Detailed information for compound 1450082

Basic information

Technical information
  • TDR Targets ID: 1450082
  • Name: 3-(3,4-dimethylphenyl)-1-(3-morpholin-4-ylpro pyl)thiourea
  • MW: 307.454 | Formula: C16H25N3OS
  • H donors: 1 H acceptors: 0 LogP: 2.55 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: SC(=NCCCN1CCOCC1)Nc1ccc(c(c1)C)C
  • InChi: 1S/C16H25N3OS/c1-13-4-5-15(12-14(13)2)18-16(21)17-6-3-7-19-8-10-20-11-9-19/h4-5,12H,3,6-11H2,1-2H3,(H2,17,18,21)
  • InChiKey: SZAOSWSGSOQHGI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3-(3,4-dimethylphenyl)-1-(3-morpholinopropyl)thiourea
  • MLS000861130
  • N-(3,4-dimethylphenyl)-N'-(3-morpholinopropyl)thiourea
  • SMR000459914

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens mitogen-activated protein kinase 1 Starlite/ChEMBL No references
Homo sapiens ATM serine/threonine kinase Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), beta Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum hypothetical protein Get druggable targets OG5_128955 All targets in OG5_128955
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128955 All targets in OG5_128955
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum ko:K04371 extracellular signal-regulated kinase 1/2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen activated protein kinase 2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Entamoeba histolytica hypothetical protein Get druggable targets OG5_128955 All targets in OG5_128955
Cryptosporidium parvum MAPK, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma congolense tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania braziliensis mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans similar to putative phosphatidylinositol kinase involved in telomere length regulation Get druggable targets OG5_128955 All targets in OG5_128955
Echinococcus granulosus mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania donovani phosphatidylinositol 3-kinase-like protein Get druggable targets OG5_128955 All targets in OG5_128955
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania infantum mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma brucei gambiense phosphatidylinositol kinase domain protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania donovani mitogen activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma congolense mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania infantum mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei gambiense mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei gambiense protein kinase, putative,tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Trypanosoma brucei mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus serine protein kinase ATM Get druggable targets OG5_128955 All targets in OG5_128955
Leishmania mexicana mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Candida albicans MAP kinase implicated in PKC1-controlled signalling pathway Get druggable targets OG5_126781 All targets in OG5_126781
Mycobacterium tuberculosis Conserved hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Toxoplasma gondii FATC domain-containing protein Get druggable targets OG5_128955 All targets in OG5_128955
Leishmania donovani mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Candida albicans identical to the C terminus of CaP19.5580 potential phosphatidylinositol kinase Get druggable targets OG5_128955 All targets in OG5_128955
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania braziliensis mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440,map kinase Get druggable targets OG5_126781 All targets in OG5_126781
Giardia lamblia Kinase, CMGC MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Cryptosporidium hominis MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania mexicana mitogen-activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma brucei gambiense mitogen-activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum hypothetical protein Get druggable targets OG5_128955 All targets in OG5_128955
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania braziliensis phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Echinococcus multilocularis mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Candida albicans similar to putative phosphatidylinositol kinase involved in telomere length regulation Get druggable targets OG5_128955 All targets in OG5_128955
Leishmania major phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Neospora caninum phosphatidylinositol 3- and 4-kinase domain- containing protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Echinococcus multilocularis serine protein kinase ATM Get druggable targets OG5_128955 All targets in OG5_128955
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Leishmania donovani mitogen-activated protein kinase 4 Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania braziliensis mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Schistosoma mansoni ataxia telangiectasia mutated (atm) Get druggable targets OG5_128955 All targets in OG5_128955
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_128955 All targets in OG5_128955
Schistosoma japonicum IPR000971,Globin;IPR012292,Globin-related;IPR009050,Globin-like,domain-containing Get druggable targets OG5_128955 All targets in OG5_128955
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein Get druggable targets OG5_128955 All targets in OG5_128955
Trypanosoma cruzi mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi MAP kinase sur-1 Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04728 ataxia telangectasia mutated family protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Leishmania mexicana mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania mexicana phosphatidylinositol 3-kinase-like protein Get druggable targets OG5_128955 All targets in OG5_128955
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania major mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase 1 360 aa 361 aa 33.2 %
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative polymerase (DNA directed), beta 335 aa 303 aa 32.3 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi hypothetical protein, conserved 0.0089 0.1968 0.1968
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0155 0.387 1
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0155 0.387 1
Toxoplasma gondii methionine aminopeptidase 0.0244 0.6475 1
Echinococcus granulosus mitogen activated protein kinase 0.0062 0.1158 0.1788
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0244 0.6475 0.6475
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.1158 0.2991
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.003 0.0238 0.0367
Echinococcus granulosus serine protein kinase ATM 0.003 0.0238 0.0367
Brugia malayi MAP kinase sur-1 0.0062 0.1158 0.1788
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.4397 0.4397
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0974 0.1504
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.4397 0.4397
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP) 0.0155 0.387 0.5
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0026 0.0115 0.0115
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0062 0.1158 0.1788
Toxoplasma gondii methionine aminopeptidase, type i, putative 0.0155 0.387 0.5977
Trypanosoma brucei methionine aminopeptidase, type I, putative 0.0244 0.6475 0.6475
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0062 0.1158 0.1158
Toxoplasma gondii hypothetical protein 0.0059 0.1079 0.1666
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0859 0.0859
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 1 1
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M) 0.0155 0.387 0.5
Toxoplasma gondii methionine aminopeptidase 0.0155 0.387 0.5977
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 1 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0022 0.0001 0.0001
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.1158 0.1158
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0365 1 1
Leishmania major methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 0.0244 0.6475 0.6475
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0173 0.4397 0.4397
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0062 0.1158 0.1158
Trypanosoma brucei protein kinase, putative 0.0062 0.1158 0.1158
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0062 0.1158 0.1158
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0974 0.1504
Leishmania major phosphatidylinositol kinase related protein, putative 0.0022 0.0001 0.0001
Toxoplasma gondii hypothetical protein 0.0089 0.1968 0.3039
Echinococcus granulosus mitogen activated protein kinase 3 0.0062 0.1158 0.1788
Plasmodium vivax methionine aminopeptidase 1b, putative 0.0244 0.6475 1
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0244 0.6475 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0974 0.1504
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.1158 1
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.1158 1
Brugia malayi Methionine aminopeptidase protein type I 0.0244 0.6475 1
Chlamydia trachomatis methionine aminopeptidase 0.0155 0.387 0.5
Loa Loa (eye worm) hypothetical protein 0.0026 0.0115 0.0178
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0062 0.1158 0.1158
Treponema pallidum methionine aminopeptidase (map) 0.0155 0.387 0.5
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0974 0.1504
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0238 0.2055
Echinococcus granulosus methionyl aminopeptidase 1 M24 family 0.0244 0.6475 1
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0062 0.1158 0.1158
Entamoeba histolytica hypothetical protein 0.003 0.0238 1
Echinococcus multilocularis mitogen activated protein kinase 3 0.0062 0.1158 0.1788
Plasmodium vivax methionine aminopeptidase 1a, putative 0.0155 0.387 0.422
Trypanosoma brucei metallo- peptidase, Clan MG, Family M24 0.0244 0.6475 0.6475
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.003 0.0238 0.0238
Trypanosoma cruzi hypothetical protein, conserved 0.0089 0.1968 0.1968
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.1158 0.1158
Echinococcus multilocularis mitogen activated protein kinase 0.0062 0.1158 0.1788
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0155 0.387 0.5977
Toxoplasma gondii FATC domain-containing protein 0.003 0.0238 0.0367
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0859 0.0859
Wolbachia endosymbiont of Brugia malayi methionine aminopeptidase 0.0155 0.387 0.5
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0859 0.0859
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.003 0.0238 0.0615
Trypanosoma brucei hypothetical protein, conserved 0.0089 0.1968 0.1968
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0244 0.6475 0.6475
Echinococcus multilocularis serine protein kinase ATM 0.003 0.0238 0.0367
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0051 0.0859 0.0859
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.003 0.0238 0.0238
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0062 0.1158 0.1788
Plasmodium falciparum methionine aminopeptidase 1b, putative 0.0244 0.6475 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0192 0.4966 1
Giardia lamblia Kinase, CMGC MAPK 0.0062 0.1158 1
Mycobacterium ulcerans hypothetical protein 0.0192 0.4966 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0974 0.1504
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0974 0.2517
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.1158 1
Trypanosoma brucei methionine aminopeptidase, putative 0.0244 0.6475 0.6475
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0062 0.1186 0.1186
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0974 0.2517
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0974 0.2517
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.1158 1
Leishmania major hypothetical protein, conserved 0.0089 0.1968 0.1968
Loa Loa (eye worm) methionine aminopeptidase type I 0.0244 0.6475 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0974 0.1504
Plasmodium falciparum methionine aminopeptidase 1a, putative 0.0155 0.387 0.422

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.7079 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying a Potential Treatment of Ataxia-Telangiectasia. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.7943 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay; Stimulation with EGF. (Class of assay: confirmatory) [Related pubchem assays: 995 ] ChEMBL. No reference
Potency (functional) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.