TDR Targets

Basic information

Technical information

TDR Targets ID: 1450358
Name: 5-(3-fluorophenyl)-N-(2-piperidin-1-ylphenyl) -1,3-oxazole-4-carboxamide
MW: 365.401 | Formula: C21H20FN3O2
H donors: 1 H acceptors: 2 LogP: 4.24 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: Fc1cccc(c1)c1ocnc1C(=O)Nc1ccccc1N1CCCCC1
InChi: 1S/C21H20FN3O2/c22-16-8-6-7-15(13-16)20-19(23-14-27-20)21(26)24-17-9-2-3-10-18(17)25-11-4-1-5-12-25/h2-3,6-10,13-14H,1,4-5,11-12H2,(H,24,26)
InChiKey: ULJOEFPNLGSQAJ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

5-(3-fluorophenyl)-N-[2-(1-piperidyl)phenyl]oxazole-4-carboxamide
5-(3-fluorophenyl)-N-[2-(1-piperidyl)phenyl]-4-oxazolecarboxamide
5-(3-fluorophenyl)-N-(2-piperidinophenyl)oxazole-4-carboxamide
ZINC04932752
ASN 10400675
MLS000529621
SMR000122096
5-(3-Fluoro-phenyl)-oxazole-4-carboxylic acid (2-piperidin-1-yl-phenyl)-amide

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	TAR DNA binding protein	Starlite/ChEMBL	No references
Homo sapiens	microtubule-associated protein tau	Starlite/ChEMBL	No references
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus multilocularis	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	microtubule-associated protein tau	Get druggable targets OG5_133504	All targets in OG5_133504
Echinococcus granulosus	microtubule associated protein 2	Get druggable targets OG5_133504	All targets in OG5_133504
Schistosoma japonicum	ko:K04380 microtubule-associated protein tau, putative	Get druggable targets OG5_133504	All targets in OG5_133504
Loa Loa (eye worm)	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus multilocularis	microtubule associated protein 2	Get druggable targets OG5_133504	All targets in OG5_133504
Echinococcus granulosus	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	RNA recognition motif domain containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	MH2 domain containing protein	0.0041	0.0144	0.0145
Brugia malayi	latrophilin 2 splice variant baaae	0.0242	0.1737	0.1743
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0112	0.0708	0.071
Toxoplasma gondii	peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein	0.0176	0.1217	1
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, FKBP-type , putative	0.1286	1	1
Treponema pallidum	peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB)	0.1281	0.9958	1
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase, putative	0.1281	0.9958	1
Plasmodium falciparum	peptidyl-prolyl cis-trans isomerase, putative	0.0176	0.1217	0.1184
Trypanosoma cruzi	macrophage infectivity potentiator, precursor, putative	0.0176	0.1217	0.1158
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0112	0.0708	0.0711
Trichomonas vaginalis	fk506-binding protein, putative	0.1281	0.9958	1
Schistosoma mansoni	Smad4	0.0041	0.0144	0.0073
Echinococcus multilocularis	GPCR, family 2	0.0112	0.0708	0.0641
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.1281	0.9958	1
Echinococcus multilocularis	Smad4	0.0041	0.0144	0.0073
Loa Loa (eye worm)	FKBP-type peptidyl-prolyl cis-trans isomerase-30	0.0176	0.1217	0.1222
Brugia malayi	MH2 domain containing protein	0.0041	0.0144	0.0145
Schistosoma mansoni	hypothetical protein	0.0242	0.1737	0.1678
Loa Loa (eye worm)	TAR-binding protein	0.0076	0.0427	0.0429
Brugia malayi	photoreceptor-specific nuclear receptor	0.0249	0.1792	0.1798
Plasmodium vivax	peptidyl-prolyl cis-trans isomerase, putative	0.0176	0.1217	0.1184
Echinococcus granulosus	Smad4	0.0041	0.0144	0.0073
Leishmania major	fk506-binding protein 1-like protein	0.1281	0.9958	1
Leishmania major	peptidylprolyl isomerase-like protein	0.1281	0.9958	1
Schistosoma mansoni	immunophilin FK506 binding protein FKBP12	0.1281	0.9958	0.9958
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.0176	0.1217	0.1158
Toxoplasma gondii	peptidyl-prolyl isomerase FKBP12, putative	0.0176	0.1217	1
Loa Loa (eye worm)	FKBP-type peptidyl-prolyl cis-trans isomerase-33	0.0176	0.1217	0.1222
Loa Loa (eye worm)	MH2 domain-containing protein	0.0599	0.4559	0.4578
Toxoplasma gondii	isocitrate dehydrogenase	0.0032	0.0071	0.0243
Schistosoma mansoni	smad1 5 8 and	0.0041	0.0144	0.0073
Giardia lamblia	70 kDa peptidylprolyl isomerase, putative	0.1281	0.9958	1
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0081	0.0464	0.0425
Echinococcus granulosus	tar DNA binding protein	0.0076	0.0427	0.0358
Wolbachia endosymbiont of Brugia malayi	FKBP-type peptidylprolyl isomerase	0.0176	0.1217	1
Trypanosoma brucei	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.1281	0.9958	1
Brugia malayi	Latrophilin receptor protein 2	0.0112	0.0708	0.071
Schistosoma mansoni	immunophilin	0.1286	1	1
Loa Loa (eye worm)	hypothetical protein	0.0249	0.1792	0.18
Trichomonas vaginalis	immunophilin, putative	0.1281	0.9958	1
Echinococcus granulosus	FK506 binding protein 2	0.0176	0.1217	0.1153
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0354	0.2624	0.2632
Schistosoma mansoni	hypothetical protein	0.0112	0.0708	0.0641
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0354	0.2624	0.2632
Toxoplasma gondii	peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein	0.0176	0.1217	1
Trypanosoma brucei	FKBP-type peptidylprolyl cis-trans isomerase, putative	0.0176	0.1217	0.1158
Leishmania major	peptidyl-prolyl cis-trans isomerase, putative	0.0176	0.1217	0.1158
Schistosoma mansoni	hypothetical protein	0.0112	0.0708	0.0641
Loa Loa (eye worm)	MH1 domain-containing protein	0.0041	0.0144	0.0145
Echinococcus multilocularis	FK506 binding protein 8, 38 kDa	0.0182	0.1258	0.1195
Trypanosoma cruzi	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.1281	0.9958	1
Echinococcus granulosus	mothers against decapentaplegic 5	0.0041	0.0144	0.0073
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0032	0.0071	0.0029
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0427	0.0358
Loa Loa (eye worm)	FKBP-type peptidyl-prolyl cis-trans isomerase-12	0.1281	0.9958	1
Loa Loa (eye worm)	hypothetical protein	0.0112	0.0708	0.0711
Trypanosoma brucei	hypothetical protein, conserved	0.0176	0.1217	0.1158
Loa Loa (eye worm)	hypothetical protein	0.0176	0.1217	0.1222
Schistosoma mansoni	peptidase Clp (S14 family)	0.0081	0.0464	0.0396
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0112	0.0708	0.0641
Toxoplasma gondii	peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein	0.0176	0.1217	1
Brugia malayi	Smad1	0.0041	0.0144	0.0145
Loa Loa (eye worm)	Smad1	0.0041	0.0144	0.0145
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0081	0.0464	0.359
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0427	0.0358
Schistosoma mansoni	hypothetical protein	0.0176	0.1217	0.1153
Echinococcus multilocularis		0.0176	0.1217	0.1153
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0112	0.0708	0.0641
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-33, BmFKBP-33	0.0176	0.1217	0.122
Echinococcus granulosus	smad	0.0041	0.0144	0.0073
Echinococcus multilocularis	microtubule associated protein 2	0.0833	0.6416	0.639
Schistosoma mansoni	hypothetical protein	0.0112	0.0708	0.0641
Leishmania major	FKBP-type peptidyl-prolyl cis-trans isomerase, putative	0.0176	0.1217	0.1158
Schistosoma mansoni	smad1 5 8 and	0.0041	0.0144	0.0073
Brugia malayi	RNA recognition motif domain containing protein	0.0076	0.0427	0.0428
Loa Loa (eye worm)	transcription factor SMAD2	0.0599	0.4559	0.4578
Schistosoma mansoni	fk506 binding protein	0.0176	0.1217	0.1153
Onchocerca volvulus		0.0178	0.1226	1
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0041	0.0144	0.0073
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-30, BmFKBP-30	0.0176	0.1217	0.122
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59	0.1282	0.9968	1
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.0176	0.1217	0.1158
Giardia lamblia	FKBP-type peptidyl-prolyl cis-trans isomerase	0.1281	0.9958	1
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0041	0.0144	0.0073
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.1281	0.9958	1
Echinococcus multilocularis	fk506 binding protein	0.1281	0.9958	0.9958
Trypanosoma cruzi	FKBP-type peptidylprolyl cis-trans isomerase, putative	0.0176	0.1217	0.1158
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0032	0.0071	0.0029
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0081	0.0464	0.0425
Plasmodium vivax	70 kDa peptidylprolyl isomerase, putative	0.1281	0.9958	1
Brugia malayi	isocitrate dehydrogenase	0.0032	0.0071	0.0072
Mycobacterium ulcerans	FK-506 binding protein, peptidyl-prolyl cis-trans isomerase	0.1281	0.9958	1
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP4	0.111	0.8605	0.8595
Brugia malayi	MH1 domain containing protein	0.0041	0.0144	0.0145
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0081	0.0464	0.359
Echinococcus granulosus	GPCR family 2	0.0112	0.0708	0.0641
Schistosoma mansoni	hypothetical protein	0.0112	0.0708	0.0641
Loa Loa (eye worm)	MH2 domain-containing protein	0.0041	0.0144	0.0145
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0053	0.0243	0.1497
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0427	0.0358
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0053	0.0243	0.1703
Plasmodium falciparum	peptidyl-prolyl cis-trans isomerase FKBP35	0.1281	0.9958	1
Mycobacterium leprae	PROBABLE TRIGGER FACTOR (TF) PROTEIN TIG	0.0176	0.1217	1
Treponema pallidum	peptidyl-prolyl cis-trans isomerase, FKBP-type (slyD)	0.0176	0.1217	0.1184
Trypanosoma brucei	macrophage infectivity potentiator, precursor, putative	0.0176	0.1217	0.1158
Mycobacterium ulcerans	hypothetical protein	0.0176	0.1217	0.0792
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0053	0.0243	0.1497
Trypanosoma cruzi	FKBP-type peptidylprolyl cis-trans isomerase, putative	0.0176	0.1217	0.1158
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0081	0.0464	0.359
Brugia malayi	Isocitrate dehydrogenase	0.0032	0.0071	0.0072
Echinococcus multilocularis	tar DNA binding protein	0.0076	0.0427	0.0358
Loa Loa (eye worm)	hypothetical protein	0.0354	0.2624	0.2635
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12	0.1281	0.9958	0.999
Schistosoma mansoni	immunophilin	0.111	0.8605	0.8595
Echinococcus granulosus	microtubule associated protein 2	0.0833	0.6416	0.639
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.1281	0.9958	1
Echinococcus multilocularis	peptidyl prolyl cis trans isomerase FKBP4	0.1286	1	1
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0053	0.0243	0.0173
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, FKBP-type, putative	0.1286	1	1
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase, putative	0.0176	0.1217	0.1158
Echinococcus granulosus	FK506 binding protein 8 38 kDa	0.0176	0.1217	0.1153
Toxoplasma gondii	isocitrate dehydrogenase	0.0032	0.0071	0.0243
Mycobacterium tuberculosis	Probable trigger factor (TF) protein Tig	0.0176	0.1217	1
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0112	0.0708	0.0641
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0464	0.0466
Loa Loa (eye worm)	FKBP5 protein	0.1281	0.9958	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0354	0.2624	0.2635
Loa Loa (eye worm)	hypothetical protein	0.1106	0.8573	0.8609
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0076	0.0427	0.0429
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP1A	0.1281	0.9958	0.9958
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0112	0.0708	0.0641
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-13, BmFKBP-13	0.0176	0.1217	0.122
Leishmania major	peptidyl-prolyl cis-trans isomerase, macrophage infectivity potentiator precursor, putative	0.0176	0.1217	0.1158
Wolbachia endosymbiont of Brugia malayi	FKBP-type peptidylprolyl isomerase	0.0176	0.1217	1
Loa Loa (eye worm)	FKBP-type peptidyl-prolyl cis-trans isomerase-13	0.0176	0.1217	0.1222
Chlamydia trachomatis	peptidyl-prolyl cis-trans isomerase	0.0176	0.1217	1
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0041	0.0144	0.0073
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0041	0.0144	0.0073
Schistosoma mansoni	smad	0.0041	0.0144	0.0073
Brugia malayi	MH1 domain containing protein	0.0041	0.0144	0.0145
Brugia malayi	RNA binding protein	0.0076	0.0427	0.0428
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0081	0.0464	0.0396
Trypanosoma cruzi	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.1281	0.9958	1
Brugia malayi	MH2 domain containing protein	0.0599	0.4559	0.4573
Echinococcus granulosus	peptidase Clp S14 family	0.0053	0.0243	0.0173
Echinococcus multilocularis	peptidyl prolyl cis trans isomerase FKBP4	0.111	0.8605	0.8595
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0032	0.0071	0.0072
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0081	0.0464	0.0425
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0427	0.0358
Schistosoma mansoni	microtubule-associated protein tau	0.0833	0.6416	0.639
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.1281	0.9958	1
Schistosoma mansoni	immunophilin	0.1286	1	1
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0427	0.0358
Loa Loa (eye worm)	RNA binding protein	0.0076	0.0427	0.0429
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0081	0.0464	0.0396
Schistosoma mansoni	smad1 5 8 and	0.0041	0.0144	0.0073
Brugia malayi	TAR-binding protein	0.0076	0.0427	0.0428
Echinococcus multilocularis	smad	0.0041	0.0144	0.0073
Brugia malayi	Probable ClpP-like protease	0.0081	0.0464	0.0466
Loa Loa (eye worm)	hypothetical protein	0.0242	0.1737	0.1744

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	9.285 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	12.5893 uM	PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	14.1254 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	18.526 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	= 19.9526 um	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ]	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402]	ChEMBL.	No reference
Potency (functional)	= 39.8107 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	50.1187 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1589148

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1450358