Detailed information for compound 1450925

Basic information

Technical information
  • TDR Targets ID: 1450925
  • Name: 2,4-dimethyl-N-(2-phenylphenyl)-1,3-oxazole-5 -carboxamide
  • MW: 292.332 | Formula: C18H16N2O2
  • H donors: 1 H acceptors: 2 LogP: 3.93 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1nc(c(o1)C(=O)Nc1ccccc1c1ccccc1)C
  • InChi: 1S/C18H16N2O2/c1-12-17(22-13(2)19-12)18(21)20-16-11-7-6-10-15(16)14-8-4-3-5-9-14/h3-11H,1-2H3,(H,20,21)
  • InChiKey: CQLQTMCWHVZRCO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2,4-dimethyl-N-(2-phenylphenyl)oxazole-5-carboxamide
  • 2,4-dimethyl-N-(2-phenylphenyl)-5-oxazolecarboxamide
  • ZINC04111347
  • MLS000092891
  • N-1,1'-biphenyl-2-yl-2,4-dimethyl-1,3-oxazole-5-carboxamide
  • SMR000028528

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens thyroid stimulating hormone receptor Starlite/ChEMBL No references
Homo sapiens chromobox homolog 1 Starlite/ChEMBL No references
Homo sapiens ubiquitin specific peptidase 2 Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Theileria parva hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Cryptosporidium hominis ubiquitin specific protease 66 Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma japonicum IPR015063,Domain of unknown function DUF1873,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Onchocerca volvulus Heterochromatin protein 1 homolog Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma japonicum Chromobox protein homolog 5, putative Get druggable targets OG5_129545 All targets in OG5_129545
Loa Loa (eye worm) heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma congolense ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi Heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania donovani ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma japonicum expressed protein Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Cryptosporidium parvum ubiquitin C-terminal hydrolase of the cysteine proteinase fold Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans ubiquitin-specific protease Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania infantum ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei gambiense ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania mexicana ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania braziliensis ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Onchocerca volvulus Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum ubiquitin specific protease, putative ubiquitin specific peptidase 2 362 aa 378 aa 25.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni retinoic acid receptor RXR 0.0065 0.0152 0.0224
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0065 0.0152 0.0122
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0065 0.0152 1
Brugia malayi Tyrosine-protein kinase abl-1 0.0413 0.2051 0.2027
Toxoplasma gondii isocitrate dehydrogenase 0.035 0.1707 1
Brugia malayi latrophilin 2 splice variant baaae 0.1036 0.5447 0.5434
Loa Loa (eye worm) TAR-binding protein 0.0524 0.2656 0.2656
Loa Loa (eye worm) hypothetical protein 0.0065 0.0152 0.0152
Brugia malayi nuclear receptor NHR-88 0.0065 0.0152 0.0122
Loa Loa (eye worm) MH1 domain-containing protein 0.0127 0.0493 0.0493
Loa Loa (eye worm) hypothetical protein 0.0047 0.0056 0.0056
Brugia malayi MH1 domain containing protein 0.007 0.0183 0.0153
Echinococcus granulosus Glycosyl transferase family 8 0.0073 0.0196 0.0385
Schistosoma mansoni smad 0.0127 0.0493 0.0855
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0681 0.3514 0.808
Schistosoma mansoni nuclear hormone receptor 0.0065 0.0152 0.0224
Echinococcus granulosus mothers against decapentaplegic 2 0.0057 0.0109 0.0183
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.035 0.1707 0.3888
Loa Loa (eye worm) hypothetical protein 0.0065 0.0152 0.0152
Echinococcus multilocularis GPCR, family 2 0.048 0.2413 0.5526
Echinococcus granulosus chromobox protein 1 0.0084 0.0257 0.0526
Loa Loa (eye worm) hypothetical protein 0.0043 0.003 0.003
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0065 0.0152 0.0282
Schistosoma mansoni tar DNA-binding protein 0.0524 0.2656 0.4848
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0065 0.0152 0.0122
Echinococcus multilocularis isocitrate dehydrogenase 0.035 0.1707 0.3888
Loa Loa (eye worm) hypothetical protein 0.1036 0.5447 0.5447
Brugia malayi Tyrosine-protein kinase abl-1 0.0278 0.1313 0.1287
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0065 0.0152 0.0282
Echinococcus multilocularis ubiquitin specific protease 41 0.0045 0.0042 0.0027
Brugia malayi hypothetical protein 0.0191 0.0842 0.0814
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0065 0.0152 0.0122
Loa Loa (eye worm) Smad1 0.0127 0.0493 0.0493
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.005 0.0073 0.0255
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.1516 0.8062 0.8056
Echinococcus multilocularis mothers against decapentaplegic 6 0.0057 0.0109 0.0183
Plasmodium falciparum ataxin-2 like protein, putative 0.0191 0.0842 0.4192
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0042 0.0027
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.035 0.1707 1
Schistosoma mansoni hypothetical protein 0.048 0.2413 0.4399
Echinococcus multilocularis Smad4 0.0127 0.0493 0.1074
Echinococcus granulosus ubiquitin specific protease 41 0.0045 0.0042 0.0027
Brugia malayi RNA binding protein 0.0524 0.2656 0.2634
Loa Loa (eye worm) hypothetical protein 0.0077 0.0217 0.0217
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.035 0.1707 0.3888
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0042 0.0027
Brugia malayi nuclear hormone receptor 0.0065 0.0152 0.0122
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0065 0.0152 0.0282
Brugia malayi isocitrate dehydrogenase 0.035 0.1707 0.1682
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0065 0.0152 0.0122
Leishmania major hypothetical protein, conserved 0.0191 0.0842 0.484
Brugia malayi MH1 domain containing protein 0.007 0.0183 0.0153
Toxoplasma gondii LsmAD domain-containing protein 0.0191 0.0842 0.4192
Schistosoma mansoni smad1 5 8 and 0.0127 0.0493 0.0855
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0065 0.0152 0.0282
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0045 0.0042 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0065 0.0152 0.0224
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0045 0.0042 0.0022
Echinococcus multilocularis glycosyltransferase protein LARGE2 0.0071 0.0183 0.0356
Schistosoma mansoni hypothetical protein 0.048 0.2413 0.4399
Schistosoma mansoni Smad4 0.0057 0.0109 0.0146
Loa Loa (eye worm) latrophilin receptor protein 2 0.048 0.2413 0.2413
Echinococcus granulosus mothers against decapentaplegic 5 0.0127 0.0493 0.1074
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0065 0.0152 0.0282
Loa Loa (eye worm) TK/ABL protein kinase 0.0681 0.3514 0.3514
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0065 0.0152 0.0152
Trypanosoma brucei isocitrate dehydrogenase, putative 0.035 0.1707 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0065 0.0152 0.0282
Echinococcus granulosus glycosyltransferase protein LARGE2 0.0071 0.0183 0.0356
Brugia malayi Calcitonin receptor-like protein seb-1 0.1516 0.8062 0.8056
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0282 0.1338 0.1338
Loa Loa (eye worm) hypothetical protein 0.0057 0.0109 0.0109
Loa Loa (eye worm) MH1 domain-containing protein 0.0057 0.0109 0.0109
Loa Loa (eye worm) RNA binding protein 0.0524 0.2656 0.2656
Echinococcus multilocularis FTZ F1 alpha 0.0065 0.0152 0.0282
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.4342 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0524 0.2656 0.2656
Echinococcus multilocularis tyrosine protein kinase Abl 0.0278 0.1313 0.2975
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0065 0.0152 0.0224
Brugia malayi Nuclear hormone receptor-like 1 0.0065 0.0152 0.0122
Loa Loa (eye worm) isocitrate dehydrogenase gamma subunit 0.0043 0.003 0.003
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0065 0.0152 0.0122
Onchocerca volvulus Bile acid receptor homolog 0.0065 0.0152 1
Echinococcus granulosus smad 0.0127 0.0493 0.1074
Schistosoma mansoni hypothetical protein 0.0086 0.0266 0.0436
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0127 0.0493 0.1074
Trypanosoma brucei PAB1-binding protein , putative 0.0191 0.0842 0.4803
Plasmodium vivax ataxin-2 like protein, putative 0.0191 0.0842 0.4192
Brugia malayi Isocitrate dehydrogenase 0.035 0.1707 0.1682
Schistosoma mansoni peptidase Clp (S14 family) 0.0077 0.0217 0.0345
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0257 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.0217 1
Echinococcus granulosus tar DNA binding protein 0.0524 0.2656 0.609
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.005 0.0073 0.2284
Brugia malayi hypothetical protein 0.0123 0.0472 0.0443
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0057 0.0109 0.7186
Loa Loa (eye worm) hypothetical protein 0.0521 0.2638 0.2638
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0077 0.0217 0.0434
Echinococcus granulosus GPCR family 2 0.048 0.2413 0.5526
Trypanosoma cruzi PAB1-binding protein , putative 0.0191 0.0842 0.4803
Echinococcus granulosus Smad4 0.0127 0.0493 0.1074
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0065 0.0152 0.0282
Loa Loa (eye worm) pigment dispersing factor receptor c 0.1516 0.8062 0.8062
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.0217 0.5
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0065 0.0152 0.0122
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0065 0.0152 0.0152
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.035 0.1707 0.3095
Echinococcus granulosus FTZ F1 alpha 0.0065 0.0152 0.0282
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0065 0.0152 0.0122
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0065 0.0152 0.0282
Echinococcus multilocularis thyroid hormone receptor alpha 0.0065 0.0152 0.0282
Schistosoma mansoni chromobox protein 0.0084 0.0257 0.0419
Loa Loa (eye worm) hypothetical protein 0.0065 0.0152 0.0152
Loa Loa (eye worm) nuclear hormone receptor 0.0517 0.2618 0.2618
Loa Loa (eye worm) MH2 domain-containing protein 0.0057 0.0109 0.0109
Schistosoma mansoni thyroid hormone receptor 0.0065 0.0152 0.0224
Schistosoma mansoni tar DNA-binding protein 0.0524 0.2656 0.4848
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0042 0.0517
Brugia malayi ecdysteroid receptor 0.0065 0.0152 0.0122
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.0217 1
Brugia malayi follicle stimulating hormone receptor 0.0282 0.1338 0.1312
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.035 0.1707 0.3888
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0045 0.0042 0.0012
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0086 0.0266 0.0547
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0065 0.0152 0.0122
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0065 0.0152 0.0224
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0056 0.1118
Echinococcus multilocularis tar DNA binding protein 0.0524 0.2656 0.609
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0077 0.0217 1
Schistosoma mansoni smad1 5 8 and 0.0127 0.0493 0.0855
Echinococcus granulosus chromobox protein 1 0.0084 0.0257 0.0526
Brugia malayi TAR-binding protein 0.0524 0.2656 0.2634
Schistosoma mansoni RAR-like nuclear receptor 0.0065 0.0152 0.0224
Echinococcus multilocularis chromobox protein 1 0.0084 0.0257 0.0526
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0065 0.0152 0.0152
Loa Loa (eye worm) MH2 domain-containing protein 0.1871 1 1
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0045 0.0042 0.007
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0056 0.1118
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0042 0.0517
Brugia malayi Steroid receptor seven-up type 2 0.0551 0.2805 0.2783
Brugia malayi Probable ClpP-like protease 0.0077 0.0217 0.0188
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0065 0.0152 0.0282
Schistosoma mansoni Smad4 0.0127 0.0493 0.0855
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0045 0.0042 0.5
Schistosoma mansoni glycosyltransferase-related 0.0073 0.0196 0.0306
Schistosoma mansoni Smad4 0.0057 0.0109 0.0146
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.035 0.1707 1
Loa Loa (eye worm) transcription factor SMAD2 0.1871 1 1
Echinococcus multilocularis mothers against decapentaplegic 5 0.0127 0.0493 0.1074
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0065 0.0152 0.0224
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0551 0.2805 0.6434
Echinococcus multilocularis peptidase Clp (S14 family) 0.005 0.0073 0.0099
Trypanosoma cruzi PAB1-binding protein , putative 0.0191 0.0842 0.4803
Echinococcus multilocularis glycosyltransferase protein LARGE2 0.0071 0.0183 0.0356
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0065 0.0152 0.0152
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0065 0.0152 0.0282
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.035 0.1707 1
Loa Loa (eye worm) hypothetical protein 0.048 0.2413 0.2413
Echinococcus multilocularis conserved hypothetical protein 0.0054 0.0094 0.0147
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0042 0.0517
Loa Loa (eye worm) hypothetical protein 0.0065 0.0152 0.0152
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0065 0.0152 0.0152
Schistosoma mansoni tar DNA-binding protein 0.0524 0.2656 0.4848
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0075 0.1979
Loa Loa (eye worm) hypothetical protein 0.0301 0.1437 0.1437
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.048 0.2413 0.239
Brugia malayi MH2 domain containing protein 0.0127 0.0493 0.0465
Loa Loa (eye worm) heterochromatin protein 1 0.0084 0.0257 0.0257
Brugia malayi RNA recognition motif domain containing protein 0.0524 0.2656 0.2634
Loa Loa (eye worm) glycosyl transferase family 8 protein 0.0073 0.0196 0.0196
Loa Loa (eye worm) hypothetical protein 0.0065 0.0152 0.0152
Echinococcus granulosus tyrosine protein kinase ABL1 0.0681 0.3514 0.808
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.048 0.2413 0.5526
Echinococcus granulosus microtubule associated protein 2 0.0833 0.4342 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.035 0.1707 0.1707
Brugia malayi Latrophilin receptor protein 2 0.048 0.2413 0.239
Echinococcus granulosus mothers against decapentaplegic 6 0.0057 0.0109 0.0183
Loa Loa (eye worm) hypothetical protein 0.0259 0.1208 0.1208
Echinococcus granulosus TGF beta signal transducer SmadC 0.0127 0.0493 0.1074
Echinococcus granulosus Glycosyltransferase protein LARGE1 0.0054 0.0094 0.0147
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0042 0.0027
Schistosoma mansoni coup transcription factor 0.0065 0.0152 0.0224
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0065 0.0152 0.0224
Echinococcus multilocularis glycosyltransferase protein LARGE2 0.0071 0.0183 0.0356
Onchocerca volvulus Protein ultraspiracle homolog 0.0065 0.0152 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0065 0.0152 0.0122
Schistosoma mansoni hypothetical protein 0.1036 0.5447 1
Echinococcus multilocularis smad 0.0127 0.0493 0.1074
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0065 0.0152 0.0152
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0045 0.0042 0.0022
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0257 1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0127 0.0493 0.0855
Brugia malayi MH2 domain containing protein 0.0127 0.0493 0.0465
Schistosoma mansoni thyroid hormone receptor 0.0065 0.0152 0.0224
Echinococcus multilocularis chromobox protein 1 0.0084 0.0257 0.0526
Brugia malayi Smad1 0.0127 0.0493 0.0465
Brugia malayi MH2 domain containing protein 0.0057 0.0109 0.0079
Echinococcus multilocularis Glycosyl transferase, family 8 0.0073 0.0196 0.0385
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0065 0.0152 0.0122
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.035 0.1707 1
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.035 0.1707 0.3888
Plasmodium falciparum ataxin-2 like protein, putative 0.0191 0.0842 0.4192
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0077 0.0217 0.5
Loa Loa (eye worm) hypothetical protein 0.0065 0.0152 0.0152
Toxoplasma gondii isocitrate dehydrogenase 0.035 0.1707 1
Echinococcus multilocularis mothers against decapentaplegic 2 0.0057 0.0109 0.0183
Loa Loa (eye worm) hypothetical protein 0.0045 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0191 0.0842 0.0842
Schistosoma mansoni steroid hormone receptor ad4bp 0.0065 0.0152 0.0224
Schistosoma mansoni tar DNA-binding protein 0.0524 0.2656 0.4848
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.005 0.0073 0.0255
Brugia malayi MH1 domain containing protein 0.0127 0.0493 0.0465
Echinococcus granulosus ecdysone induced protein 78C 0.0065 0.0152 0.0282
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0065 0.0152 0.0282
Schistosoma mansoni tar DNA-binding protein 0.0524 0.2656 0.4848
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0042 0.0027
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0065 0.0152 0.0122
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.035 0.1707 1
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.0217 0.5
Loa Loa (eye worm) hypothetical protein 0.007 0.0183 0.0183
Loa Loa (eye worm) steroid hormone receptor 0.0065 0.0152 0.0152
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0065 0.0152 0.0152
Schistosoma mansoni hypothetical protein 0.048 0.2413 0.4399
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0065 0.0152 0.0122
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.4342 0.796
Loa Loa (eye worm) hypothetical protein 0.1516 0.8062 0.8062
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0551 0.2805 0.6434
Brugia malayi mothers against decapentaplegic homolog 3 0.0057 0.0109 0.0079
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.035 0.1707 1
Brugia malayi MH1 domain containing protein 0.0127 0.0493 0.0465
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.035 0.1707 0.3888
Brugia malayi chromobox protein homolog 3 0.0047 0.0056 0.0025
Onchocerca volvulus 0.0065 0.0152 1
Schistosoma mansoni hypothetical protein 0.048 0.2413 0.4399
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0065 0.0152 0.0122
Schistosoma mansoni tyrosine kinase 0.0672 0.3461 0.6333
Loa Loa (eye worm) MH2 domain-containing protein 0.0127 0.0493 0.0493
Brugia malayi photoreceptor-specific nuclear receptor 0.0301 0.1437 0.1411
Echinococcus granulosus peptidase Clp S14 family 0.005 0.0073 0.0099
Schistosoma mansoni smad1 5 8 and 0.0127 0.0493 0.0855
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0077 0.0217 0.0434
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0056 0.3661
Brugia malayi Glycosyl transferase family 8 protein 0.0073 0.0196 0.0166
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.035 0.1707 1
Loa Loa (eye worm) hypothetical protein 0.0065 0.0152 0.0152
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0051 0.0075 0.4947
Loa Loa (eye worm) nuclear factor I 0.007 0.0183 0.0183
Schistosoma mansoni chromobox protein 0.0084 0.0257 0.0419
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0065 0.0152 0.0224
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.048 0.2413 0.5526
Echinococcus multilocularis ecdysone induced protein 78C 0.0065 0.0152 0.0282
Brugia malayi steroid hormone receptor 0.0065 0.0152 0.0122
Schistosoma mansoni smad 0.0057 0.0109 0.0146
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0077 0.0217 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.048 0.2413 0.5526
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0075 0.1979
Brugia malayi Heterochromatin protein 1 0.0084 0.0257 0.0228
Echinococcus multilocularis Glycosyltransferase protein LARGE1 0.0054 0.0094 0.0147
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.048 0.2413 0.5526
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0086 0.0266 0.0547

Activities

Activity type Activity value Assay description Source Reference
Potency (binding) = 10 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 89.1251 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.