis epidermal growth factor receptor 0.0086 0.0128 0.0169
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0111 0.0186 0.0246
Schistosoma mansoni voltage-gated ion channel 0.0052 0.005 0.005
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0079 0.0113 0.7524
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0259 0.052 0.139
Schistosoma mansoni voltage-gated potassium channel 0.0052 0.005 0.005
Schistosoma mansoni voltage-gated potassium channel 0.0052 0.005 0.005
Brugia malayi voltage-dependent calcium channel 0.0052 0.005 0.0127
Echinococcus granulosus glycine receptor subunit beta 0.0306 0.0626 0.0828
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.052 0.9741
Trypanosoma brucei btb/poz domain containing protein, putative 0.006 0.0069 0.1009
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0111 0.0186 0.0246
Echinococcus granulosus voltage dependent calcium channel 0.0052 0.005 0.0067
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0052 0.005 0.0067
Onchocerca volvulus 0.0334 0.069 0.6194
Loa Loa (eye worm) voltage-gated calcium channel 0.0052 0.005 0.0155
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.0339 0.6346
Loa Loa (eye worm) hypothetical protein 0.0052 0.005 0.0155
Loa Loa (eye worm) ryanodine receptor 0.0052 0.005 0.0155
Loa Loa (eye worm) hypothetical protein 0.0308 0.0632 0.2071
Echinococcus granulosus heat shock protein 90 0.0063 0.0077 0.0102
Loa Loa (eye worm) hypothetical protein 0.0111 0.0186 0.0602
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0031 0.0003 0.0004
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0052 0.005 0.0127
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0334 0.069 0.0913
Trypanosoma cruzi potassium voltage-gated channel, putative 0.006 0.0069 0.8617
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0519 0.111 0.1468
Echinococcus granulosus sodium channel protein 0.0052 0.005 0.0067
Schistosoma mansoni voltage-gated potassium channel 0.0052 0.005 0.005
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0334 0.069 0.0913
Schistosoma mansoni lamin 0.0033 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0334 0.069 0.2264
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0334 0.069 0.185
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0318 0.5957
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.052 0.9741
Trypanosoma brucei heat shock protein 90, putative 0.0063 0.0077 0.123
Schistosoma mansoni voltage-gated potassium channel 0.0111 0.0186 0.0186
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0111 0.0186 0.0492
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0306 0.0626 0.1676
Loa Loa (eye worm) hypothetical protein 0.0141 0.0253 0.0822
Loa Loa (eye worm) hypothetical protein 0.0165 0.0306 0.0999
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0052 0.005 0.0067
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0165 0.0306 0.0816
Echinococcus granulosus neuropeptide receptor 0.3365 0.7561 1
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0047 0.0041 0.0749
Brugia malayi hypothetical protein 0.0141 0.0253 0.0672
Loa Loa (eye worm) neuropeptide F receptor 0.0334 0.069 0.2264
Loa Loa (eye worm) hypothetical protein 0.0334 0.069 0.2264
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0052 0.005 0.0127
Echinococcus granulosus two pore calcium channel protein 2 0.0052 0.005 0.0067
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0306 0.0626 0.1676
Echinococcus granulosus peptide allatostatin:somatostatin 0.0334 0.069 0.0913
Loa Loa (eye worm) hypothetical protein 0.0407 0.0855 0.2806
Trypanosoma cruzi btb/poz domain containing protein, putative 0.006 0.0069 0.8617
Leishmania major heat shock protein 83-1 0.0063 0.0077 1
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0306 0.0626 0.0626
Mycobacterium leprae 3-dehydroquinate dehydratase AroD (AroQ) (3-dehydroquinase) (Type II DHQase) 0.1153 0.2546 1
Loa Loa (eye worm) voltage-gated potassium channel 0.0052 0.005 0.0155
Trypanosoma cruzi CYC2-like cyclin, putative 0.0043 0.0032 0.2315
Loa Loa (eye worm) hypothetical protein 0.0334 0.069 0.2264
Brugia malayi Voltage-gated potassium channel, Shal-family (KCND, Kv4-like) alpha-subunit. C. elegans shl-1 ortholog 0.006 0.0069 0.0177
Loa Loa (eye worm) LGC-31 protein 0.0306 0.0626 0.2051
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0165 0.0306 0.0306
Loa Loa (eye worm) hypothetical protein 0.0141 0.0253 0.0822
Echinococcus granulosus potassium voltage gated channel protein 0.0052 0.005 0.0067
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0519 0.111 0.1468
Loa Loa (eye worm) calcium channel 0.0052 0.005 0.0155
Onchocerca volvulus 0.006 0.0069 0.0561
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0334 0.069 0.069
Echinococcus granulosus fmrfamide receptor 0.0334 0.069 0.0913
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.006 0.0069 0.8535
Loa Loa (eye worm) hypothetical protein 0.0334 0.069 0.2264
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0051 0.0049 0.0065
Echinococcus multilocularis neuropeptide receptor 0.0334 0.069 0.0913
Echinococcus granulosus tissue type plasminogen activator 0.004 0.0025 0.0033
Trypanosoma cruzi btb/poz domain containing protein, putative 0.006 0.0069 0.8617
Schistosoma mansoni voltage-gated cation channel 0.0052 0.005 0.005
Echinococcus granulosus glycine receptor subunit alpha 1 0.0306 0.0626 0.0828
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0052 0.005 0.0155
Brugia malayi putative neuropeptide receptor 0.0334 0.069 0.185
Echinococcus granulosus hyperpolarization activated cyclic 0.0052 0.005 0.0067
Echinococcus multilocularis sodium leak channel non selective protein 0.0052 0.005 0.0067
Echinococcus multilocularis neuropeptide Y receptor 0.0334 0.069 0.0913
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0306 0.0626 0.2051
Loa Loa (eye worm) hypothetical protein 0.0052 0.005 0.0155
Echinococcus multilocularis rhodopsin orphan GPCR 0.0334 0.069 0.0913
Brugia malayi RE15519p 0.0334 0.069 0.185
Echinococcus granulosus g-protein coupled receptor 0.0334 0.069 0.0913
Schistosoma mansoni hypothetical protein 0.0206 0.04 0.04
Echinococcus granulosus rhodopsin orphan GPCR 0.0334 0.069 0.0913
Brugia malayi hypothetical protein 0.0334 0.069 0.185
Schistosoma mansoni serine-type protease inhibitor 0.4441 1 1
Echinococcus granulosus epidermal growth factor receptor 0.0086 0.0128 0.0169
Loa Loa (eye worm) hypothetical protein 0.0306 0.0626 0.2051
Echinococcus multilocularis serotonin receptor 0.0334 0.069 0.0913
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0052 0.005 0.0392
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0306 0.0626 0.0828
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0038 0.0019 0.0019
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0334 0.069 0.0913
Leishmania major heat shock protein 83-1 0.0063 0.0077 1
Loa Loa (eye worm) hypothetical protein 0.0334 0.069 0.2264
Onchocerca volvulus 0.0334 0.069 0.6194
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0047 0.0041 0.0041
Mycobacterium ulcerans glutaminase 0.0265 0.0534 0.1944
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0519 0.111 0.298
Brugia malayi hypothetical protein 0.0334 0.069 0.185
Onchocerca volvulus 0.0141 0.0253 0.2227
Loa Loa (eye worm) acetylcholine receptor protein 0.0141 0.0253 0.0822
Echinococcus granulosus allatostatin A receptor 0.0334 0.069 0.0913
Echinococcus multilocularis two pore calcium channel protein 1 0.0052 0.005 0.0067
Trypanosoma brucei potassium voltage-gated channel, putative 0.006 0.0069 0.1009
Loa Loa (eye worm) hypothetical protein 0.0089 0.0134 0.0431
Echinococcus granulosus rhodopsin orphan GPCR 0.0334 0.069 0.0913
Schistosoma mansoni hypothetical protein 0.0334 0.069 0.069
Schistosoma mansoni acetylcholine receptor-related 0.0141 0.0253 0.0253
Onchocerca volvulus 0.0449 0.0951 0.8559
Trypanosoma brucei heat shock protein, putative 0.0063 0.0077 0.123
Echinococcus granulosus neuropeptide s receptor 0.0334 0.069 0.0913
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0031 0.0003 0.0004
Echinococcus granulosus epidermal growth factor receptor 0.016 0.0296 0.0391
Trypanosoma cruzi btb/poz domain containing protein, putative 0.006 0.0069 0.8617
Schistosoma mansoni histamine h1 receptor 0.0334 0.069 0.069
Schistosoma mansoni amine GPCR 0.0334 0.069 0.069
Loa Loa (eye worm) glutaminase 2 0.0265 0.0534 0.1747
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0306 0.0626 0.1676
Loa Loa (eye worm) hypothetical protein 0.0165 0.0306 0.0999
Echinococcus multilocularis g protein coupled receptor 0.0334 0.069 0.0913
Echinococcus granulosus serotonin transporter 0.0089 0.0134 0.0177
Trypanosoma brucei heat shock protein, putative 0.0063 0.0077 0.123
Loa Loa (eye worm) hypothetical protein 0.0052 0.005 0.0155
Trichomonas vaginalis cyclin B, putative 0.0043 0.0032 0.0585
Loa Loa (eye worm) hypothetical protein 0.0334 0.069 0.2264
Echinococcus granulosus G protein coupled receptor 139 0.0334 0.069 0.0913
Loa Loa (eye worm) hypothetical protein 0.0334 0.069 0.2264
Brugia malayi hypothetical protein 0.0334 0.069 0.185
Schistosoma mansoni adenoreceptor 0.0334 0.069 0.069
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0052 0.005 0.0127
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0052 0.005 0.005
Trypanosoma cruzi cyclin 6, putative 0.0043 0.0032 0.2315
Schistosoma mansoni voltage-dependent calcium channel 0.0052 0.005 0.005
Echinococcus granulosus two pore calcium channel protein 1 0.0052 0.005 0.0067
Echinococcus multilocularis tissue type plasminogen activator 0.004 0.0025 0.0033
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.052 0.9741
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0031 0.0003 0.0004
Schistosoma mansoni voltage-gated potassium channel 0.0111 0.0186 0.0186
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0334 0.069 0.2264
Echinococcus granulosus biogenic amine 5HT receptor 0.0334 0.069 0.0913
Loa Loa (eye worm) hypothetical protein 0.0334 0.069 0.2264
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.052 0.9741
Giardia lamblia Heat shock protein HSP 90-alpha 0.0063 0.0077 1
Echinococcus multilocularis neuropeptide receptor 0.3365 0.7561 1
Echinococcus granulosus orexin receptor type 2 0.0334 0.069 0.0913
Onchocerca volvulus 0.0306 0.0626 0.5609
Brugia malayi hypothetical protein 0.0141 0.0253 0.0672
Schistosoma mansoni neuropeptide receptor 0.0334 0.069 0.069
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0007 0.0013
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0141 0.0253 0.0334
Toxoplasma gondii hypothetical protein 0.0052 0.005 0.4906
Schistosoma mansoni nAChR subunit 0.0141 0.0253 0.0253
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0141 0.0253 0.0672
Loa Loa (eye worm) hypothetical protein 0.0519 0.111 0.3647
Echinococcus granulosus hypothetical protein 0.0334 0.069 0.0913
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0141 0.0253 0.0672
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0052 0.005 0.0155
Echinococcus granulosus potassium voltage gated channel protein 0.137 0.3038 0.4018
Schistosoma mansoni lozenge 0.0054 0.0055 0.0055
Brugia malayi Cyclin, N-terminal domain containing protein 0.0043 0.0032 0.0077
Loa Loa (eye worm) latrophilin receptor protein 2 0.0158 0.0292 0.0952
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0052 0.005 0.4906
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0334 0.069 0.069
Leishmania major hypothetical protein, unknown function 0.0052 0.005 0.4906
Echinococcus granulosus neuropeptide receptor A26 0.0334 0.069 0.0913
Echinococcus multilocularis g protein coupled receptor 0.0334 0.069 0.0913
Onchocerca volvulus 0.0052 0.005 0.0392
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.131 0.2903 0.3839
Echinococcus granulosus dnaJ subfamily B 0.0396 0.0831 0.11
Loa Loa (eye worm) hypothetical protein 0.0052 0.005 0.0155
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0052 0.005 0.546
Echinococcus multilocularis rhodopsin orphan GPCR 0.0334 0.069 0.0913
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0052 0.005 0.0127
Brugia malayi GnHR receptor homolog 0.167 0.3718 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0334 0.069 0.069
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0047 0.0039 0.0052
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0052 0.005 0.005
Plasmodium falciparum kelch protein K13 0.006 0.0069 0.8535
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0052 0.005 0.0067
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0334 0.069 0.069
Schistosoma mansoni voltage-gated potassium channel 0.0052 0.005 0.005
Onchocerca volvulus 0.0165 0.0306 0.2713
Schistosoma mansoni voltage-gated potassium channel 0.006 0.0069 0.0069
Schistosoma mansoni hypothetical protein 0.0158 0.0292 0.0292
Schistosoma mansoni neuropeptide f receptor 76f 0.0334 0.069 0.069
Echinococcus multilocularis transient receptor potential cation channel 0.0052 0.005 0.0067
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0051 0.0049 0.0065
Loa Loa (eye worm) hypothetical protein 0.0334 0.069 0.2264
Leishmania major hypothetical protein, conserved 0.006 0.0069 0.8449
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0089 0.0134 0.0352
Brugia malayi Cation transporter family protein 0.0306 0.0626 0.1676
Loa Loa (eye worm) hypothetical protein 0.0334 0.069 0.2264
Echinococcus granulosus cyclin B 0.0043 0.0032 0.0042
Loa Loa (eye worm) hypothetical protein 0.0141 0.0253 0.0822
Schistosoma mansoni tyrosine kinase 0.0051 0.0049 0.0049
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0334 0.069 0.2264
Loa Loa (eye worm) hypothetical protein 0.0306 0.0626 0.2051
Trypanosoma brucei Heat shock protein 83, putative 0.0063 0.0077 0.123
Echinococcus multilocularis insulin receptor 0.0051 0.0049 0.0065
Schistosoma mansoni hypothetical protein 0.0031 0.0003 0.0003
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0318 0.5957
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0052 0.005 0.546
Onchocerca volvulus 0.0334 0.069 0.6194
Echinococcus granulosus voltage gated potassium channel 0.0111 0.0186 0.0246
Brugia malayi AKH receptor 0.0334 0.069 0.185
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0141 0.0253 0.0672
Loa Loa (eye worm) hypothetical protein 0.0334 0.069 0.2264
Loa Loa (eye worm) hypothetical protein 0.0334 0.069 0.2264
Echinococcus granulosus tm gpcr rhodopsin 0.0334 0.069 0.0913
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0334 0.069 0.185
Echinococcus multilocularis voltage gated potassium channel 0.0052 0.005 0.0067
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0047 0.0041 0.0054
Echinococcus multilocularis hyperpolarization activated cyclic 0.0052 0.005 0.0067
Loa Loa (eye worm) hypothetical protein 0.0334 0.069 0.2264
Loa Loa (eye worm) hypothetical protein 0.0334 0.069 0.2264
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0052 0.005 0.0067
Schistosoma mansoni hypothetical protein 0.0334 0.069 0.069
Brugia malayi hypothetical protein 0.0429 0.0906 0.243
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0306 0.0626 0.1676
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0052 0.005 0.0067
Loa Loa (eye worm) hypothetical protein 0.0334 0.069 0.2264
Loa Loa (eye worm) hypothetical protein 0.0334 0.069 0.2264
Giardia lamblia Heat shock protein HSP 90-alpha 0.0051 0.0048 0.3533
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0318 0.5957
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0165 0.0306 0.0816
Loa Loa (eye worm) hypothetical protein 0.0306 0.0626 0.2051
Brugia malayi hypothetical protein 0.0334 0.069 0.185
Leishmania major heat shock protein 83-1 0.0063 0.0077 1
Onchocerca volvulus 0.0334 0.069 0.6194
Trichomonas vaginalis cyclin B, putative 0.0043 0.0032 0.0585
Echinococcus multilocularis serotonin receptor 0.0334 0.069 0.0913
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0052 0.005 0.0067
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0334 0.069 0.069
Trypanosoma cruzi hypothetical protein, conserved 0.006 0.0069 0.8617
Toxoplasma gondii heat shock protein HSP90 0.0063 0.0077 1
Loa Loa (eye worm) hypothetical protein 0.0306 0.0626 0.2051
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0306 0.0626 0.1676
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0306 0.0626 0.0828
Schistosoma mansoni glutamate receptor AMPA 0.0031 0.0003 0.0003
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.0339 0.6346
Trypanosoma cruzi heat shock protein 90, putative 0.0063 0.0077 1
Loa Loa (eye worm) hypothetical protein 0.0334 0.069 0.2264
Echinococcus multilocularis epidermal growth factor receptor 0.016 0.0296 0.0391
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0111 0.0186 0.0246
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0052 0.005 0.0127
Schistosoma mansoni voltage-gated potassium channel 0.0052 0.005 0.005
Echinococcus multilocularis lamin dm0 0.0033 0.0007 0.0009
Echinococcus granulosus glycine receptor subunit alpha 1 0.0306 0.0626 0.0828
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0052 0.005 0.0067
Loa Loa (eye worm) hypothetical protein 0.006 0.0069 0.0216
Echinococcus granulosus glutamate receptor 2 0.0047 0.0039 0.0052
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0052 0.005 0.4906
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0519 0.111 0.1468
Echinococcus multilocularis G-protein coupled receptor, putative 0.0334 0.069 0.0913
Leishmania major heat shock protein 83-1 0.0063 0.0077 1
Trichomonas vaginalis cyclins, putative 0.0043 0.0032 0.0585
Echinococcus granulosus lamin 0.0033 0.0007 0.0009
Loa Loa (eye worm) hypothetical protein 0.0141 0.0253 0.0822
Echinococcus multilocularis fmrfamide receptor 0.0334 0.069 0.0913
Loa Loa (eye worm) hypothetical protein 0.0052 0.005 0.0155
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0334 0.069 0.069
Onchocerca volvulus 0.0407 0.0855 0.7685
Loa Loa (eye worm) hypothetical protein 0.0043 0.0032 0.0094
Loa Loa (eye worm) hypothetical protein 0.0334 0.069 0.2264
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0306 0.0626 0.2051
Loa Loa (eye worm) hypothetical protein 0.0334 0.069 0.2264
Trypanosoma brucei btb/poz domain containing protein, putative 0.006 0.0069 0.1009
Schistosoma mansoni calcium-activated potassium channel 0.0052 0.005 0.005
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0334 0.069 0.069
Trichomonas vaginalis heat shock protein, putative 0.0051 0.0048 0.0885
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0079 0.0113 0.7524
Loa Loa (eye worm) hypothetical protein 0.0032 0.0006 0.0008
Brugia malayi G-protein coupled receptor 0.0334 0.069 0.185
Trypanosoma cruzi heat shock protein 85, putative 0.0063 0.0077 1
Toxoplasma gondii transporter, cation channel family protein 0.0052 0.005 0.4906
Loa Loa (eye worm) glutaminase 0.0265 0.0534 0.1747
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0111 0.0186 0.0246
Loa Loa (eye worm) hypothetical protein 0.0334 0.069 0.2264
Loa Loa (eye worm) hypothetical protein 0.0089 0.0134 0.0431
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0334 0.069 0.0913
Trypanosoma brucei BTB/POZ domain/Regulator of chromosome condensation (RCC1) repeat, putative 0.006 0.0069 0.1009
Leishmania major potassium voltage-gated channel, putative 0.006 0.0069 0.8449
Schistosoma mansoni transient receptor potential channel 0.0052 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0334 0.069 0.2264
Echinococcus granulosus potassium voltage gated channel subfamily A 0.137 0.3038 0.4018
Loa Loa (eye worm) hypothetical protein 0.0165 0.0306 0.0999
Brugia malayi K+ channel tetramerisation domain containing protein 0.006 0.0069 0.0177
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0334 0.069 0.185
Brugia malayi hypothetical protein 0.0334 0.069 0.185
Schistosoma mansoni biogenic amine receptor 0.0334 0.069 0.069
Echinococcus granulosus neuropeptide FF receptor 2 0.0334 0.069 0.0913
Schistosoma mansoni hypothetical protein 0.0396 0.0831 0.0831
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0306 0.0626 0.1676
Schistosoma mansoni acetylcholine receptor subunit beta 0.0141 0.0253 0.0253
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0334 0.069 0.069
Trypanosoma cruzi btb/poz domain containing protein, putative 0.006 0.0069 0.8617
Loa Loa (eye worm) hypothetical protein 0.006 0.0069 0.0216
Schistosoma mansoni growth hormone secretagogue receptor 0.0334 0.069 0.069
Schistosoma mansoni nAChR subunit 0.0141 0.0253 0.0253
Brugia malayi Calcitonin receptor-like protein seb-1 0.1237 0.2738 0.7362
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0334 0.069 0.0913
Loa Loa (eye worm) hypothetical protein 0.0033 0.0007 0.0013
Toxoplasma gondii transporter, cation channel family protein 0.0052 0.005 0.4906
Loa Loa (eye worm) hypothetical protein 0.0334 0.069 0.2264
Loa Loa (eye worm) TK/EGFR protein kinase 0.016 0.0296 0.0963
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0318 0.5957
Loa Loa (eye worm) hypothetical protein 0.0334 0.069 0.2264
Onchocerca volvulus 0.0043 0.0032 0.0224
Schistosoma mansoni ATP-binding cassette transporter 0.0031 0.0003 0.0003

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.1169 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 26.8545 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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