Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.001 | 0.0838 | 0.0838 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0022 | 0.3348 | 0.274 |
Brugia malayi | nuclear hormone receptor | 0.001 | 0.0838 | 0.0838 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0022 | 0.3348 | 1 |
Plasmodium falciparum | DNA repair protein REV1, putative | 0.0007 | 0 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.001 | 0.0838 | 0.0838 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.0838 | 0.0838 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.0838 | 0.0838 |
Leishmania major | DNA polymerase kappa, putative | 0.0022 | 0.3348 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.0838 | 0.0838 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0022 | 0.3348 | 0.3348 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.001 | 0.0838 | 0.0838 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0022 | 0.3348 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.001 | 0.0838 | 0.0838 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0051 | 1 | 1 |
Schistosoma mansoni | DNA polymerase eta | 0.0022 | 0.3348 | 0.3348 |
Echinococcus multilocularis | dna polymerase kappa | 0.0022 | 0.3348 | 0.274 |
Echinococcus granulosus | dna polymerase eta | 0.0022 | 0.3348 | 0.274 |
Trypanosoma brucei | unspecified product | 0.0022 | 0.3348 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0015 | 0.1841 | 0.55 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.001 | 0.0838 | 0.0838 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0051 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.0838 | 0.0838 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0022 | 0.3348 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.001 | 0.0838 | 0.0838 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0022 | 0.3348 | 1 |
Trypanosoma brucei | unspecified product | 0.0015 | 0.1841 | 0.55 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.3348 | 0.3348 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0838 | 0.0838 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0022 | 0.3348 | 0.3348 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0022 | 0.3348 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.3348 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.0838 | 0.0838 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.3348 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.001 | 0.0838 | 0.0838 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.001 | 0.0838 | 0.0838 |
Onchocerca volvulus | Bile acid receptor homolog | 0.001 | 0.0838 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0838 | 0.0838 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 1 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0022 | 0.3348 | 1 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0022 | 0.3348 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.001 | 0.0838 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0838 | 0.0838 |
Brugia malayi | ecdysteroid receptor | 0.001 | 0.0838 | 0.0838 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.0838 | 0.0838 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0015 | 0.1841 | 0.55 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0022 | 0.3348 | 0.3348 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.001 | 0.0838 | 0.0838 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0022 | 0.3348 | 1 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0022 | 0.3348 | 0.3348 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.3348 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0051 | 1 | 1 |
Leishmania major | DNA polymerase eta, putative | 0.0022 | 0.3348 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0022 | 0.3348 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0022 | 0.3348 | 0.3348 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.001 | 0.0838 | 0.0838 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0022 | 0.3348 | 0.5 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0022 | 0.3348 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0838 | 0.0838 |
Echinococcus multilocularis | dna polymerase eta | 0.0022 | 0.3348 | 0.274 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.001 | 0.0838 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.001 | 0.0838 | 0.0838 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.001 | 0.0838 | 0.0838 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0007 | 0 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0022 | 0.3348 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.001 | 0.0838 | 0.0838 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0051 | 1 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.001 | 0.0838 | 0.0838 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0022 | 0.3348 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.001 | 0.0838 | 0.0838 |
Onchocerca volvulus | 0.001 | 0.0838 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0838 | 0.0838 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.0838 | 0.0838 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.001 | 0.0838 | 0.0838 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0022 | 0.3348 | 1 |
Echinococcus granulosus | dna polymerase kappa | 0.0022 | 0.3348 | 0.274 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.001 | 0.0838 | 0.0838 |
Schistosoma mansoni | coup transcription factor | 0.001 | 0.0838 | 0.0838 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.001 | 0.0838 | 0.0838 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.001 | 0.0838 | 0.0838 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.3348 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0838 | 0.0838 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0838 | 0.0838 |
Brugia malayi | nuclear receptor NHR-88 | 0.001 | 0.0838 | 0.0838 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0022 | 0.3348 | 0.274 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 1 | 1 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0022 | 0.3348 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.3348 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.001 | 0.0838 | 0.0838 |
Toxoplasma gondii | BRCA1 C Terminus (BRCT) domain-containing protein | 0.0007 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.001 | 0.0838 | 0.0838 |
Plasmodium vivax | DNA repair protein REV1, putative | 0.0007 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.3348 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.001 | 0.0838 | 0.0838 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0022 | 0.3348 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.3348 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.001 | 0.0838 | 0.0838 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0015 | 0.1841 | 0.55 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0022 | 0.3348 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.3348 | 1 |
Trypanosoma brucei | unspecified product | 0.0015 | 0.1841 | 0.55 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0051 | 1 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.001 | 0.0838 | 0.0838 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.0838 | 0.0838 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.001 | 0.0838 | 0.0838 |
Giardia lamblia | DINP protein human, muc B family | 0.0022 | 0.3348 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.001 | 0.0838 | 0.0838 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.001 | 0.0838 | 0.0838 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.3348 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.3348 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.001 | 0.0838 | 0.0838 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0838 | 0.0838 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.001 | 0.0838 | 0.0838 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0007 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 1 uM | Evaluated for inhibition of growth of CEM/VLB1000 cell line using multidrug resistance (MDR) potentiation assay | ChEMBL. | 11128632 |
ED50 (functional) | = 1 uM | Evaluated for inhibition of growth of CEM/VLB1000 cell line using multidrug resistance (MDR) potentiation assay | ChEMBL. | 11128632 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.