Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | penicillin-binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium tuberculosis | Possible penicillin-binding protein | Get druggable targets OG5_149948 | All targets in OG5_149948 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Wolbachia endosymbiont of Brugia malayi | methionine aminopeptidase | 0.0087 | 0.1614 | 0.5 |
Mycobacterium ulcerans | methionine aminopeptidase MapB | 0.0087 | 0.1614 | 0.5 |
Trypanosoma brucei | methionine aminopeptidase, type I, putative | 0.0137 | 0.3826 | 1 |
Plasmodium vivax | methionine aminopeptidase 1b, putative | 0.0137 | 0.3826 | 1 |
Echinococcus multilocularis | methionyl aminopeptidase 1 (M24 family) | 0.0137 | 0.3826 | 1 |
Brugia malayi | Methionine aminopeptidase protein type I | 0.0137 | 0.3826 | 0.5 |
Plasmodium falciparum | methionine aminopeptidase 1b, putative | 0.0137 | 0.3826 | 1 |
Trypanosoma cruzi | metallo- peptidase, Clan MG, Family M24 | 0.0137 | 0.3826 | 1 |
Trypanosoma cruzi | metallo- peptidase, Clan MG, Family M24 | 0.0137 | 0.3826 | 1 |
Mycobacterium leprae | PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M) | 0.0087 | 0.1614 | 0.5 |
Mycobacterium ulcerans | methionine aminopeptidase | 0.0087 | 0.1614 | 0.5 |
Echinococcus granulosus | methionyl aminopeptidase 1 M24 family | 0.0137 | 0.3826 | 0.5 |
Toxoplasma gondii | methionine aminopeptidase | 0.0087 | 0.1614 | 0.422 |
Mycobacterium leprae | PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP) | 0.0087 | 0.1614 | 0.5 |
Chlamydia trachomatis | methionine aminopeptidase | 0.0087 | 0.1614 | 0.5 |
Trypanosoma brucei | methionine aminopeptidase, putative | 0.0137 | 0.3826 | 1 |
Loa Loa (eye worm) | methionine aminopeptidase type I | 0.0137 | 0.3826 | 0.5 |
Leishmania major | methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 | 0.0137 | 0.3826 | 1 |
Plasmodium vivax | methionine aminopeptidase 1a, putative | 0.0087 | 0.1614 | 0.422 |
Toxoplasma gondii | methionine aminopeptidase | 0.0137 | 0.3826 | 1 |
Trypanosoma brucei | metallo- peptidase, Clan MG, Family M24 | 0.0137 | 0.3826 | 1 |
Plasmodium falciparum | methionine aminopeptidase 1a, putative | 0.0087 | 0.1614 | 0.422 |
Toxoplasma gondii | methionine aminopeptidase, type i, putative | 0.0087 | 0.1614 | 0.422 |
Schistosoma mansoni | methionyl aminopeptidase 1 (M24 family) | 0.0087 | 0.1614 | 0.5 |
Schistosoma mansoni | methionyl aminopeptidase 1 (M24 family) | 0.0087 | 0.1614 | 0.5 |
Treponema pallidum | methionine aminopeptidase (map) | 0.0087 | 0.1614 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 2.5119 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.