TDR Targets

Basic information

Technical information

TDR Targets ID: 145002
Name: 3-(5-methylhex-4-enoylamino)-N-(1,3-thiazol-2 -yl)pyridine-2-carboxamide
MW: 330.405 | Formula: C16H18N4O2S
H donors: 2 H acceptors: 4 LogP: 3.01 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Nc1cccnc1C(=O)Nc1nccs1)CCC=C(C)C
InChi: 1S/C16H18N4O2S/c1-11(2)5-3-7-13(21)19-12-6-4-8-17-14(12)15(22)20-16-18-9-10-23-16/h4-6,8-10H,3,7H2,1-2H3,(H,19,21)(H,18,20,22)
InChiKey: VYOHOVAKDQFNDT-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

3-(5-methylhex-4-enoylamino)-N-thiazol-2-yl-pyridine-2-carboxamide
3-[(5-methyl-1-oxohex-4-enyl)amino]-N-(2-thiazolyl)-2-pyridinecarboxamide
3-(5-methylhex-4-enoylamino)-N-thiazol-2-yl-picolinamide

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Saccharomyces cerevisiae	Map1p	Starlite/ChEMBL	References
Escherichia coli	methionine aminopeptidase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Candida albicans	methionine aminopeptidase	Get druggable targets OG5_126721	All targets in OG5_126721
Toxoplasma gondii	methionine aminopeptidase, type i, putative	Get druggable targets OG5_126721	All targets in OG5_126721
Echinococcus multilocularis	methionyl aminopeptidase 1 (M24 family)	Get druggable targets OG5_126721	All targets in OG5_126721
Trypanosoma brucei	metallo- peptidase, Clan MG, Family M24	Get druggable targets OG5_126721	All targets in OG5_126721
Chlamydia trachomatis	methionine aminopeptidase	Get druggable targets OG5_126721	All targets in OG5_126721
Trypanosoma cruzi	metallo- peptidase, Clan MG, Family M24	Get druggable targets OG5_126721	All targets in OG5_126721
Trypanosoma brucei gambiense	methionine aminopeptidase, putative,metallo- peptidase, Clan MG, Family M24	Get druggable targets OG5_126721	All targets in OG5_126721
Plasmodium vivax	methionine aminopeptidase 1a, putative	Get druggable targets OG5_126721	All targets in OG5_126721
Babesia bovis	methionine aminopeptidase, putative	Get druggable targets OG5_126721	All targets in OG5_126721
Leishmania infantum	methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24	Get druggable targets OG5_126721	All targets in OG5_126721
Cryptosporidium hominis	methionine aminopeptidase 1 (MetAP 1) (MAP 1) (Peptidase M 1)	Get druggable targets OG5_126721	All targets in OG5_126721
Mycobacterium tuberculosis	Methionine aminopeptidase MapA (map) (peptidase M) (MetAP)	Get druggable targets OG5_126721	All targets in OG5_126721
Echinococcus multilocularis	methionyl aminopeptidase 1 (M24 family)	Get druggable targets OG5_126721	All targets in OG5_126721
Plasmodium berghei	methionine aminopeptidase 1a, putative	Get druggable targets OG5_126721	All targets in OG5_126721
Plasmodium berghei	methionine aminopeptidase 1b, putative	Get druggable targets OG5_126721	All targets in OG5_126721
Theileria parva	methionine aminopeptidase, type I, putative	Get druggable targets OG5_126721	All targets in OG5_126721
Mycobacterium ulcerans	methionine aminopeptidase	Get druggable targets OG5_126721	All targets in OG5_126721
Neospora caninum	methionine aminopeptidase, putative	Get druggable targets OG5_126721	All targets in OG5_126721
Toxoplasma gondii	methionine aminopeptidase	Get druggable targets OG5_126721	All targets in OG5_126721
Wolbachia endosymbiont of Brugia malayi	methionine aminopeptidase	Get druggable targets OG5_126721	All targets in OG5_126721
Plasmodium knowlesi	methionine aminopeptidase 1b, putative	Get druggable targets OG5_126721	All targets in OG5_126721
Loa Loa (eye worm)	methionine aminopeptidase type I	Get druggable targets OG5_126721	All targets in OG5_126721
Leishmania major	methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24	Get druggable targets OG5_126721	All targets in OG5_126721
Trypanosoma brucei	methionine aminopeptidase, putative	Get druggable targets OG5_126721	All targets in OG5_126721
Cryptosporidium parvum	methionine aminopeptidase with MYND finger at N-terminus	Get druggable targets OG5_126721	All targets in OG5_126721
Treponema pallidum	methionine aminopeptidase (map)	Get druggable targets OG5_126721	All targets in OG5_126721
Plasmodium falciparum	methionine aminopeptidase 1a, putative	Get druggable targets OG5_126721	All targets in OG5_126721
Toxoplasma gondii	methionine aminopeptidase	Get druggable targets OG5_126721	All targets in OG5_126721
Plasmodium falciparum	methionine aminopeptidase 1b, putative	Get druggable targets OG5_126721	All targets in OG5_126721
Trypanosoma congolense	metallo- peptidase, Clan MG, Family M24	Get druggable targets OG5_126721	All targets in OG5_126721
Neospora caninum	methionine aminopeptidase, putative	Get druggable targets OG5_126721	All targets in OG5_126721
Mycobacterium tuberculosis	Methionine aminopeptidase MapB (map) (peptidase M)	Get druggable targets OG5_126721	All targets in OG5_126721
Neospora caninum	methionine aminopeptidase, putative	Get druggable targets OG5_126721	All targets in OG5_126721
Leishmania braziliensis	methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24	Get druggable targets OG5_126721	All targets in OG5_126721
Theileria parva	methionine aminopeptidase, type I, putative	Get druggable targets OG5_126721	All targets in OG5_126721
Plasmodium vivax	methionine aminopeptidase 1b, putative	Get druggable targets OG5_126721	All targets in OG5_126721
Candida albicans	methionine aminopeptidase	Get druggable targets OG5_126721	All targets in OG5_126721
Plasmodium yoelii	methionine aminopeptidase, type I, putative	Get druggable targets OG5_126721	All targets in OG5_126721
Mycobacterium leprae	PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP)	Get druggable targets OG5_126721	All targets in OG5_126721
Schistosoma japonicum	ko:K01265 methionyl aminopeptidase [EC3.4.11.18], putative	Get druggable targets OG5_126721	All targets in OG5_126721
Plasmodium knowlesi	methionine aminopeptidase 1a, putative	Get druggable targets OG5_126721	All targets in OG5_126721
Trypanosoma cruzi	metallo- peptidase, Clan MG, Family M24	Get druggable targets OG5_126721	All targets in OG5_126721
Mycobacterium leprae	PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M)	Get druggable targets OG5_126721	All targets in OG5_126721
Echinococcus granulosus	methionyl aminopeptidase 1 M24 family	Get druggable targets OG5_126721	All targets in OG5_126721
Brugia malayi	Methionine aminopeptidase protein type I	Get druggable targets OG5_126721	All targets in OG5_126721
Schistosoma japonicum	ko:K01265 methionyl aminopeptidase [EC3.4.11.18], putative	Get druggable targets OG5_126721	All targets in OG5_126721
Babesia bovis	methionine aminopeptidase, putative	Get druggable targets OG5_126721	All targets in OG5_126721
Schistosoma japonicum	Methionine aminopeptidase 1, putative	Get druggable targets OG5_126721	All targets in OG5_126721
Leishmania donovani	metallo- peptidase, Clan MG, Family M24	Get druggable targets OG5_126721	All targets in OG5_126721
Plasmodium yoelii	methionine aminopeptidase, type I	Get druggable targets OG5_126721	All targets in OG5_126721
Leishmania mexicana	methionine aminopeptidase	Get druggable targets OG5_126721	All targets in OG5_126721
Trypanosoma brucei	methionine aminopeptidase, type I, putative	Get druggable targets OG5_126721	All targets in OG5_126721
Mycobacterium ulcerans	methionine aminopeptidase MapB	Get druggable targets OG5_126721	All targets in OG5_126721
Schistosoma mansoni	methionyl aminopeptidase 1 (M24 family)	Get druggable targets OG5_126721	All targets in OG5_126721
Schistosoma mansoni	methionyl aminopeptidase 1 (M24 family)	Get druggable targets OG5_126721	All targets in OG5_126721

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Common central domain of tyrosinase family protein	0.0297	0.4215	1
Loa Loa (eye worm)	CBP-B	0.007	0.0776	0.1841
Giardia lamblia	Kinase, PLK	0.0093	0.1126	1
Mycobacterium ulcerans	methionine aminopeptidase	0.0147	0.1947	1
Echinococcus multilocularis	flap endonuclease 1	0.0026	0.0107	0.0107
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0106	0.1326	0.6809
Toxoplasma gondii	flap structure-specific endonuclease 1, putative	0.0026	0.0107	0.0383
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.0297	0.4215	1
Plasmodium vivax	hypothetical protein, conserved	0.0055	0.0555	0.1993
Trichomonas vaginalis	alpha-glucosidase, putative	0.0036	0.0257	0.2284
Schistosoma mansoni	microtubule-associated protein tau	0.068	1	1
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0118	0.1505	0.773
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0093	0.1126	0.4045
Plasmodium vivax	methionine aminopeptidase 1a, putative	0.0147	0.1947	0.6995
Trichomonas vaginalis	flap endonuclease-1, putative	0.0026	0.0107	0.0946
Schistosoma mansoni	alpha-glucosidase	0.0138	0.1808	0.1808
Trypanosoma cruzi	metallo- peptidase, Clan MG, Family M24	0.0203	0.2783	1
Schistosoma mansoni	tyrosinase precursor	0.0297	0.4215	0.4215
Mycobacterium tuberculosis	Methionine aminopeptidase MapA (map) (peptidase M) (MetAP)	0.0147	0.1947	1
Mycobacterium tuberculosis	Probable dehydrogenase	0.0106	0.1326	0.6809
Schistosoma mansoni	CREB-binding protein 1 (SmCBP1)	0.0101	0.1241	0.1241
Trichomonas vaginalis	CAMK family protein kinase	0.0093	0.1126	1
Loa Loa (eye worm)	ShTK domain-containing protein	0.0297	0.4215	1
Plasmodium vivax	methionine aminopeptidase 1b, putative	0.0203	0.2783	1
Trichomonas vaginalis	CAMK family protein kinase	0.0093	0.1126	1
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0036	0.0257	0.061
Loa Loa (eye worm)	thioredoxin reductase	0.0047	0.0423	0.1004
Brugia malayi	ShTK domain containing protein	0.0297	0.4215	1
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0036	0.0257	0.0924
Loa Loa (eye worm)	flap endonuclease-1	0.0026	0.0107	0.0253
Plasmodium falciparum	methionine aminopeptidase 1a, putative	0.0147	0.1947	0.6995
Mycobacterium ulcerans	methionine aminopeptidase MapB	0.0147	0.1947	1
Toxoplasma gondii	thioredoxin reductase	0.0047	0.0423	0.152
Echinococcus granulosus	methionyl aminopeptidase 1 M24 family	0.0203	0.2783	0.2783
Brugia malayi	Methionine aminopeptidase protein type I	0.0203	0.2783	0.6603
Plasmodium falciparum	flap endonuclease 1	0.0026	0.0107	0.0383
Echinococcus granulosus	CREB binding protein	0.0062	0.0658	0.0658
Loa Loa (eye worm)	hypothetical protein	0.0297	0.4215	1
Trypanosoma brucei	flap endonuclease-1 (FEN-1), putative	0.0026	0.0107	0.0383
Trichomonas vaginalis	alpha-glucosidase, putative	0.0036	0.0257	0.2284
Schistosoma mansoni	flap endonuclease-1	0.0023	0.0069	0.0069
Trypanosoma brucei	metallo- peptidase, Clan MG, Family M24	0.0203	0.2783	1
Mycobacterium leprae	PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP)	0.0147	0.1947	1
Schistosoma mansoni	tyrosinase precursor	0.0297	0.4215	0.4215
Loa Loa (eye worm)	ShTK domain-containing protein	0.0297	0.4215	1
Toxoplasma gondii	methionine aminopeptidase	0.0147	0.1947	0.6995
Trichomonas vaginalis	CAMK family protein kinase	0.0093	0.1126	1
Plasmodium falciparum	HP12 protein homolog, putative	0.0055	0.0555	0.1993
Brugia malayi	serine/threonine-protein kinase plk-2	0.0093	0.1126	0.2671
Trichomonas vaginalis	CAMK family protein kinase	0.0093	0.1126	1
Brugia malayi	TAZ zinc finger family protein	0.0101	0.1241	0.2945
Schistosoma mansoni	methionyl aminopeptidase 1 (M24 family)	0.0147	0.1947	0.1947
Trypanosoma brucei	hypothetical protein, conserved	0.0055	0.0555	0.1993
Echinococcus multilocularis	methionyl aminopeptidase 1 (M24 family)	0.0147	0.1947	0.1947
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0106	0.1326	0.6809
Leishmania major	flap endonuclease-1 (FEN-1), putative	0.0026	0.0107	0.0383
Loa Loa (eye worm)	glutathione reductase	0.0047	0.0423	0.1004
Trichomonas vaginalis	CAMK family protein kinase	0.0093	0.1126	1
Mycobacterium tuberculosis	Methionine aminopeptidase MapB (map) (peptidase M)	0.0147	0.1947	1
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0118	0.1505	0.773
Plasmodium vivax	flap endonuclease 1, putative	0.0026	0.0107	0.0383
Mycobacterium leprae	PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M)	0.0147	0.1947	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0257	0.0924
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0093	0.1126	0.1126
Toxoplasma gondii	hypothetical protein	0.0055	0.0555	0.1993
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0161	0.2146	0.5091
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0047	0.0423	0.2173
Mycobacterium tuberculosis	Probable reductase	0.0106	0.1326	0.6809
Schistosoma mansoni	serine/threonine protein kinase	0.0093	0.1126	0.1126
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0036	0.0257	0.061
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0433	0.1028
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0036	0.0257	0.2284
Trypanosoma cruzi	flap endonuclease-1 (FEN-1), putative	0.0026	0.0107	0.0383
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0093	0.1126	1
Trypanosoma brucei	trypanothione reductase	0.0047	0.0423	0.152
Entamoeba histolytica	Flap nuclease, putative	0.0026	0.0107	0.0946
Echinococcus multilocularis	methionyl aminopeptidase 1 (M24 family)	0.0203	0.2783	0.2783
Trypanosoma cruzi	hypothetical protein, conserved	0.0055	0.0555	0.1993
Echinococcus multilocularis	CREB binding protein	0.0069	0.0763	0.0763
Trypanosoma cruzi	trypanothione reductase, putative	0.0047	0.0423	0.152
Giardia lamblia	Flap structure-specific endonuclease	0.0026	0.0107	0.0946
Brugia malayi	Hypothetical tyrosinase-like protein F21C3.2 in chromosome I	0.0297	0.4215	1
Trypanosoma cruzi	polo-like protein kinase, putative	0.0093	0.1126	0.4045
Loa Loa (eye worm)	tyrosinase 1	0.0297	0.4215	1
Trypanosoma brucei	polo-like protein kinase	0.0093	0.1126	0.4045
Trichomonas vaginalis	alpha-glucosidase, putative	0.0036	0.0257	0.2284
Wolbachia endosymbiont of Brugia malayi	methionine aminopeptidase	0.0147	0.1947	1
Schistosoma mansoni	alpha-glucosidase	0.0138	0.1808	0.1808
Toxoplasma gondii	methionine aminopeptidase	0.0203	0.2783	1
Leishmania major	methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24	0.0203	0.2783	1
Brugia malayi	glutathione reductase	0.0047	0.0423	0.1004
Trichomonas vaginalis	CAMK family protein kinase	0.0093	0.1126	1
Trypanosoma brucei	methionine aminopeptidase, putative	0.0203	0.2783	1
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.0297	0.4215	1
Plasmodium vivax	thioredoxin reductase, putative	0.0047	0.0423	0.152
Leishmania major	hypothetical protein, conserved	0.0055	0.0555	0.1993
Mycobacterium tuberculosis	Probable oxidoreductase	0.0118	0.1505	0.773
Schistosoma mansoni	CREB-binding protein 2	0.0101	0.1241	0.1241
Echinococcus granulosus	CREB binding protein	0.0101	0.1241	0.1241
Echinococcus granulosus	neutral alpha glucosidase AB	0.0036	0.0257	0.0257
Onchocerca volvulus		0.0297	0.4215	1
Schistosoma mansoni	methionyl aminopeptidase 1 (M24 family)	0.0147	0.1947	0.1947
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.0297	0.4215	1
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0036	0.0257	0.2284
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0118	0.1505	0.773
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0093	0.1126	0.2671
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0106	0.1326	0.6809
Onchocerca volvulus		0.0093	0.1122	0.2663
Loa Loa (eye worm)	methionine aminopeptidase type I	0.0203	0.2783	0.6603
Schistosoma mansoni	alpha glucosidase	0.0036	0.0257	0.0257
Leishmania major	alpha glucosidase II subunit, putative	0.0036	0.0257	0.0924
Brugia malayi	Flap endonuclease-1	0.0026	0.0107	0.0253
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0036	0.0257	0.0257
Onchocerca volvulus		0.0297	0.4215	1
Loa Loa (eye worm)	hypothetical protein	0.0297	0.4215	1
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0161	0.2146	0.2146
Toxoplasma gondii	methionine aminopeptidase, type i, putative	0.0147	0.1947	0.6995
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0161	0.2146	0.2146
Onchocerca volvulus		0.0297	0.4215	1
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0036	0.0257	0.2284
Schistosoma mansoni	kinase	0.0047	0.0434	0.0434
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0093	0.1126	0.2671
Trichomonas vaginalis	alpha-glucosidase, putative	0.0036	0.0257	0.2284
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0257	0.0924
Trypanosoma brucei	glucosidase, putative	0.0036	0.0257	0.0924
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0106	0.1326	0.6809
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0106	0.1326	0.6809
Trypanosoma cruzi	polo-like protein kinase, putative	0.0093	0.1126	0.4045
Plasmodium falciparum	thioredoxin reductase	0.0047	0.0423	0.152
Plasmodium vivax	glutathione reductase, putative	0.0047	0.0423	0.152
Echinococcus granulosus	flap endonuclease 1	0.0026	0.0107	0.0107
Leishmania major	trypanothione reductase	0.0047	0.0423	0.152
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0161	0.2146	0.5091
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0093	0.1126	0.1126
Trichomonas vaginalis	CAMK family protein kinase	0.0093	0.1126	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0055	0.0555	0.1993
Trypanosoma cruzi	metallo- peptidase, Clan MG, Family M24	0.0203	0.2783	1
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0036	0.0257	0.2284
Echinococcus multilocularis	microtubule associated protein 2	0.068	1	1
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0047	0.0423	0.0423
Onchocerca volvulus		0.0297	0.4215	1
Echinococcus granulosus	lysosomal alpha glucosidase	0.0161	0.2146	0.2146
Plasmodium falciparum	glutathione reductase	0.0047	0.0423	0.152
Chlamydia trachomatis	methionine aminopeptidase	0.0147	0.1947	1
Trichomonas vaginalis	CAMK family protein kinase	0.0046	0.0415	0.3688
Trichomonas vaginalis	alpha-glucosidase, putative	0.0036	0.0257	0.2284
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0036	0.0257	0.2284
Echinococcus granulosus	thioredoxin glutathione reductase	0.0047	0.0423	0.0423
Trichomonas vaginalis	CAMK family protein kinase	0.0046	0.0415	0.3688
Brugia malayi	Thioredoxin reductase	0.0047	0.0423	0.1004
Plasmodium falciparum	methionine aminopeptidase 1b, putative	0.0203	0.2783	1
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0036	0.0257	0.2284
Treponema pallidum	methionine aminopeptidase (map)	0.0147	0.1947	1
Trypanosoma brucei	methionine aminopeptidase, type I, putative	0.0203	0.2783	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.31 uM	Inhibitory activity against type I methionine aminopeptidase from Saccharomyces cerevisiae	ChEMBL.	12801227
IC50 (binding)	= 0.31 uM	Inhibitory concentration against Methionine aminopeptidase-1 (ScMetAP1)	ChEMBL.	15664829
IC50 (binding)	= 0.31 uM	Inhibitory activity against type I methionine aminopeptidase from Saccharomyces cerevisiae	ChEMBL.	12801227
IC50 (binding)	= 0.61 uM	Inhibitory activity against Methionine aminopeptidase 1 from Escherichia coli	ChEMBL.	12801227
IC50 (binding)	= 0.61 uM	Inhibitory concentration against Methionine aminopeptidase-1 (EcMetAP1)	ChEMBL.	15664829
IC50 (binding)	= 0.61 uM	Inhibitory activity against Methionine aminopeptidase 1 from Escherichia coli	ChEMBL.	12801227
Ratio (binding)	= 2	Selectivity of inhibitory activity of Methionine aminopeptidase 1 from Escherichia coli to Methionine aminopeptidase 1 from Saccharomyces cerevisiae	ChEMBL.	12801227

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL89612
PubChem: 10882088

Bibliographic References

2 literature references were collected for this gene.

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Detailed information for compound 145002