Detailed information for compound 1451174

Basic information

Technical information
  • TDR Targets ID: 1451174
  • Name: N-(3-morpholin-4-ylsulfonylphenyl)pyrazine-2- carboxamide
  • MW: 348.377 | Formula: C15H16N4O4S
  • H donors: 1 H acceptors: 5 LogP: -0.27 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1cnccn1)Nc1cccc(c1)S(=O)(=O)N1CCOCC1
  • InChi: 1S/C15H16N4O4S/c20-15(14-11-16-4-5-17-14)18-12-2-1-3-13(10-12)24(21,22)19-6-8-23-9-7-19/h1-5,10-11H,6-9H2,(H,18,20)
  • InChiKey: CSWVBGLASBJOBD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(3-morpholinosulfonylphenyl)pyrazine-2-carboxamide
  • N-(3-morpholinosulfonylphenyl)-2-pyrazinecarboxamide
  • N-(3-morpholinosulfonylphenyl)pyrazinamide
  • ZINC07140967
  • SMR000371851
  • T5222656
  • MLS000776612

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references
Homo sapiens snurportin 1 No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.02 0.5179 0.5079
Schistosoma mansoni importin beta-1 0.0035 0.0527 0.0331
Trichomonas vaginalis glutaminase, putative 0.0316 0.844 1
Plasmodium vivax SET domain protein, putative 0.0036 0.0562 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0203 0.3858
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0203 0.3858
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0944 0.0899
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0342 0.0168
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0269 0.0067
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0203 0.3858
Brugia malayi RNA, U transporter 1 0.0099 0.2332 0.2584
Leishmania major GTP-binding protein, putative 0.0026 0.0269 0.471
Schistosoma mansoni tar DNA-binding protein 0.02 0.5179 0.5079
Schistosoma mansoni tar DNA-binding protein 0.02 0.5179 0.5079
Trypanosoma brucei DNA polymerase eta, putative 0.0023 0.0203 0.3858
Loa Loa (eye worm) hypothetical protein 0.0034 0.0502 0.0305
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0203 0.3858
Echinococcus granulosus tar DNA binding protein 0.02 0.5179 0.5079
Schistosoma mansoni hypothetical protein 0.0034 0.0502 0.0305
Echinococcus multilocularis tar DNA binding protein 0.02 0.5179 0.5079
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0562 0.0366
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0944 0.0756
Brugia malayi RNA recognition motif domain containing protein 0.02 0.5179 0.6041
Brugia malayi Pre-SET motif family protein 0.0251 0.6615 0.7784
Loa Loa (eye worm) hypothetical protein 0.0036 0.0562 0.0366
Entamoeba histolytica hypothetical protein 0.0028 0.0342 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0203 0.3858
Brugia malayi glutaminase DH11.1 0.0316 0.844 1
Brugia malayi RNA binding protein 0.02 0.5179 0.6041
Trypanosoma brucei unspecified product 0.0023 0.0203 0.3858
Brugia malayi Pre-SET motif family protein 0.0036 0.0562 0.0435
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0203 0.3858
Loa Loa (eye worm) hypothetical protein 0.0035 0.0527 0.0331
Schistosoma mansoni tar DNA-binding protein 0.02 0.5179 0.5079
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0342 0.0168
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0562 0.0366
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0524 0.0328
Schistosoma mansoni hypothetical protein 0.0372 1 1
Mycobacterium ulcerans glutaminase 0.0316 0.844 1
Echinococcus multilocularis snurportin 1 0.0372 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0203 0.3858
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0502 0.0363
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0562 0.0366
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0342 1
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0203 0.3858
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0527 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0944 0.0899
Schistosoma mansoni tar DNA-binding protein 0.02 0.5179 0.5079
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0203 0.3858
Loa Loa (eye worm) hypothetical protein 0.005 0.0944 0.0756
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0269 0.5097
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0203 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0203 0.3858
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0562 0.0366
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0527 0.8822
Loa Loa (eye worm) glutaminase 0.0316 0.844 0.8408
Brugia malayi Importin beta-1 subunit 0.0035 0.0527 0.0393
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0527 1
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0269 0.0067
Loa Loa (eye worm) TAR-binding protein 0.02 0.5179 0.5079
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.6615 0.6544
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0203 0.3858
Plasmodium vivax importin-beta 2, putative 0.0035 0.0527 0.8822
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0269 0.471
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0527 0.0331
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0342 0.0168
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0269 0.0067
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0562 0.0366
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0562 1
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0269 1
Trichomonas vaginalis set domain proteins, putative 0.0286 0.7591 0.8969
Entamoeba histolytica Ran family GTPase 0.0026 0.0269 0.471
Schistosoma mansoni ran 0.0026 0.0269 0.0067
Echinococcus granulosus importin subunit beta 1 0.0035 0.0527 0.0331
Brugia malayi TAR-binding protein 0.02 0.5179 0.6041
Onchocerca volvulus 0.0286 0.7591 1
Plasmodium falciparum importin beta, putative 0.0035 0.0527 1
Schistosoma mansoni glutaminase 0.0316 0.844 0.8408
Leishmania major importin beta-1 subunit, putative 0.0028 0.0342 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0203 0.3858
Schistosoma mansoni tar DNA-binding protein 0.02 0.5179 0.5079
Loa Loa (eye worm) glutaminase 2 0.0316 0.844 0.8408
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0269 0.0079
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0269 0.471
Trichomonas vaginalis ran, putative 0.0026 0.0269 0.0079
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0562 0.0366
Loa Loa (eye worm) RNA binding protein 0.02 0.5179 0.5079
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0203 0.5
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0203 0.3858
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0562 0.0366
Schistosoma mansoni ran 0.0026 0.0269 0.0067

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0282 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 2.8184 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 16.5113 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 18.3564 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) [Related pubchem assays: 1379 ] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) = 100 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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