Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | glutaminase | 0.0306 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0077 | 0.1524 | 0.1524 |
Loa Loa (eye worm) | TAR-binding protein | 0.0136 | 0.3693 | 0.3693 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.0291 | 0.0789 |
Schistosoma mansoni | tar DNA-binding protein | 0.0136 | 0.3693 | 0.3693 |
Echinococcus multilocularis | tar DNA binding protein | 0.0136 | 0.3693 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.0291 | 0.0291 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.1524 | 0.1524 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0136 | 0.3693 | 0.3693 |
Schistosoma mansoni | tar DNA-binding protein | 0.0136 | 0.3693 | 0.3693 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0136 | 0.3693 | 0.3693 |
Loa Loa (eye worm) | glutaminase 2 | 0.0306 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0136 | 0.3693 | 0.3693 |
Echinococcus granulosus | tar DNA binding protein | 0.0136 | 0.3693 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0136 | 0.3693 | 0.3693 |
Trichomonas vaginalis | glutaminase, putative | 0.0306 | 1 | 0.5 |
Loa Loa (eye worm) | glutaminase | 0.0306 | 1 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.0291 | 0.0789 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0132 | 0.3547 | 0.3547 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0112 | 0.2836 | 0.2836 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0291 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0112 | 0.2836 | 0.2836 |
Schistosoma mansoni | tar DNA-binding protein | 0.0136 | 0.3693 | 0.3693 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.0291 | 0.0291 |
Brugia malayi | hypothetical protein | 0.0043 | 0.0291 | 0.0291 |
Mycobacterium ulcerans | glutaminase | 0.0306 | 1 | 0.5 |
Brugia malayi | RNA binding protein | 0.0136 | 0.3693 | 0.3693 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0077 | 0.1524 | 0.1524 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0291 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0132 | 0.3547 | 0.3547 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0112 | 0.2836 | 0.2836 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0291 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0136 | 0.3693 | 0.3693 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0132 | 0.3547 | 0.3547 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0291 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.2836 | 0.2836 |
Brugia malayi | TAR-binding protein | 0.0136 | 0.3693 | 0.3693 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.2995 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 8.2753 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 8.9125 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 20.5962 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | = 22.3872 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.