Detailed information for compound 1450247

Basic information

Technical information
  • TDR Targets ID: 1450247
  • Name: 4-(diethylsulfamoyl)-N-[2-[2,4-dioxo-5-(pyrid in-3-ylmethylidene)-1,3-thiazolidin-3-yl]ethy l]benzamide
  • MW: 488.58 | Formula: C22H24N4O5S2
  • H donors: 1 H acceptors: 6 LogP: 2.16 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(S(=O)(=O)c1ccc(cc1)C(=O)NCCN1C(=O)S/C(=C\c2cccnc2)/C1=O)CC
  • InChi: 1S/C22H24N4O5S2/c1-3-25(4-2)33(30,31)18-9-7-17(8-10-18)20(27)24-12-13-26-21(28)19(32-22(26)29)14-16-6-5-11-23-15-16/h5-11,14-15H,3-4,12-13H2,1-2H3,(H,24,27)/b19-14-
  • InChiKey: JOGMCUAKKBPWEV-RGEXLXHISA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-(diethylsulfamoyl)-N-[2-[(5Z)-2,4-dioxo-5-(pyridin-3-ylmethylidene)-1,3-thiazolidin-3-yl]ethyl]benzamide
  • 4-(diethylsulfamoyl)-N-[2-[(5Z)-2,4-dioxo-5-(3-pyridylmethylene)thiazolidin-3-yl]ethyl]benzamide
  • 4-(diethylsulfamoyl)-N-[2-[2,4-dioxo-5-(3-pyridylmethylene)thiazolidin-3-yl]ethyl]benzamide
  • 4-(diethylsulfamoyl)-N-[2-[(5Z)-2,4-dioxo-5-(3-pyridylmethylene)-3-thiazolidinyl]ethyl]benzamide
  • 4-(diethylsulfamoyl)-N-[2-[2,4-dioxo-5-(3-pyridylmethylene)-3-thiazolidinyl]ethyl]benzamide
  • 4-(diethylsulfamoyl)-N-[2-[(5Z)-2,4-diketo-5-(3-pyridylmethylene)thiazolidin-3-yl]ethyl]benzamide
  • 4-(diethylsulfamoyl)-N-[2-[2,4-diketo-5-(3-pyridylmethylene)thiazolidin-3-yl]ethyl]benzamide
  • SMR000371164
  • T0510-5091
  • MLS000776167

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens relaxin/insulin-like family peptide receptor 1 Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens relaxin/insulin-like family peptide receptor 2 Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0169 0.1117 0.1117
Loa Loa (eye worm) hypothetical protein 0.0051 0.0281 0.0281
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0097 0.0605 0.0605
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0097 0.0605 0.0605
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0149 0.0149
Echinococcus granulosus intermediate filament protein 0.0033 0.0149 0.0149
Onchocerca volvulus Protein ultraspiracle homolog 0.0097 0.0605 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0046 0.0243 0.0243
Loa Loa (eye worm) hypothetical protein 0.0015 0.0025 0.0025
Loa Loa (eye worm) nuclear hormone receptor 0.0046 0.0243 0.0243
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0097 0.0605 0.0605
Loa Loa (eye worm) hypothetical protein 0.0046 0.0243 0.0243
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0046 0.0243 0.0243
Echinococcus multilocularis traf and tnf receptor associated protein 0.0172 0.1136 0.1136
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0097 0.0605 0.0605
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0046 0.0243 0.0243
Schistosoma mansoni nuclear receptor 0.0046 0.0243 0.0243
Brugia malayi steroid hormone receptor 0.0097 0.0605 0.0605
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0097 0.0605 0.0605
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.1425 1 0.5
Onchocerca volvulus 0.0046 0.0243 0.4006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0097 0.0605 0.0605
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0097 0.0605 0.0605
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0097 0.0605 0.0605
Loa Loa (eye worm) hypothetical protein 0.0097 0.0605 0.0605
Loa Loa (eye worm) hypothetical protein 0.0051 0.0281 0.0281
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0097 0.0605 0.0605
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.1425 1 1
Brugia malayi nuclear hormone receptor 0.0046 0.0243 0.0243
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0097 0.0605 0.0605
Echinococcus granulosus Nuclear hormone receptor HR96 0.0046 0.0243 0.0243
Loa Loa (eye worm) steroid hormone receptor 0.0097 0.0605 0.0605
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0051 0.0281 0.0281
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0309 0.0309
Brugia malayi conserved hypotetical protein 0.0046 0.0243 0.0243
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0051 0.0281 0.0281
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0046 0.0243 0.4006
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0097 0.0605 0.0605
Echinococcus granulosus thyroid hormone receptor alpha 0.0046 0.0243 0.0243
Echinococcus granulosus ecdysone induced protein 78C 0.0097 0.0605 0.0605
Loa Loa (eye worm) hypothetical protein 0.0046 0.0243 0.0243
Schistosoma mansoni lamin 0.0033 0.0149 0.0149
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0309 0.0309
Brugia malayi nuclear receptor NHR-88 0.0046 0.0243 0.0243
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0097 0.0605 1
Schistosoma mansoni coup transcription factor 0.0097 0.0605 0.0605
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0097 0.0605 0.0605
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0046 0.0243 0.0243
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0097 0.0605 0.0605
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0046 0.0243 0.0243
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0097 0.0605 0.0605
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0051 0.0281 0.0281
Loa Loa (eye worm) hypothetical protein 0.0097 0.0605 0.0605
Loa Loa (eye worm) hypothetical protein 0.0046 0.0243 0.0243
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0309 0.0309
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0097 0.0605 0.0605
Loa Loa (eye worm) hypothetical protein 0.0033 0.0149 0.0149
Loa Loa (eye worm) hypothetical protein 0.0051 0.0281 0.0281
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0097 0.0605 0.0605
Loa Loa (eye worm) hypothetical protein 0.0051 0.0281 0.0281
Schistosoma mansoni nuclear hormone receptor 0.0097 0.0605 0.0605
Schistosoma mansoni lamin 0.0033 0.0149 0.0149
Loa Loa (eye worm) nuclear receptor NHR-67 0.0046 0.0243 0.0243
Schistosoma mansoni thyroid hormone receptor 0.0097 0.0605 0.0605
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0051 0.0281 0.0281
Brugia malayi nuclear receptor RXR 0.0046 0.0243 0.0243
Echinococcus multilocularis transcription factor Dp 1 0.0825 0.5754 0.5754
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0046 0.0243 0.0243
Loa Loa (eye worm) hypothetical protein 0.0097 0.0605 0.0605
Loa Loa (eye worm) hypothetical protein 0.0097 0.0605 0.0605
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.1425 1 0.5
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0016 0.003 0.003
Echinococcus granulosus nuclear receptor nhr 48 0.0046 0.0243 0.0243
Loa Loa (eye worm) hypothetical protein 0.0046 0.0243 0.0243
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.1425 1 0.5
Brugia malayi intermediate filament protein 0.0033 0.0149 0.0149
Loa Loa (eye worm) hypothetical protein 0.0016 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0032 0.0145 0.0145
Brugia malayi Nuclear hormone receptor-like 1 0.0097 0.0605 0.0605
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0097 0.0605 0.0605
Schistosoma mansoni nuclear hormone receptor 0.0046 0.0243 0.0243
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0097 0.0605 0.0605
Echinococcus granulosus lamin dm0 0.0033 0.0149 0.0149
Schistosoma mansoni steroid hormone receptor ad4bp 0.0097 0.0605 0.0605
Schistosoma mansoni RAR-like nuclear receptor 0.0097 0.0605 0.0605
Echinococcus granulosus retinoic acid receptor rxr beta a 0.1201 0.8417 0.8417
Loa Loa (eye worm) hypothetical protein 0.0046 0.0243 0.0243
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0097 0.0605 0.0605
Loa Loa (eye worm) hypothetical protein 0.0046 0.0243 0.0243
Loa Loa (eye worm) hypothetical protein 0.0051 0.0281 0.0281
Brugia malayi nuclear hormone receptor family member odr-7 0.0046 0.0243 0.0243
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0097 0.0605 0.0605
Echinococcus multilocularis thyroid hormone receptor alpha 0.0097 0.0605 0.0605
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0046 0.0243 0.0243
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0097 0.0605 0.0605
Loa Loa (eye worm) hypothetical protein 0.0097 0.0605 0.0605
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0097 0.0605 0.0605
Schistosoma mansoni nuclear receptor 0.0046 0.0243 0.0243
Schistosoma mansoni nuclear hormone receptor 0.0046 0.0243 0.0243
Onchocerca volvulus 0.0033 0.0149 0.246
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0097 0.0605 0.0605
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0042 0.0042
Echinococcus granulosus FTZ F1 alpha 0.0097 0.0605 0.0605
Echinococcus granulosus Nuclear hormone receptor HR96 0.0046 0.0243 0.0243
Brugia malayi Nuclear hormone receptor-like 1 0.0051 0.0281 0.0281
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.115 0.8054 0.8054
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0097 0.0605 0.0605
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0097 0.0605 0.0605
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0309 0.0309
Brugia malayi hypothetical protein 0.0051 0.0281 0.0281
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.1425 1 1
Brugia malayi nuclear hormone receptor 0.0097 0.0605 0.0605
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0097 0.0605 0.0605
Loa Loa (eye worm) hypothetical protein 0.0046 0.0243 0.0243
Echinococcus multilocularis musashi 0.0033 0.0149 0.0149
Loa Loa (eye worm) hypothetical protein 0.0097 0.0605 0.0605
Brugia malayi nuclear hormone receptor family member nhr-6 0.0046 0.0243 0.0243
Schistosoma mansoni thyroid hormone receptor 0.0097 0.0605 0.0605
Brugia malayi Nuclear hormone receptor E75 0.0046 0.0243 0.0243
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0051 0.0281 0.0281
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0149 0.0149
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0309 0.0309
Loa Loa (eye worm) hypothetical protein 0.0046 0.0243 0.0243
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0309 0.0309
Onchocerca volvulus 0.0046 0.0243 0.4006
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.1425 1 0.5
Echinococcus granulosus lamin 0.0033 0.0149 0.0149
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0046 0.0243 0.0243
Brugia malayi ecdysone receptor 0.0046 0.0243 0.0243
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0097 0.0605 0.0605
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.1425 1 1
Brugia malayi hypothetical protein 0.0046 0.0243 0.0243
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0309 0.0309
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0097 0.0605 0.0605
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0097 0.0605 0.0605
Echinococcus granulosus transcription factor Dp 1 0.0825 0.5754 0.5754
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.1425 1 0.5
Brugia malayi Nuclear hormone receptor E75 0.0046 0.0243 0.0243
Loa Loa (eye worm) hypothetical protein 0.0015 0.0025 0.0025
Echinococcus multilocularis ecdysone induced protein 78C 0.0097 0.0605 0.0605
Schistosoma mansoni nuclear receptor nhr-48 0.0046 0.0243 0.0243
Brugia malayi nuclear receptor NHR-88 0.0097 0.0605 0.0605
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0046 0.0243 0.0243
Loa Loa (eye worm) hypothetical protein 0.0046 0.0243 0.0243
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0097 0.0605 0.0605
Brugia malayi nuclear receptor RXR 0.0051 0.0281 0.0281
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0167 0.11 0.5
Schistosoma mansoni intermediate filament proteins 0.0033 0.0149 0.0149
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.1425 1 1
Onchocerca volvulus 0.0033 0.0149 0.246
Brugia malayi hypothetical protein 0.0046 0.0243 0.0243
Loa Loa (eye worm) hypothetical protein 0.0097 0.0605 0.0605
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0097 0.0605 0.0605
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.6848 0.6848
Echinococcus multilocularis nuclear receptor nhr 48 0.0046 0.0243 0.0243
Loa Loa (eye worm) hypothetical protein 0.0097 0.0605 0.0605
Loa Loa (eye worm) DR-78 0.0046 0.0243 0.0243
Echinococcus multilocularis lamin 0.0033 0.0149 0.0149
Schistosoma mansoni zinc finger protein 0.0046 0.0243 0.0243
Onchocerca volvulus 0.0097 0.0605 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0243 0.0243
Brugia malayi nuclear receptor NHR-67 0.0046 0.0243 0.0243
Brugia malayi photoreceptor-specific nuclear receptor 0.0097 0.0605 0.0605
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0097 0.0605 0.0605
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0149 0.0149
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0097 0.0605 0.0605
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0309 0.0309
Loa Loa (eye worm) hypothetical protein 0.0046 0.0243 0.0243
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0046 0.0243 0.4006
Loa Loa (eye worm) hypothetical protein 0.0046 0.0243 0.0243
Loa Loa (eye worm) hypothetical protein 0.0046 0.0243 0.0243
Echinococcus granulosus traf and tnf receptor associated protein 0.0172 0.1136 0.1136
Echinococcus multilocularis lamin dm0 0.0033 0.0149 0.0149
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0097 0.0605 0.0605
Brugia malayi ecdysteroid receptor 0.0097 0.0605 0.0605
Brugia malayi Nuclear hormone receptor-like 1 0.0051 0.0281 0.0281
Brugia malayi Steroid receptor seven-up type 2 0.0097 0.0605 0.0605
Brugia malayi tailless protein 0.0046 0.0243 0.0243
Onchocerca volvulus Bile acid receptor homolog 0.0097 0.0605 1
Brugia malayi hypothetical protein 0.0051 0.0281 0.0281
Echinococcus multilocularis FTZ F1 alpha 0.0097 0.0605 0.0605
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0309 0.0309
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0097 0.0605 0.0605
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0046 0.0243 0.0243
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0016 0.003 0.003
Brugia malayi orphan nuclear receptor NR2E1 0.0046 0.0243 0.0243
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0097 0.0605 0.0605
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0097 0.0605 0.0605
Schistosoma mansoni retinoic acid receptor RXR 0.1201 0.8417 0.8417
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0172 0.1136 0.1136
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0097 0.0605 0.0605
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0042 0.0042

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.3548 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.757 uM PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Relaxin Receptor RXFP1: THP1 Hit Validation. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 13.794 uM PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Relaxin Receptor RXFP1: RXFP2 Hit Validation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2676, AID2703, AID489012] ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Relaxin Receptor RXFP1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.575 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 24.5297 uM PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Relaxin Receptor RXFP1: RXFP1 Hit Validation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2676, AID2703, AID489043, AID492948] ChEMBL. No reference
Potency (functional) 24.5297 uM PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Relaxin Receptor RXFP1: V1B Hit Validation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2676, AID2703, AID489012] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 29.081 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 32.6427 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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