Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | K(lysine) acetyltransferase 2A | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | relaxin/insulin-like family peptide receptor 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | GPCR family 2 | 0.0016 | 0.0246 | 0.0253 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0246 | 0.0253 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0894 | 0.0665 |
Loa Loa (eye worm) | acetyltransferase | 0.0175 | 1 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0246 | 0.0246 |
Brugia malayi | TAR-binding protein | 0.0064 | 0.318 | 0.3008 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.318 | 0.318 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.318 | 0.318 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.318 | 0.318 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0047 | 0.2165 | 0.5 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.017 | 0.9699 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.1375 | 0.1157 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0246 | 0.0253 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.2658 | 0.2473 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0047 | 0.2165 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.318 | 0.318 |
Brugia malayi | hypothetical protein | 0.0026 | 0.0894 | 0.0665 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0246 | 0.0246 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.2348 | 0.2155 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.0894 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0026 | 0.0894 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0064 | 0.318 | 0.318 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0051 | 0.2427 | 0.2503 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0175 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0064 | 0.318 | 0.3278 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0064 | 0.318 | 0.3008 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.2658 | 0.2658 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0064 | 0.318 | 0.3008 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.318 | 0.318 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0051 | 0.2427 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0246 | 0.0246 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.1375 | 0.1157 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.2348 | 0.2155 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0051 | 0.2427 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0026 | 0.0894 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.2658 | 0.2658 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0047 | 0.2165 | 1 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0175 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0064 | 0.318 | 0.3008 |
Brugia malayi | RNA binding protein | 0.0064 | 0.318 | 0.3008 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.2658 | 0.2473 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.0894 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.2658 | 0.2658 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.2658 | 0.2741 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.2348 | 0.2155 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.2658 | 0.2741 |
Echinococcus multilocularis | GPCR, family 2 | 0.0016 | 0.0246 | 0.0246 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0246 | 0.0246 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0051 | 0.2427 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0246 | 0.0246 |
Brugia malayi | hypothetical protein | 0.0017 | 0.0319 | 0.0076 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.2658 | 0.2658 |
Loa Loa (eye worm) | RNA binding protein | 0.0064 | 0.318 | 0.3008 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.2348 | 0.2155 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.2658 | 0.2658 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0051 | 0.2427 | 0.5 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0051 | 0.2427 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0246 | 0.0246 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.1375 | 0.1375 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.0418 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 4.4668 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] | ChEMBL. | No reference |
Potency (functional) | 10 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 17.7828 um | PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Relaxin Receptor RXFP1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 38.8769 uM | PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Relaxin Receptor RXFP1: RXFP2 Hit Validation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2676, AID2703, AID489012] | ChEMBL. | No reference |
Potency (functional) | 38.8769 uM | PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Relaxin Receptor RXFP1: RXFP1 Hit Validation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2676, AID2703, AID489043, AID492948] | ChEMBL. | No reference |
Potency (functional) | 43.6206 uM | PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Relaxin Receptor RXFP1: V1B Hit Validation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2676, AID2703, AID489012] | ChEMBL. | No reference |
Potency (functional) | 43.6206 uM | PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Relaxin Receptor RXFP1: THP1 Hit Validation. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 100 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.