Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | bromodomain adjacent to zinc finger domain, 2B | Starlite/ChEMBL | No references |
Homo sapiens | breast cancer 1, early onset | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0021 | 0.0294 | 0.0366 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0043 | 0.3456 | 0.4427 |
Leishmania major | hypothetical protein, conserved | 0.0018 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0025 | 0.0894 | 0.1112 |
Echinococcus granulosus | zinc finger protein | 0.0024 | 0.0717 | 0.0592 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0021 | 0.0294 | 0.0366 |
Schistosoma mansoni | bromodomain containing protein | 0.0076 | 0.8037 | 1 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0027 | 0.1214 | 0.1287 |
Trypanosoma brucei | ISWI complex protein | 0.0018 | 0 | 0.5 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0043 | 0.3456 | 0.4427 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0025 | 0.0894 | 0.0667 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0021 | 0.0397 | 0.0114 |
Brugia malayi | Bromodomain containing protein | 0.0046 | 0.3853 | 0.2673 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0027 | 0.1214 | 0.151 |
Trypanosoma cruzi | ISWI complex protein | 0.0018 | 0 | 0.5 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0027 | 0.1214 | 0.1287 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0021 | 0.0294 | 0.0366 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0072 | 0.7437 | 1 |
Trypanosoma cruzi | ISWI complex protein | 0.0018 | 0 | 0.5 |
Echinococcus multilocularis | zinc finger protein | 0.0024 | 0.0717 | 0.0592 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.4581 | 0.4769 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.4261 | 0.4413 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0021 | 0.0294 | 0.0366 |
Schistosoma mansoni | zinc finger protein | 0.0024 | 0.0717 | 0.0891 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0072 | 0.7437 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.9283 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.3864 | 0.3972 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 10 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 28.1838 um | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.