Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0141 | 0.6275 | 0.5 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase large chain CoxL | 0.0084 | 0.2915 | 0.5951 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase large chain CoxL | 0.0053 | 0.1096 | 0.2238 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase medium chain CoxM | 0.006 | 0.1524 | 0.3111 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.6275 | 0.5 |
Mycobacterium ulcerans | aerobic-type carbon monoxide dehydrogenase subunit CoxL_2 | 0.0084 | 0.2915 | 0.5951 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0141 | 0.6275 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.6275 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0141 | 0.6275 | 0.5 |
Mycobacterium ulcerans | carbon monoxide dehydrogenase | 0.0118 | 0.4898 | 1 |
Mycobacterium tuberculosis | Probable carbon monoxyde dehydrogenase (large chain) | 0.0084 | 0.2915 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Mycobacterium tuberculosis | Probable carbon monoxyde dehydrogenase (medium chain) | 0.006 | 0.1524 | 0.5229 |
Mycobacterium ulcerans | aerobic-type carbon monoxide dehydrogenase subunit CoxM_2 | 0.006 | 0.1524 | 0.3111 |
Trichomonas vaginalis | aldehyde oxidase, putative | 0.0177 | 0.8406 | 0.5 |
Trichomonas vaginalis | xanthine dehydrogenase, putative | 0.0177 | 0.8406 | 0.5 |
Trichomonas vaginalis | xanthine dehydrogenase, putative | 0.0177 | 0.8406 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0141 | 0.6275 | 0.5 |
Echinococcus multilocularis | geminin | 0.0205 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 6.5131 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 100 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.