Detailed information for compound 1449980

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 246.351 | Formula: C12H10N2S2
  • H donors: 0 H acceptors: 2 LogP: 2.8 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc2c(c1)c1nc(S)ncc1CS2
  • InChi: 1S/C12H10N2S2/c1-7-2-3-10-9(4-7)11-8(6-16-10)5-13-12(15)14-11/h2-5H,6H2,1H3,(H,13,14,15)
  • InChiKey: RXSNAQZRAYFRHK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens polo-like kinase 1 Starlite/ChEMBL No references
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma japonicum ko:K06631 polo-like kinase 1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum Serine/threonine-protein kinase PLK1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus granulosus serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Giardia lamblia Kinase, PLK Get druggable targets OG5_127396 All targets in OG5_127396
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei polo-like protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Brugia malayi serine/threonine-protein kinase plk-2 Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense polo-like protein kinase,protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Onchocerca volvulus Serine\/threonine kinase homolog Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica serine/threonine protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) PLK/PLK1 protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania infantum protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania major protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 539 aa 22.3 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.3 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 540 aa 23.3 %
Leishmania donovani acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 518 aa 24.9 %
Leishmania braziliensis 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 450 aa 25.6 %
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 460 aa 25.4 %
Leishmania mexicana acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 24.4 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Leishmania mexicana 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 452 aa 25.7 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Leishmania braziliensis acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 22.8 %
Neospora caninum hypothetical protein Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.0 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.6 %
Leishmania braziliensis dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 488 aa 21.9 %
Leishmania donovani dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Leishmania infantum acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.5 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.5 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.5 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 462 aa 25.8 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Leishmania major acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 519 aa 23.7 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 529 aa 31.8 %
Neospora caninum glutathione reductase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 32.7 %
Leishmania infantum dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.9 %
Plasmodium falciparum glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 500 aa 32.2 %
Onchocerca volvulus Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 57.3 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin reductase 1, cytoplasmic   499 aa 506 aa 23.7 %
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.2 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.2 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.3 %
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 454 aa 25.3 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Trypanosoma brucei dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.4 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, point mutation,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.3 %
Plasmodium falciparum thioredoxin reductase Thioredoxin reductase 1, cytoplasmic   499 aa 511 aa 45.2 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Plasmodium berghei dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 26.9 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin reductase 1, cytoplasmic   499 aa 464 aa 24.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) proprotein convertase 2 0.0106 0.114 0.2142
Treponema pallidum NADH oxidase 0.002 0.0088 0.5
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0024 0.0137 0.0137
Schistosoma mansoni high-affinity choline transporter 0.0347 0.4072 0.4072
Brugia malayi hypothetical protein 0.0028 0.019 0.0358
Schistosoma mansoni site-1 peptidase (S08 family) 0.0019 0.0081 0.0081
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.002 0.0088 0.0151
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0273 0.3176 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0106 0.114 0.3423
Echinococcus multilocularis membrane bound transcription factor site 1 0.0019 0.0081 0.0081
Echinococcus granulosus neuroendocrine convertase 2 0.0283 0.3289 0.3289
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0015 0.0024 0.0045
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0114 0.1237 0.1237
Loa Loa (eye worm) hypothetical protein 0.0028 0.019 0.0358
Brugia malayi Sodium:solute symporter family protein 0.0038 0.0313 0.0587
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0273 0.3176 0.3176
Schistosoma mansoni cpg binding protein 0.0037 0.0293 0.0293
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.013 0.1434 0.8843
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.002 0.0088 0.0088
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1237 0.3734
Leishmania major hypothetical protein, conserved 0.0028 0.019 0.0948
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.002 0.0088 0.0151
Entamoeba histolytica serine/threonine protein kinase, putative 0.0114 0.1237 0.5
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.002 0.0088 0.5
Echinococcus multilocularis FTZ F1 alpha 0.0024 0.0137 0.0137
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0024 0.0137 0.0137
Trypanosoma brucei polo-like protein kinase 0.0114 0.1237 0.4339
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0088 0.006
Schistosoma mansoni cpg binding protein 0.0037 0.0293 0.0293
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0024 0.0137 0.0137
Schistosoma mansoni hypothetical protein 0.0087 0.0906 0.0906
Onchocerca volvulus 0.0035 0.0269 0.163
Schistosoma mansoni coup transcription factor 0.0024 0.0137 0.0137
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0137 0.0137
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.045 0.5324 0.5324
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0038 0.0313 0.0313
Onchocerca volvulus 0.0038 0.0313 0.2006
Loa Loa (eye worm) endoprotease bli-4 0.045 0.5324 1
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0137 0.0137
Echinococcus granulosus dnaJ subfamily B 0.0494 0.5865 0.5865
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0024 0.0137 0.0137
Loa Loa (eye worm) hypothetical protein 0.0176 0.1995 0.3747
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0535 0.1466
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1237 0.3734
Loa Loa (eye worm) subtilase 0.0019 0.0081 0.0152
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.019 0.2375
Giardia lamblia Kinase, PLK 0.0114 0.1237 0.6402
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.002 0.0088 0.0151
Loa Loa (eye worm) glutathione reductase 0.0057 0.0542 0.1019
Brugia malayi Nuclear hormone receptor-like 1 0.0286 0.3337 0.6267
Loa Loa (eye worm) hypothetical protein 0.0285 0.3321 0.6237
Loa Loa (eye worm) thioredoxin reductase 0.0057 0.0542 0.1019
Echinococcus granulosus membrane bound transcription factor site 1 0.0019 0.0081 0.0081
Leishmania major trypanothione reductase 0.0057 0.0542 0.3994
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0024 0.0137 0.0137
Onchocerca volvulus Serine\/threonine kinase homolog 0.0114 0.1237 1
Schistosoma mansoni inositol transporter 0.0038 0.0313 0.0313
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0024 0.0137 0.0257
Brugia malayi neuroendocrine convertase 1 precursor 0.0283 0.3289 0.6177
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0024 0.0137 0.0257
Plasmodium falciparum thioredoxin reductase 0.002 0.0088 0.0151
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.019 0.0412
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0024 0.0137 0.0257
Giardia lamblia High cysteine membrane protein Group 2 0.0167 0.1882 1
Schistosoma mansoni hypothetical protein 0.0238 0.2744 0.2744
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0137 0.0137
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0024 0.0137 0.0257
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.002 0.0088 0.006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0024 0.0137 0.0257
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.002 0.0088 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.052 0.052
Trichomonas vaginalis glutathione reductase, putative 0.002 0.0088 0.0023
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0024 0.0137 0.0137
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0087 0.0906 0.2667
Schistosoma mansoni hypothetical protein 0.0494 0.5865 0.5865
Schistosoma mansoni retinoic acid receptor RXR 0.0024 0.0137 0.0137
Leishmania major dihydrolipoamide dehydrogenase, putative 0.002 0.0088 0.006
Loa Loa (eye worm) hypothetical protein 0.0347 0.4072 0.7647
Schistosoma mansoni sodium/solute symporter 0.0038 0.0313 0.0313
Brugia malayi steroid hormone receptor 0.0024 0.0137 0.0257
Echinococcus granulosus cpg binding protein 0.0037 0.0293 0.0293
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1237 0.3734
Schistosoma mansoni kinase 0.0058 0.0553 0.0553
Brugia malayi serine/threonine-protein kinase plk-2 0.0114 0.1237 0.2322
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0024 0.0137 0.0257
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.0743 0.0743
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.019 0.2375
Echinococcus multilocularis solute carrier family 5 0.0038 0.0313 0.0313
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.019 0.1935
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0013 0.0001 0.0001
Brugia malayi photoreceptor-specific nuclear receptor 0.0024 0.0137 0.0257
Brugia malayi nuclear receptor NHR-88 0.0024 0.0137 0.0257
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0273 0.3176 0.3176
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0106 0.114 0.3423
Echinococcus multilocularis Furin 1 0.0106 0.114 0.114
Echinococcus multilocularis 0.0363 0.4265 0.4265
Echinococcus multilocularis geminin 0.0169 0.1906 0.1906
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1237 0.3734
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0019 0.0081 0.0081
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.052 0.052
Schistosoma mansoni site-1 peptidase (S08 family) 0.0019 0.0081 0.0081
Trichomonas vaginalis conserved hypothetical protein 0.0087 0.0906 0.2667
Brugia malayi proprotein convertase 2 0.0283 0.3289 0.6177
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0038 0.0313 0.0313
Schistosoma mansoni RAR-like nuclear receptor 0.0024 0.0137 0.0137
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.052 0.052
Schistosoma mansoni hypothetical protein 0.0169 0.1906 0.1906
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0057 0.0542 0.3017
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0106 0.114 0.3423
Loa Loa (eye worm) hypothetical protein 0.0024 0.0137 0.0257
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.052 0.0976
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.002 0.0088 0.006
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0087 0.0906 0.2667
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0145 0.1611 1
Trichomonas vaginalis conserved hypothetical protein 0.0087 0.0906 0.2667
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0024 0.0137 0.0257
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0088 0.006
Giardia lamblia Furin precursor putative serine protease 0.0087 0.0906 0.4561
Schistosoma mansoni cpg binding protein 0.0035 0.0269 0.0269
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1237 0.3734
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.052 0.052
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.002 0.0088 0.0088
Brugia malayi ecdysteroid receptor 0.0024 0.0137 0.0257
Loa Loa (eye worm) hypothetical protein 0.0024 0.0137 0.0257
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.019 0.0948
Trypanosoma cruzi trypanothione reductase, putative 0.002 0.0088 0.006
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.002 0.0088 0.0088
Echinococcus granulosus sodium:glucose cotransporter 0.0038 0.0313 0.0313
Plasmodium vivax thioredoxin reductase, putative 0.0057 0.0542 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.002 0.0088 0.5
Loa Loa (eye worm) hypothetical protein 0.0024 0.0137 0.0257
Echinococcus granulosus thioredoxin glutathione reductase 0.0057 0.0542 0.0542
Mycobacterium ulcerans flavoprotein disulfide reductase 0.002 0.0088 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0024 0.0137 0.0137
Leishmania major dihydrolipoamide dehydrogenase, putative 0.002 0.0088 0.006
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0024 0.0137 0.0257
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.002 0.0088 0.0046
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0024 0.0137 0.0257
Trichomonas vaginalis conserved hypothetical protein 0.0087 0.0906 0.2667
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.002 0.0088 0.0026
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0024 0.0137 0.0257
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0024 0.0137 0.0257
Loa Loa (eye worm) hypothetical protein 0.0024 0.0137 0.0257
Plasmodium vivax glutathione reductase, putative 0.0057 0.0542 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0088 0.006
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0114 0.1237 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0145 0.1611 1
Echinococcus multilocularis cpg binding protein 0.0037 0.0293 0.0293
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.002 0.0088 0.0151
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0106 0.114 0.3423
Trichomonas vaginalis hypothetical protein 0.0087 0.0906 0.2667
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.019 0.2375
Onchocerca volvulus Bile acid receptor homolog 0.0024 0.0137 0.0485
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.002 0.0088 0.0026
Leishmania major acetoin dehydrogenase e3 component-like protein 0.002 0.0088 0.006
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.002 0.0088 0.006
Loa Loa (eye worm) hypothetical protein 0.0024 0.0137 0.0257
Onchocerca volvulus Protein ultraspiracle homolog 0.0024 0.0137 0.0485
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0024 0.0137 0.0257
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0114 0.1237 0.2322
Brugia malayi Nuclear hormone receptor-like 1 0.0286 0.3337 0.6267
Schistosoma mansoni thyroid hormone receptor 0.0024 0.0137 0.0137
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.0647 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0024 0.0137 0.0137
Echinococcus multilocularis high affinity choline transporter 1 0.0347 0.4072 0.4072
Brugia malayi endoprotease bli-4 precursor 0.045 0.5324 1
Trichomonas vaginalis conserved hypothetical protein 0.0087 0.0906 0.2667
Trichomonas vaginalis conserved hypothetical protein 0.0087 0.0906 0.2667
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0106 0.114 0.3423
Echinococcus multilocularis thyroid hormone receptor alpha 0.0024 0.0137 0.0137
Loa Loa (eye worm) hypothetical protein 0.0024 0.0137 0.0257
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0024 0.0137 0.0257
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.052 0.052
Loa Loa (eye worm) hypothetical protein 0.0024 0.0137 0.0257
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0013 0.0001 0.0001
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0088 0.006
Schistosoma mansoni thyroid hormone receptor 0.0024 0.0137 0.0137
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0145 0.1611 1
Schistosoma mansoni inositol transporter 0.0038 0.0313 0.0313
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0286 0.3337 0.6267
Brugia malayi glutathione reductase 0.0057 0.0542 0.1019
Schistosoma mansoni hypothetical protein 0.0169 0.1906 0.1906
Brugia malayi Steroid receptor seven-up type 2 0.0024 0.0137 0.0257
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.019 0.0948
Echinococcus multilocularis microtubule associated protein 2 0.0833 1 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.013 0.1434 0.8843
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.052 0.052
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0024 0.0137 0.0257
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0024 0.0137 0.0257
Echinococcus granulosus sodium:glucose cotransporter 2 0.0038 0.0313 0.0313
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0106 0.114 0.3423
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.013 0.1434 0.8843
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0024 0.0137 0.0137
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0019 0.0081 0.0152
Trypanosoma cruzi trypanothione reductase, putative 0.0057 0.0542 0.3994
Toxoplasma gondii NADPH-glutathione reductase 0.002 0.0088 0.0123
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0038 0.0313 0.0313
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.002 0.0088 0.0165
Echinococcus multilocularis neuroendocrine convertase 2 0.0283 0.3289 0.3289
Plasmodium falciparum glutathione reductase 0.0057 0.0542 1
Echinococcus granulosus sodium:myo inositol cotransporter 0.0038 0.0313 0.0313
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.002 0.0088 0.0123
Schistosoma mansoni steroid hormone receptor ad4bp 0.0024 0.0137 0.0137
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.002 0.0088 0.0026
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0269 0.0506
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0024 0.0137 0.0137
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0038 0.0313 0.0313
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0024 0.0137 0.0137
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.002 0.0088 0.0026
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0024 0.0137 0.0257
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0019 0.0081 0.0081
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0024 0.0137 0.0257
Brugia malayi hypothetical protein 0.0018 0.0069 0.0129
Toxoplasma gondii thioredoxin reductase 0.0057 0.0542 0.8149
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0024 0.0137 0.0137
Trichomonas vaginalis conserved hypothetical protein 0.0087 0.0906 0.2667
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0145 0.1611 1
Loa Loa (eye worm) hypothetical protein 0.045 0.5324 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0088 0.006
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0088 0.006
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0273 0.3176 1
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0038 0.0313 0.4093
Trichomonas vaginalis conserved hypothetical protein 0.0087 0.0906 0.2667
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0015 0.0024 0.0045
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0087 0.0906 0.2667
Brugia malayi nuclear hormone receptor 0.0024 0.0137 0.0257
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0137 0.0137
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0024 0.0137 0.0137
Echinococcus granulosus ecdysone induced protein 78C 0.0024 0.0137 0.0137
Mycobacterium tuberculosis Probable reductase 0.013 0.1434 0.8843
Echinococcus granulosus geminin 0.0169 0.1906 0.1906
Loa Loa (eye worm) hypothetical protein 0.0019 0.0081 0.0152
Trichomonas vaginalis mercuric reductase, putative 0.002 0.0088 0.0023
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0019 0.0081 0.0081
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0019 0.0081 0.0152
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1237 0.3734
Schistosoma mansoni furin-1 (S08 family) 0.0196 0.2229 0.2229
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0024 0.0137 0.0485
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.5865 0.5865
Brugia malayi Subtilase family protein 0.0019 0.0081 0.0152
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.052 0.0976
Trichomonas vaginalis conserved hypothetical protein 0.0087 0.0906 0.2667
Brugia malayi Thioredoxin reductase 0.0057 0.0542 0.1019
Brugia malayi CXXC zinc finger family protein 0.0035 0.0269 0.0506
Trichomonas vaginalis conserved hypothetical protein 0.0087 0.0906 0.2667
Mycobacterium tuberculosis Probable dehydrogenase 0.013 0.1434 0.8843
Trypanosoma brucei RNA helicase, putative 0.0238 0.2744 1
Brugia malayi celfurPC protein 0.0363 0.4265 0.801
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0024 0.0137 0.0257
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.1237 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0024 0.0137 0.0137
Trichomonas vaginalis conserved hypothetical protein 0.0087 0.0906 0.2667
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.1237 1
Echinococcus granulosus Furin 1 0.0106 0.114 0.114
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0019 0.0081 0.0081
Plasmodium falciparum glutathione reductase 0.002 0.0088 0.0151
Schistosoma mansoni microtubule-associated protein tau 0.0833 1 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.013 0.1434 0.8843
Onchocerca volvulus 0.0024 0.0137 0.0485
Loa Loa (eye worm) steroid hormone receptor 0.0024 0.0137 0.0257
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0106 0.114 0.114
Trichomonas vaginalis conserved hypothetical protein 0.0087 0.0906 0.2667
Echinococcus granulosus FTZ F1 alpha 0.0024 0.0137 0.0137
Echinococcus granulosus furin 0.045 0.5324 0.5324
Echinococcus granulosus high affinity choline transporter 1 0.0347 0.4072 0.4072
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0024 0.0137 0.0137
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0024 0.0137 0.0257
Schistosoma mansoni hypothetical protein 0.0013 0.0001 0.0001
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0137 0.0137
Echinococcus multilocularis ecdysone induced protein 78C 0.0024 0.0137 0.0137
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0024 0.0137 0.0257
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.1237 0.1237
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1237 0.3734
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.002 0.0088 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0057 0.0542 0.0542
Brugia malayi Nuclear hormone receptor-like 1 0.0298 0.3474 0.6524
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0535 0.1466
Plasmodium falciparum thioredoxin reductase 0.0057 0.0542 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.013 0.1434 0.8843
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.002 0.0088 0.5
Echinococcus granulosus solute carrier family 5 0.0038 0.0313 0.0313
Brugia malayi GH02984p 0.0347 0.4072 0.7647
Trypanosoma brucei trypanothione reductase 0.0057 0.0542 0.1733
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.052 0.052
Loa Loa (eye worm) hypothetical protein 0.0038 0.0313 0.0587
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0114 0.1237 0.1237
Loa Loa (eye worm) hypothetical protein 0.0024 0.0137 0.0257

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.7943 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 2.2387 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.5481 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 4.2284 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.0795 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 15.8489 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (binding) = 100 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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