Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | v-ets avian erythroblastosis virus E26 oncogene homolog | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | GA binding protein alpha chain | 0.0087 | 0.058 | 0.1296 |
Brugia malayi | Ets-domain containing protein | 0.0087 | 0.058 | 0.058 |
Brugia malayi | Carboxylesterase family protein | 0.0161 | 0.4473 | 0.4473 |
Loa Loa (eye worm) | D-ets-4 DNA binding domain-containing protein | 0.0087 | 0.058 | 0.058 |
Schistosoma mansoni | gabp alpha | 0.0087 | 0.058 | 0.058 |
Schistosoma mansoni | ets-related | 0.0265 | 1 | 1 |
Echinococcus multilocularis | GA binding protein alpha chain | 0.0087 | 0.058 | 0.1296 |
Brugia malayi | Carboxylesterase family protein | 0.0161 | 0.4473 | 0.4473 |
Echinococcus multilocularis | acetylcholinesterase | 0.0161 | 0.4473 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0161 | 0.4473 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 0.4473 | 0.4473 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0161 | 0.4473 | 0.4473 |
Loa Loa (eye worm) | fli-1 protein | 0.0265 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0161 | 0.4473 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0161 | 0.4473 | 0.4473 |
Echinococcus granulosus | carboxylesterase 5A | 0.0161 | 0.4473 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0161 | 0.4473 | 1 |
Brugia malayi | Ets-domain containing protein | 0.0087 | 0.058 | 0.058 |
Echinococcus granulosus | acetylcholinesterase | 0.0161 | 0.4473 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 0.4473 | 0.4473 |
Loa Loa (eye worm) | carboxylesterase | 0.0161 | 0.4473 | 0.4473 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.5481 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS for Small Molecule Inhibitors of the ERG Ets/DNA interaction. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 28.1838 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.