Detailed information for compound 1449885

Basic information

Technical information
  • TDR Targets ID: 1449885
  • Name: 1-[(2-fluorophenyl)methyl]-5,6-dimethyl-3-(ph enylmethyl)thieno[3,2-e]pyrimidine-2,4-dione
  • MW: 394.462 | Formula: C22H19FN2O2S
  • H donors: 0 H acceptors: 2 LogP: 4.68 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccccc1Cn1c(=O)n(Cc2ccccc2)c(=O)c2c1sc(c2C)C
  • InChi: 1S/C22H19FN2O2S/c1-14-15(2)28-21-19(14)20(26)24(12-16-8-4-3-5-9-16)22(27)25(21)13-17-10-6-7-11-18(17)23/h3-11H,12-13H2,1-2H3
  • InChiKey: XGMXQJQCYZVPLW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-(benzyl)-1-(2-fluorobenzyl)-5,6-dimethyl-thieno[3,2-e]pyrimidine-2,4-quinone
  • UNM000003612301

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi GH02984p 0.0354 0.7405 0.7388
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0204 0.418 0.4865
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0064 0.0064
Plasmodium falciparum hexose transporter 0.0204 0.418 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0064 0.0064
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0112 0.2216 0.2166
Schistosoma mansoni cpg binding protein 0.0029 0.0426 0.0364
Brugia malayi Sodium:solute symporter family protein 0.0039 0.0647 0.0587
Trypanosoma cruzi hexose transporter, putative 0.0063 0.1165 1
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0424 0.0311
Trichomonas vaginalis glucose transporter, putative 0.0063 0.1165 0.1598
Leishmania major glucose transporter/membrane transporter D2, putative 0.0063 0.1165 1
Echinococcus granulosus Furin 1 0.0112 0.2216 0.2216
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0064 0.0064
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.1165 0.1598
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.0424 0.0362
Trypanosoma cruzi sugar transporter, putative 0.0029 0.0424 0.1946
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.002 0.0245 0.0182
Trypanosoma cruzi hexose transporter, putative 0.0063 0.1165 1
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.0424 0.0362
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0064 0.0075
Toxoplasma gondii sugar transporter ST3 0.0029 0.0424 0.0455
Trypanosoma brucei glucose transporter, putative 0.0063 0.1165 0.1922
Loa Loa (eye worm) proprotein convertase 2 0.0112 0.2216 0.2216
Echinococcus granulosus solute carrier family 22 0.0029 0.0424 0.0424
Brugia malayi Subtilase family protein 0.002 0.0245 0.0182
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.002 0.0245 0.0182
Loa Loa (eye worm) endoprotease bli-4 0.0476 1 1
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.0424 0.0362
Schistosoma mansoni hypothetical protein 0.0204 0.418 0.4143
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0429 0.0385
Loa Loa (eye worm) hypothetical protein 0.0012 0.0064 0.0064
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0424 0.0311
Schistosoma mansoni glucose transport protein 0.0204 0.418 0.4143
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.002 0.0245 0.0182
Loa Loa (eye worm) hypothetical protein 0.0187 0.3806 0.3806
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0424 0.0311
Loa Loa (eye worm) sugar transporter 0.0204 0.418 0.418
Trypanosoma brucei THT1 - hexose transporter, putative 0.0063 0.1165 0.1922
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0064 0.0064
Brugia malayi proprotein convertase 2 0.0299 0.6213 0.6189
Onchocerca volvulus 0.0029 0.0424 0.6171
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0424 0.0311
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0112 0.2216 0.3423
Schistosoma mansoni hypothetical protein 0.0173 0.3512 0.347
Loa Loa (eye worm) hypothetical protein 0.0029 0.0424 0.0424
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0039 0.0647 0.0753
Echinococcus multilocularis neuroendocrine convertase 2 0.0299 0.6213 0.7231
Trichomonas vaginalis sugar transporter, putative 0.0063 0.1165 0.1598
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.002 0.0245 0.0285
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0064 0.0075
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0426 0.0426
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0112 0.2216 0.3423
Trypanosoma cruzi hexose transporter 0.0063 0.1165 1
Schistosoma mansoni cpg binding protein 0.003 0.0461 0.0399
Schistosoma mansoni inositol transporter 0.0039 0.0647 0.0587
Giardia lamblia High cysteine membrane protein Group 2 0.0177 0.3596 1
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0476 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0092 0.178 0.2667
Onchocerca volvulus 0.0029 0.0424 0.6171
Toxoplasma gondii transporter, major facilitator family protein 0.0029 0.0424 0.0455
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0424 0.0311
Trichomonas vaginalis conserved hypothetical protein 0.0092 0.178 0.2667
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0424 0.0311
Schistosoma mansoni site-1 peptidase (S08 family) 0.002 0.0245 0.0182
Loa Loa (eye worm) hypothetical protein 0.0029 0.0424 0.0424
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0429 0.2001
Schistosoma mansoni site-1 peptidase (S08 family) 0.002 0.0245 0.0182
Echinococcus multilocularis synaptic vesicle 2 protein 0.0029 0.0424 0.0493
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0429 0.2001
Echinococcus multilocularis high affinity choline transporter 1 0.0354 0.7405 0.8618
Schistosoma mansoni hypothetical protein 0.0013 0.0087 0.0023
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0029 0.0424 1
Trypanosoma brucei glucose transporter 2A 0.0063 0.1165 0.1922
Schistosoma mansoni hypothetical protein 0.041 0.8592 0.8583
Loa Loa (eye worm) hypothetical protein 0.0012 0.0064 0.0064
Trichomonas vaginalis conserved hypothetical protein 0.0092 0.178 0.2667
Echinococcus multilocularis solute carrier family 22 0.0029 0.0424 0.0493
Trypanosoma brucei glucose transporter, putative 0.0063 0.1165 0.1922
Onchocerca volvulus 0.0029 0.0424 0.6171
Toxoplasma gondii sugar transporter ST2 0.0029 0.0424 0.0455
Trypanosoma brucei THT1 - hexose transporter, putative 0.0063 0.1165 0.1922
Trypanosoma brucei THT1 - hexose transporter, putative 0.0063 0.1165 0.1922
Brugia malayi neuroendocrine convertase 1 precursor 0.0299 0.6213 0.6189
Echinococcus multilocularis 0.0384 0.8029 0.9344
Plasmodium vivax hexose transporter 0.0204 0.418 1
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0289 0.6003 0.6003
Trypanosoma brucei glucose transporter, putative 0.0063 0.1165 0.1922
Onchocerca volvulus 0.0029 0.0424 0.6171
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0039 0.0647 0.1022
Onchocerca volvulus 0.0029 0.0424 0.6171
Loa Loa (eye worm) hypothetical protein 0.0029 0.0424 0.0424
Schistosoma mansoni sugar transporter 0.0029 0.0424 0.0362
Schistosoma mansoni glucose transport protein 0.0204 0.418 0.4143
Brugia malayi CXXC zinc finger family protein 0.0029 0.0426 0.0364
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.002 0.0245 0.0245
Loa Loa (eye worm) hypothetical protein 0.0012 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0029 0.0424 0.0424
Loa Loa (eye worm) subtilase 0.002 0.0245 0.0245
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0978 0.1862
Loa Loa (eye worm) hypothetical protein 0.0029 0.0424 0.0424
Brugia malayi Sugar transporter family protein 0.0029 0.0424 0.0362
Loa Loa (eye worm) hypothetical protein 0.0029 0.0424 0.0424
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0029 0.0424 0.5
Loa Loa (eye worm) hypothetical protein 0.0029 0.0424 0.0424
Brugia malayi hypothetical protein 0.0029 0.0429 0.0367
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0424 0.0311
Echinococcus granulosus solute carrier family 22 0.0029 0.0424 0.0424
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0424 0.0311
Trypanosoma brucei glucose transporter, putative 0.0063 0.1165 0.1922
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0064 0.0064
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0289 0.6003 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0112 0.2216 0.3423
Loa Loa (eye worm) hypothetical protein 0.0029 0.0424 0.0424
Echinococcus granulosus synaptic vesicle 2 protein 0.0029 0.0424 0.0424
Onchocerca volvulus 0.0029 0.0424 0.6171
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0424 0.0311
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0424 0.0311
Trichomonas vaginalis conserved hypothetical protein 0.0204 0.418 0.6835
Trichomonas vaginalis conserved hypothetical protein 0.0092 0.178 0.2667
Trichomonas vaginalis conserved hypothetical protein 0.0092 0.178 0.2667
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0424 0.0311
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0424 0.0311
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0064 0.0075
Loa Loa (eye worm) hypothetical protein 0.0029 0.0429 0.0429
Brugia malayi major facilitator superfamily protein 0.0029 0.0424 0.0362
Leishmania major glucose transporter, lmgt1 0.0063 0.1165 1
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.002 0.0245 0.0182
Onchocerca volvulus 0.0029 0.0426 0.6206
Trypanosoma cruzi hexose transporter, putative 0.0035 0.055 0.332
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0029 0.0424 0.0362
Trypanosoma brucei RNA helicase, putative 0.0244 0.5032 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0064 0.0064
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0424 0.0311
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0064 0.0064
Brugia malayi celfurPC protein 0.0384 0.8029 0.8016
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0204 0.418 0.418
Trichomonas vaginalis sugar transporter, putative 0.0063 0.1165 0.1598
Brugia malayi Sugar transporter family protein 0.0029 0.0424 0.0362
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0424 0.0311
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0424 0.0311
Toxoplasma gondii facilitative glucose transporter GT1 0.0204 0.418 1
Schistosoma mansoni sugar transporter 0.0029 0.0424 0.0362
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0204 0.418 0.418
Echinococcus granulosus furin 0.0476 1 1
Schistosoma mansoni sugar transporter 0.0029 0.0424 0.0362
Onchocerca volvulus 0.0029 0.0424 0.6171
Schistosoma mansoni hypothetical protein 0.0092 0.178 0.1727
Echinococcus granulosus cpg binding protein 0.003 0.0461 0.0461
Loa Loa (eye worm) major facilitator superfamily transporter 0.0029 0.0424 0.0424
Onchocerca volvulus 0.0029 0.0424 0.6171
Schistosoma mansoni sodium/solute symporter 0.0039 0.0647 0.0587
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0424 0.0311
Brugia malayi hypothetical protein 0.0029 0.0424 0.0362
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0424 0.0311
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0029 0.0424 0.0374
Onchocerca volvulus 0.0029 0.0424 0.6171
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0064 0.0064
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0429 0.0468
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0424 0.0311
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.1117 0.106
Onchocerca volvulus 0.002 0.0245 0.3098
Trichomonas vaginalis sugar transporter, putative 0.0063 0.1165 0.1598
Brugia malayi Nuclear hormone receptor-like 1 0.0287 0.596 0.5934
Echinococcus multilocularis cpg binding protein 0.003 0.0461 0.0537
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0424 0.0311
Schistosoma mansoni hypothetical protein 0.0173 0.3512 0.347
Onchocerca volvulus 0.0029 0.0424 0.6171
Trypanosoma brucei glucose transporter, putative 0.0063 0.1165 0.1922
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0112 0.2216 0.3423
Echinococcus multilocularis solute carrier family 22 0.0029 0.0424 0.0493
Loa Loa (eye worm) hypothetical protein 0.0012 0.0064 0.0064
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0029 0.0424 1
Mycobacterium ulcerans sugar transporter 0.0029 0.0424 1
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0029 0.0424 0.0493
Loa Loa (eye worm) hypothetical protein 0.002 0.0245 0.0245
Schistosoma mansoni hypothetical protein 0.0244 0.5032 0.5
Trypanosoma brucei glucose transporter, putative 0.0063 0.1165 0.1922
Loa Loa (eye worm) major facilitator superfamily transporter 0.0029 0.0424 0.0424
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0064 0.0075
Echinococcus granulosus sodium:glucose cotransporter 0.0039 0.0647 0.0647
Onchocerca volvulus 0.0029 0.0424 0.6171
Onchocerca volvulus 0.0029 0.0424 0.6171
Echinococcus granulosus dnaJ subfamily B 0.041 0.8592 0.8592
Giardia lamblia Furin precursor putative serine protease 0.0092 0.178 0.4277
Loa Loa (eye worm) hypothetical protein 0.0029 0.0424 0.0424
Echinococcus granulosus solute carrier family 5 0.0039 0.0647 0.0647
Trichomonas vaginalis myo-inositol transporter, putative 0.0029 0.0424 0.0311
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0424 0.0311
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0204 0.418 0.4865
Trypanosoma cruzi glucose transporter, putative 0.0029 0.0424 0.1946
Onchocerca volvulus 0.0029 0.0424 0.6171
Echinococcus multilocularis solute carrier family 22 0.0029 0.0424 0.0493
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0424 0.0311
Schistosoma mansoni high-affinity choline transporter 0.0354 0.7405 0.7388
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0064 0.0064
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0064 0.0075
Plasmodium vivax sugar transporter, putative 0.0029 0.0424 0.0455
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0029 0.0424 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0429 0.0468
Brugia malayi hypothetical protein 0.0029 0.0424 0.0362
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0013 0.0087 0.0101
Onchocerca volvulus 0.0029 0.0424 0.6171
Loa Loa (eye worm) hypothetical protein 0.0029 0.0424 0.0424
Loa Loa (eye worm) hypothetical protein 0.0029 0.0424 0.0424
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0064 0.0064
Echinococcus granulosus Sugar transporter ERD6 protein 0.0029 0.0424 0.0424
Toxoplasma gondii sugar transporter ST1 0.0029 0.0424 0.0455
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0424 0.0311
Loa Loa (eye worm) sugar transporter 0.0029 0.0424 0.0424
Loa Loa (eye worm) hypothetical protein 0.0012 0.0064 0.0064
Leishmania major glucose transporter, lmgt3 0.0063 0.1165 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0424 0.0424
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0029 0.0424 1
Trichomonas vaginalis conserved hypothetical protein 0.0092 0.178 0.2667
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0424 0.0311
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0424 0.0311
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0064 0.0075
Onchocerca volvulus 0.0039 0.0647 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0064 0.0064
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0039 0.0647 0.0647
Echinococcus multilocularis solute carrier family 5 0.0039 0.0647 0.0753
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0289 0.6003 1
Trichomonas vaginalis conserved hypothetical protein 0.0092 0.178 0.2667
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0092 0.178 0.2667
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.1165 0.1598
Schistosoma mansoni glucose transport protein 0.0204 0.418 0.4143
Leishmania major myo-inositol/proton symporter (MIT) 0.0029 0.0424 0.1946
Echinococcus granulosus sodium:myo inositol cotransporter 0.0039 0.0647 0.0647
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0064 0.0064
Trichomonas vaginalis conserved hypothetical protein 0.0092 0.178 0.2667
Trichomonas vaginalis conserved hypothetical protein 0.0092 0.178 0.2667
Echinococcus granulosus solute carrier family 22 0.0029 0.0424 0.0424
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0424 0.0311
Schistosoma mansoni inositol transporter 0.0039 0.0647 0.0587
Echinococcus multilocularis geminin 0.0173 0.3512 0.4087
Loa Loa (eye worm) hypothetical protein 0.0354 0.7405 0.7405
Brugia malayi Sugar transporter family protein 0.0204 0.418 0.4143
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0424 0.0311
Trypanosoma brucei glucose transporter 1E 0.0063 0.1165 0.1922
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0424 0.0311
Loa Loa (eye worm) hypothetical protein 0.0029 0.0424 0.0424
Loa Loa (eye worm) hypothetical protein 0.0012 0.0064 0.0064
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0424 0.0311
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0039 0.0647 0.0753
Echinococcus multilocularis General substrate transporter 0.0175 0.3566 0.415
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0039 0.0647 0.0647
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0064 0.0075
Onchocerca volvulus 0.0029 0.0424 0.6171
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0204 0.418 0.4865
Trichomonas vaginalis conserved hypothetical protein 0.0092 0.178 0.2667
Loa Loa (eye worm) hypothetical protein 0.0012 0.0064 0.0064
Trypanosoma brucei glucose transporter, putative 0.0063 0.1165 0.1922
Brugia malayi hypothetical protein 0.0019 0.0209 0.0146
Echinococcus granulosus membrane bound transcription factor site 1 0.002 0.0245 0.0245
Brugia malayi major facilitator superfamily protein 0.0029 0.0424 0.0362
Loa Loa (eye worm) hypothetical protein 0.0012 0.0064 0.0064
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0424 0.0311
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0204 0.418 0.418
Schistosoma mansoni furin-1 (S08 family) 0.0207 0.4242 0.4205
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0424 0.0311
Echinococcus granulosus General substrate transporter 0.0175 0.3566 0.3566
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0424 0.0311
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0424 0.0311
Echinococcus granulosus geminin 0.0173 0.3512 0.3512
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0424 0.0311
Trypanosoma brucei glucose transporter, putative 0.0063 0.1165 0.1922
Onchocerca volvulus Putative transporter 0.0029 0.0424 0.6171
Echinococcus granulosus solute carrier family 22 0.0029 0.0424 0.0424
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0064 0.0075
Trichomonas vaginalis hypothetical protein 0.0092 0.178 0.2667
Schistosoma mansoni glucose transporter 0.0029 0.0424 0.0362
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0429 0.0468
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0424 0.0311
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0424 0.0311
Leishmania major hypothetical protein, conserved 0.0029 0.0424 0.1946
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0424 0.0311
Schistosoma mansoni sugar transporter 0.0029 0.0424 0.0362
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0429 0.0468
Loa Loa (eye worm) hypothetical protein 0.0029 0.0424 0.0424
Echinococcus granulosus neuroendocrine convertase 2 0.0299 0.6213 0.6213
Trichomonas vaginalis conserved hypothetical protein 0.0092 0.178 0.2667
Echinococcus multilocularis Furin 1 0.0112 0.2216 0.2579
Trichomonas vaginalis sugar transport protein, putative 0.0029 0.0424 0.0311
Onchocerca volvulus 0.0029 0.0424 0.6171
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0092 0.178 0.2667
Loa Loa (eye worm) hypothetical protein 0.0286 0.5945 0.5945
Trichomonas vaginalis glucose transporter, putative 0.0029 0.0424 0.0311
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0424 0.0311
Echinococcus multilocularis membrane bound transcription factor site 1 0.002 0.0245 0.0285
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0287 0.596 0.596
Mycobacterium leprae Possible secreted protease 0.002 0.0245 0.5
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0092 0.178 0.2667
Brugia malayi hypothetical protein 0.0029 0.0424 0.0362
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.002 0.0245 0.5
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0289 0.6003 0.6986
Trypanosoma cruzi hexose transporter, putative 0.0063 0.1165 1
Trichomonas vaginalis glucose transporter, putative 0.0063 0.1165 0.1598
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0029 0.0424 0.0455
Brugia malayi Nuclear hormone receptor-like 1 0.0287 0.596 0.5934
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0424 0.0311
Mycobacterium ulcerans integral membrane transport protein 0.0029 0.0424 1
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0424 0.0311
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0112 0.2216 0.3423
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0013 0.0087 0.0087
Brugia malayi Nuclear hormone receptor-like 1 0.0293 0.608 0.6055
Leishmania major glucose transporter, lmgt2 0.0063 0.1165 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0204 0.418 0.418
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0064 0.0064
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0029 0.0424 0.0424
Echinococcus multilocularis solute carrier family 22 0.0029 0.0424 0.0493
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0424 0.0311
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0064 0.0064
Leishmania major hypothetical protein, conserved 0.0029 0.0429 0.2001
Echinococcus multilocularis dnaJ subfamily B 0.041 0.8592 1
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0064 0.0064
Trypanosoma cruzi hexose transporter, putative 0.0029 0.0424 0.1946
Loa Loa (eye worm) hypothetical protein 0.0476 1 1
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0039 0.0647 0.0753
Schistosoma mansoni cpg binding protein 0.003 0.0461 0.0399
Echinococcus granulosus high affinity choline transporter 1 0.0354 0.7405 0.7405
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0112 0.2216 0.3423
Echinococcus granulosus sodium:glucose cotransporter 2 0.0039 0.0647 0.0647
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0064 0.0075
Trypanosoma brucei sugar transporter, putative 0.0029 0.0424 0.0374
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.002 0.0245 0.5
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0204 0.418 0.4865

Activities

Activity type Activity value Assay description Source Reference
KI_MICROM (functional) > 44.3 um PUBCHEM_BIOASSAY: Formylpeptide Receptor (FPR) Ligand Structure Activity Relationship (SAR) Analysis: Dose Response Assay. (Class of assay: confirmatory) [Related pubchem assays: 519, 520, 440, 699, 441 ] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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