Detailed information for compound 1449988

Basic information

Technical information
  • TDR Targets ID: 1449988
  • Name: N-[1-(3-fluorophenyl)-5-oxopyrrolidin-3-yl]cy clohexanecarboxamide
  • MW: 304.359 | Formula: C17H21FN2O2
  • H donors: 1 H acceptors: 2 LogP: 2.55 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C1CCCCC1)NC1CC(=O)N(C1)c1cccc(c1)F
  • InChi: 1S/C17H21FN2O2/c18-13-7-4-8-15(9-13)20-11-14(10-16(20)21)19-17(22)12-5-2-1-3-6-12/h4,7-9,12,14H,1-3,5-6,10-11H2,(H,19,22)
  • InChiKey: HSKYZHOTAHNTFH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[1-(3-fluorophenyl)-5-oxo-pyrrolidin-3-yl]cyclohexanecarboxamide
  • N-[1-(3-fluorophenyl)-5-oxo-3-pyrrolidinyl]cyclohexanecarboxamide
  • N-[1-(3-fluorophenyl)-5-keto-pyrrolidin-3-yl]cyclohexanecarboxamide
  • G856-7456
  • NCGC00136574-01

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major ubiquitin-activating enzyme-like protein 0.0035 0.0013 0.0116
Leishmania major heat shock protein 83-1 0.003 0.0007 0.0059
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0034 0.0012 0.0105
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0094 0.01 0.0888
Echinococcus multilocularis survival motor neuron protein 1 0.0759 0.1086 0.1085
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0057 0.0046 0.0838
Entamoeba histolytica DNA topoisomerase III, putative 0.0031 0.0008 0.0036
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0034 0.0012 0.0092
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0073 0.0069 0.0063
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.0031 0.0008 0.003
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0076 0.0074 0.0068
Loa Loa (eye worm) hypothetical protein 0.0076 0.0074 0.0074
Brugia malayi serine/threonine-protein kinase plk-2 0.0104 0.0115 0.0115
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0034 0.0012 0.007
Leishmania major developmentally regulated phosphoprotein-like protein 0.003 0.0007 0.0059
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0003 0.001
Loa Loa (eye worm) hypothetical protein 0.0072 0.0068 0.0068
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0022 0.0184
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0045 0.0029 0.0027
Echinococcus multilocularis dna polymerase eta 0.0041 0.0022 0.0021
Brugia malayi Intermediate filament tail domain containing protein 0.0085 0.0087 0.0087
Leishmania major telomerase reverse transcriptase, putative 0.0094 0.01 0.0899
Mycobacterium leprae putative cytochrome p450 0.0034 0.0012 0.0109
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.0036 0.0036
Plasmodium falciparum DNA gyrase subunit B 0.0339 0.0464 0.4155
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0034 0.0012 0.007
Brugia malayi GRF zinc finger family protein 0.0031 0.0008 0.0008
Echinococcus multilocularis sentrin specific protease 8 0.0073 0.0069 0.0068
Trichomonas vaginalis CAMK family protein kinase 0.0052 0.0038 0.0164
Echinococcus granulosus flap endonuclease 1 0.0028 0.0004 0.0002
Echinococcus multilocularis acetylcholinesterase 0.6776 1 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1536 0.2237 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0022 0.0184
Chlamydia trachomatis DNA gyrase subunit A 0.0125 0.0147 0.3045
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0016 0.0072
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.0115 0.0509
Brugia malayi Muscleblind-like protein 0.0315 0.0429 0.0429
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.1088 0.1573 0.7032
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0034 0.0012 0.007
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0045 0.0029 0.0027
Entamoeba histolytica heat shock protein 90, putative 0.003 0.0007 0.0029
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0052 0.0039 0.0338
Trypanosoma brucei glucosidase, putative 0.0037 0.0016 0.0126
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0582 0.0824 0.0822
Plasmodium vivax SUMO-activating enzyme subunit 2, putative 0.0035 0.0013 0.0098
Echinococcus multilocularis DNA topoisomerase 3 beta 1 0.0031 0.0008 0.0007
Loa Loa (eye worm) glutaminase 2 0.0296 0.04 0.04
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1536 0.2237 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0041 0.0022 0.0022
Brugia malayi jmjC domain containing protein 0.006 0.005 0.005
Echinococcus granulosus BC026374 protein S09 family 0.1145 0.1658 0.1657
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0076 0.0074 0.0068
Echinococcus granulosus sentrin specific protease 8 0.0073 0.0069 0.0068
Brugia malayi cytoplasmic intermediate filament protein 0.0045 0.0029 0.0029
Loa Loa (eye worm) cytochrome P450 0.0034 0.0012 0.0012
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0045 0.0029 0.0022
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.0074 0.0326
Loa Loa (eye worm) hypothetical protein 0.0759 0.1086 0.1086
Schistosoma mansoni DNA topoisomerase type I 0.0778 0.1114 0.1109
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0045 0.0029 0.0022
Mycobacterium ulcerans two component sensor kinase MprB 0.003 0.0007 0.0039
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0034 0.0012 0.007
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0022 0.0179
Brugia malayi Inositol-1 0.0119 0.0137 0.0137
Loa Loa (eye worm) hypothetical protein 0.1145 0.1658 0.1658
Mycobacterium tuberculosis Conserved hypothetical protein 0.0041 0.0022 0.0132
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0104 0.0115 0.0115
Brugia malayi RNA binding protein 0.0065 0.0057 0.0057
Mycobacterium tuberculosis Probable sensor protein KdpD 0.003 0.0007 0.0039
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0045 0.0029 0.0029
Onchocerca volvulus Huntingtin homolog 0.0134 0.016 0.0965
Plasmodium falciparum DNA topoisomerase 3, putative 0.0031 0.0008 0.0054
Plasmodium vivax DNA gyrase subunit B, putative 0.0339 0.0464 0.4155
Trypanosoma cruzi DNA topoisomerase II, putative 0.055 0.0777 0.6969
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0045 0.0029 0.0173
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.003 0.0007 0.0023
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0045 0.0029 0.0027
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0045 0.0029 0.0029
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0016 0.0014
Trypanosoma brucei heat shock protein, putative 0.003 0.0007 0.004
Brugia malayi Bromodomain containing protein 0.0076 0.0075 0.0075
Entamoeba histolytica hypothetical protein 0.0039 0.002 0.0089
Mycobacterium leprae Possible regulatory protein 0.0027 0.0001 0.0013
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0104 0.0115 0.0114
Loa Loa (eye worm) hypothetical protein 0.1145 0.1658 0.1658
Echinococcus multilocularis lysosomal alpha glucosidase 0.0166 0.0207 0.0206
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0027 0.0001 0.0001
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0045 0.0029 0.0027
Echinococcus multilocularis p2X purinoceptor 4 0.0067 0.0061 0.0059
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0073 0.0069 0.0303
Brugia malayi Carboxylesterase family protein 0.1145 0.1658 0.1658
Plasmodium vivax hypothetical protein, conserved 0.0076 0.0074 0.0649
Trypanosoma brucei hypothetical protein, conserved 0.0076 0.0074 0.0649
Trichomonas vaginalis protein kinase inhibitor, putative 0.0062 0.0054 0.0235
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.003 0.0007 0.0039
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0022 0.0179
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.001 0.0071
Entamoeba histolytica Flap nuclease, putative 0.0028 0.0004 0.0017
Brugia malayi follicle stimulating hormone receptor 0.0526 0.0741 0.0741
Loa Loa (eye worm) hypothetical protein 0.0045 0.0029 0.0029
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0119 0.0137 0.122
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.075 0.1073 0.6472
Echinococcus granulosus acetylcholinesterase 0.6776 1 1
Brugia malayi DNA topoisomerase III beta-1 0.0031 0.0008 0.0008
Trypanosoma brucei protein kinase, putative 0.0052 0.0039 0.0332
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0052 0.0039 0.035
Loa Loa (eye worm) hypothetical protein 0.0045 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0046 0.003 0.003
Schistosoma mansoni P2X receptor subunit 0.0067 0.0061 0.0054
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0016 0.0066
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.006 0.005 0.0049
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0045 0.0029 0.0029
Leishmania major DNA topoisomerase IB, large subunit 0.0778 0.1114 1
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0073 0.0069 0.0303
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0034 0.0012 0.007
Leishmania major heat shock protein 83-1 0.003 0.0007 0.0059
Schistosoma mansoni P2X receptor subunit 0.0067 0.0061 0.0054
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1536 0.2237 1
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0034 0.0012 0.007
Echinococcus granulosus dna polymerase eta 0.0041 0.0022 0.0021
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0057 0.0057
Schistosoma mansoni BC026374 protein (S09 family) 0.1145 0.1658 0.1652
Schistosoma mansoni neuroligin 3 (S09 family) 0.1145 0.1658 0.1652
Echinococcus granulosus heat shock protein 0.003 0.0007 0.0005
Mycobacterium leprae Probable two component sensor kinase MprB 0.003 0.0007 0.0061
Entamoeba histolytica hypothetical protein 0.0039 0.002 0.0089
Leishmania major heat shock protein 83-1 0.003 0.0007 0.0059
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.003 0.0007 0.0005
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0076 0.0074 0.0448
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.0115 0.0509
Leishmania major heat shock protein 83-1 0.003 0.0007 0.0059
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.003 0.0007 0.0039
Loa Loa (eye worm) hypothetical protein 0.0054 0.0042 0.0042
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0034 0.0012 0.007
Schistosoma mansoni hypothetical protein 0.0057 0.0046 0.0039
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0045 0.0029 0.0027
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.001 0.0009
Schistosoma mansoni prokaryotic DNA topoisomerase 0.0031 0.0008 0.0002
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0073 0.0069 0.0309
Leishmania major heat shock protein 83-1 0.003 0.0007 0.0059
Schistosoma mansoni retinoic acid receptor RXR 0.0045 0.0029 0.0022
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0022 0.0184
Loa Loa (eye worm) DNA topoisomerase III beta-1 0.0031 0.0008 0.0008
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0061 0.0052 0.005
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0003 0.001
Plasmodium vivax endoplasmin, putative 0.003 0.0007 0.004
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0022 0.0184
Mycobacterium tuberculosis Probable esterase LipL 0.0076 0.0074 0.0448
Toxoplasma gondii hypothetical protein 0.0053 0.004 0.0338
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0886 0.1274 0.1273
Trypanosoma cruzi heat shock protein 85, putative 0.003 0.0007 0.0046
Toxoplasma gondii DNA gyrase/topoisomerase IV, A subunit domain-containing protein 0.0125 0.0147 0.1303
Mycobacterium tuberculosis Conserved protein 0.003 0.0007 0.0039
Echinococcus multilocularis neuropeptide s receptor 0.0524 0.0738 0.0737
Schistosoma mansoni cytochrome P450 0.0034 0.0012 0.0005
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1536 0.2237 1
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0034 0.0012 0.007
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0045 0.0029 0.0027
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0022 0.0179
Brugia malayi Carboxylesterase family protein 0.6776 1 1
Echinococcus multilocularis SUMO activating enzyme subunit 1 0.0053 0.004 0.0038
Brugia malayi Endoplasmin precursor 0.003 0.0007 0.0007
Loa Loa (eye worm) DnaJ domain-containing protein 0.0062 0.0054 0.0054
Trypanosoma brucei heat shock protein 90, putative 0.003 0.0007 0.004
Trypanosoma brucei Heat shock protein 83, putative 0.003 0.0007 0.004
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0041 0.0022 0.0021
Leishmania major heat shock protein 83-1 0.003 0.0007 0.0059
Echinococcus granulosus p2X purinoceptor 4 0.0067 0.0061 0.0059
Echinococcus multilocularis para nitrobenzyl esterase 0.1145 0.1658 0.1657
Echinococcus granulosus heat shock protein 90 0.003 0.0007 0.0005
Schistosoma mansoni alpha-glucosidase 0.0143 0.0173 0.0167
Trypanosoma cruzi cytochrome P450, putative 0.008 0.008 0.0702
Giardia lamblia DNA topoisomerase III 0.0031 0.0008 0.002
Echinococcus multilocularis mitogen activated protein kinase 3 0.0052 0.0039 0.0038
Trypanosoma cruzi DNA topoisomerase IA, putative 0.0031 0.0008 0.006
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0034 0.0012 0.007
Onchocerca volvulus 0.0076 0.0074 0.0448
Chlamydia trachomatis DNA gyrase subunit A 0.0125 0.0147 0.3045
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.0036 0.0036
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0034 0.0012 0.007
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0052 0.0039 0.0039
Brugia malayi Cytochrome P450 family protein 0.008 0.008 0.008
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0034 0.0012 0.007
Plasmodium vivax DNA topoisomerase 3, putative 0.0031 0.0008 0.0054
Brugia malayi hypothetical protein 0.0759 0.1086 0.1086
Brugia malayi cytochrome P450 0.0034 0.0012 0.0012
Leishmania major DNA topoisomerase ii 0.055 0.0777 0.6973
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0041 0.0022 0.0015
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0119 0.0137 0.1215
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0027 0.0001 0.0013
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0016 0.0132
Echinococcus multilocularis neuropeptide receptor A26 0.0524 0.0738 0.0737
Plasmodium vivax DNA topoisomerase II, putative 0.0582 0.0824 0.7386
Trypanosoma brucei DNA polymerase eta, putative 0.0041 0.0022 0.0179
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0119 0.0137 0.0614
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.1145 0.1658 0.1652
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0034 0.0012 0.007
Loa Loa (eye worm) hypothetical protein 0.0237 0.0312 0.0312
Trypanosoma cruzi heat shock protein 85, putative 0.003 0.0007 0.0046
Trypanosoma brucei C-8 sterol isomerase, putative 0.0402 0.0558 0.4994
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0045 0.0029 0.0027
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0052 0.0038 0.0171
Mycobacterium ulcerans putative regulatory protein 0.0077 0.0075 0.0452
Toxoplasma gondii DNA topoisomerase I, putative 0.0778 0.1114 1
Onchocerca volvulus Bile acid receptor homolog 0.0045 0.0029 0.0173
Trypanosoma brucei heat shock protein 90, putative 0.003 0.0007 0.004
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.003 0.0007 0.004
Brugia malayi hypothetical protein 0.0134 0.016 0.016
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.003 0.0007 0.0039
Loa Loa (eye worm) DNA topoisomerase I 0.0778 0.1114 0.1114
Echinococcus granulosus carboxylesterase 5A 0.6776 1 1
Schistosoma mansoni acetylcholinesterase 0.1145 0.1658 0.1652
Schistosoma mansoni microtubule-associated protein tau 0.2918 0.4285 0.4281
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0008 0.0007
Mycobacterium leprae Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) 0.0151 0.0186 0.173
Plasmodium falciparum topoisomerase I 0.0778 0.1114 1
Echinococcus granulosus muscleblind protein 0.0315 0.0429 0.0427
Trypanosoma cruzi DNA topoisomerase III, putative 0.0031 0.0008 0.006
Loa Loa (eye worm) acetylcholinesterase 1 0.6776 1 1
Mycobacterium ulcerans putative regultory protein 0.003 0.0007 0.0039
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0036 0.0029
Leishmania major cytochrome p450-like protein 0.0034 0.0012 0.0105
Leishmania major hypothetical protein, conserved 0.003 0.0007 0.0059
Echinococcus multilocularis muscleblind protein 1 0.0315 0.0429 0.0427
Brugia malayi Steroid receptor seven-up type 2 0.0045 0.0029 0.0029
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1536 0.2237 1
Loa Loa (eye worm) steroid hormone receptor 0.0045 0.0029 0.0029
Echinococcus multilocularis rho GTPase activating protein 20 0.0031 0.0008 0.0007
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0036 0.0029
Entamoeba histolytica hypothetical protein 0.0309 0.042 0.1878
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0034 0.0012 0.007
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0052 0.0039 0.0332
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.0031 0.0008 0.003
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0582 0.0824 0.0824
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.003 0.0007 0.0039
Brugia malayi heat shock protein 90 0.003 0.0007 0.0007
Loa Loa (eye worm) ThiF family protein 0.0035 0.0013 0.0013
Leishmania major heat shock protein 83-1 0.003 0.0007 0.0059
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.003 0.0007 0.0039
Leishmania major C-8 sterol isomerase-like protein 0.0402 0.0558 0.5003
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0034 0.0012 0.0092
Giardia lamblia Pms1-like protein 0.003 0.0007 0.0012
Trypanosoma brucei DNA topoisomerase IB, large subunit 0.0778 0.1114 1
Onchocerca volvulus 0.1145 0.1658 1
Trypanosoma cruzi DNA topoisomerase IB, large subunit, putative 0.0778 0.1114 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0085 0.0087 0.0087
Brugia malayi Flap endonuclease-1 0.0028 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0039 0.002 0.002
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0022 0.0179
Echinococcus granulosus SUMO activating enzyme subunit 1 0.0053 0.004 0.0038
Loa Loa (eye worm) inositol-1 0.0119 0.0137 0.0137
Schistosoma mansoni nuclear hormone receptor 0.0045 0.0029 0.0022
Chlamydia trachomatis DNA gyrase subunit B 0.0268 0.0359 0.7687
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.003 0.0007 0.0023
Brugia malayi Nuclear hormone receptor-like 1 0.0045 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0237 0.0312 0.0312
Loa Loa (eye worm) hypothetical protein 0.6776 1 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0076 0.0074 0.0326
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0045 0.0029 0.0029
Echinococcus multilocularis lysine specific demethylase 5A 0.006 0.005 0.0049
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0016 0.0015
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0653 0.0929 0.8335
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0045 0.0029 0.0027
Brugia malayi Glycosyl hydrolases family 31 protein 0.0166 0.0207 0.0207
Onchocerca volvulus 0.0077 0.0075 0.0452
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0061 0.0052 0.005
Brugia malayi Pre-SET motif family protein 0.0227 0.0298 0.0298
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0045 0.0029 0.0029
Mycobacterium ulcerans carboxylesterase, LipT 0.1145 0.1658 1
Leishmania major DNA polymerase kappa, putative 0.0041 0.0022 0.0197
Trypanosoma cruzi DNA topoisomerase II, putative 0.055 0.0777 0.6969
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0034 0.0012 0.007
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0031 0.0008 0.0054
Echinococcus granulosus lysosomal alpha glucosidase 0.0166 0.0207 0.0206
Echinococcus granulosus lysine specific demethylase 5A 0.0062 0.0053 0.0052
Schistosoma mansoni lamin 0.0085 0.0087 0.008
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1536 0.2237 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0045 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0045 0.0029 0.0029
Onchocerca volvulus 0.0085 0.0087 0.0524
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0106 0.0119 0.1108
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0057 0.0051
Echinococcus multilocularis DNA topoisomerase 1 0.0778 0.1114 0.1113
Echinococcus multilocularis dnaJ subfamily C 6 0.0062 0.0054 0.0053
Schistosoma mansoni hypothetical protein 0.0358 0.0492 0.0485
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0034 0.0012 0.007
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.005 0.0036 0.0029
Plasmodium vivax telomerase reverse transcriptase, putative 0.0579 0.082 0.7351
Loa Loa (eye worm) hypothetical protein 0.0039 0.002 0.002
Toxoplasma gondii heat shock protein 90, putative 0.003 0.0007 0.004
Mycobacterium ulcerans beta-lactamase 0.0076 0.0074 0.0448
Brugia malayi ThiF family protein 0.0035 0.0013 0.0013
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.003 0.0007 0.0046
Loa Loa (eye worm) hypothetical protein 0.0027 0.0002 0.0002
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.0115 0.0509
Onchocerca volvulus 0.0076 0.0074 0.0448
Schistosoma mansoni ubiquitin-activating enzyme E1b 0.0035 0.0013 0.0006
Schistosoma mansoni DNA topoisomerase II 0.0582 0.0824 0.0818
Toxoplasma gondii ThiF family protein 0.0035 0.0013 0.0098
Trichomonas vaginalis heat shock protein, putative 0.003 0.0007 0.0023
Echinococcus granulosus neuropeptide s receptor 0.0524 0.0738 0.0737
Brugia malayi ecdysteroid receptor 0.0045 0.0029 0.0029
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0039 0.0168
Mycobacterium ulcerans two component regulator - sensor kinase 0.003 0.0007 0.0039
Brugia malayi Carboxylesterase family protein 0.1145 0.1658 0.1658
Brugia malayi ImpB/MucB/SamB family protein 0.0041 0.0022 0.0022
Brugia malayi beta-lactamase 0.0076 0.0074 0.0074
Brugia malayi PAS domain containing protein 0.0103 0.0115 0.0115
Loa Loa (eye worm) heat shock protein 90 0.003 0.0007 0.0007
Plasmodium falciparum DNA gyrase subunit A 0.0125 0.0147 0.1303
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.055 0.0777 0.6967
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.6776 1 1
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.0115 0.0509
Echinococcus multilocularis dna polymerase kappa 0.0041 0.0022 0.0021
Mycobacterium ulcerans lipase LipD 0.0076 0.0074 0.0448
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0347 0.0476 0.0476
Schistosoma mansoni single-minded 0.0103 0.0115 0.0108
Wolbachia endosymbiont of Brugia malayi topoisomerase IA, TopA 0.0031 0.0008 0.0035
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.0074 0.0326
Onchocerca volvulus 0.0155 0.0191 0.1152
Giardia lamblia DNA topoisomerase III 0.0031 0.0008 0.002
Brugia malayi hypothetical protein 0.0076 0.0074 0.0074
Toxoplasma gondii DNA topoisomerase family protein 0.0031 0.0008 0.0054
Brugia malayi bHLH-PAS transcription factor 0.0077 0.0075 0.0075
Mycobacterium ulcerans cell division protein FtsZ 0.0331 0.0452 0.2725
Schistosoma mansoni gliotactin 0.1145 0.1658 0.1652
Echinococcus multilocularis transfer RNA-Lys 0.0077 0.0075 0.0074
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0309 0.042 0.1878
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0034 0.0012 0.007
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0119 0.0137 0.0608
Trichomonas vaginalis CAMK family protein kinase 0.0052 0.0038 0.0164
Echinococcus multilocularis acetylcholinesterase 0.6776 1 1
Schistosoma mansoni intermediate filament proteins 0.0085 0.0087 0.008
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0016 0.0072
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0016 0.0016
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.003 0.0007 0.004
Echinococcus granulosus mitogen activated protein kinase 0.0052 0.0039 0.0038
Loa Loa (eye worm) hypothetical protein 0.008 0.008 0.008
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.075 0.1073 1
Plasmodium vivax ubiquitin activating enzyme, putative 0.0053 0.004 0.0338
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.003 0.0007 0.0039
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0119 0.0137 0.0608
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0045 0.0029 0.0029
Echinococcus granulosus microtubule associated protein 2 0.2918 0.4285 0.4284
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0582 0.0824 0.0824
Echinococcus multilocularis geminin 0.0358 0.0492 0.049
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0016 0.0066
Echinococcus granulosus sumo-activating enzyme subunit 2 0.0035 0.0013 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0045 0.0029 0.0029
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0057 0.0051
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0526 0.0741 0.0741
Onchocerca volvulus 0.1145 0.1658 1
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.003 0.0007 0.0039
Onchocerca volvulus 0.0085 0.0087 0.0524
Brugia malayi nuclear receptor NHR-88 0.0045 0.0029 0.0029
Trichomonas vaginalis inositol monophosphatase, putative 0.0119 0.0137 0.0608
Schistosoma mansoni inositol monophosphatase 0.0119 0.0137 0.0131
Schistosoma mansoni terminal deoxycytidyl transferase 0.0041 0.0022 0.0015
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1536 0.2237 1
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0034 0.0012 0.007
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0034 0.0012 0.007
Trypanosoma cruzi heat shock protein 90, putative 0.003 0.0007 0.0046
Mycobacterium ulcerans hypothetical protein 0.0076 0.0074 0.0448
Schistosoma mansoni hypothetical protein 0.0034 0.0012 0.0005
Brugia malayi Cell division protein ftsZ 0.0159 0.0197 0.0197
Trichomonas vaginalis DNA polymerase eta, putative 0.0041 0.0022 0.0092
Loa Loa (eye worm) hypothetical protein 0.0045 0.0029 0.0029
Plasmodium vivax topoisomerase I, putative 0.0778 0.1114 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0053 0.0053
Entamoeba histolytica hypothetical protein 0.0039 0.002 0.0089
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.003 0.0007 0.0039
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0119 0.0137 0.1232
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0028 0.0003 0.0011
Loa Loa (eye worm) hypothetical protein 0.0315 0.0429 0.0429
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0022 0.0179
Brugia malayi DNA topoisomerase I 0.0778 0.1114 0.1114
Trypanosoma brucei ubiquitin-activating enzyme E1, putative 0.0035 0.0013 0.0098
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.003 0.0007 0.0061
Mycobacterium tuberculosis Conserved protein 0.0076 0.0074 0.0448
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.003 0.0007 0.0023
Echinococcus granulosus inositol monophosphatase 1 0.0119 0.0137 0.0136
Echinococcus multilocularis conserved hypothetical protein 0.0754 0.1079 0.1077
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0076 0.0074 0.0074
Trypanosoma cruzi polo-like protein kinase, putative 0.0104 0.0115 0.1022
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0016 0.0066
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0039 0.0168
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0053 0.004 0.0033
Echinococcus multilocularis lamin 0.0085 0.0087 0.0085
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0653 0.0929 0.8335
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0028 0.0003 0.0011
Echinococcus granulosus family S9 non peptidase ue S09 family 0.1145 0.1658 0.1657
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0057 0.0056
Brugia malayi hypothetical protein 0.1145 0.1658 0.1658
Plasmodium falciparum heat shock protein 90 0.003 0.0007 0.004
Echinococcus granulosus hypothetical protein 0.0776 0.1111 0.1109
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.003 0.0007 0.0046
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.003 0.0007 0.0005
Echinococcus granulosus intermediate filament protein 0.0085 0.0087 0.0085
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0034 0.0012 0.007
Echinococcus multilocularis heat shock protein 0.003 0.0007 0.0005
Onchocerca volvulus 0.0045 0.0029 0.0173
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0041 0.0022 0.0092
Echinococcus multilocularis lamin dm0 0.0085 0.0087 0.0085
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0039 0.0033
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.0042 0.0042
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.0074 0.0654
Mycobacterium ulcerans esterase/lipase LipP 0.0076 0.0074 0.0448
Schistosoma mansoni P2X receptor subunit 0.0067 0.0061 0.0054
Loa Loa (eye worm) hypothetical protein 0.0402 0.0558 0.0558
Trichomonas vaginalis hypothetical protein 0.0037 0.0016 0.0067
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0016 0.0132
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.1145 0.1658 1
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.0074 0.0654
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0045 0.0029 0.0027
Leishmania major hypothetical protein, conserved 0.0027 0.0002 0.0019
Loa Loa (eye worm) cytochrome P450 family protein 0.008 0.008 0.008
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0034 0.0012 0.007
Schistosoma mansoni bromodomain containing protein 0.0064 0.0057 0.0051
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0022 0.0179
Brugia malayi hypothetical protein 0.0027 0.0002 0.0002
Schistosoma mansoni DNA topoisomerase type I 0.0778 0.1114 0.1109
Treponema pallidum DNA gyrase, subunit A (gyrA) 0.0125 0.0147 0.063
Mycobacterium tuberculosis Cell division protein FtsZ 0.0331 0.0452 0.2725
Echinococcus granulosus survival motor neuron protein 1 0.0759 0.1086 0.1085
Leishmania major mitochondrial DNA topoisomerase II 0.0653 0.0929 0.8337
Echinococcus multilocularis FTZ F1 alpha 0.0045 0.0029 0.0027
Mycobacterium tuberculosis Conserved protein 0.0076 0.0074 0.0448
Mycobacterium leprae Probable DNA topoisomerase I TopA (omega-protein) (relaxing enzyme) (untwisting enzyme) (swivelase) (type I DNA topoisomerase) ( 0.0031 0.0008 0.0076
Plasmodium falciparum SUMO-activating enzyme subunit 1 0.0053 0.004 0.0338
Schistosoma mansoni inositol monophosphatase 0.0119 0.0137 0.0131
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0045 0.0029 0.0027
Loa Loa (eye worm) hypothetical protein 0.0037 0.0017 0.0017
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0028 0.0004 0.0034
Trypanosoma cruzi hypothetical protein 0.0073 0.0069 0.0608
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0034 0.0012 0.0086
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.1145 0.1658 0.1652
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0022 0.0179
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0119 0.0137 0.122
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0022 0.0179
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0331 0.0452 0.9726
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0034 0.0012 0.007
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0582 0.0824 0.0822
Trypanosoma cruzi DNA polymerase eta, putative 0.0041 0.0022 0.0184
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0073 0.0069 0.0069
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0028 0.0004 0.0015
Echinococcus multilocularis mitogen activated protein kinase 0.0052 0.0039 0.0038
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1536 0.2237 1
Plasmodium vivax DNA gyrase subunit A, putative 0.0125 0.0147 0.1303
Leishmania major heat shock protein 83-1 0.003 0.0007 0.0059
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0016 0.0066
Echinococcus granulosus neuroligin 0.1145 0.1658 0.1657
Leishmania major heat shock protein 83-1 0.003 0.0007 0.0059
Loa Loa (eye worm) hypothetical protein 0.0134 0.016 0.016
Trypanosoma cruzi ubiquitin-activating enzyme, putative 0.0035 0.0013 0.0104
Schistosoma mansoni alpha-glucosidase 0.0143 0.0173 0.0167
Trichomonas vaginalis heat shock protein, putative 0.003 0.0007 0.0023
Trypanosoma cruzi heat shock protein 90, putative 0.003 0.0007 0.0046
Schistosoma mansoni glutaminase 0.0296 0.04 0.0394
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0045 0.0029 0.0029
Echinococcus granulosus lamin 0.0085 0.0087 0.0085
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0076 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0039 0.002 0.002
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0045 0.0029 0.0029
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.003 0.0007 0.0039
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0402 0.0558 0.4997
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0002 0.0006
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.1145 0.1658 0.1652
Echinococcus multilocularis musashi 0.0085 0.0087 0.0085
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0028 0.0004 0.0015
Brugia malayi DNA topoisomerase III 0.0031 0.0008 0.0008
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0022 0.0132
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0076 0.0074 0.0073
Echinococcus multilocularis inositol monophosphatase 1 0.0119 0.0137 0.0136
Leishmania major heat shock protein 83-1 0.003 0.0007 0.0059
Brugia malayi jmjC domain containing protein 0.0062 0.0053 0.0053
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0016 0.0066
Echinococcus multilocularis muscleblind protein 0.0315 0.0429 0.0427
Echinococcus multilocularis neuroligin 0.1145 0.1658 0.1657
Mycobacterium tuberculosis DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0125 0.0147 0.0887
Loa Loa (eye worm) carboxylesterase 0.6776 1 1
Schistosoma mansoni thyroid hormone receptor 0.0045 0.0029 0.0022
Mycobacterium tuberculosis Probable hydrolase 0.0076 0.0074 0.0448
Onchocerca volvulus 0.0031 0.0008 0.0049
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0034 0.0012 0.007
Trypanosoma cruzi DNA topoisomerase III, putative 0.0031 0.0008 0.006
Loa Loa (eye worm) cytochrome P450 family protein 0.0034 0.0012 0.0012
Echinococcus granulosus p2X purinoceptor 4 0.0067 0.0061 0.0059
Loa Loa (eye worm) carboxylesterase 0.1145 0.1658 0.1658
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.008 0.008 0.048
Loa Loa (eye worm) hypothetical protein 0.0041 0.0022 0.0022
Echinococcus granulosus dna polymerase kappa 0.0041 0.0022 0.0021
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0016 0.0014
Loa Loa (eye worm) CYP4Cod1 0.008 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0041 0.0023 0.0023
Trypanosoma brucei unspecified product 0.0041 0.0022 0.0179
Toxoplasma gondii cytochrome p450 superfamily protein 0.0034 0.0012 0.0086
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0003 0.001
Giardia lamblia Heat shock protein HSP 90-alpha 0.003 0.0007 0.0012
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0076 0.0074 0.0073
Brugia malayi kinase, mitochondrial precursor 0.003 0.0007 0.0007
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.0115 0.0509
Trichomonas vaginalis DNA topoisomerase II, putative 0.0582 0.0824 0.3679
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0034 0.0012 0.007
Echinococcus granulosus single minded 2 0.0077 0.0075 0.0074
Trypanosoma brucei DNA topoisomerase III, putative 0.0031 0.0008 0.0054
Loa Loa (eye worm) hypothetical protein 0.0076 0.0074 0.0074
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0393 0.0544 0.3283
Schistosoma mansoni tsg101-related 0.0052 0.0038 0.0032
Schistosoma mansoni hypothetical protein 0.0358 0.0492 0.0485
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0016 0.0066
Trichomonas vaginalis flap endonuclease-1, putative 0.0028 0.0004 0.001
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0034 0.0012 0.007
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0041 0.0022 0.0021
Loa Loa (eye worm) hypothetical protein 0.0076 0.0074 0.0074
Trichomonas vaginalis sensor histidine kinase, putative 0.003 0.0007 0.0023
Loa Loa (eye worm) hypothetical protein 0.003 0.0007 0.0007
Onchocerca volvulus Serine\/threonine kinase homolog 0.0104 0.0115 0.0695
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0057 0.0057
Schistosoma mansoni P2X receptor subunit 0.0067 0.0061 0.0054
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0022 0.0179
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.003 0.0007 0.0039
Brugia malayi intermediate filament protein 0.0085 0.0087 0.0087
Brugia malayi ImpB/MucB/SamB family protein 0.0041 0.0022 0.0022
Trypanosoma brucei DNA topoisomerase III, putative 0.0031 0.0008 0.0054
Schistosoma mansoni DNA polymerase eta 0.0041 0.0022 0.0015
Brugia malayi beta-lactamase family protein 0.0076 0.0074 0.0074
Leishmania major DNA topoisomerase III, putative 0.0031 0.0008 0.0073
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.001 0.0003
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0016 0.0066
Loa Loa (eye worm) hypothetical protein 0.0315 0.0429 0.0429
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.003 0.0007 0.0039
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0104 0.0115 0.1034
Entamoeba histolytica heat shock protein 90, putative 0.003 0.0007 0.0029
Trichomonas vaginalis endoplasmin, putative 0.003 0.0007 0.0023
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0486 0.0681 0.4108
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.003 0.0007 0.0039
Brugia malayi ThiF family protein 0.0053 0.004 0.004
Trypanosoma brucei DNA topoisomerase II beta, putative 0.055 0.0777 0.6967
Giardia lamblia Kinase, PLK 0.0104 0.0115 0.0499
Trichomonas vaginalis spcc417.12 protein, putative 0.1145 0.1658 0.741
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0016 0.0126
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0041 0.0022 0.0021
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.003 0.0007 0.0061
Brugia malayi Carboxylesterase family protein 0.1145 0.1658 0.1658
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0119 0.0137 0.0828
Leishmania major heat shock protein 83-1 0.003 0.0007 0.0059
Brugia malayi nuclear hormone receptor 0.0045 0.0029 0.0029
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0057 0.0051
Onchocerca volvulus 0.0076 0.0074 0.0448
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.0115 0.0509
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.003 0.0007 0.0039
Plasmodium vivax hypothetical protein, conserved 0.003 0.0007 0.004
Trypanosoma cruzi ubiquitin-activating enzyme, putative 0.003 0.0006 0.0039
Trypanosoma brucei unspecified product 0.0028 0.0003 0.001
Mycobacterium leprae Probable two-component sensor kinase 0.003 0.0007 0.0061
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0054 0.0042 0.0042
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0045 0.0029 0.0029
Wolbachia endosymbiont of Brugia malayi DNA gyrase subunit A 0.0125 0.0147 0.3069
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0339 0.0464 0.2053
Leishmania major DNA polymerase eta, putative 0.0041 0.0022 0.0197
Echinococcus multilocularis 0.0034 0.0012 0.001
Schistosoma mansoni hypothetical protein 0.0155 0.0191 0.0185
Mycobacterium tuberculosis Possible two component sensor kinase 0.003 0.0007 0.0039
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0119 0.0137 0.2856
Toxoplasma gondii heat shock protein HSP90 0.003 0.0007 0.004
Echinococcus multilocularis beta LACTamase domain containing family member 0.0076 0.0074 0.0073
Schistosoma mansoni lamin 0.0085 0.0087 0.008
Loa Loa (eye worm) hypothetical protein 0.0083 0.0085 0.0085
Loa Loa (eye worm) hypoxia-induced factor 1 0.032 0.0436 0.0436
Schistosoma mansoni serine/threonine protein kinase 0.0104 0.0115 0.0109
Loa Loa (eye worm) hypothetical protein 0.0045 0.0029 0.0029
Treponema pallidum fructose-bisphosphate aldolase 0.1536 0.2237 1
Schistosoma mansoni tsg101-related 0.0063 0.0055 0.0049
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0076 0.0074 0.0448
Trypanosoma brucei unspecified product 0.0028 0.0003 0.001
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0076 0.0074 0.0448
Trypanosoma brucei developmentally regulated phosphoprotein 0.003 0.0007 0.004
Schistosoma mansoni hypothetical protein 0.0039 0.002 0.0013
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0034 0.0012 0.007
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.1145 0.1658 0.741
Brugia malayi photoreceptor-specific nuclear receptor 0.0045 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0076 0.0074 0.0074
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0034 0.0012 0.007
Echinococcus granulosus geminin 0.0358 0.0492 0.049
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0052 0.0039 0.035
Echinococcus multilocularis microtubule associated protein 2 0.2918 0.4285 0.4284
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0034 0.0012 0.007
Schistosoma mansoni alpha glucosidase 0.0037 0.0016 0.001
Mycobacterium tuberculosis Probable lipase LipD 0.0076 0.0074 0.0448
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0041 0.0022 0.0021
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0036 0.0034
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0045 0.0029 0.0029
Toxoplasma gondii DNA topoisomerase 2, putative 0.0582 0.0824 0.7386
Loa Loa (eye worm) hypothetical protein 0.1145 0.1658 0.1658
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0034 0.0012 0.007
Echinococcus multilocularis heat shock protein 90 0.003 0.0007 0.0005
Loa Loa (eye worm) intermediate filament protein 0.0085 0.0087 0.0087
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.003 0.0007 0.004
Trypanosoma cruzi cytochrome P450, putative 0.008 0.008 0.0702
Schistosoma mansoni aryl hydrocarbon receptor 0.0103 0.0115 0.0108
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0028 0.0003 0.0011
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0104 0.0115 0.0114
Schistosoma mansoni DNA topoisomerase type I 0.0778 0.1114 0.1109
Brugia malayi Probable DNA topoisomerase II 0.0582 0.0824 0.0824
Echinococcus multilocularis p2X purinoceptor 4 0.0067 0.0061 0.0059
Leishmania major heat shock protein 83-1 0.003 0.0007 0.0059
Trypanosoma brucei polo-like protein kinase 0.0104 0.0115 0.1017
Loa Loa (eye worm) carboxylesterase 0.1145 0.1658 0.1658
Mycobacterium tuberculosis Probable two component sensor kinase 0.003 0.0007 0.0039
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0339 0.0464 1
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0052 0.0039 0.0338
Brugia malayi Cell division protein ftsZ 0.0163 0.0204 0.0204
Loa Loa (eye worm) beta-lactamase 0.0076 0.0074 0.0074
Plasmodium vivax heat shock protein 86, putative 0.003 0.0007 0.004
Onchocerca volvulus Protein ultraspiracle homolog 0.0045 0.0029 0.0173
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0045 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0076 0.0074 0.0074
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.003 0.0007 0.0023
Loa Loa (eye worm) hypothetical protein 0.6776 1 1
Trichomonas vaginalis Sentrin-specific protease, putative 0.0073 0.0069 0.0303
Loa Loa (eye worm) hypothetical protein 0.0041 0.0022 0.0022
Trypanosoma brucei DNA topoisomerase ii 0.0653 0.0929 0.8334
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0034 0.0012 0.007
Leishmania major hypothetical protein, conserved 0.0076 0.0074 0.0666
Brugia malayi hypoxia-induced factor 1 0.032 0.0436 0.0436
Mycobacterium leprae cell division protein FtsZ 0.0331 0.0452 0.421
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0028 0.0003 0.0011
Plasmodium vivax flap endonuclease 1, putative 0.0028 0.0004 0.0015
Brugia malayi Bromodomain containing protein 0.0039 0.0019 0.0019
Echinococcus granulosus p2X purinoceptor 4 0.0067 0.0061 0.0059
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0039 0.0338
Giardia lamblia Telomerase catalytic subunit 0.0094 0.01 0.0432
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.003 0.0007 0.0039
Echinococcus multilocularis SUMO activating enzyme subunit 2 0.0035 0.0013 0.0012
Brugia malayi hypothetical protein 0.0347 0.0476 0.0476
Loa Loa (eye worm) TOPoisomerase family member 0.0582 0.0824 0.0824
Loa Loa (eye worm) hypothetical protein 0.0076 0.0074 0.0074
Brugia malayi TAR-binding protein 0.0065 0.0057 0.0057
Plasmodium falciparum endoplasmin, putative 0.003 0.0007 0.004
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0041 0.0022 0.0197
Brugia malayi MAP kinase sur-1 0.0052 0.0039 0.0039
Onchocerca volvulus 0.1145 0.1658 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0045 0.0029 0.0027
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0045 0.0029 0.0029
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0045 0.0029 0.0022
Leishmania major heat shock protein 83-1 0.003 0.0007 0.0059
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0034 0.0012 0.007
Echinococcus multilocularis flap endonuclease 1 0.0028 0.0004 0.0002
Giardia lamblia Kinase, CMGC MAPK 0.0052 0.0039 0.0158
Mycobacterium ulcerans DNA gyrase subunit B 0.0339 0.0464 0.2801
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0106 0.0119 0.0717
Leishmania major heat shock protein 83-1 0.003 0.0007 0.0059
Mycobacterium ulcerans DNA gyrase subunit A 0.0125 0.0147 0.0887
Trypanosoma brucei heat shock protein, putative 0.003 0.0007 0.004
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.002 0.0018
Loa Loa (eye worm) hypothetical protein 0.0076 0.0074 0.0074
Trichomonas vaginalis penicillin-binding protein, putative 0.0076 0.0074 0.0326
Echinococcus granulosus dnaJ subfamily C 6 0.0062 0.0054 0.0053
Leishmania major protein kinase, putative 0.0028 0.0003 0.0024
Loa Loa (eye worm) hypothetical protein 0.0134 0.016 0.016
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0017 0.0017
Entamoeba histolytica hypothetical protein 0.0039 0.002 0.0089
Loa Loa (eye worm) hypothetical protein 0.1145 0.1658 0.1658
Trichomonas vaginalis receptor histidine kinase, putative 0.003 0.0007 0.0023
Echinococcus granulosus mitogen activated protein kinase 3 0.0052 0.0039 0.0038
Entamoeba histolytica serine/threonine protein kinase, putative 0.0104 0.0115 0.0515
Trypanosoma cruzi DNA topoisomerase IA, putative 0.0031 0.0008 0.006
Schistosoma mansoni jumonji domain containing protein 0.006 0.005 0.0044
Trichomonas vaginalis receptor histidine kinase, putative 0.003 0.0007 0.0023
Echinococcus granulosus lamin dm0 0.0085 0.0087 0.0085
Treponema pallidum cell division protein FtsZ 0.0331 0.0452 0.1996
Mycobacterium ulcerans DNA topoisomerase I 0.0031 0.0008 0.0049
Echinococcus granulosus histone lysine methyltransferase setb 0.005 0.0036 0.0034
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0016 0.0145
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0039 0.0338
Loa Loa (eye worm) cytochrome P450 family protein 0.008 0.008 0.008
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.075 0.1073 0.6472
Giardia lamblia DNA topoisomerase II 0.0552 0.0779 0.3471
Trichomonas vaginalis esterase, putative 0.0076 0.0074 0.0326
Trypanosoma brucei heat shock protein, putative 0.003 0.0007 0.004
Echinococcus granulosus para nitrobenzyl esterase 0.1145 0.1658 0.1657
Echinococcus granulosus beta LACTamase domain containing family member 0.0076 0.0074 0.0073
Trypanosoma brucei heat shock protein, putative 0.003 0.0007 0.004
Brugia malayi beta-lactamase family protein 0.0076 0.0074 0.0074
Entamoeba histolytica deoxycytidyl transferase, putative 0.0041 0.0022 0.0098
Echinococcus granulosus neuropeptide receptor A26 0.0524 0.0738 0.0737
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0034 0.0012 0.007
Loa Loa (eye worm) hypothetical protein 0.0394 0.0545 0.0545
Loa Loa (eye worm) hypothetical protein 0.008 0.008 0.008
Mycobacterium leprae conserved hypothetical protein 0.0076 0.0074 0.0692
Echinococcus granulosus DNA topoisomerase 1 0.0778 0.1114 0.1113
Loa Loa (eye worm) Ulp1 protease 0.0073 0.0069 0.0069
Trypanosoma brucei cytochrome P450, putative 0.008 0.008 0.0696
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0402 0.0558 0.0558
Mycobacterium tuberculosis Carboxylesterase LipT 0.1145 0.1658 1
Loa Loa (eye worm) hypothetical protein 0.1145 0.1658 0.1658
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.0115 0.0509
Plasmodium falciparum telomerase reverse transcriptase 0.0579 0.082 0.7351
Loa Loa (eye worm) RNA binding protein 0.0065 0.0057 0.0057
Loa Loa (eye worm) DNA topoisomerase III 0.0031 0.0008 0.0008
Giardia lamblia DNA repair protein RAD52 0.1088 0.1573 0.7027
Loa Loa (eye worm) hypothetical protein 0.0206 0.0266 0.0266
Loa Loa (eye worm) hypothetical protein 0.0394 0.0545 0.0545
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0036 0.0034
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0034 0.0012 0.007
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0039 0.0168
Trichomonas vaginalis glutaminase, putative 0.0296 0.04 0.1785
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0166 0.0207 0.0207
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0155 0.0191 0.0191
Trypanosoma brucei heat shock protein, putative 0.003 0.0007 0.004
Loa Loa (eye worm) hypothetical protein 0.005 0.0036 0.0036
Schistosoma mansoni survival motor neuron protein 0.0155 0.0191 0.0185
Echinococcus granulosus FTZ F1 alpha 0.0045 0.0029 0.0027
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.0074 0.0326
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.1145 0.1658 1
Mycobacterium tuberculosis Conserved protein 0.0076 0.0074 0.0448
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0034 0.0012 0.007
Trypanosoma brucei heat shock protein, putative 0.003 0.0007 0.004
Brugia malayi Cytochrome P450 family protein 0.0034 0.0012 0.0012
Echinococcus granulosus ecdysone induced protein 78C 0.0045 0.0029 0.0027
Loa Loa (eye worm) endoplasmin 0.003 0.0007 0.0007
Echinococcus multilocularis ecdysone induced protein 78C 0.0045 0.0029 0.0027
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.003 0.0007 0.0039
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0036 0.0029
Mycobacterium tuberculosis Probable lipase LipE 0.0076 0.0074 0.0448
Trichomonas vaginalis set domain proteins, putative 0.0259 0.0345 0.1537
Schistosoma mansoni steroid hormone receptor ad4bp 0.0045 0.0029 0.0022
Echinococcus granulosus DNA topoisomerase 3 beta 1 0.0031 0.0008 0.0007
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.005 0.0036 0.0034
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.0094 0.01 0.0605
Trypanosoma cruzi Heat shock protein 83, putative 0.003 0.0007 0.0046
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.003 0.0007 0.0023
Leishmania major cytochrome p450-like protein 0.008 0.008 0.0714
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0028 0.0004 0.0021
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0119 0.0137 0.1215
Leishmania major DNA topoisomerase III, putative 0.0031 0.0008 0.0073
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0045 0.0029 0.0029
Schistosoma mansoni hypothetical protein 0.0062 0.0054 0.0047
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.002 0.0013
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.005 0.0036 0.0029
Schistosoma mansoni kinase 0.0053 0.004 0.0034
Onchocerca volvulus Huntingtin homolog 0.0134 0.016 0.0965
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.1536 0.2237 1
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0034 0.0012 0.007
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0016 0.0066
Plasmodium vivax SET domain protein, putative 0.0033 0.001 0.0071
Schistosoma mansoni coup transcription factor 0.0045 0.0029 0.0022
Schistosoma mansoni prokaryotic DNA topoisomerase 0.0031 0.0008 0.0002
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0041 0.0022 0.0132
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0022 0.0179
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0393 0.0544 0.3283
Giardia lamblia Fructose-bisphosphate aldolase 0.1536 0.2237 1
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0034 0.0012 0.007
Schistosoma mansoni hypothetical protein 0.0037 0.0017 0.001
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0022 0.0179
Trypanosoma brucei heat shock protein, putative 0.003 0.0007 0.004
Mycobacterium tuberculosis Two component sensor kinase MprB 0.003 0.0007 0.0039
Trypanosoma brucei telomerase reverse transcriptase 0.0094 0.01 0.0882
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0057 0.0051
Leishmania major heat shock protein 83-1 0.003 0.0007 0.0059
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0045 0.0029 0.0029
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.003 0.0007 0.0039
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0036 0.0034
Plasmodium falciparum DNA topoisomerase 2 0.0582 0.0824 0.7386
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0393 0.0544 0.3283
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0048 0.0032 0.0026
Toxoplasma gondii ABC1 family protein 0.0076 0.0074 0.0649
Leishmania major protein kinase, putative 0.0028 0.0003 0.0024
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0045 0.0029 0.0029
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.1536 0.2237 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0062 0.0053 0.0047
Loa Loa (eye worm) hypothetical protein 0.0043 0.0026 0.0026
Brugia malayi steroid hormone receptor 0.0045 0.0029 0.0029
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0045 0.0029 0.0022
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0045 0.0029 0.0029
Onchocerca volvulus 0.1145 0.1658 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0022 0.0179
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0045 0.0029 0.0022
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0022 0.0179
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0022 0.0132
Brugia malayi glutaminase DH11.1 0.0296 0.04 0.04
Schistosoma mansoni jumonji/arid domain-containing protein 0.0062 0.0053 0.0047
Echinococcus multilocularis lysosomal alpha glucosidase 0.0166 0.0207 0.0206
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0016 0.0015
Trypanosoma brucei heat shock protein, putative 0.003 0.0007 0.004
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0016 0.0016
Trypanosoma cruzi heat shock protein 85, putative 0.003 0.0007 0.0046
Echinococcus granulosus cytochrome P450 2K1 0.0034 0.0012 0.001
Mycobacterium leprae Conserved hypothetical protein 0.0034 0.0012 0.0109
Chlamydia trachomatis DNA gyrase subunit B 0.0339 0.0464 1
Loa Loa (eye worm) flap endonuclease-1 0.0028 0.0004 0.0004
Trypanosoma cruzi polo-like protein kinase, putative 0.0104 0.0115 0.1022
Leishmania major heat shock protein 83-1 0.003 0.0007 0.0059
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0057 0.0057
Plasmodium falciparum flap endonuclease 1 0.0028 0.0004 0.0015
Onchocerca volvulus 0.0027 0.0001 0.0009
Giardia lamblia DINP protein human, muc B family 0.0041 0.0022 0.0081
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0076 0.0074 0.0448
Brugia malayi Pre-SET motif family protein 0.0033 0.001 0.001
Onchocerca volvulus 0.1145 0.1658 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.002 0.0018
Echinococcus multilocularis p2X purinoceptor 4 0.0067 0.0061 0.0059
Trypanosoma brucei DNA topoisomerase IA, putative 0.0031 0.0008 0.0054
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0073 0.0069 0.0303
Loa Loa (eye worm) hypothetical protein 0.008 0.008 0.008
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0034 0.0012 0.007
Mycobacterium ulcerans glutaminase 0.0296 0.04 0.2415
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0045 0.0029 0.0022
Loa Loa (eye worm) hypothetical protein 0.0045 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0027 0.0001 0.0001
Brugia malayi Cytochrome P450 family protein 0.0034 0.0012 0.0012
Echinococcus granulosus acetylcholinesterase 0.6776 1 1
Loa Loa (eye worm) hypothetical protein 0.1145 0.1658 0.1658
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0052 0.0039 0.0332
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.006 0.005 0.0049
Schistosoma mansoni RAR-like nuclear receptor 0.0045 0.0029 0.0022
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.001 0.0003
Onchocerca volvulus 0.0096 0.0104 0.0625
Treponema pallidum DNA topoisomerase I (topA) 0.0031 0.0008 0.0007
Echinococcus multilocularis carboxylesterase 5A 0.6776 1 1
Echinococcus granulosus tar DNA binding protein 0.0065 0.0057 0.0056
Loa Loa (eye worm) hypothetical protein 0.0045 0.0029 0.0029
Onchocerca volvulus 0.0033 0.001 0.006
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0016 0.0066
Schistosoma mansoni thyroid hormone receptor 0.0045 0.0029 0.0022
Brugia malayi hypothetical protein 0.0039 0.002 0.002
Echinococcus multilocularis thyroid hormone receptor alpha 0.0045 0.0029 0.0027
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0002 0.0006
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0034 0.0012 0.007
Plasmodium falciparum SUMO-activating enzyme subunit 2 0.0035 0.0013 0.0098
Leishmania major DNA topoisomerase 1A 0.0031 0.0008 0.0073
Brugia malayi Cytochrome P450 family protein 0.008 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.1145 0.1658 0.1658
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0034 0.0012 0.0092
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0045 0.0029 0.0029
Brugia malayi Carboxylesterase family protein 0.1145 0.1658 0.1658
Echinococcus granulosus DNA topoisomerase 3 alpha 0.0031 0.0008 0.0007
Brugia malayi DnaJ domain containing protein 0.0062 0.0054 0.0054
Onchocerca volvulus 0.0259 0.0345 0.2081
Trypanosoma cruzi DNA topoisomerase III, putative 0.0031 0.0008 0.006
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0036 0.0034
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0045 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0045 0.0029 0.0029
Loa Loa (eye worm) glutaminase 0.0296 0.04 0.04
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0034 0.0012 0.007
Schistosoma mansoni tsg101-related 0.0063 0.0055 0.0049
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0034 0.0012 0.007
Loa Loa (eye worm) hypothetical protein 0.0085 0.0087 0.0087
Leishmania major heat shock protein 83-1 0.003 0.0007 0.0059
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0339 0.0464 0.4155
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0045 0.0029 0.0027
Entamoeba histolytica DNA topoisomerase III, putative 0.0031 0.0008 0.0036
Leishmania major cytochrome p450-like protein 0.0034 0.0012 0.0105
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0227 0.0298 0.0298
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0094 0.01 0.0888
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.003 0.0007 0.0005
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0039 0.0168
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.003 0.0007 0.004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0045 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0053 0.004 0.004
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0034 0.0012 0.007
Entamoeba histolytica DNA topoisomerase II, putative 0.0582 0.0824 0.3683
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0045 0.0029 0.0027
Mycobacterium leprae Probable lipase LipE 0.0076 0.0074 0.0692
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.1145 0.1658 0.1657
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0339 0.0464 0.2801
Toxoplasma gondii RNA-directed DNA polymerase 0.0094 0.01 0.0882
Echinococcus multilocularis BC026374 protein (S09 family) 0.1145 0.1658 0.1657
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0057 0.0051

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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