Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | chromobox homolog 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.12 | 0.12 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.2177 | 0.2177 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.12 | 0.2196 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0067 | 0.0111 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0047 | 0.1947 | 0.1947 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 1 | 1 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0114 | 0.5993 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0067 | 0.0122 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0051 | 0.2177 | 0.2177 |
Loa Loa (eye worm) | glutamate receptor | 0.0036 | 0.1296 | 0.1296 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.3724 | 0.3724 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0114 | 0.5993 | 1 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0084 | 0.4187 | 0.4187 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0016 | 0.0067 | 0.0067 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0047 | 0.1947 | 0.2714 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3724 | 0.6813 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0047 | 0.1947 | 0.2714 |
Echinococcus multilocularis | chromobox protein 1 | 0.0084 | 0.4187 | 0.6986 |
Echinococcus multilocularis | GPCR, family 2 | 0.0016 | 0.0067 | 0.0111 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.3724 | 0.6214 |
Trichomonas vaginalis | chromobox protein, putative | 0.0084 | 0.4187 | 1 |
Echinococcus granulosus | chromobox protein 1 | 0.0084 | 0.4187 | 0.6986 |
Schistosoma mansoni | chromobox protein | 0.0084 | 0.4187 | 0.766 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0067 | 0.0122 |
Loa Loa (eye worm) | receptor family ligand binding region containing protein | 0.0024 | 0.0527 | 0.0527 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0051 | 0.2164 | 0.2164 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.3724 | 0.3724 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.0024 | 0.0527 | 0.0527 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3724 | 0.6813 |
Onchocerca volvulus | 0.0037 | 0.133 | 0.133 | |
Echinococcus multilocularis | chromobox protein 1 | 0.0084 | 0.4187 | 0.6986 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3724 | 0.6813 |
Loa Loa (eye worm) | metabotropic GABA-B receptor subtype 2 | 0.0024 | 0.0527 | 0.0527 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0067 | 0.0111 |
Brugia malayi | RNA binding protein | 0.0076 | 0.3724 | 0.3724 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0045 | 0.1823 | 0.1823 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0067 | 0.0111 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0045 | 0.1823 | 0.3335 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3724 | 0.6813 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.133 | 0.133 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0051 | 0.2177 | 0.2177 |
Echinococcus granulosus | chromobox protein 1 | 0.0084 | 0.4187 | 0.6986 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.3724 | 0.3724 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.3724 | 0.3724 |
Trichomonas vaginalis | chromobox protein, putative | 0.0084 | 0.4187 | 1 |
Loa Loa (eye worm) | glutamate receptor | 0.0093 | 0.4697 | 0.4697 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0105 | 0.5466 | 1 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0093 | 0.4697 | 0.4697 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.5993 | 0.5993 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0527 | 0.0527 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0016 | 0.0067 | 0.0067 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0078 | 0.3787 | 0.6929 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0051 | 0.2177 | 0.2177 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0067 | 0.0067 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.12 | 0.12 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0067 | 0.0111 |
Brugia malayi | chromobox protein homolog 3 | 0.0047 | 0.1947 | 0.1947 |
Schistosoma mansoni | chromobox protein | 0.0084 | 0.4187 | 0.766 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3724 | 0.6813 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.018 | 1 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0051 | 0.2164 | 0.3419 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.1947 | 0.1947 |
Trichomonas vaginalis | chromobox protein, putative | 0.0051 | 0.2164 | 0.3419 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0078 | 0.3787 | 0.6319 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0078 | 0.3787 | 0.6319 |
Brugia malayi | Heterochromatin protein 1 | 0.0084 | 0.4187 | 0.4187 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0016 | 0.0067 | 0.0067 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0084 | 0.417 | 0.417 |
Echinococcus granulosus | GPCR family 2 | 0.0016 | 0.0067 | 0.0111 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0067 | 0.0122 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0067 | 0.0122 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.3724 | 0.6214 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.3724 | 0.3724 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 17.7828 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.