Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | penicillin-binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium tuberculosis | Possible penicillin-binding protein | Get druggable targets OG5_149948 | All targets in OG5_149948 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.027 | 0.9686 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0043 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0212 | 0.7189 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0212 | 0.7189 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0212 | 0.7189 | 1 |
Onchocerca volvulus | 0.0043 | 0 | 0.5 | |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.027 | 0.9686 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0212 | 0.7189 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0185 | 0.6034 | 0.623 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0 | 0.5 |
Onchocerca volvulus | 0.0043 | 0 | 0.5 | |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0212 | 0.7189 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0212 | 0.7189 | 0.7422 |
Mycobacterium leprae | Probable lipase LipE | 0.0043 | 0 | 0.5 |
Trichomonas vaginalis | esterase, putative | 0.0043 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0086 | 0.1796 | 0.2499 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0212 | 0.7189 | 0.7422 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0086 | 0.1796 | 0.2499 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.027 | 0.9686 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0212 | 0.7189 | 0.7422 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0086 | 0.1796 | 0.2499 |
Brugia malayi | TAR-binding protein | 0.0212 | 0.7189 | 0.7422 |
Schistosoma mansoni | hypothetical protein | 0.0086 | 0.1796 | 0.2499 |
Brugia malayi | RNA binding protein | 0.0212 | 0.7189 | 0.7422 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0086 | 0.1796 | 0.1854 |
Mycobacterium ulcerans | hypothetical protein | 0.0043 | 0 | 0.5 |
Mycobacterium leprae | conserved hypothetical protein | 0.0043 | 0 | 0.5 |
Onchocerca volvulus | 0.0043 | 0 | 0.5 | |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0086 | 0.1796 | 0.2499 |
Mycobacterium ulcerans | beta-lactamase | 0.0043 | 0 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0212 | 0.7189 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.027 | 0.9686 | 1 |
Toxoplasma gondii | ABC1 family protein | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0086 | 0.1796 | 0.1854 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0212 | 0.7189 | 0.7422 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0086 | 0.1796 | 0.2499 |
Schistosoma mansoni | hypothetical protein | 0.0185 | 0.6034 | 0.8394 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0043 | 0 | 0.5 |
Mycobacterium ulcerans | lipase LipD | 0.0043 | 0 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0185 | 0.6034 | 0.623 |
Echinococcus granulosus | GPCR family 2 | 0.0086 | 0.1796 | 0.2499 |
Plasmodium vivax | hypothetical protein, conserved | 0.0043 | 0 | 0.5 |
Echinococcus multilocularis | GPCR, family 2 | 0.0086 | 0.1796 | 0.2499 |
Schistosoma mansoni | hypothetical protein | 0.0086 | 0.1796 | 0.2499 |
Schistosoma mansoni | hypothetical protein | 0.0086 | 0.1796 | 0.2499 |
Schistosoma mansoni | tar DNA-binding protein | 0.0212 | 0.7189 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0086 | 0.1796 | 0.1854 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1796 | 0.1854 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0043 | 0 | 0.5 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0043 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 15.8489 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.