Detailed information for compound 1450068

Basic information

Technical information
  • TDR Targets ID: 1450068
  • Name: [(amino-phenylmethylidene)amino] 4-(phenoxy)b utanoate
  • MW: 298.336 | Formula: C17H18N2O3
  • H donors: 1 H acceptors: 1 LogP: 3.33 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(ONC(=N)c1ccccc1)CCCOc1ccccc1
  • InChi: 1S/C17H18N2O3/c18-17(14-8-3-1-4-9-14)19-22-16(20)12-7-13-21-15-10-5-2-6-11-15/h1-6,8-11H,7,12-13H2,(H2,18,19)
  • InChiKey: MKNLBAAYTVOHKM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [(amino-phenyl-methylene)amino] 4-(phenoxy)butanoate
  • 4-(phenoxy)butanoic acid [(amino-phenylmethylene)amino] ester
  • 4-(phenoxy)butyric acid [(amino-phenyl-methylene)amino] ester
  • [(amino-phenyl-methylidene)amino] 4-(phenoxy)butanoate
  • MLS000579459
  • N'-[(4-phenoxybutanoyl)oxy]benzenecarboximidamide
  • SMR000198893

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens tyrosyl-DNA phosphodiesterase 1 Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania major tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma brucei gambiense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania infantum tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_129037 All targets in OG5_129037
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus granulosus transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania donovani tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus multilocularis transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma japonicum ko:K01113 phosphodiesterase/alkaline phosphatase D [EC3.1.4.1], putative Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania mexicana tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma mansoni tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma congolense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Cryptosporidium parvum tyrosyl-DNA phodphodiesterase 1 (tdp1) Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania braziliensis tyrosyl-DNA phosphodiesterase, putative;with=GeneDB:LinJ33_V3.3210 Get druggable targets OG5_129037 All targets in OG5_129037
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0027 0.009 0.1934
Loa Loa (eye worm) hypothetical protein 0.003 0.0116 0.0344
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0257 0.0708
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0027 0.0045
Loa Loa (eye worm) hypothetical protein 0.0192 0.1456 0.4317
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.0116 0.0118
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0257 0.0971
Schistosoma mansoni apoferritin-2 0.0027 0.009 0.0091
Schistosoma mansoni zinc finger protein 0.0016 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0013
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0035 0.0159 0.0581
Echinococcus granulosus histone acetyltransferase myst3 0.0016 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.0035 0.0159 0.0471
Toxoplasma gondii selenide, water dikinase 0.0017 0.0013 0.0061
Toxoplasma gondii hypothetical protein 0.0098 0.0681 0.4662
Brugia malayi Bromodomain containing protein 0.0456 0.3623 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0431 0.3422 0.8958
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.0004 0.0005
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0066 0.041 0.2792
Schistosoma mansoni apoferritin-2 0.0027 0.009 0.0091
Brugia malayi glutamate synthase 0.0017 0.0013 0.0037
Brugia malayi PHD-finger family protein 0.0016 0.0004 0.0012
Onchocerca volvulus 0.0017 0.0013 0.0061
Plasmodium vivax glutathione reductase, putative 0.0189 0.1427 0.9806
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0047 0.0257 0.0971
Brugia malayi CXXC zinc finger family protein 0.0085 0.0569 0.1571
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0192 0.1456 0.4017
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0028 0.0104
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.2303 1
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.008 0.0527 0.1562
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0431 0.3422 0.3414
Brugia malayi Steroid receptor seven-up type 2 0.003 0.0116 0.032
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0017 0.0013 0.0018
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0027 0.009 0.0077
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.0116 0.0118
Onchocerca volvulus 0.0192 0.1456 1
Onchocerca volvulus 0.0192 0.1456 1
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0016 0.0004 0.0005
Brugia malayi PHD-finger family protein 0.0016 0.0004 0.0012
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0257 0.0971
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0027 0.0058
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0017 0.0013 0.0018
Plasmodium falciparum thioredoxin reductase 0.0066 0.041 0.2848
Schistosoma mansoni jumonji/arid domain-containing protein 0.0016 0.0004 0.0005
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0192 0.1456 0.5757
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.0004 0.0005
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0066 0.041 1
Trypanosoma cruzi ISWI complex protein 0.0092 0.0627 0.1273
Trypanosoma cruzi trypanothione reductase, putative 0.0189 0.1427 0.2907
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.0116 0.0118
Trypanosoma cruzi NADH dehydrogenase, putative 0.0017 0.0013 0.0018
Brugia malayi PHD-finger family protein 0.0016 0.0004 0.0012
Mycobacterium ulcerans hypothetical protein 0.0047 0.0257 0.0971
Brugia malayi TAR-binding protein 0.0077 0.0504 0.1392
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.2303 1
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.0116 0.0769
Brugia malayi Hypothetical C28H8.9 in chromosome III 0.0016 0.0004 0.0012
Schistosoma mansoni ferritin 0.0027 0.009 0.0091
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0027 0.009 0.0077
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.2303 1
Schistosoma mansoni myst histone acetyltransferase 0.0016 0.0004 0.0005
Brugia malayi PHD-finger family protein 0.0155 0.1143 0.3155
Loa Loa (eye worm) hypothetical protein 0.003 0.0116 0.0344
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0027 0.0079
Schistosoma mansoni hypothetical protein 0.1209 0.983 1
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0017 0.0013 0.0038
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0066 0.041 0.0811
Mycobacterium ulcerans lipase LipD 0.0192 0.1456 0.5757
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0013
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0026 0.0086 0.0088
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0017 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0013
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0027 0.0045
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0017 0.0013 0.0061
Echinococcus multilocularis glutamate synthase 0.0017 0.0013 0.0013
Schistosoma mansoni myst-related protein 0.0021 0.0047 0.0048
Mycobacterium tuberculosis Probable dehydrogenase 0.0431 0.3422 0.3414
Loa Loa (eye worm) beta-lactamase 0.0192 0.1456 0.4317
Schistosoma mansoni ferritin 0.0027 0.009 0.0091
Loa Loa (eye worm) hypothetical protein 0.0192 0.1456 0.4317
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0027 0.0045
Loa Loa (eye worm) hypothetical protein 0.0261 0.2021 0.5995
Loa Loa (eye worm) hypothetical protein 0.0047 0.0257 0.0761
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0028 0.0104
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0028 0.0104
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.0116 0.032
Schistosoma mansoni hypothetical protein 0.0016 0.0004 0.0005
Schistosoma mansoni ferritin light chain 0.0027 0.009 0.0091
Echinococcus granulosus uro adherence factor A 0.0016 0.0004 0.0005
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0028 0.0104
Echinococcus multilocularis Zinc finger, DBF type 0.0016 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.0192 0.1456 0.4317
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0028 0.0104
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.0116 0.0344
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0144 0.1059 0.2747
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0364 0.2866 0.2915
Echinococcus granulosus histone acetyltransferase myst4 0.0016 0.0004 0.0005
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0066 0.041 0.0417
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0027 0.0073
Schistosoma mansoni phd finger protein 0.0016 0.0004 0.0005
Mycobacterium tuberculosis Probable oxidoreductase 0.0479 0.3819 0.3811
Schistosoma mansoni phd finger protein 0.0016 0.0004 0.0005
Loa Loa (eye worm) histone methyltransferase 0.0026 0.0086 0.0256
Toxoplasma gondii ABC1 family protein 0.0192 0.1456 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0027 0.0155
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0017 0.0013 0.0013
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.0116 0.0344
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0066 0.041 0.0417
Onchocerca volvulus 0.003 0.0116 0.0769
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0066 0.041 0.2848
Schistosoma mansoni glutamate synthase 0.0017 0.0013 0.0013
Toxoplasma gondii thioredoxin reductase 0.0189 0.1427 0.9805
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0017 0.0013 0.0013
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.0116 0.032
Trichomonas vaginalis penicillin-binding protein, putative 0.0192 0.1456 0.6313
Echinococcus granulosus fetal alzheimer antigen falz 0.014 0.1026 0.1044
Loa Loa (eye worm) thioredoxin reductase 0.0189 0.1427 0.4234
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0066 0.041 0.0828
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0066 0.041 0.0397
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0192 0.1456 0.1444
Echinococcus granulosus tar DNA binding protein 0.0077 0.0504 0.0513
Schistosoma mansoni hypothetical protein 0.0124 0.0892 0.0907
Echinococcus granulosus TAF3 RNA polymerase II TATA box binding protein 0.0016 0.0004 0.0005
Echinococcus granulosus glutamate synthase 0.0017 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0013
Echinococcus multilocularis beta LACTamase domain containing family member 0.0192 0.1456 0.1481
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.0116 0.032
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0431 0.3422 0.3414
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0066 0.041 0.0828
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0066 0.041 0.0828
Trypanosoma brucei mitochondrial DNA polymerase beta 0.061 0.4898 1
Loa Loa (eye worm) hypothetical protein 0.0192 0.1456 0.4317
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0216 0.1649 0.1678
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0364 0.2866 0.2915
Onchocerca volvulus 0.0085 0.0569 0.3892
Echinococcus multilocularis remodeling and spacing factor 1 0.0016 0.0004 0.0005
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0017 0.0013 0.0018
Brugia malayi beta-lactamase family protein 0.0192 0.1456 0.4017
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.008 0.0527 0.1051
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0017 0.0013 0.0061
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0479 0.3819 1
Schistosoma mansoni sulfide quinone reductase 0.0017 0.0013 0.0013
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0527 0.1067
Trypanosoma cruzi hypothetical protein, conserved 0.0192 0.1456 0.2965
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0017 0.0013 0.0037
Schistosoma mansoni zinc finger protein 0.0123 0.0879 0.0894
Onchocerca volvulus 0.0192 0.1456 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0192 0.1456 0.1481
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0192 0.1456 0.1444
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.0116 0.032
Schistosoma mansoni fyve-containing 0.0016 0.0004 0.0005
Schistosoma mansoni SET domain protein 0.0018 0.002 0.002
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0066 0.041 0.0828
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0027 0.0096
Mycobacterium ulcerans esterase/lipase LipP 0.0192 0.1456 0.5757
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.008 0.0527 0.1453
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0017 0.0013 0.0018
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0017 0.0013 0.0038
Echinococcus multilocularis dnaJ subfamily B 0.1209 0.983 1
Brugia malayi RNA binding protein 0.0077 0.0504 0.1392
Echinococcus granulosus FTZ F1 alpha 0.003 0.0116 0.0118
Plasmodium vivax hypothetical protein, conserved 0.0016 0.0004 0.0013
Loa Loa (eye worm) PHD-finger family protein 0.0016 0.0004 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.0116 0.032
Schistosoma mansoni tar DNA-binding protein 0.0077 0.0504 0.0513
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0028 0.0104
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0016 0.0004 0.0005
Brugia malayi glutathione reductase 0.0189 0.1427 0.3939
Schistosoma mansoni tar DNA-binding protein 0.0077 0.0504 0.0513
Treponema pallidum fructose-bisphosphate aldolase 0.0295 0.2303 1
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0017 0.0013 0.0018
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0143 0.013
Trichomonas vaginalis glutathione reductase, putative 0.0066 0.041 0.1763
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0077 0.0504 0.1496
Brugia malayi Muscleblind-like protein 0.0306 0.239 0.6596
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0027 0.0053
Loa Loa (eye worm) hypothetical protein 0.0035 0.0159 0.0471
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0017 0.0013 0.0038
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0017 0.0013 0.0038
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0104 0.073 0.0742
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0021 0.0044 0.0044
Echinococcus multilocularis thioredoxin glutathione reductase 0.0192 0.1448 0.1473
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0028 0.0104
Loa Loa (eye worm) glutathione reductase 0.0189 0.1427 0.4234
Plasmodium falciparum ferrodoxin reductase-like protein 0.0017 0.0013 0.0062
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0257 0.0498
Schistosoma mansoni thyroid hormone receptor 0.003 0.0116 0.0118
Plasmodium falciparum thioredoxin reductase 0.0189 0.1427 1
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0144 0.1059 0.1047
Plasmodium vivax ferrodoxin reductase, putative 0.0017 0.0013 0.0074
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0017 0.0013 0.0062
Loa Loa (eye worm) hypothetical protein 0.0306 0.239 0.7088
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0116 0.032
Echinococcus granulosus dnaJ subfamily B 0.1209 0.983 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0066 0.041 0.0811
Schistosoma mansoni mixed-lineage leukemia protein mll 0.018 0.1353 0.1377
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0047 0.0257 0.0971
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0116 0.0118
Schistosoma mansoni requim req/dpf2 0.0016 0.0004 0.0005
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0028 0.0104
Onchocerca volvulus 0.0047 0.0257 0.1738
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.0116 0.0118
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0066 0.041 0.0828
Loa Loa (eye worm) hypothetical protein 0.003 0.0116 0.0344
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0116 0.0118
Schistosoma mansoni methyl-cpg binding protein mbd 0.0103 0.0714 0.0727
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0257 0.0708
Loa Loa (eye worm) hypothetical protein 0.003 0.0116 0.0344
Plasmodium falciparum glutathione reductase 0.0066 0.041 0.2848
Schistosoma mansoni hypothetical protein 0.0092 0.0627 0.0638
Loa Loa (eye worm) hypothetical protein 0.0231 0.177 0.5249
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.0116 0.0118
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0527 0.1067
Loa Loa (eye worm) hypothetical protein 0.0031 0.0122 0.0361
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0017 0.0013 0.0074
Leishmania major mitochondrial DNA polymerase beta 0.061 0.4898 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0066 0.041 0.2848
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.0116 0.032
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0017 0.0013 0.0018
Trypanosoma brucei hypothetical protein, conserved 0.0192 0.1456 0.2965
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0028 0.0104
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0021 0.0044 0.0044
Trichomonas vaginalis apoptosis inducing factor, putative 0.0017 0.0013 0.0038
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0017 0.0013 0.0038
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0431 0.3422 0.3414
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0192 0.1456 0.4317
Echinococcus granulosus methyl CpG binding domain protein 2 0.0103 0.0714 0.0727
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0066 0.041 0.0811
Toxoplasma gondii histone lysine methyltransferase SET1 0.0175 0.1312 0.9011
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0289 0.225 0.4578
Loa Loa (eye worm) hypothetical protein 0.0035 0.0159 0.0471
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0017 0.0013 0.0038
Toxoplasma gondii NADPH-glutathione reductase 0.0066 0.041 0.2792
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.0116 0.0118
Loa Loa (eye worm) hypothetical protein 0.0306 0.239 0.7088
Schistosoma mansoni ap endonuclease 0.0019 0.0027 0.0027
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0066 0.041 0.1131
Echinococcus multilocularis uro adherence factor A 0.0016 0.0004 0.0005
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0066 0.041 0.0828
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0004 0.0013
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0192 0.1456 0.1481
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0192 0.1456 0.1444
Brugia malayi ecdysteroid receptor 0.003 0.0116 0.032
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0086 0.0577 0.117
Schistosoma mansoni hypothetical protein 0.0016 0.0004 0.0005
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0017 0.0013 0.0013
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0027 0.0096
Treponema pallidum NADH oxidase 0.0066 0.041 0.1731
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.0116 0.0118
Leishmania major hypothetical protein, conserved 0.0192 0.1456 0.2953
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0047 0.0257 0.0971
Loa Loa (eye worm) hypothetical protein 0.0192 0.1456 0.4317
Loa Loa (eye worm) hypothetical protein 0.0035 0.0159 0.0471
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0035 0.0159 0.0146
Trichomonas vaginalis D-aminoacylase, putative 0.0192 0.1456 0.6313
Mycobacterium tuberculosis Probable lipase LipD 0.0192 0.1456 0.1444
Echinococcus granulosus mixed lineage leukemia protein mll 0.0021 0.0044 0.0044
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.2303 1
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0016 0.0004 0.0005
Plasmodium vivax acyl-CoA synthetase, putative 0.0035 0.0159 0.1076
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0017 0.0013 0.0013
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0116 0.0118
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0026 0.0086 0.0088
Echinococcus multilocularis fetal alzheimer antigen, falz 0.014 0.1026 0.1044
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0028 0.0104
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.0116 0.0118
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.0116 0.0344
Mycobacterium tuberculosis Conserved protein 0.0192 0.1456 0.1444
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.0116 0.0118
Brugia malayi CHD4 protein 0.0016 0.0004 0.0012
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0027 0.0166
Schistosoma mansoni hepatitis B virus X associated protein hbxa 0.0016 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.0192 0.1456 0.4317
Leishmania major hypothetical protein, conserved 0.0092 0.0627 0.1257
Mycobacterium tuberculosis Conserved protein 0.0192 0.1456 0.1444
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0066 0.041 1
Mycobacterium tuberculosis Probable esterase LipL 0.0192 0.1456 0.1444
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.0116 0.0118
Echinococcus multilocularis TAF3 RNA polymerase II, TATA box binding protein 0.0016 0.0004 0.0005
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0027 0.0013
Giardia lamblia NADH oxidase lateral transfer candidate 0.0066 0.041 0.1731
Echinococcus multilocularis PHD finger protein 14 0.0016 0.0004 0.0005
Trypanosoma cruzi ISWI complex protein 0.0092 0.0627 0.1273
Mycobacterium ulcerans bacterioferritin BfrA 0.0027 0.009 0.0306
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0192 0.1456 0.1481
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0066 0.041 0.0811
Echinococcus granulosus phd finger protein 10 0.0016 0.0004 0.0005
Schistosoma mansoni hypothetical protein 0.0016 0.0004 0.0005
Schistosoma mansoni hypothetical protein 0.0017 0.0013 0.0013
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0066 0.041 0.1582
Mycobacterium tuberculosis Conserved hypothetical protein 0.0322 0.2519 0.2509
Plasmodium vivax thioredoxin reductase, putative 0.0189 0.1427 0.9806
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0016 0.0004 0.0005
Schistosoma mansoni ferritin light chain 0.0027 0.009 0.0091
Trypanosoma cruzi trypanothione reductase, putative 0.0066 0.041 0.0828
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0066 0.041 0.0828
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.2303 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.0116 0.0118
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.008 0.0527 0.2242
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0013 0.0018
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0143 0.013
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0143 0.013
Mycobacterium ulcerans beta-lactamase 0.0192 0.1456 0.5757
Echinococcus multilocularis phd finger protein 10 0.0016 0.0004 0.0005
Echinococcus granulosus zinc finger protein 0.0123 0.0879 0.0894
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0066 0.041 0.0417
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.2303 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0085 0.0569 0.1689
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.061 0.4898 1
Brugia malayi jmjC domain containing protein 0.0016 0.0004 0.0012
Echinococcus multilocularis histone acetyltransferase myst3 0.0016 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.003 0.0116 0.0344
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0066 0.041 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0027 0.0027
Mycobacterium ulcerans hypothetical protein 0.0192 0.1456 0.5757
Echinococcus granulosus expressed protein 0.0027 0.009 0.0091
Echinococcus multilocularis FTZ F1 alpha 0.003 0.0116 0.0118
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0013
Brugia malayi nuclear receptor NHR-88 0.003 0.0116 0.032
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.0116 0.0344
Echinococcus multilocularis lysine specific demethylase 5B 0.0016 0.0004 0.0005
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.0116 0.0118
Loa Loa (eye worm) hypothetical protein 0.003 0.0116 0.0344
Entamoeba histolytica acyl-coA synthetase, putative 0.0047 0.0257 0.1063
Brugia malayi beta-lactamase family protein 0.0192 0.1456 0.4017
Loa Loa (eye worm) steroid hormone receptor 0.003 0.0116 0.0344
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0104 0.073 0.0742
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0017 0.0013 0.0013
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0104 0.073 0.0742
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.0116 0.032
Loa Loa (eye worm) hypothetical protein 0.0047 0.0257 0.0761
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0027 0.0058
Echinococcus multilocularis expressed protein 0.0027 0.009 0.0091
Echinococcus granulosus lysine specific demethylase 5B 0.0016 0.0004 0.0005
Schistosoma mansoni bromodomain containing protein 0.0031 0.0122 0.0124
Schistosoma mansoni coup transcription factor 0.003 0.0116 0.0118
Schistosoma mansoni cpg binding protein 0.0085 0.0569 0.0579
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.014 0.1026 0.1044
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0047 0.0257 0.0244
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0257 0.1063
Loa Loa (eye worm) hypothetical protein 0.0245 0.1887 0.5597
Trichomonas vaginalis helicase, putative 0.0019 0.0028 0.0104
Brugia malayi Thioredoxin reductase 0.0189 0.1427 0.3939
Trichomonas vaginalis mercuric reductase, putative 0.0066 0.041 0.1763
Trypanosoma cruzi hypothetical protein, conserved 0.0192 0.1456 0.2965
Trypanosoma brucei hypothetical protein, conserved 0.0017 0.0013 0.0018
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0021 0.0044 0.0044
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0257 0.0498
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.0116 0.0769
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0028 0.0104
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0066 0.041 0.2802
Echinococcus multilocularis histone acetyltransferase myst4 0.0016 0.0004 0.0005
Echinococcus multilocularis cpg binding protein 0.0101 0.0704 0.0716
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0066 0.041 0.0828
Echinococcus granulosus PHD and RING finger domain containing protein 1 0.0016 0.0004 0.0005
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.0116 0.0118
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0035 0.0159 0.3674
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0116 0.032
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0086 0.0577 0.117
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0066 0.041 0.0828
Toxoplasma gondii exonuclease III APE 0.0019 0.0027 0.0152
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.0116 0.0118
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0047 0.0257 0.0244
Brugia malayi hypothetical protein 0.0016 0.0004 0.0012
Mycobacterium ulcerans hypothetical protein 0.0322 0.2519 1
Trypanosoma brucei NADH dehydrogenase 0.0017 0.0013 0.0018
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0295 0.2303 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0116 0.032
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.0116 0.0344
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0116 0.0118
Trichomonas vaginalis glutamate synthase, putative 0.0017 0.0013 0.0038
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0013 0.0018
Plasmodium falciparum glutathione reductase 0.0189 0.1427 1
Loa Loa (eye worm) hypothetical protein 0.0104 0.073 0.2164
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0017 0.0013 0.0013
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0431 0.3422 0.3414
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0143 0.013
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0116 0.032
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0289 0.225 0.4588
Brugia malayi beta-lactamase 0.0192 0.1456 0.4017
Trichomonas vaginalis penicillin-binding protein, putative 0.0192 0.1456 0.6313
Treponema pallidum bacterioferrin (TpF1) 0.0027 0.009 0.0335
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0289 0.225 0.4588
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0048 0.0266 0.0735
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0047 0.0257 0.0971
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0257 0.1063
Loa Loa (eye worm) programmed cell death 8 0.0017 0.0013 0.0039
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.0116 0.0118
Schistosoma mansoni tar DNA-binding protein 0.0077 0.0504 0.0513
Schistosoma mansoni cpg binding protein 0.0101 0.0704 0.0716
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0479 0.3819 0.3811
Loa Loa (eye worm) F/Y-rich family protein 0.0016 0.0004 0.0013
Trichomonas vaginalis ferritin, putative 0.0027 0.009 0.0372
Trichomonas vaginalis D-aminoacylase, putative 0.0192 0.1456 0.6313
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.0116 0.0118
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0086 0.0577 0.117
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0086 0.0577 0.117
Schistosoma mansoni zinc finger protein 0.0016 0.0004 0.0005
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0017 0.0013 0.0018
Echinococcus multilocularis thyroid hormone receptor alpha 0.003 0.0116 0.0118
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0039
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0257 0.0708
Schistosoma mansoni ferritin 0.0027 0.009 0.0091
Schistosoma mansoni ap endonuclease 0.0019 0.0027 0.0027
Schistosoma mansoni dpf3 0.0016 0.0004 0.0005
Schistosoma mansoni methyl-cpg binding protein mbd 0.0103 0.0714 0.0727
Mycobacterium tuberculosis Conserved protein 0.0192 0.1456 0.1444
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.0116 0.032
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0013
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0013
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0017 0.0013 0.0038
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0017 0.0013 0.0013
Trichomonas vaginalis esterase, putative 0.0192 0.1456 0.6313
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0017 0.0013 0.0013
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.0116 0.0118
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0116 0.032
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0028 0.0104
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0103 0.0714 0.0727
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0048 0.0266 0.0735
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0066 0.041 0.1582
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0017 0.0013 0.0013
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0257 0.0498
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0028 0.0104
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0066 0.041 0.0828
Echinococcus multilocularis muscleblind protein 0.0306 0.239 0.2431
Plasmodium falciparum acyl-CoA synthetase 0.0035 0.0159 0.1085
Trypanosoma brucei ISWI complex protein 0.0092 0.0627 0.1273
Echinococcus granulosus thioredoxin glutathione reductase 0.0192 0.1448 0.1473
Trypanosoma brucei trypanothione reductase 0.0189 0.1427 0.2907
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.0116 0.0118
Schistosoma mansoni glutamate synthase 0.0017 0.0013 0.0013
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.0116 0.0344
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0017 0.0013 0.0037
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0116 0.0118
Echinococcus granulosus muscleblind protein 0.0306 0.239 0.2431
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0116 0.032
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0027 0.009 0.0201
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0144 0.1059 0.4172
Echinococcus multilocularis zinc finger protein 0.0123 0.0879 0.0894
Loa Loa (eye worm) PHD-finger family protein 0.0124 0.0892 0.2644
Giardia lamblia Fructose-bisphosphate aldolase 0.0295 0.2303 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.2303 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0257 0.0971
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0189 0.1427 0.1416
Mycobacterium tuberculosis Probable lipase LipE 0.0192 0.1456 0.1444
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.0116 0.0118
Mycobacterium ulcerans bacterioferritin BfrB 0.0027 0.009 0.0306
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0116 0.032
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0017 0.0013 0.0061
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0017 0.0013 0.0013
Entamoeba histolytica hypothetical protein 0.0021 0.0047 0.0148
Loa Loa (eye worm) RNA binding protein 0.0077 0.0504 0.1496
Plasmodium vivax hypothetical protein, conserved 0.0192 0.1456 1
Loa Loa (eye worm) bromodomain containing protein 0.0106 0.0745 0.2209
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0066 0.041 0.2802
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.008 0.0527 0.0536
Loa Loa (eye worm) TAR-binding protein 0.0077 0.0504 0.1496
Brugia malayi steroid hormone receptor 0.003 0.0116 0.032
Brugia malayi hypothetical protein 0.0016 0.0004 0.0012
Schistosoma mansoni disulfide oxidoreductase 0.0017 0.0013 0.0013
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0066 0.041 0.1582
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0013
Echinococcus multilocularis phd finger protein 12 0.0016 0.0004 0.0005
Mycobacterium leprae conserved hypothetical protein 0.0192 0.1456 0.379
Onchocerca volvulus Bile acid receptor homolog 0.003 0.0116 0.0769
Brugia malayi F/Y-rich N-terminus family protein 0.0037 0.0178 0.0492
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0017 0.0013 0.0013
Schistosoma mansoni glutamate synthase 0.0017 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.003 0.0116 0.0344
Schistosoma mansoni tar DNA-binding protein 0.0077 0.0504 0.0513
Echinococcus granulosus PHD finger protein 14 0.0016 0.0004 0.0005
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0066 0.041 0.0828
Loa Loa (eye worm) hypothetical protein 0.003 0.0116 0.0344
Plasmodium vivax SNF2 family N-terminal domain containing protein 0.0016 0.0004 0.0013
Schistosoma mansoni jumonji/arid domain-containing protein 0.0016 0.0004 0.0005
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0105 0.0732 0.1486
Schistosoma mansoni hypothetical protein 0.0016 0.0004 0.0005
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0028 0.0104
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0017 0.0013 0.0074
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0017 0.0013 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0028 0.0104
Loa Loa (eye worm) hypothetical protein 0.0425 0.3371 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0066 0.041 0.0828
Echinococcus granulosus transcription factor Dp 1 0.0046 0.025 0.0254
Schistosoma mansoni PHD zinc finger protein XAP135-related 0.0016 0.0004 0.0005
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0021 0.0044 0.0044
Mycobacterium tuberculosis Probable reductase 0.0431 0.3422 0.3414
Leishmania major trypanothione reductase 0.0189 0.1427 0.2895
Echinococcus granulosus histone lysine methyltransferase setb 0.0104 0.073 0.0742
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0017 0.0013 0.0037
Trypanosoma cruzi NADH dehydrogenase, putative 0.0017 0.0013 0.0018
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0017 0.0013 0.0061
Schistosoma mansoni nuclear hormone receptor 0.003 0.0116 0.0118
Brugia malayi Bromodomain associated family protein 0.0016 0.0004 0.0012
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0017 0.0013 0.0062
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0017 0.0013 0.0018
Mycobacterium leprae Probable lipase LipE 0.0192 0.1456 0.379
Schistosoma mansoni hypothetical protein 0.0016 0.0004 0.0005
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0017 0.0013 0.0038
Schistosoma mansoni bromodomain containing protein 0.0385 0.3043 0.3096
Loa Loa (eye worm) CHromoDomain protein family member 0.0016 0.0004 0.0013
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0027 0.0058
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.008 0.0527 0.0536
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0027 0.0027
Echinococcus granulosus Zinc finger DBF type 0.0016 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0013
Schistosoma mansoni zinc finger protein 0.0092 0.0627 0.0638
Plasmodium falciparum zinc finger protein, putative 0.0021 0.0047 0.03
Loa Loa (eye worm) hypothetical protein 0.0047 0.0257 0.0761
Echinococcus multilocularis tar DNA binding protein 0.0077 0.0504 0.0513
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0216 0.1649 0.1678
Echinococcus granulosus ferritin 0.0027 0.009 0.0091
Echinococcus multilocularis ferritin 0.0027 0.009 0.0091
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.008 0.0527 0.0536
Echinococcus granulosus lysine specific demethylase 5A 0.0016 0.0004 0.0005
Echinococcus granulosus remodeling and spacing factor 1 0.0016 0.0004 0.0005
Schistosoma mansoni ferritin 0.0027 0.009 0.0091
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.0116 0.0344
Mycobacterium tuberculosis Probable hydrolase 0.0192 0.1456 0.1444
Onchocerca volvulus 0.0018 0.002 0.0105
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0479 0.3819 0.3811
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0257 0.0639
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0028 0.0104
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0016 0.0004 0.0005
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.061 0.4898 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0028 0.0104
Loa Loa (eye worm) PHD-finger family protein 0.0016 0.0004 0.0013
Echinococcus multilocularis PHD and RING finger domain containing protein 1 0.0016 0.0004 0.0005
Echinococcus granulosus phd finger protein 12 0.0016 0.0004 0.0005
Echinococcus multilocularis muscleblind protein 1 0.0306 0.239 0.2431
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0027 0.0336
Brugia malayi nuclear hormone receptor 0.003 0.0116 0.032
Brugia malayi Bromodomain containing protein 0.023 0.1766 0.4875
Trichomonas vaginalis glutamate synthase, putative 0.0017 0.0013 0.0038
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0527 0.1067
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0027 0.0027
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0017 0.0013 0.0038
Loa Loa (eye worm) hypothetical protein 0.0035 0.0159 0.0471
Schistosoma mansoni tar DNA-binding protein 0.0077 0.0504 0.0513
Schistosoma mansoni sulfide quinone reductase 0.0017 0.0013 0.0013
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0017 0.0013 0.0039
Brugia malayi RNA recognition motif domain containing protein 0.0077 0.0504 0.1392
Echinococcus granulosus cpg binding protein 0.0101 0.0704 0.0716
Brugia malayi PHD-finger family protein 0.0016 0.0004 0.0012
Brugia malayi SET domain containing protein 0.0018 0.002 0.0054
Brugia malayi PHD-finger family protein 0.0016 0.0004 0.0012
Trichomonas vaginalis D-aminoacylase, putative 0.0192 0.1456 0.6313
Schistosoma mansoni thyroid hormone receptor 0.003 0.0116 0.0118
Echinococcus multilocularis transcription factor Dp 1 0.0046 0.025 0.0254
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0017 0.0013 0.0061
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0017 0.0013 0.0038
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0295 0.2303 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0257 0.0639
Schistosoma mansoni cpg binding protein 0.0101 0.0704 0.0716
Schistosoma mansoni myst-related protein 0.0021 0.0047 0.0048
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.2303 1

Activities

Activity type Activity value Assay description Source Reference
Potency (binding) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 21.3313 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (binding) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1484, AID504370, AID504374, AID504375] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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