Detailed information for compound 1451306

Basic information

Technical information
  • TDR Targets ID: 1451306
  • Name: 2-bromo-5-(4-naphthalen-2-ylsulfonylpiperazin -1-yl)sulfonylbenzoic acid
  • MW: 539.419 | Formula: C21H19BrN2O6S2
  • H donors: 1 H acceptors: 6 LogP: 3.16 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC(=O)c1cc(ccc1Br)S(=O)(=O)N1CCN(CC1)S(=O)(=O)c1ccc2c(c1)cccc2
  • InChi: 1S/C21H19BrN2O6S2/c22-20-8-7-18(14-19(20)21(25)26)32(29,30)24-11-9-23(10-12-24)31(27,28)17-6-5-15-3-1-2-4-16(15)13-17/h1-8,13-14H,9-12H2,(H,25,26)
  • InChiKey: UECHUVBNGULLLF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-bromo-5-[4-(2-naphthylsulfonyl)piperazin-1-yl]sulfonyl-benzoic acid
  • 2-bromo-5-[[4-(2-naphthylsulfonyl)-1-piperazinyl]sulfonyl]benzoic acid
  • 2-bromo-5-(4-naphthalen-2-ylsulfonylpiperazin-1-yl)sulfonyl-benzoic acid
  • T5371846

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens polymerase (DNA directed) kappa Starlite/ChEMBL No references
Homo sapiens CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), eta Starlite/ChEMBL No references
Homo sapiens Rap guanine nucleotide exchange factor (GEF) 3 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus granulosus dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis dullard protein, putative Get druggable targets OG5_127075 All targets in OG5_127075
Plasmodium vivax NLI interacting factor-like phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Toxoplasma gondii Dullard family phosphatase domain-containing protein Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania braziliensis DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) Get druggable targets OG5_127393 All targets in OG5_127393
Plasmodium knowlesi NLI interacting factor-like phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium vivax NLI interacting factor-like phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Neospora caninum hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma brucei DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Cryptosporidium parvum hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium yoelii NLI interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania mexicana DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans Plasma membrane Sodium Response 1 Get druggable targets OG5_127075 All targets in OG5_127075
Brugia malayi ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania infantum hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma japonicum ko:K03511 DNA polymerase kappa subunit, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Giardia lamblia DINP protein human, muc B family Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum CTD small phosphatase-like protein, putative Get druggable targets OG5_127075 All targets in OG5_127075
Trichomonas vaginalis DNA polymerase eta, putative Get druggable targets OG5_127393 All targets in OG5_127393
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131726 All targets in OG5_131726
Leishmania donovani dullard-like phosphatase domain containing protein, putative Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania braziliensis hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma congolense hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Plasmodium knowlesi NLI interacting factor-like phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania braziliensis DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Toxoplasma gondii ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Mycobacterium ulcerans DNA polymerase IV Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus multilocularis Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei gambiense DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus granulosus CTD small phosphatase protein like Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania infantum DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania mexicana Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania mexicana hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania major DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma congolense TFIIF-stimulated CTD phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Candida albicans Plasma membrane Sodium Response 1 Get druggable targets OG5_127075 All targets in OG5_127075
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Plasmodium berghei NLI interacting factor-like phosphatase Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Theileria parva nuclear LIM interactor-interacting factor 1, putative Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma brucei Mitochondrial import inner membrane translocase subunit TIM50 Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania donovani DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei gambiense DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Brugia malayi polk-prov protein Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei gambiense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania mexicana DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma congolense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Mycobacterium tuberculosis Probable DNA polymerase IV DinX (pol IV 1) (DNA nucleotidyltransferase (DNA-directed)) Get druggable targets OG5_127393 All targets in OG5_127393
Trichomonas vaginalis dullard protein, putative Get druggable targets OG5_127075 All targets in OG5_127075
Echinococcus granulosus Carboxy terminal domain RNA polymerase II Get druggable targets OG5_127075 All targets in OG5_127075
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Plasmodium yoelii NLI interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania infantum DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei gambiense DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma japonicum ko:K01090 protein phosphatase [EC3.1.3.16], putative Get druggable targets OG5_127075 All targets in OG5_127075
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II Get druggable targets OG5_127075 All targets in OG5_127075
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Echinococcus multilocularis dna polymerase kappa Get druggable targets OG5_127393 All targets in OG5_127393
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog Get druggable targets OG5_131726 All targets in OG5_131726
Schistosoma mansoni DNA polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma mansoni hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Giardia lamblia Nuclear LIM interactor-interacting factor 1 Get druggable targets OG5_127075 All targets in OG5_127075
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 Get druggable targets OG5_127075 All targets in OG5_127075
Plasmodium berghei NLI interacting factor-like phosphatase Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Entamoeba histolytica NLI interacting factor-like phosphatase domain-containing protein Get druggable targets OG5_127075 All targets in OG5_127075
Neospora caninum Pc21g17280 protein, related Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania donovani DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Cryptosporidium parvum DinB/family X-type DNA polymerase Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania mexicana DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis DNA polymerase IV / kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Plasmodium falciparum NLI interacting factor-like phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma cruzi hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Echinococcus granulosus dna polymerase kappa Get druggable targets OG5_127393 All targets in OG5_127393
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trichomonas vaginalis dullard protein, putative Get druggable targets OG5_127075 All targets in OG5_127075
Echinococcus multilocularis dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Neospora caninum hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Babesia bovis Dullard-like phosphatase domain containing protein Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma brucei gambiense hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Mycobacterium ulcerans DNA polymerase IV Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma congolense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi N-terminal motif family protein Get druggable targets OG5_131726 All targets in OG5_131726
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei TFIIF-stimulated CTD phosphatase, putative CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 260 aa 263 aa 27.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major DNA polymerase eta, putative 0.0043 0.0207 0.5027
Toxoplasma gondii Dullard family phosphatase domain-containing protein 0.0015 0.0008 0.0344
Echinococcus granulosus dna polymerase kappa 0.0073 0.0412 0.0933
Trypanosoma cruzi DNA polymerase kappa, putative 0.0073 0.0412 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0041 0.0188 0.0182
Echinococcus multilocularis tar DNA binding protein 0.0636 0.434 1
Schistosoma mansoni tar DNA-binding protein 0.0636 0.434 0.6374
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.002 0.0044 0.2014
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0048 0.0238 0.053
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0027 0.0094 0.355
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0048 0.0238 1
Loa Loa (eye worm) hypothetical protein 0.1446 1 1
Loa Loa (eye worm) MH1 domain-containing protein 0.0041 0.0189 0.0183
Brugia malayi MH2 domain containing protein 0.0041 0.0189 0.0181
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0028 0.0101 0.0093
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0048 0.0238 0.5679
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0048 0.0238 0.9736
Schistosoma mansoni smad1 5 8 and 0.0041 0.0189 0.0268
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0075 0.1643
Mycobacterium ulcerans thioesterase TesA 0.0023 0.0063 0.0858
Schistosoma mansoni Smad4 0.0041 0.0189 0.0268
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0075 0.2893
Loa Loa (eye worm) transcription factor SMAD2 0.0601 0.4097 0.4093
Loa Loa (eye worm) RasGEF domain-containing protein 0.002 0.0044 0.0038
Brugia malayi DIX domain containing protein 0.0028 0.0101 0.0093
Loa Loa (eye worm) pigment dispersing factor receptor c 0.1446 1 1
Echinococcus multilocularis isocitrate dehydrogenase 0.0048 0.0238 0.053
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0216 0.5143
Brugia malayi N-terminal motif family protein 0.0575 0.3919 0.3914
Schistosoma mansoni tar DNA-binding protein 0.0636 0.434 0.6374
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0026 0.0082 0.301
Loa Loa (eye worm) hypothetical protein 0.0024 0.0075 0.0068
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0075 0.2893
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0026 0.0089 0.3298
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0029 0.0106 0.4062
Echinococcus multilocularis dna polymerase eta 0.0072 0.0403 0.0911
Echinococcus granulosus segment polarity protein dishevelled 0.0028 0.0101 0.0215
Brugia malayi hypothetical protein 0.0024 0.0075 0.0066
Brugia malayi RNA recognition motif domain containing protein 0.0636 0.434 0.4335
Brugia malayi RNA binding protein 0.0636 0.434 0.4335
Leishmania major hypothetical protein, conserved 0.0024 0.0075 0.1682
Echinococcus granulosus rap guanine nucleotide exchange factor 1 0.002 0.0044 0.0084
Loa Loa (eye worm) nuclear factor I 0.0023 0.0062 0.0055
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0041 0.0189 0.0418
Mycobacterium ulcerans Type I modular polyketide synthase 0.0027 0.0094 0.1689
Loa Loa (eye worm) DIX domain-containing protein 0.0028 0.0101 0.0094
Schistosoma mansoni smad 0.0041 0.0189 0.0268
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0041 0.0188 0.0267
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0043 0.0207 0.8693
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.002 0.0044 0.0034
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.0412 1
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0028 0.0101 0.0094
Echinococcus multilocularis mothers against decapentaplegic 6 0.0018 0.0031 0.0053
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0029 0.0106 0.4062
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0027 0.0094 0.355
Loa Loa (eye worm) MH1 domain-containing protein 0.0018 0.0031 0.0024
Trichomonas vaginalis guanine nucleotide exchange factor, putative 0.002 0.0044 0.0897
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0458 0.3098 0.7133
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0048 0.0238 0.5679
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0029 0.0106 0.481
Echinococcus multilocularis rap guanine nucleotide exchange factor 6 0.002 0.0044 0.0084
Mycobacterium leprae Probable polyketide synthase Pks1 0.0029 0.0106 0.481
Schistosoma mansoni dishevelled 0.0028 0.0101 0.0139
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.002 0.0044 0.2014
Trypanosoma cruzi DNA polymerase kappa, putative 0.0073 0.0412 1
Brugia malayi RasGEF domain containing protein 0.002 0.0044 0.0036
Brugia malayi N-terminal motif family protein 0.002 0.0044 0.0036
Toxoplasma gondii isocitrate dehydrogenase 0.0048 0.0238 1
Trypanosoma cruzi hypothetical protein 0.002 0.0044 0.0897
Echinococcus granulosus TGF beta signal transducer SmadC 0.0041 0.0189 0.0418
Onchocerca volvulus 0.0028 0.0101 0.018
Onchocerca volvulus 0.0026 0.0082 0.013
Brugia malayi latrophilin 2 splice variant baaae 0.0989 0.6805 0.6803
Schistosoma mansoni regulator of G protein signaling 0.0028 0.0101 0.0139
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0048 0.0238 0.5679
Loa Loa (eye worm) hypothetical protein 0.0023 0.0062 0.0055
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0075 0.1643
Schistosoma mansoni dishevelled 0.0028 0.0101 0.0139
Brugia malayi RasGEF domain containing protein 0.002 0.0044 0.0036
Echinococcus multilocularis segment polarity protein dishevelled 0.0028 0.0101 0.0215
Trypanosoma cruzi DNA polymerase kappa, putative 0.0073 0.0412 1
Schistosoma mansoni smad1 5 8 and 0.0041 0.0189 0.0268
Mycobacterium ulcerans polyketide synthase Pks13 0.0041 0.0189 0.4154
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0041 0.0189 0.762
Onchocerca volvulus 0.0048 0.0236 0.0526
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0023 0.0063 0.2064
Brugia malayi MH1 domain containing protein 0.0023 0.0062 0.0053
Trichomonas vaginalis ras GTP exchange factor, putative 0.002 0.0044 0.0897
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0458 0.3098 0.7133
Echinococcus granulosus Protein son of sevenless 0.002 0.0044 0.0084
Trypanosoma brucei DNA polymerase IV, putative 0.0073 0.0412 1
Brugia malayi hypothetical protein 0.0159 0.1012 0.1005
Echinococcus multilocularis smad 0.0041 0.0189 0.0418
Echinococcus granulosus dna polymerase eta 0.0072 0.0403 0.0911
Echinococcus granulosus Smad4 0.0041 0.0189 0.0418
Echinococcus multilocularis segment polarity protein dishevelled 0.0028 0.0101 0.0215
Schistosoma mansoni hypothetical protein 0.0458 0.3098 0.4547
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0041 0.0188 0.0416
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0028 0.0101 0.018
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0156 0.3645
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.002 0.0044 0.2014
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0027 0.0094 0.4065
Loa Loa (eye worm) Smad1 0.0041 0.0189 0.0183
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0049 0.0244 0.597
Echinococcus granulosus tar DNA binding protein 0.0636 0.434 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0224 0.0217
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0027 0.0094 0.355
Loa Loa (eye worm) hypothetical protein 0.0028 0.0101 0.0094
Loa Loa (eye worm) hypothetical protein 0.0072 0.0403 0.0396
Schistosoma mansoni ras GTP exchange factor 0.002 0.0044 0.0055
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.0412 1
Toxoplasma gondii type I fatty acid synthase, putative 0.0029 0.0106 0.4467
Trypanosoma cruzi DNA polymerase eta, putative 0.0072 0.0403 0.9767
Echinococcus multilocularis Smad4 0.0041 0.0189 0.0418
Schistosoma mansoni hypothetical protein 0.0458 0.3098 0.4547
Schistosoma mansoni tar DNA-binding protein 0.0636 0.434 0.6374
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0027 0.0094 0.1689
Mycobacterium ulcerans polyketide synthase 0.0029 0.0106 0.1998
Brugia malayi hypothetical protein 0.0016 0.0014 0.0006
Echinococcus granulosus smad 0.0041 0.0189 0.0418
Brugia malayi Latrophilin receptor protein 2 0.0458 0.3098 0.3092
Echinococcus granulosus segment polarity protein dishevelled 0.0028 0.0101 0.0215
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0021 0.0048 0.2
Mycobacterium ulcerans polyketide synthase 0.0027 0.0094 0.1689
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0029 0.0106 0.481
Schistosoma mansoni hypothetical protein 0.0989 0.6805 1
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0052 0.0265 0.0257
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0028 0.0101 0.0215
Loa Loa (eye worm) hypothetical protein 0.002 0.0044 0.0038
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.002 0.0044 0.0055
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.002 0.0044 0.2014
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.002 0.0044 0.0055
Brugia malayi MH2 domain containing protein 0.0041 0.0189 0.0181
Loa Loa (eye worm) fatty acid synthase 0.0027 0.0092 0.0085
Echinococcus multilocularis mothers against decapentaplegic 2 0.0018 0.0031 0.0053
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.0412 1
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0575 0.3919 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0216 0.5143
Entamoeba histolytica deoxycytidyl transferase, putative 0.0041 0.0188 1
Loa Loa (eye worm) hypothetical protein 0.0159 0.1012 0.1006
Loa Loa (eye worm) isocitrate dehydrogenase 0.0048 0.0238 0.0231
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.0412 1
Echinococcus granulosus mothers against decapentaplegic 5 0.0041 0.0189 0.0418
Brugia malayi MH2 domain containing protein 0.0601 0.4097 0.4092
Echinococcus multilocularis ras GTP exchange factor 0.002 0.0044 0.0084
Echinococcus granulosus mothers against decapentaplegic 6 0.0018 0.0031 0.0053
Echinococcus multilocularis mothers against decapentaplegic 5 0.0041 0.0189 0.0418
Loa Loa (eye worm) MH2 domain-containing protein 0.0041 0.0189 0.0183
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0027 0.0094 0.0086
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0026 0.0089 0.3298
Loa Loa (eye worm) hypothetical protein 0.0028 0.0101 0.0094
Toxoplasma gondii isocitrate dehydrogenase 0.0048 0.0238 1
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0022 0.006 0.2051
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0027 0.0094 0.4065
Toxoplasma gondii type I fatty acid synthase, putative 0.0019 0.0039 0.1656
Loa Loa (eye worm) hypothetical protein 0.0018 0.0031 0.0024
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0458 0.3098 0.3092
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.0412 1
Brugia malayi Smad1 0.0041 0.0189 0.0181
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0015 0.0008 0.0002
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0022 0.0057 0.0714
Loa Loa (eye worm) hypothetical protein 0.002 0.0044 0.0038
Brugia malayi Calcitonin receptor-like protein seb-1 0.1446 1 1
Schistosoma mansoni smad1 5 8 and 0.0041 0.0189 0.0268
Onchocerca volvulus 0.002 0.0044 0.0034
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.002 0.0044 0.2014
Loa Loa (eye worm) hypothetical protein 0.0028 0.0101 0.0094
Echinococcus multilocularis son of sevenless 1 0.002 0.0044 0.0084
Echinococcus granulosus Pleckstrin G protein interacting region 0.0028 0.0101 0.0215
Brugia malayi polk-prov protein 0.0045 0.0216 0.0208
Loa Loa (eye worm) MH2 domain-containing protein 0.0601 0.4097 0.4093
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0156 0.3645
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0048 0.0238 1
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.002 0.0044 0.0055
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.002 0.0044 0.2014
Trypanosoma cruzi DNA polymerase kappa, putative 0.0073 0.0412 1
Mycobacterium ulcerans Type I modular polyketide synthase 0.0027 0.0094 0.1689
Echinococcus granulosus mothers against decapentaplegic 2 0.0018 0.0031 0.0053
Echinococcus multilocularis GPCR, family 2 0.0458 0.3098 0.7133
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0026 0.0082 0.0075
Trypanosoma cruzi DNA polymerase eta, putative 0.0043 0.0207 0.491
Onchocerca volvulus 0.0159 0.1012 0.2524
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0029 0.0106 0.4062
Brugia malayi regulator of G-protein signaling egl-10 0.0028 0.0101 0.0093
Echinococcus multilocularis regulator of G protein signaling 7 0.0028 0.0101 0.0215
Trichomonas vaginalis DNA polymerase eta, putative 0.0073 0.0412 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0075 0.2893
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0022 0.0057 0.0714
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0001
Entamoeba histolytica hypothetical protein 0.002 0.0044 0.2014
Trichomonas vaginalis ras GTP exchange factor, son of sevenless, putative 0.002 0.0044 0.0897
Trypanosoma brucei DNA polymerase eta, putative 0.0072 0.0403 0.9767
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.0412 1
Schistosoma mansoni hypothetical protein 0.0458 0.3098 0.4547
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0048 0.0238 0.5815
Brugia malayi ImpB/MucB/SamB family protein 0.0072 0.0403 0.0395
Onchocerca volvulus Fatty acid synthase homolog 0.0049 0.0247 0.0556
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.002 0.0044 0.2014
Giardia lamblia DINP protein human, muc B family 0.0049 0.0244 1
Brugia malayi mothers against decapentaplegic homolog 3 0.0018 0.0031 0.0023
Mycobacterium ulcerans Type I modular polyketide synthase 0.0027 0.0094 0.1689
Leishmania major DNA polymerase kappa, putative 0.0049 0.0244 0.597
Echinococcus granulosus regulator of G protein signaling 7 0.0028 0.0101 0.0215
Brugia malayi TAR-binding protein 0.0636 0.434 0.4335
Brugia malayi MH1 domain containing protein 0.0041 0.0189 0.0181
Echinococcus multilocularis Protein son of sevenless 0.002 0.0044 0.0084
Echinococcus granulosus regulator of G protein signaling 7 0.0028 0.0101 0.0215
Schistosoma mansoni Smad4 0.0018 0.0031 0.0036
Loa Loa (eye worm) latrophilin receptor protein 2 0.0458 0.3098 0.3093
Schistosoma mansoni smad 0.0018 0.0031 0.0036
Echinococcus multilocularis dna polymerase kappa 0.0073 0.0412 0.0933
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0041 0.0188 0.0416
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0049 0.0244 1
Trypanosoma brucei unspecified product 0.0028 0.01 0.2269
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0015 0.0008 0.0002
Brugia malayi MH1 domain containing protein 0.0023 0.0062 0.0053
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0041 0.0189 0.762
Mycobacterium leprae Polyketide synthase Pks13 0.0041 0.0189 1
Loa Loa (eye worm) TAR-binding protein 0.0636 0.434 0.4336
Trypanosoma brucei DNA polymerase IV, putative 0.0073 0.0412 1
Echinococcus multilocularis rap guanine nucleotide exchange factor 1 0.002 0.0044 0.0084
Echinococcus granulosus son of sevenless 1 0.002 0.0044 0.0084
Brugia malayi RasGEF domain containing protein 0.002 0.0044 0.0036
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.0004
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0082 0.0074
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0458 0.3098 0.7133
Mycobacterium tuberculosis Conserved hypothetical protein 0.0041 0.0188 0.7601
Brugia malayi ImpB/MucB/SamB family protein 0.0041 0.0188 0.018
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0048 0.0238 0.5679
Mycobacterium ulcerans DNA polymerase IV 0.0073 0.0412 1
Schistosoma mansoni Smad4 0.0018 0.0031 0.0036
Echinococcus multilocularis regulator of G protein signaling 7 0.0028 0.0101 0.0215
Echinococcus granulosus ras GTP exchange factor 0.002 0.0044 0.0084
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.002 0.0044 0.2014
Brugia malayi MH2 domain containing protein 0.0018 0.0031 0.0023
Brugia malayi N-terminal motif family protein 0.002 0.0044 0.0036
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0075 0.1643
Echinococcus granulosus rap guanine nucleotide exchange factor 6 0.002 0.0044 0.0084
Brugia malayi MH1 domain containing protein 0.0041 0.0189 0.0181
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.002 0.0044 0.2014
Loa Loa (eye worm) hypothetical protein 0.0989 0.6805 0.6803
Leishmania major DNA polymerase eta, putative 0.0072 0.0403 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0216 0.0209
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0048 0.0238 0.053
Schistosoma mansoni tar DNA-binding protein 0.0636 0.434 0.6374
Trypanosoma cruzi guanine nucleotide releasing protein, putative 0.002 0.0044 0.0897
Schistosoma mansoni hypothetical protein 0.0458 0.3098 0.4547
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0075 0.3138
Loa Loa (eye worm) RNA binding protein 0.0636 0.434 0.4336
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0458 0.3098 0.7133
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0019 0.0038 0.0045
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0048 0.0238 0.034
Schistosoma mansoni dep domain containing protein 0.0028 0.0101 0.0139
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.002 0.0044 0.0055
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.0412 1
Brugia malayi hypothetical protein 0.0028 0.0101 0.0093
Trichomonas vaginalis ras GTP exchange factor, putative 0.002 0.0044 0.0897
Trypanosoma cruzi hypothetical protein 0.002 0.0044 0.0897
Mycobacterium ulcerans DNA polymerase IV 0.0073 0.0412 1
Loa Loa (eye worm) RasGEF domain-containing protein 0.002 0.0044 0.0038
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.002 0.0041 0.1233
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0022 0.0057 0.172
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0073 0.0412 1
Brugia malayi Isocitrate dehydrogenase 0.0048 0.0238 0.023
Trypanosoma brucei unspecified product 0.0028 0.01 0.2269
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0018 0.0027 0.115
Trypanosoma brucei DNA polymerase IV, putative 0.0065 0.0357 0.8624
Echinococcus granulosus GPCR family 2 0.0458 0.3098 0.7133
Schistosoma mansoni z-protein (S1r protein) 0.0028 0.0101 0.0139
Loa Loa (eye worm) hypothetical protein 0.0575 0.3919 0.3914
Trypanosoma brucei unspecified product 0.0065 0.0357 0.8624
Toxoplasma gondii hypothetical protein 0.0028 0.0101 0.4256
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0028 0.0101 0.0139
Schistosoma mansoni tar DNA-binding protein 0.0636 0.434 0.6374
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0029 0.0106 0.1998
Trypanosoma brucei DNA polymerase kappa, putative 0.0049 0.0244 0.5831
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0636 0.434 0.4336
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.002 0.0044 0.2014
Mycobacterium tuberculosis Probable thioesterase TesA 0.0023 0.0063 0.2179
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0041 0.0189 0.0268
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.002 0.0044 0.2014
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.0412 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0156 0.3645
Brugia malayi hypothetical protein 0.0028 0.0101 0.0093
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0048 0.0238 0.053
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.0412 1
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.002 0.0044 0.2014
Brugia malayi isocitrate dehydrogenase 0.0048 0.0238 0.023
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0028 0.0101 0.0093
Loa Loa (eye worm) RasGEF domain-containing protein 0.002 0.0044 0.0038
Loa Loa (eye worm) MH2 domain-containing protein 0.0018 0.0031 0.0024
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0048 0.0238 0.053
Loa Loa (eye worm) hypothetical protein 0.0458 0.3098 0.3093
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.002 0.0044 0.2014
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0029 0.0106 0.1998
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0048 0.0238 0.053
Schistosoma mansoni DNA polymerase eta 0.0072 0.0403 0.0583
Mycobacterium ulcerans thioesterase 0.0023 0.0063 0.0858
Schistosoma mansoni terminal deoxycytidyl transferase 0.0041 0.0188 0.0267

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 6.218 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS hits for Scp-1 phosphatase using a colorimetric assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493091, AID493120] ChEMBL. No reference
Potency (functional) 3.5481 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.8336 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Kappa: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 20.5878 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (binding) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) 47.7548 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Eta: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 67.0158 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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