TDR Targets

Basic information

Technical information

TDR Targets ID: 1450335
Name: N-(2-ethyl-6-methylphenyl)-1-[[3-methyl-5-[(E )-2-(2,4,6-trimethylphenyl)ethenyl]-1,2-oxazo l-4-yl]sulfonyl]piperidine-4-carboxamide
MW: 535.697 | Formula: C30H37N3O4S
H donors: 1 H acceptors: 4 LogP: 5.81 Rotable bonds: 8
Rule of 5 violations (Lipinski): 2
SMILES: CCc1cccc(c1NC(=O)C1CCN(CC1)S(=O)(=O)c1c(C)noc1/C=C/c1c(C)cc(cc1C)C)C
InChi: 1S/C30H37N3O4S/c1-7-24-10-8-9-20(3)28(24)31-30(34)25-13-15-33(16-14-25)38(35,36)29-23(6)32-37-27(29)12-11-26-21(4)17-19(2)18-22(26)5/h8-12,17-18,25H,7,13-16H2,1-6H3,(H,31,34)/b12-11+
InChiKey: PHERGYYQXOCKKH-VAWYXSNFSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(2-ethyl-6-methyl-phenyl)-1-[3-methyl-5-[(E)-2-(2,4,6-trimethylphenyl)vinyl]isoxazol-4-yl]sulfonyl-piperidine-4-carboxamide
N-(2-ethyl-6-methylphenyl)-1-[[3-methyl-5-[(E)-2-(2,4,6-trimethylphenyl)vinyl]-4-isoxazolyl]sulfonyl]-4-piperidinecarboxamide
N-(2-ethyl-6-methyl-phenyl)-1-[3-methyl-5-[(E)-2-(2,4,6-trimethylphenyl)vinyl]isoxazol-4-yl]sulfonyl-isonipecotamide
N-(2-ethyl-6-methyl-phenyl)-1-[[3-methyl-5-[(E)-2-(2,4,6-trimethylphenyl)ethenyl]-1,2-oxazol-4-yl]sulfonyl]piperidine-4-carboxamide
G637-1411
NCGC00132774-01

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	ubiquitin specific peptidase 1	Starlite/ChEMBL	No references
Homo sapiens	chromobox homolog 1	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	chromobox protein 1	Get druggable targets OG5_129545	All targets in OG5_129545
Trichomonas vaginalis	chromobox protein, putative	Get druggable targets OG5_129545	All targets in OG5_129545
Theileria parva	hypothetical protein	Get druggable targets OG5_129545	All targets in OG5_129545
Schistosoma mansoni	chromobox protein	Get druggable targets OG5_129545	All targets in OG5_129545
Brugia malayi	Heterochromatin protein 1	Get druggable targets OG5_129545	All targets in OG5_129545
Onchocerca volvulus	Heterochromatin protein 1 homolog	Get druggable targets OG5_129545	All targets in OG5_129545
Echinococcus multilocularis	chromobox protein 1	Get druggable targets OG5_129545	All targets in OG5_129545
Loa Loa (eye worm)	heterochromatin protein 1	Get druggable targets OG5_129545	All targets in OG5_129545
Echinococcus multilocularis	chromobox protein 1	Get druggable targets OG5_129545	All targets in OG5_129545
Trichomonas vaginalis	chromobox protein, putative	Get druggable targets OG5_129545	All targets in OG5_129545
Schistosoma japonicum	Chromobox protein homolog 5, putative	Get druggable targets OG5_129545	All targets in OG5_129545
Trichomonas vaginalis	chromobox protein, putative	Get druggable targets OG5_129545	All targets in OG5_129545
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129545	All targets in OG5_129545
Echinococcus granulosus	chromobox protein 1	Get druggable targets OG5_129545	All targets in OG5_129545
Schistosoma mansoni	chromobox protein	Get druggable targets OG5_129545	All targets in OG5_129545
Onchocerca volvulus		Get druggable targets OG5_129545	All targets in OG5_129545
Trichomonas vaginalis	chromobox protein, putative	Get druggable targets OG5_129545	All targets in OG5_129545

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0033	0.0198	0.0198
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0019	0.0856
Trypanosoma brucei	Aminopeptidase M1, putative	0.0024	0.0089	0.3933
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0226	0.247
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0344	0.0616
Trypanosoma brucei	hypothetical protein, conserved	0.0035	0.0226	1
Schistosoma mansoni	hypothetical protein	0.0033	0.0198	0.0355
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0226	0.0404
Trichomonas vaginalis	chromobox protein, putative	0.0051	0.0428	0.4894
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0104	0.1102	0.4073
Echinococcus granulosus	beta LACTamase domain containing family member	0.0035	0.0226	0.0404
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0019	0.0019	0.5
Brugia malayi	hypothetical protein	0.0209	0.2452	0.9057
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0019	0.0019	0.0856
Toxoplasma gondii	aminopeptidase N protein	0.0024	0.0089	0.3933
Mycobacterium ulcerans	aminopeptidase N PepN	0.0024	0.0089	0.3365
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0226	0.0404
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0226	0.0404
Plasmodium vivax	M1-family alanyl aminopeptidase, putative	0.0024	0.0089	0.3933
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1	0.0024	0.0089	0.3933
Echinococcus multilocularis	chromobox protein 1	0.0084	0.0855	0.0855
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.0233	0.0233
Brugia malayi	Latrophilin receptor protein 2	0.0033	0.0198	0.0733
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0035	0.0226	0.0834
Onchocerca volvulus		0.0035	0.0226	0.4034
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0024	0.0089	0.0089
Loa Loa (eye worm)	TATA binding protein associated factor	0.0024	0.0089	0.0159
Mycobacterium tuberculosis	Probable hydrolase	0.0035	0.0226	0.0859
Schistosoma mansoni	hypothetical protein	0.0047	0.0377	0.0674
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0226	0.247
Schistosoma mansoni	Tata binding protein associated factor (M01 family)	0.0024	0.0089	0.0159
Trypanosoma cruzi	metallo-peptidase, clan MA(E), family M1, putative	0.0024	0.0089	0.3933
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0019	0.0019	0.5
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0024	0.0089	0.0159
Onchocerca volvulus		0.0035	0.0226	0.4034
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0051	0.0428	1
Trypanosoma brucei	Aminopeptidase M1, putative	0.0024	0.0089	0.3933
Schistosoma mansoni	hypothetical protein	0.0033	0.0198	0.0355
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0024	0.0089	0.0159
Echinococcus multilocularis	survival motor neuron protein 1	0.0229	0.2707	0.2707
Entamoeba histolytica	aminopeptidase, putative	0.0024	0.0089	0.3243
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0033	0.0198	0.0355
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0344	0.0616
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0198	0.0355
Brugia malayi	MH2 domain containing protein	0.0116	0.1258	0.4646
Onchocerca volvulus		0.0037	0.0252	0.4818
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0226	0.0859
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0019	0.0019	0.0035
Loa Loa (eye worm)	peptidase family M1 containing protein	0.0024	0.0089	0.0159
Leishmania major	aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1	0.0024	0.0089	0.3933
Entamoeba histolytica	hypothetical protein	0.0035	0.0233	1
Brugia malayi	beta-lactamase	0.0035	0.0226	0.0834
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0226	0.0859
Trichomonas vaginalis	conserved hypothetical protein	0.0047	0.0382	0.4347
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0104	0.1102	0.1972
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0223	0.2627	1
Mycobacterium ulcerans	esterase/lipase LipP	0.0035	0.0226	1
Echinococcus granulosus	chromobox protein 1	0.0084	0.0855	0.1528
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0019	0.0019	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0089	0.0159
Trichomonas vaginalis	esterase, putative	0.0035	0.0226	0.247
Trypanosoma cruzi	metallo-peptidase, Clan MA(E) Family M1	0.0024	0.0089	0.3933
Echinococcus multilocularis	leukotriene A 4 hydrolase	0.0455	0.5592	0.5592
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0024	0.0089	0.0159
Mycobacterium tuberculosis	Probable esterase LipL	0.0035	0.0226	0.0859
Schistosoma mansoni	hypothetical protein	0.0033	0.0198	0.0355
Schistosoma mansoni	hypothetical protein	0.0033	0.0198	0.0355
Echinococcus granulosus	leukotriene A 4 hydrolase	0.0455	0.5592	1
Schistosoma mansoni	hypothetical protein	0.0035	0.0233	0.0417
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0019	0.0856
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0226	0.0859
Echinococcus multilocularis	Peptidase M1, membrane alanine aminopeptidase, N terminal	0.0024	0.0089	0.0089
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0089	0.0159
Trypanosoma cruzi	metallo-peptidase, clan MA(E), family M1, putative	0.0024	0.0089	0.3933
Brugia malayi	hypothetical protein	0.0035	0.0233	0.0862
Trichomonas vaginalis	chromobox protein, putative	0.0084	0.0855	1
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0024	0.0089	0.0159
Entamoeba histolytica	hypothetical protein	0.0035	0.0233	1
Schistosoma mansoni	leukotriene A4 hydrolase (M01 family)	0.0455	0.5592	1
Schistosoma mansoni	ap endonuclease	0.0019	0.0019	0.0035
Mycobacterium ulcerans	lipase LipD	0.0035	0.0226	1
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0035	0.0226	0.0859
Brugia malayi	beta-lactamase family protein	0.0035	0.0226	0.0834
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0024	0.0089	0.0831
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1	0.0024	0.0089	0.3933
Echinococcus multilocularis	chromobox protein 1	0.0084	0.0855	0.0855
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0024	0.0089	0.0089
Trypanosoma cruzi	puromycin-sensitive aminopeptidase-like protein, putative	0.0024	0.0089	0.3933
Mycobacterium leprae	Probable lipase LipE	0.0035	0.0226	0.5
Brugia malayi	hypothetical protein	0.0024	0.0089	0.0328
Trypanosoma cruzi	puromycin-sensitive aminopeptidase-like protein, putative	0.0024	0.0089	0.3933
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0226	0.0404
Brugia malayi	latrophilin 2 splice variant baaae	0.0071	0.0684	0.2527
Schistosoma mansoni	chromobox protein	0.0084	0.0855	0.1528
Brugia malayi	Peptidase family M1 containing protein	0.0024	0.0089	0.0328
Trichomonas vaginalis	conserved hypothetical protein	0.0047	0.0382	0.4347
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0019	0.0019	0.0035
Toxoplasma gondii	exonuclease III APE	0.0019	0.0019	0.0856
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0019	0.0019	0.0856
Loa Loa (eye worm)	MH2 domain-containing protein	0.0116	0.1258	0.2249
Toxoplasma gondii	ABC1 family protein	0.0035	0.0226	1
Entamoeba histolytica	hypothetical protein	0.0035	0.0233	1
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.0233	0.0417
Brugia malayi	Peptidase family M1 containing protein	0.0024	0.0089	0.0328
Brugia malayi	chromobox protein homolog 3	0.0047	0.0382	0.1413
Brugia malayi	exodeoxyribonuclease III family protein	0.0019	0.0019	0.0071
Brugia malayi	hypothetical protein	0.0024	0.0089	0.0328
Loa Loa (eye worm)	transcription factor SMAD2	0.0116	0.1258	0.2249
Mycobacterium ulcerans	hypothetical protein	0.0035	0.0226	1
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0024	0.0089	0.0089
Trypanosoma cruzi	aminopeptidase, putative	0.0024	0.0089	0.3933
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0344	0.0616
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0019	0.0019	0.5
Leishmania major	puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1	0.0024	0.0089	0.3933
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0226	0.247
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0044	0.0344	0.1272
Toxoplasma gondii	aminopeptidase N, putative	0.0024	0.0089	0.3933
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0019	0.0019	0.0074
Plasmodium falciparum	M1-family alanyl aminopeptidase, putative	0.0024	0.0089	1
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0019	0.0856
Loa Loa (eye worm)	hypothetical protein	0.0229	0.2707	0.4841
Plasmodium vivax	M1-family alanyl aminopeptidase, putative	0.0024	0.0089	0.3933
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.0233	0.0417
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0226	0.247
Trypanosoma brucei	aminopeptidase, putative	0.0024	0.0089	0.3933
Loa Loa (eye worm)	leukotriene A4 hydrolase	0.0455	0.5592	1
Schistosoma mansoni	chromobox protein	0.0084	0.0855	0.1528
Echinococcus multilocularis	GPCR, family 2	0.0033	0.0198	0.0198
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0226	0.0404
Echinococcus granulosus	aminopeptidase N	0.0024	0.0089	0.0159
Trichomonas vaginalis	chromobox protein, putative	0.0051	0.0428	0.4894
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0226	0.0404
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0024	0.0089	0.0159
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0382	0.0684
Schistosoma mansoni	ap endonuclease	0.0019	0.0019	0.0035
Loa Loa (eye worm)	aminopeptidase N	0.0024	0.0089	0.0159
Brugia malayi	TATA binding protein associated factor	0.0024	0.0089	0.0328
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0033	0.0198	0.0733
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0344	0.0616
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0104	0.1102	0.4073
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0207	0.2241
Schistosoma mansoni	hypothetical protein	0.0071	0.0684	0.1223
Mycobacterium ulcerans	beta-lactamase	0.0035	0.0226	1
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0035	0.0226	0.0226
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0226	0.0404
Trypanosoma cruzi	Aminopeptidase M1, putative	0.0024	0.0089	0.3933
Mycobacterium tuberculosis	Probable lipase LipE	0.0035	0.0226	0.0859
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0024	0.0089	0.0089
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0033	0.0198	0.0355
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0344	0.0616
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0226	1
Schistosoma mansoni	survival motor neuron protein	0.0047	0.0377	0.0674
Entamoeba histolytica	hypothetical protein	0.0035	0.0233	1
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0024	0.0089	0.0831
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0252	0.0451
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0226	0.0404
Loa Loa (eye worm)	heterochromatin protein 1	0.0084	0.0855	0.1528
Schistosoma mansoni	aminopeptidase A (M01 family)	0.0024	0.0089	0.0159
Brugia malayi	beta-lactamase family protein	0.0035	0.0226	0.0834
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.0226	1
Mycobacterium ulcerans	aminopeptidase N PepN	0.0024	0.0089	0.3365
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0033	0.0198	0.0198
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0344	0.0344
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0035	0.0226	0.0859
Echinococcus multilocularis	aminopeptidase N	0.0024	0.0089	0.0089
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0035	0.0226	0.0859
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0047	0.0377	0.1393
Toxoplasma gondii	aminopeptidase n, putative	0.0024	0.0089	0.3933
Echinococcus granulosus	GPCR family 2	0.0033	0.0198	0.0355
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0044	0.0344	0.0616
Schistosoma mansoni	cytosol alanyl aminopeptidase (M01 family)	0.0024	0.0089	0.0159
Plasmodium falciparum	M1-family alanyl aminopeptidase	0.0024	0.0089	1
Echinococcus granulosus	survival motor neuron protein 1	0.0229	0.2707	0.4841
Leishmania major	hypothetical protein, conserved	0.0035	0.0226	1
Trypanosoma brucei	metallo-peptidase, Clan MA(E) Family M1	0.0024	0.0089	0.3933
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0344	0.0344
Onchocerca volvulus		0.0035	0.0226	0.4034
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0024	0.0089	0.0089
Onchocerca volvulus		0.0047	0.0377	0.8493
Brugia malayi	hypothetical protein	0.0229	0.2707	1
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0024	0.0089	0.0159
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0207	0.2241
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0226	0.247
Brugia malayi	Heterochromatin protein 1	0.0084	0.0855	0.3157
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0684	0.1223
Loa Loa (eye worm)	beta-lactamase	0.0035	0.0226	0.0404
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0035	0.0226	1
Trichomonas vaginalis	chromobox protein, putative	0.0084	0.0855	1
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0024	0.0089	0.0831
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0035	0.0226	0.0404
Mycobacterium tuberculosis	Probable lipase LipD	0.0035	0.0226	0.0859
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0089	0.0159
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0226	1
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0024	0.0089	0.0159
Echinococcus granulosus	chromobox protein 1	0.0084	0.0855	0.1528
Mycobacterium leprae	conserved hypothetical protein	0.0035	0.0226	0.5
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0047	0.0382	0.8652
Trypanosoma cruzi	aminopeptidase, putative	0.0024	0.0089	0.3933
Brugia malayi	Peptidase family M1 containing protein	0.0024	0.0089	0.0328
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0033	0.0198	0.0355
Loa Loa (eye worm)	hypothetical protein	0.0104	0.1102	0.1972
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0019	0.2177

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	6.3096 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference
Potency (functional)	11.2202 uM	PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	12.5893 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249]	ChEMBL.	No reference
Potency (functional)	= 89.1251 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	100 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1590027

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1450335