Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | tumor protein p53 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | tumor protein p63 | Get druggable targets OG5_140038 | All targets in OG5_140038 |
Echinococcus granulosus | tumor protein p63 | Get druggable targets OG5_140038 | All targets in OG5_140038 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | smad | 0.0033 | 0.0266 | 0.0266 |
Brugia malayi | MH1 domain containing protein | 0.0018 | 0.0035 | 0.0035 |
Brugia malayi | TAR-binding protein | 0.066 | 1 | 1 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.006 | 0.0676 | 0.0676 |
Schistosoma mansoni | hypothetical protein | 0.0149 | 0.2055 | 0.2055 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0149 | 0.2055 | 0.2055 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0036 | 0.0311 | 0.0311 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.066 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0676 | 0.0676 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0033 | 0.0266 | 0.0266 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0081 | 0.1003 | 1 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0033 | 0.0266 | 0.0266 |
Brugia malayi | MH2 domain containing protein | 0.0033 | 0.0266 | 0.0266 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0469 | 0.7039 | 0.7039 |
Echinococcus multilocularis | tar DNA binding protein | 0.066 | 1 | 1 |
Loa Loa (eye worm) | Smad1 | 0.0033 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0489 | 0.7349 | 0.7349 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.2504 | 0.2504 |
Schistosoma mansoni | tar DNA-binding protein | 0.066 | 1 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0149 | 0.2055 | 0.2055 |
Brugia malayi | RNA recognition motif domain containing protein | 0.066 | 1 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0081 | 0.1003 | 1 |
Brugia malayi | Smad1 | 0.0033 | 0.0266 | 0.0266 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0081 | 0.1003 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0149 | 0.2055 | 0.2055 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0033 | 0.0266 | 0.0266 |
Schistosoma mansoni | hypothetical protein | 0.0149 | 0.2055 | 0.2055 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0311 | 0.0311 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0081 | 0.1003 | 1 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0033 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0149 | 0.2055 | 0.2055 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0469 | 0.7039 | 0.7039 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0081 | 0.1003 | 1 |
Schistosoma mansoni | smad1 5 8 and | 0.0033 | 0.0266 | 0.0266 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0177 | 0.2504 | 1 |
Schistosoma mansoni | Smad4 | 0.0033 | 0.0266 | 0.0266 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0016 | 0 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0489 | 0.7349 | 0.7349 |
Schistosoma mansoni | smad1 5 8 and | 0.0033 | 0.0266 | 0.0266 |
Schistosoma mansoni | smad | 0.0033 | 0.0266 | 0.0266 |
Schistosoma mansoni | hypothetical protein | 0.0149 | 0.2055 | 0.2055 |
Brugia malayi | N-terminal motif family protein | 0.0177 | 0.2504 | 0.2504 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0033 | 0.0266 | 0.0266 |
Leishmania major | hypothetical protein, conserved | 0.0081 | 0.1003 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0081 | 0.1003 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0149 | 0.2055 | 0.2055 |
Brugia malayi | MH2 domain containing protein | 0.0489 | 0.7349 | 0.7349 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.2055 | 0.2055 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0081 | 0.1003 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0321 | 0.4732 | 0.4732 |
Brugia malayi | MH2 domain containing protein | 0.0033 | 0.0266 | 0.0266 |
Echinococcus granulosus | tumor protein p63 | 0.0408 | 0.6085 | 0.6085 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0149 | 0.2055 | 0.2055 |
Echinococcus granulosus | tar DNA binding protein | 0.066 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.066 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.066 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.066 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.066 | 1 | 1 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0036 | 0.0311 | 0.0311 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0149 | 0.2055 | 0.2055 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0035 | 0.0035 |
Brugia malayi | MH1 domain containing protein | 0.0033 | 0.0266 | 0.0266 |
Schistosoma mansoni | smad1 5 8 and | 0.0033 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.1003 | 0.1003 |
Loa Loa (eye worm) | RNA binding protein | 0.066 | 1 | 1 |
Echinococcus multilocularis | smad | 0.0033 | 0.0266 | 0.0266 |
Brugia malayi | hypothetical protein | 0.0052 | 0.0559 | 0.0559 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0033 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | hypothetical protein | 0.0469 | 0.7039 | 0.7039 |
Schistosoma mansoni | hypothetical protein | 0.0321 | 0.4732 | 0.4732 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0033 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0469 | 0.7039 | 0.7039 |
Echinococcus multilocularis | Smad4 | 0.0033 | 0.0266 | 0.0266 |
Brugia malayi | MH1 domain containing protein | 0.0033 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | nuclear factor I | 0.0018 | 0.0035 | 0.0035 |
Schistosoma mansoni | tar DNA-binding protein | 0.066 | 1 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0149 | 0.2055 | 0.2055 |
Echinococcus multilocularis | tumor protein p63 | 0.0408 | 0.6085 | 0.6085 |
Brugia malayi | hypothetical protein | 0.0081 | 0.1003 | 0.1003 |
Schistosoma mansoni | hypothetical protein | 0.0149 | 0.2055 | 0.2055 |
Echinococcus granulosus | Smad4 | 0.0033 | 0.0266 | 0.0266 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0149 | 0.2055 | 0.2055 |
Loa Loa (eye worm) | hypothetical protein | 0.0321 | 0.4732 | 0.4732 |
Brugia malayi | MH1 domain containing protein | 0.0018 | 0.0035 | 0.0035 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.0398 um | PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.