Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.3076 | 0.3076 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.3076 | 0.3076 |
Loa Loa (eye worm) | TAR-binding protein | 0.0123 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0123 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0123 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0123 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0123 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0123 | 1 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0116 | 0.9352 | 0.9352 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.3076 | 0.3076 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0123 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0123 | 1 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0116 | 0.9352 | 0.9352 |
Loa Loa (eye worm) | RNA binding protein | 0.0123 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0123 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.1652 | 0.1652 |
Schistosoma mansoni | tar DNA-binding protein | 0.0123 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0123 | 1 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0116 | 0.9352 | 0.9352 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.1652 | 0.1652 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.1652 | 0.1652 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.3076 | 0.3076 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.1122 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 5.8584 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | ||
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.