Detailed information for compound 1449716

Basic information

Technical information
  • TDR Targets ID: 1449716
  • Name: 5-methyl-N-(3-methylphenyl)-4-oxo-3-[2-oxo-2- (4-pyridin-2-ylpiperazin-1-yl)ethyl]thieno[5, 4-d]pyrimidine-6-carboxamide
  • MW: 502.588 | Formula: C26H26N6O3S
  • H donors: 1 H acceptors: 4 LogP: 3.18 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 2
  • SMILES: Cc1cccc(c1)NC(=O)c1sc2c(c1C)c(=O)n(cn2)CC(=O)N1CCN(CC1)c1ccccn1
  • InChi: 1S/C26H26N6O3S/c1-17-6-5-7-19(14-17)29-24(34)23-18(2)22-25(36-23)28-16-32(26(22)35)15-21(33)31-12-10-30(11-13-31)20-8-3-4-9-27-20/h3-9,14,16H,10-13,15H2,1-2H3,(H,29,34)
  • InChiKey: XQCUBAVADWEJKN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-methyl-N-(3-methylphenyl)-4-oxo-3-[2-oxo-2-[4-(2-pyridyl)piperazin-1-yl]ethyl]thieno[5,4-d]pyrimidine-6-carboxamide
  • 5-methyl-N-(3-methylphenyl)-4-oxo-3-[2-oxo-2-[4-(2-pyridyl)-1-piperazinyl]ethyl]-6-thieno[5,4-d]pyrimidinecarboxamide
  • 4-keto-3-[2-keto-2-[4-(2-pyridyl)piperazin-1-yl]ethyl]-5-methyl-N-(3-methylphenyl)thieno[5,4-d]pyrimidine-6-carboxamide
  • Oprea1_758757

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni tyrosine kinase 0.0457 0.04 0.0514
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0358 0.0306 0.0644
Schistosoma mansoni glutamate receptor kainate 0.0066 0.0028 0.0035
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.01 0.006 0.0125
Toxoplasma gondii subtilisin SUB7 0.0358 0.0306 0.958
Trichomonas vaginalis conserved hypothetical protein 0.1618 0.1508 0.3187
Trichomonas vaginalis hypothetical protein 0.1618 0.1508 0.3187
Loa Loa (eye worm) hypothetical protein 0.0092 0.0053 0.0052
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.038 0.0327 0.5268
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0046 0.0008 0.001
Schistosoma mansoni glutamate receptor AMPA 0.0066 0.0028 0.0035
Loa Loa (eye worm) hypothetical protein 0.1616 0.1506 0.1505
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0358 0.0306 0.0414
Echinococcus multilocularis protein arginine N methyltransferase 8 0.0061 0.0023 0.003
Leishmania major UDP-galactopyranose mutase 0.0085 0.0046 0.0586
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0358 0.0306 0.0644
Echinococcus granulosus c-Jun N-terminal kinases 0.024 0.0194 0.0249
Toxoplasma gondii subtilisin SUB6 0.0358 0.0306 0.958
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0782 0.071 0.0962
Schistosoma mansoni growth factor receptor-bound protein 0.0123 0.0082 0.0104
Loa Loa (eye worm) glutamate receptor 2 0.0066 0.0028 0.0027
Schistosoma mansoni growth factor receptor-bound protein 0.0123 0.0082 0.0104
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0358 0.0306 0.491
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0022 0.0021
Leishmania major hypothetical protein, conserved 0.0086 0.0047 0.0606
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0018 0.0016
Giardia lamblia High cysteine protein 0.0228 0.0182 0.0606
Brugia malayi Angiotensin-converting enzyme family protein 0.0606 0.0542 0.0541
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0052 0.0014 0.0466
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0018 0.0021
Brugia malayi transcriptional regulator, Sir2 family protein 0.01 0.006 0.0059
Echinococcus granulosus integrin beta 2 0.7765 0.737 0.9485
Echinococcus granulosus disintegrin and metalloproteinase 0.0099 0.0059 0.0075
Echinococcus granulosus lysine specific histone demethylase 1A 0.0085 0.0046 0.0057
Brugia malayi NAD-dependent deacetylase SIRT1 0.01 0.006 0.0059
Schistosoma mansoni integrin beta subunit 0.6149 0.5829 0.7501
Loa Loa (eye worm) hypothetical protein 0.1177 0.1087 0.1086
Loa Loa (eye worm) apoptosis regulator protein 0.0062 0.0024 0.0023
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0358 0.0306 0.0392
Schistosoma mansoni glutamate receptor kainate 0.0066 0.0028 0.0035
Mycobacterium ulcerans NAD-dependent deacetylase 0.01 0.006 0.1436
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0084 0.0045 0.0059
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0086 0.0047 0.0956
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0084 0.0045 0.0059
Echinococcus multilocularis glutamate receptor 2 0.0084 0.0045 0.0059
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0239 0.0193 0.0246
Echinococcus granulosus integrin alpha ps 0.0541 0.0481 0.0617
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.009 0.0051 0.0049
Mycobacterium ulcerans thioesterase 0.0076 0.0037 0.063
Schistosoma mansoni integrin alpha-ps 0.0655 0.059 0.0758
Echinococcus granulosus tissue type plasminogen activator 0.0086 0.0047 0.0059
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.01 0.006 0.0833
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0095 0.0056 0.0757
Toxoplasma gondii hypothetical protein 0.0228 0.0182 0.5689
Echinococcus granulosus eukaryotic initiation factor 4A III 0.0048 0.001 0.0012
Echinococcus multilocularis serine:threonine protein kinase N2 0.0082 0.0043 0.0057
Loa Loa (eye worm) metalloprotease 0.0066 0.0028 0.0027
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0049 0.0011 0.001
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.007 0.0032 0.0435
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0059 0.0021 0.0627
Schistosoma mansoni hypothetical protein 0.0541 0.0481 0.0617
Mycobacterium tuberculosis Possible oxidoreductase 0.0085 0.0046 0.1489
Brugia malayi hypothetical protein 0.1616 0.1506 0.1505
Loa Loa (eye worm) proprotein convertase 2 0.1976 0.1849 0.1848
Loa Loa (eye worm) hypothetical protein 0.0239 0.0193 0.0191
Brugia malayi endoprotease bli-4 precursor 0.8185 0.777 0.777
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0133 0.0092 0.2997
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.01 0.006 0.0125
Loa Loa (eye worm) hypothetical protein 0.0228 0.0182 0.0181
Trichomonas vaginalis conserved hypothetical protein 0.1618 0.1508 0.3187
Onchocerca volvulus 0.0133 0.0092 0.2302
Loa Loa (eye worm) hypothetical protein 0.1764 0.1647 0.1646
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0148 0.0106 0.0135
Schistosoma mansoni glutamate receptor NMDA 0.0315 0.0265 0.034
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.01 0.006 0.0125
Brugia malayi SWIRM domain containing protein 0.0452 0.0395 0.0394
Echinococcus granulosus nmda type glutamate receptor 0.0131 0.009 0.0115
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0062 0.0024 0.0023
Onchocerca volvulus 0.0067 0.0029 0.0696
Echinococcus multilocularis disintegrin and metalloproteinase 0.0099 0.0059 0.0079
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.01 0.006 0.0833
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0358 0.0306 0.0644
Brugia malayi metalloprotease 0.0066 0.0028 0.0027
Giardia lamblia Transcriptional regulator, Sir2 family 0.01 0.006 0.0177
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0679 0.0612 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0018 0.0021
Brugia malayi Kelch motif family protein 0.1639 0.1528 0.1527
Schistosoma mansoni protein kinase 0.0148 0.0106 0.0134
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0085 0.0046 0.1317
Plasmodium falciparum cysteine repeat modular protein 1 0.0086 0.0047 0.1353
Echinococcus granulosus eukaryotic initiation factor 4A 0.0048 0.001 0.0012
Trichomonas vaginalis teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative 0.0228 0.0182 0.0382
Loa Loa (eye worm) subtilase 0.0358 0.0306 0.0305
Giardia lamblia Tenascin precursor 0.0228 0.0182 0.0606
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0004 0.0003
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.1618 0.1508 0.3187
Toxoplasma gondii aspartyl protease ASP5 0.0356 0.0304 0.9523
Plasmodium vivax subtilisin-like protease 2, putative 0.0358 0.0306 0.9069
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0088 0.0049 0.1591
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0018 0.0022
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0358 0.0306 0.0644
Schistosoma mansoni ADAMTS14 peptidase (M12 family) 0.0066 0.0028 0.0034
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0358 0.0306 0.0644
Brugia malayi Trypsin family protein 0.0202 0.0157 0.0156
Plasmodium falciparum ribonucleoside-diphosphate reductase large subunit, putative 0.0203 0.0159 0.4682
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.024 0.0194 0.0193
Mycobacterium tuberculosis Probable ribonucleoside-diphosphate reductase (large subunit) NrdZ (ribonucleotide reductase) 0.0062 0.0024 0.077
Wolbachia endosymbiont of Brugia malayi ribonucleotide-diphosphate reductase subunit alpha 0.0171 0.0128 0.5
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0358 0.0306 0.0392
Loa Loa (eye worm) hypothetical protein 0.0452 0.0395 0.0394
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0088 0.0049 0.1606
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0088 0.0049 0.1027
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0018 0.0021
Brugia malayi Glutamate receptor 1 precursor 0.0066 0.0028 0.0027
Toxoplasma gondii histone lysine-specific demethylase 0.0085 0.0046 0.1392
Brugia malayi Stress-activated protein kinase jnk-1 0.024 0.0194 0.0193
Toxoplasma gondii subtilisin SUB2 0.0358 0.0306 0.958
Echinococcus multilocularis adam 0.054 0.048 0.065
Schistosoma mansoni hypothetical protein 0.0092 0.0053 0.0066
Brugia malayi hypothetical protein 0.0092 0.0053 0.0052
Toxoplasma gondii type I fatty acid synthase, putative 0.0065 0.0027 0.08
Schistosoma mansoni furin-1 (S08 family) 0.3546 0.3347 0.4306
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0084 0.0045 0.0056
Loa Loa (eye worm) TK/ROR protein kinase 0.0086 0.0047 0.0045
Toxoplasma gondii subtilisin SUB10 0.0358 0.0306 0.958
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0358 0.0306 0.0644
Plasmodium falciparum transcriptional regulatory protein sir2b 0.01 0.006 0.1759
Mycobacterium tuberculosis Possible arabinofuranosyltransferase AftD 0.0038 0.0001 0.0043
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.007 0.0031 0.0039
Loa Loa (eye worm) WD40 repeat protein 0.0067 0.0029 0.0027
Echinococcus multilocularis protein jagged 2 0.0228 0.0182 0.0246
Mycobacterium ulcerans thioesterase TesA 0.0076 0.0037 0.063
Brugia malayi Kringle domain containing protein 0.0086 0.0047 0.0045
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0061 0.0023 0.0046
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0358 0.0306 0.0644
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0018 0.0022
Echinococcus multilocularis integrin alpha ps 0.0541 0.0481 0.0651
Trypanosoma brucei ribonucleoside-diphosphate reductase large chain 0.0203 0.0159 0.2463
Giardia lamblia Neurogenic locus notch-like protein 0.0228 0.0182 0.0606
Mycobacterium tuberculosis Transcriptional regulatory protein 0.01 0.006 0.1974
Echinococcus granulosus ribonucleoside diphosphate reductase large 0.0203 0.0159 0.0203
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0085 0.0046 0.0918
Toxoplasma gondii subtilisin SUB8 0.0358 0.0306 0.958
Echinococcus granulosus serine:threonine protein kinase N2 0.0073 0.0035 0.0044
Leishmania major subtilisin-like serine peptidase 0.0358 0.0306 0.491
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0094 0.0054 0.1216
Loa Loa (eye worm) integrin alpha pat-2 0.3341 0.3151 0.315
Mycobacterium tuberculosis Probable thioesterase TesA 0.0076 0.0037 0.1219
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0782 0.071 0.0913
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0358 0.0306 0.0644
Schistosoma mansoni ribonucleoside-diphosphate reductase alpha subunit 0.0203 0.0159 0.0202
Echinococcus granulosus glutamate receptor subunit protein glur 0.0046 0.0008 0.0009
Mycobacterium ulcerans polyketide synthase 0.0094 0.0054 0.1216
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.01 0.006 0.0833
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0062 0.0024 0.003
Toxoplasma gondii subtilisin SUB4 0.0358 0.0306 0.958
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0084 0.0045 0.0056
Schistosoma mansoni serine/threonine protein kinase 0.024 0.0194 0.0248
Leishmania major ribonucleoside-diphosphate reductase large chain, putative 0.0203 0.0159 0.2463
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0085 0.0046 0.0045
Loa Loa (eye worm) transcriptional regulator 0.01 0.006 0.0059
Loa Loa (eye worm) hypothetical protein 0.0358 0.0306 0.0305
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0071 0.0033 0.1073
Loa Loa (eye worm) hypothetical protein 0.0087 0.0048 0.0047
Toxoplasma gondii ribonucleoside-diphosphate reductase large chain 0.0203 0.0159 0.4946
Brugia malayi hypothetical protein 0.0085 0.0046 0.0044
Loa Loa (eye worm) hypothetical protein 0.0099 0.0059 0.0058
Loa Loa (eye worm) hypothetical protein 0.0041 0.0004 0.0003
Schistosoma mansoni amine oxidase 0.0085 0.0046 0.0057
Toxoplasma gondii kringle domain-containing protein 0.0086 0.0047 0.143
Mycobacterium ulcerans ribonucleotide-diphosphate reductase subunit alpha 0.0171 0.0128 0.3801
Trichomonas vaginalis conserved hypothetical protein 0.0358 0.0306 0.0644
Toxoplasma gondii subtilisin SUB12 0.0372 0.0319 1
Loa Loa (eye worm) hypothetical protein 0.0228 0.0182 0.0181
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0046 0.0008 0.0009
Echinococcus multilocularis integrin alpha 3 0.1717 0.1603 0.2174
Loa Loa (eye worm) TK/EGFR protein kinase 0.0457 0.04 0.0399
Schistosoma mansoni chromatin regulatory protein sir2 0.0679 0.0612 0.0786
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1976 0.1849 0.3908
Trichomonas vaginalis conserved hypothetical protein 0.1618 0.1508 0.3187
Schistosoma mansoni site-1 peptidase (S08 family) 0.0358 0.0306 0.0392
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0088 0.0049 0.1591
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.007 0.0032 0.0998
Brugia malayi ADAMTS-like protease 0.014 0.0098 0.0097
Brugia malayi eukaryotic initiation factor 4A 0.0048 0.001 0.0009
Echinococcus multilocularis ribonucleoside diphosphate reductase large 0.0203 0.0159 0.0214
Giardia lamblia Furin precursor putative serine protease 0.1618 0.1508 0.5283
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0084 0.0045 0.0059
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.01 0.006 0.0076
Loa Loa (eye worm) hypothetical protein 0.0086 0.0047 0.0045
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0088 0.0049 0.1555
Brugia malayi amine oxidase, flavin-containing family protein 0.012 0.0079 0.0078
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0224 0.0179 0.0228
Echinococcus multilocularis growth factor receptor bound protein 2 0.0123 0.0082 0.011
Echinococcus granulosus chromatin regulatory protein sir2 0.0679 0.0612 0.0787
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.01 0.006 0.0125
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.007 0.0032 0.0435
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0085 0.0046 0.0918
Echinococcus multilocularis epidermal growth factor receptor 0.0457 0.04 0.0542
Mycobacterium ulcerans Type I modular polyketide synthase 0.0088 0.0049 0.1027
Brugia malayi hypothetical protein 0.0095 0.0056 0.0055
Mycobacterium ulcerans polyketide synthase 0.0088 0.0049 0.1027
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.01 0.006 0.0081
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0088 0.0049 0.1555
Echinococcus granulosus growth factor receptor bound protein 2 0.0123 0.0082 0.0104
Plasmodium falciparum subtilisin-like protease 3 0.0358 0.0306 0.9069
Echinococcus granulosus Tolloid protein 1 0.0049 0.0011 0.0013
Mycobacterium ulcerans dehydrogenase 0.0085 0.0046 0.0918
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0358 0.0306 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1976 0.1849 0.3908
Echinococcus granulosus adam 0.054 0.048 0.0617
Brugia malayi hypothetical protein 0.0312 0.0263 0.0262
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.01 0.006 0.0177
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0085 0.0046 0.1317
Trichomonas vaginalis conserved hypothetical protein 0.0358 0.0306 0.0644
Onchocerca volvulus 0.0086 0.0047 0.1153
Echinococcus granulosus glutamate NMDA receptor subunit 0.0315 0.0265 0.034
Loa Loa (eye worm) hypothetical protein 0.015 0.0108 0.0106
Plasmodium vivax subtilisin-like protease 1 0.0358 0.0306 0.9069
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0086 0.0047 0.2454
Giardia lamblia Sirtuin type 2 0.01 0.006 0.0177
Plasmodium falciparum subtilisin-like protease 2 0.0358 0.0306 0.9069
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.0048 0.001 0.0281
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.01 0.006 0.0125
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0046 0.0009 0.0235
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0046 0.0008 0.001
Echinococcus multilocularis Furin 1 0.1976 0.1849 0.2508
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0085 0.0046 0.0057
Plasmodium falciparum subtilisin-like protease 1 0.0358 0.0306 0.9069
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0358 0.0306 1
Entamoeba histolytica PH domain containing protein kinase, putative 0.0073 0.0035 0.041
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.01 0.006 0.0125
Brugia malayi Calcium binding EGF domain containing protein 0.0041 0.0004 0.0003
Onchocerca volvulus 0.0085 0.0046 0.1136
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0239 0.0193 0.0247
Plasmodium falciparum transcriptional regulatory protein sir2a 0.01 0.006 0.1759
Plasmodium vivax ribonucleoside-diphosphate reductase large chain, putative 0.0203 0.0159 0.4682
Loa Loa (eye worm) hypothetical protein 0.0416 0.0362 0.0361
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0239 0.0193 0.0246
Echinococcus granulosus protein arginine N methyltransferase 8 0.0061 0.0023 0.0028
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0048 0.001 0.0019
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0358 0.0306 0.0644
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0084 0.0045 0.0056
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0239 0.0193 0.026
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.0203 0.0159 0.2463
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.4996 0.473 0.6417
Brugia malayi Integrin alpha cytoplasmic region family protein 0.1645 0.1534 0.1533
Schistosoma mansoni dihydroceramide desaturase 0.0099 0.0059 0.0075
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.01 0.006 0.0125
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0051 0.0014 0.0016
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein) 0.0171 0.0128 0.419
Brugia malayi Disintegrin family protein 0.0099 0.0059 0.0058
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0358 0.0306 0.0305
Toxoplasma gondii subtilisin SUB5 0.0358 0.0306 0.958
Echinococcus multilocularis protein kinase c epsilon type 0.009 0.0051 0.0067
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.01 0.006 0.0081
Loa Loa (eye worm) hypothetical protein 0.0095 0.0056 0.0055
Loa Loa (eye worm) hypothetical protein 0.0228 0.0182 0.0181
Echinococcus granulosus MAM 0.0092 0.0053 0.0067
Loa Loa (eye worm) hypothetical protein 0.01 0.006 0.0059
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0046 0.0008 0.0009
Schistosoma mansoni apoptosis regulator bax 0.0062 0.0024 0.003
Echinococcus multilocularis protoporphyrinogen oxidase 0.0085 0.0046 0.006
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0018 0.0021
Schistosoma mansoni hypothetical protein 0.0086 0.0047 0.0058
Brugia malayi celfurPC protein 0.6567 0.6227 0.6227
Toxoplasma gondii histone deacetylase SIR2 0.01 0.006 0.1858
Echinococcus granulosus adam 17 protease 0.0099 0.0059 0.0075
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0358 0.0306 0.0644
Plasmodium vivax hypothetical protein, conserved 0.0085 0.0046 0.1317
Echinococcus multilocularis 0.0085 0.0046 0.006
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0358 0.0306 1
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0133 0.0092 0.2997
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.0048 0.001 0.0335
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0088 0.0049 0.1606
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0084 0.0045 0.0056
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0358 0.0306 0.0644
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0022 0.0021
Toxoplasma gondii histone deacetylase SIR2-like 0.01 0.006 0.1858
Trichomonas vaginalis conserved hypothetical protein 0.1618 0.1508 0.3187
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0085 0.0046 0.1317
Schistosoma mansoni hypothetical protein 0.1618 0.1508 0.1939
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0148 0.0106 0.0142
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0358 0.0306 0.0644
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0358 0.0306 0.0644
Plasmodium vivax hypothetical protein, conserved 0.0085 0.0046 0.1317
Schistosoma mansoni protein kinase 0.0148 0.0106 0.0134
Giardia lamblia Tenascin-like 0.0228 0.0182 0.0606
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.0899 0.1218
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0094 0.0054 0.1768
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0169 0.0126 0.0125
Onchocerca volvulus 0.0202 0.0157 0.395
Loa Loa (eye worm) glutamate receptor 1 0.0066 0.0028 0.0027
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0358 0.0306 1
Leishmania major silent information regulator 2, putative 0.0679 0.0612 1
Mycobacterium ulcerans oxidoreductase 0.0085 0.0046 0.0918
Schistosoma mansoni integrin alpha-ps 0.1128 0.1041 0.1338
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0085 0.0046 0.1506
Echinococcus multilocularis eukaryotic initiation factor 4A 0.0048 0.001 0.0013
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0358 0.0306 0.0644
Loa Loa (eye worm) ribonucleoside-diphosphate reductase large subunit 0.0203 0.0159 0.0157
Loa Loa (eye worm) hypothetical protein 0.014 0.0098 0.0097
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1976 0.1849 0.3908
Trichomonas vaginalis conserved hypothetical protein 0.1618 0.1508 0.3187
Onchocerca volvulus 0.0173 0.013 0.3253
Echinococcus granulosus neuroendocrine convertase 2 0.5164 0.489 0.6292
Schistosoma mansoni hypothetical protein 0.0062 0.0024 0.003
Loa Loa (eye worm) hypothetical protein 0.0085 0.0046 0.0044
Echinococcus granulosus protein will die slowly 0.0067 0.0029 0.0036
Onchocerca volvulus 0.0159 0.0116 0.2913
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0416 0.0362 0.0464
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.4996 0.473 1
Mycobacterium leprae Probable polyketide synthase Pks1 0.0094 0.0054 0.1733
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.01 0.006 0.0833
Brugia malayi transcriptional regulator, Sir2 family protein 0.01 0.006 0.0059
Brugia malayi Sex muscle abnormal protein 5 0.0123 0.0082 0.0081
Echinococcus granulosus epidermal growth factor receptor 0.0457 0.04 0.0514
Loa Loa (eye worm) hypothetical protein 0.0048 0.001 0.0009
Plasmodium vivax subtilisin-like serine protease, putative 0.0358 0.0306 0.9069
Echinococcus granulosus furin 0.8185 0.777 1
Toxoplasma gondii type I fatty acid synthase, putative 0.0094 0.0054 0.166
Trichomonas vaginalis conserved hypothetical protein 0.1618 0.1508 0.3187
Echinococcus multilocularis protein will die slowly 0.0067 0.0029 0.0038
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0085 0.0046 0.1392
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0679 0.0612 0.1292
Brugia malayi Reprolysin 0.014 0.0098 0.0097
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0202 0.0157 0.02
Echinococcus multilocularis neuroendocrine convertase 2 0.5164 0.489 0.6634
Trichomonas vaginalis hypothetical protein 0.0228 0.0182 0.0382
Giardia lamblia High cysteine protein 0.0228 0.0182 0.0606
Toxoplasma gondii subtilisin SUB11 0.0358 0.0306 0.958
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0095 0.0056 0.0757
Leishmania major sir2-family protein-like protein 0.01 0.006 0.0833
Plasmodium vivax protein arginine N-methyltransferase 1, putative 0.0061 0.0023 0.0648
Trypanosoma cruzi hypothetical protein, conserved 0.0086 0.0047 0.0606
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0086 0.0047 0.1524
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.01 0.006 0.0076
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.0048 0.001 0.0227
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.1618 0.1508 0.3187
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1976 0.1849 0.3908
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0086 0.0047 0.0096
Trichomonas vaginalis WD repeat domain, putative 0.0067 0.0029 0.0058
Giardia lamblia Tenascin-X 0.0228 0.0182 0.0606
Loa Loa (eye worm) angiogenesis inhibito 0.0066 0.0028 0.0027
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0358 0.0306 0.0644
Loa Loa (eye worm) hypothetical protein 0.0609 0.0546 0.0544
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0416 0.0362 0.049
Loa Loa (eye worm) hypothetical protein 0.0655 0.059 0.0589
Mycobacterium ulcerans Type I modular polyketide synthase 0.0088 0.0049 0.1027
Echinococcus multilocularis integrin alpha ps 0.1196 0.1106 0.1499
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0061 0.0023 0.0028
Onchocerca volvulus 0.0092 0.0053 0.131
Schistosoma mansoni serine/threonine protein kinase 0.009 0.0051 0.0063
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0129 0.0088 0.0087
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0022 0.0021
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0061 0.0023 0.0028
Echinococcus multilocularis fibrillin 2 0.0228 0.0182 0.0246
Echinococcus multilocularis c Jun NH2 terminal kinase 0.024 0.0194 0.0262
Loa Loa (eye worm) acyl carrier protein 0.0042 0.0005 0.0004
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.0053 0.0015 0.0078
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0049 0.0011 0.0013
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0061 0.0023 0.0046
Loa Loa (eye worm) hypothetical protein 0.0048 0.001 0.0009
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0061 0.0023 0.0028
Brugia malayi protein kinase C II. 0.009 0.0051 0.0049
Brugia malayi angiogenesis inhibito 0.014 0.0098 0.0097
Mycobacterium leprae Polyketide synthase Pks13 0.0133 0.0092 0.2967
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.01 0.006 0.0833
Entamoeba histolytica hypothetical protein 0.0095 0.0056 0.0757
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0088 0.0049 0.0047
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0046 0.0008 0.0009
Schistosoma mansoni hypothetical protein 0.0092 0.0053 0.0066
Treponema pallidum ribonucleotide-diphosphate reductase subunit alpha 0.0203 0.0159 1
Brugia malayi ADAM-TS Spacer 1 family protein 0.014 0.0098 0.0097
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0315 0.0265 0.0359
Loa Loa (eye worm) hypothetical protein 0.0066 0.0028 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0358 0.0306 0.0644
Schistosoma mansoni glutamate receptor NMDA 0.0084 0.0045 0.0056
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.0048 0.001 0.0013
Giardia lamblia Neurogenic locus Notch protein precursor 0.0228 0.0182 0.0606
Trypanosoma brucei Silent information regulator 2 related protein 3 0.01 0.006 0.0833
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1976 0.1849 0.3908
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0062 0.0024 0.0032
Giardia lamblia Tenascin-37 0.0228 0.0182 0.0606
Echinococcus multilocularis integrin beta 2 0.7765 0.737 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0018 0.0016
Schistosoma mansoni protein kinase 0.0148 0.0106 0.0134
Trichomonas vaginalis conserved hypothetical protein 0.1618 0.1508 0.3187
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0094 0.0054 0.1733
Loa Loa (eye worm) hypothetical protein 0.0049 0.0011 0.001
Plasmodium falciparum eukaryotic initiation factor 4A 0.0048 0.001 0.0266
Loa Loa (eye worm) integrin beta-2 1.0523 1 1
Mycobacterium ulcerans Type I modular polyketide synthase 0.0088 0.0049 0.1027
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0358 0.0306 0.0644
Echinococcus multilocularis tissue type plasminogen activator 0.0086 0.0047 0.0062
Schistosoma mansoni ATP-binding cassette transporter 0.0069 0.0031 0.0038
Loa Loa (eye worm) transcriptional regulator 0.0679 0.0612 0.0611
Onchocerca volvulus 0.0092 0.0053 0.131
Brugia malayi EGF-like domain containing protein 0.0228 0.0182 0.0181
Loa Loa (eye worm) hypothetical protein 0.0092 0.0053 0.0052
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0358 0.0306 0.0644
Schistosoma mansoni chromatin regulatory protein sir2 0.01 0.006 0.0076
Plasmodium falciparum plasmepsin V 0.039 0.0337 1
Mycobacterium ulcerans polyketide synthase Pks13 0.0133 0.0092 0.2527
Loa Loa (eye worm) hypothetical protein 0.0202 0.0157 0.0156
Schistosoma mansoni hypothetical protein 0.0067 0.0029 0.0035
Brugia malayi Integrin alpha pat-2 precursor 0.2305 0.2163 0.2162
Onchocerca volvulus Putative cubilin 0.0041 0.0004 0.0072
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0046 0.0008 0.001
Schistosoma mansoni chromatin regulatory protein sir2 0.0679 0.0612 0.0786
Mycobacterium leprae Possible secreted protease 0.0358 0.0306 1
Mycobacterium ulcerans monoamine oxidase 0.0085 0.0046 0.0918
Echinococcus multilocularis 0.6567 0.6227 0.8449
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.4996 0.473 1
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0679 0.0612 1
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0606 0.0542 0.0541
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0358 0.0306 0.0644
Loa Loa (eye worm) fatty acid synthase 0.009 0.0051 0.0049
Echinococcus granulosus lysine specific histone demethylase 1A 0.0416 0.0362 0.0464
Echinococcus granulosus integrin alpha 3 0.1717 0.1603 0.2062
Plasmodium vivax NAD-dependent deacetylase, putative 0.01 0.006 0.1759
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0048 0.001 0.0019
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0358 0.0306 0.0644
Echinococcus multilocularis glutamate receptor 2 0.0066 0.0028 0.0037
Toxoplasma gondii subtilisin SUB9 0.0358 0.0306 0.958
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0123 0.0082 0.0081
Loa Loa (eye worm) hypothetical protein 0.1645 0.1534 0.1533
Giardia lamblia hypothetical protein 0.0228 0.0182 0.0606
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0223 0.0177 0.0227
Loa Loa (eye worm) hypothetical protein 0.012 0.0079 0.0078
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0358 0.0306 1
Plasmodium falciparum protein arginine N-methyltransferase 1 0.0061 0.0023 0.0648
Plasmodium vivax plasmepsin V, putative 0.039 0.0337 1
Chlamydia trachomatis ribonucleoside-diphosphate reductase subunit alpha 0.0203 0.0159 1
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0358 0.0306 1
Echinococcus granulosus glutamate receptor 2 0.0084 0.0045 0.0056
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0094 0.0054 0.1768
Trypanosoma brucei SIR2-like protein 4, putative 0.01 0.006 0.0833
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0358 0.0306 1
Brugia malayi ribonucleoside-diphosphate reductase large chain, putative 0.0203 0.0159 0.0157
Onchocerca volvulus 0.0228 0.0182 0.4587
Echinococcus granulosus integrin alpha ps 0.1196 0.1106 0.1422
Loa Loa (eye worm) kelch domain-containing protein family protein 0.1639 0.1528 0.1527
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0679 0.0612 0.1292
Loa Loa (eye worm) hypothetical protein 0.0228 0.0182 0.0181
Echinococcus granulosus fibrillin 2 0.0228 0.0182 0.0233
Schistosoma mansoni chromatin regulatory protein sir2 0.01 0.006 0.0076
Toxoplasma gondii subtilisin SUB1 0.0358 0.0306 0.958
Echinococcus multilocularis Tolloid protein 1 0.0049 0.0011 0.0014
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0358 0.0306 0.0644
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0358 0.0306 1
Onchocerca volvulus 0.0452 0.0395 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0004 0.0003
Onchocerca volvulus Fatty acid synthase homolog 0.0164 0.0122 0.305
Giardia lamblia Hypothetical protein 0.0679 0.0612 0.2123
Onchocerca volvulus 0.0358 0.0306 0.7725
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0358 0.0306 0.0644
Schistosoma mansoni chromatin regulatory protein sir2 0.01 0.006 0.0076
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.038 0.0327 0.5268
Loa Loa (eye worm) sirtuin 4 0.01 0.006 0.0059
Schistosoma mansoni septate junction protein 0.0057 0.0019 0.0023
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0679 0.0612 1
Giardia lamblia High cysteine membrane protein Group 2 0.3021 0.2846 1
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.01 0.006 0.0125
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0679 0.0612 1
Brugia malayi transcriptional regulator, Sir2 family protein 0.0679 0.0612 0.0611
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.0099 0.0059 0.0075
Loa Loa (eye worm) transcriptional regulator 0.01 0.006 0.0059
Brugia malayi proprotein convertase 2 0.5164 0.489 0.4889
Loa Loa (eye worm) hypothetical protein 0.014 0.0098 0.0097
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0358 0.0306 1
Trypanosoma cruzi UDP-galactopyranose mutase 0.0085 0.0046 0.0586
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0679 0.0612 1
Echinococcus granulosus membrane bound transcription factor site 1 0.0358 0.0306 0.0392
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.01 0.006 0.0081
Trichomonas vaginalis conserved hypothetical protein 0.0358 0.0306 0.0644
Loa Loa (eye worm) hypothetical protein 0.0202 0.0157 0.0156
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0312 0.0263 0.0337
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0094 0.0054 0.1733
Mycobacterium ulcerans Sir2-like regulatory protein 0.01 0.006 0.1436
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0358 0.0306 0.0644
Echinococcus multilocularis chromatin regulatory protein sir2 0.0679 0.0612 0.0829
Trichomonas vaginalis conserved hypothetical protein 0.1618 0.1508 0.3187
Trichomonas vaginalis conserved hypothetical protein 0.1618 0.1508 0.3187
Schistosoma mansoni site-1 peptidase (S08 family) 0.0358 0.0306 0.0392
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1226 0.1134 0.1458
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0048 0.001 0.0019
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0085 0.0046 0.0918
Echinococcus multilocularis membrane bound transcription factor site 1 0.0358 0.0306 0.0414
Loa Loa (eye worm) hypothetical protein 0.006 0.0022 0.0021
Echinococcus granulosus protein kinase c epsilon type 0.009 0.0051 0.0064
Loa Loa (eye worm) hypothetical protein 0.0062 0.0024 0.0023
Trypanosoma brucei subtilisin peptidase 0.0358 0.0306 0.491
Toxoplasma gondii histone arginine methyltransferase PRMT1 0.0061 0.0023 0.0684
Brugia malayi Protein kinase domain containing protein 0.0086 0.0047 0.0045
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0094 0.0054 0.1768
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0062 0.0024 0.003
Plasmodium vivax hypothetical protein, conserved 0.01 0.006 0.1759
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0358 0.0306 0.0305
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0076 0.0037 0.1182
Leishmania major arginine N-methyltransferase-like protein 0.0061 0.0023 0.0213
Mycobacterium leprae RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN) 0.0171 0.0128 0.4165
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0085 0.0046 0.1317
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0679 0.0612 0.0829
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.8185 0.777 1
Trypanosoma cruzi UDP-galactopyranose mutase 0.0085 0.0046 0.0586
Loa Loa (eye worm) TK/ALK protein kinase 0.0092 0.0053 0.0052
Schistosoma mansoni hypothetical protein 0.0041 0.0004 0.0004
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0088 0.0049 0.1591
Brugia malayi EGF-like domain containing protein 0.0228 0.0182 0.0181
Brugia malayi neuroendocrine convertase 1 precursor 0.5164 0.489 0.4889
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0358 0.0306 0.0644
Schistosoma mansoni hypothetical protein 0.0062 0.0024 0.003
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0018 0.0021
Echinococcus granulosus protein arginine methyltransferase 0.0061 0.0023 0.0028
Loa Loa (eye worm) hypothetical protein 0.0416 0.0362 0.0361
Echinococcus multilocularis nmda type glutamate receptor 0.0131 0.009 0.0121
Loa Loa (eye worm) hypothetical protein 0.3188 0.3006 0.3005
Brugia malayi AMP-binding enzyme family protein 0.0085 0.0046 0.0045
Echinococcus multilocularis integrin alpha ps 0.1128 0.1041 0.1411
Trypanosoma cruzi subtilisin peptidase 0.0358 0.0306 0.491
Schistosoma mansoni integrin alpha 0.2305 0.2163 0.2782
Echinococcus multilocularis NMDA receptor 0.0046 0.0008 0.001
Trichomonas vaginalis conserved hypothetical protein 0.1618 0.1508 0.3187
Trypanosoma brucei Protein arginine N-methyltransferase 1 catalytic subunit 0.0095 0.0056 0.0757
Brugia malayi Glutamate receptor 2 precursor 0.0066 0.0028 0.0027
Echinococcus multilocularis MAM 0.0092 0.0053 0.007
Schistosoma mansoni chromatin regulatory protein sir2 0.01 0.006 0.0076
Brugia malayi Furin-like cysteine rich region family protein 0.0457 0.04 0.0399
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.01 0.006 0.0125
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0061 0.0023 0.0046
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0085 0.0046 0.1452
Schistosoma mansoni hypothetical protein 0.0046 0.0008 0.0009
Entamoeba histolytica arginine N-methyltransferase protein, putative 0.0095 0.0056 0.0757
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.0099 0.0059 0.0079
Plasmodium vivax RNA helicase-1, putative 0.0048 0.001 0.0266
Loa Loa (eye worm) hypothetical protein 0.8185 0.777 0.777
Loa Loa (eye worm) hypothetical protein 0.0068 0.003 0.0029
Loa Loa (eye worm) endoprotease bli-4 0.8185 0.777 0.777
Brugia malayi EGF-like domain containing protein 0.0228 0.0182 0.0181
Mycobacterium tuberculosis Conserved hypothetical protein 0.0085 0.0046 0.1489
Trichomonas vaginalis conserved hypothetical protein 0.0358 0.0306 0.0644
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.01 0.006 0.0076
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.038 0.0327 0.5268
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0094 0.0054 0.1216
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.1618 0.1508 0.3187
Plasmodium falciparum protoporphyrinogen oxidase 0.0085 0.0046 0.1317
Schistosoma mansoni glutamate receptor AMPA 0.0066 0.0028 0.0035
Echinococcus granulosus Furin 1 0.1976 0.1849 0.2379
Loa Loa (eye worm) hypothetical protein 0.0085 0.0046 0.0044
Chlamydia trachomatis glutamine binding protein 0.0086 0.0047 0.0096
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0048 0.001 0.0011
Schistosoma mansoni amine oxidase 0.0085 0.0046 0.0057
Loa Loa (eye worm) hypothetical protein 0.0074 0.0035 0.0034
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0048 0.001 0.0011
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.1976 0.1849 0.2378
Trichomonas vaginalis ribonucleoside-diphosphate reductase alpha chain, putative 0.0171 0.0128 0.0268
Brugia malayi Protein kinase domain containing protein 0.0092 0.0053 0.0052
Trichomonas vaginalis conserved hypothetical protein 0.1618 0.1508 0.3187
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0679 0.0612 0.0787
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0086 0.0047 0.1353
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0084 0.0045 0.0059
Echinococcus granulosus fibrillin 1 0.0229 0.0184 0.0235
Brugia malayi Subtilase family protein 0.0358 0.0306 0.0305
Loa Loa (eye worm) hypothetical protein 0.0092 0.0053 0.0052
Echinococcus multilocularis fibrillin 1 0.0255 0.0209 0.0282
Brugia malayi Will die slowly protein 0.0067 0.0029 0.0027
Entamoeba histolytica hypothetical protein, conserved 0.01 0.006 0.0833
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0358 0.0306 0.0644
Brugia malayi EGF-like domain containing protein 0.0228 0.0182 0.0181
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0057 0.0019 0.0588
Schistosoma mansoni glutamate receptor kainate 0.0066 0.0028 0.0035
Schistosoma mansoni hypothetical protein 0.0062 0.0024 0.003
Loa Loa (eye worm) reprolysin 0.0239 0.0193 0.0191
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.4996 0.473 0.6086
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0065 0.0027 0.0892
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0086 0.0047 0.2454
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0358 0.0306 0.0392
Echinococcus multilocularis protein arginine methyltransferase 0.0061 0.0023 0.003
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1976 0.1849 0.3908
Schistosoma mansoni chromatin regulatory protein sir2 0.0679 0.0612 0.0786
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0131 0.009 0.0121
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0129 0.0088 0.0087

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 2.5119 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.3489 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 21.3313 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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