Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | survival of motor neuron 2, centromeric | Starlite/ChEMBL | No references |
Human immunodeficiency virus 1 | Aberrant vpr protein | Starlite/ChEMBL | No references |
Escherichia coli | penicillin-binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | survival motor neuron protein 1 | Get druggable targets OG5_132873 | All targets in OG5_132873 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132873 | All targets in OG5_132873 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | Get druggable targets OG5_149948 | All targets in OG5_149948 |
Echinococcus multilocularis | survival motor neuron protein 1 | Get druggable targets OG5_132873 | All targets in OG5_132873 |
Brugia malayi | hypothetical protein | Get druggable targets OG5_132873 | All targets in OG5_132873 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0 | 0.5 |
Mycobacterium leprae | conserved hypothetical protein | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | survival motor neuron protein | 0.0058 | 0.061 | 0.0623 |
Plasmodium vivax | hypothetical protein, conserved | 0.0043 | 0 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0256 | 0.877 | 0.877 |
Schistosoma mansoni | tar DNA-binding protein | 0.0256 | 0.877 | 0.8957 |
Schistosoma mansoni | hypothetical protein | 0.0058 | 0.061 | 0.0623 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0256 | 0.877 | 0.877 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0256 | 0.877 | 0.877 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0043 | 0 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0256 | 0.877 | 0.877 |
Loa Loa (eye worm) | RNA binding protein | 0.0256 | 0.877 | 0.877 |
Brugia malayi | RNA binding protein | 0.0256 | 0.877 | 0.877 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0058 | 0.061 | 0.061 |
Schistosoma mansoni | tar DNA-binding protein | 0.0256 | 0.877 | 0.8957 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0286 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0256 | 0.877 | 0.877 |
Schistosoma mansoni | tar DNA-binding protein | 0.0256 | 0.877 | 0.8957 |
Onchocerca volvulus | 0.0058 | 0.061 | 1 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0256 | 0.877 | 0.8957 |
Mycobacterium leprae | Probable lipase LipE | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0256 | 0.877 | 0.8957 |
Toxoplasma gondii | ABC1 family protein | 0.0043 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0278 | 0.9679 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0286 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0043 | 0 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0256 | 0.877 | 0.877 |
Loa Loa (eye worm) | glutaminase | 0.028 | 0.979 | 0.979 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0286 | 1 | 1 |
Loa Loa (eye worm) | glutaminase 2 | 0.028 | 0.979 | 0.979 |
Brugia malayi | glutaminase DH11.1 | 0.028 | 0.979 | 0.979 |
Mycobacterium ulcerans | glutaminase | 0.028 | 0.979 | 1 |
Trichomonas vaginalis | glutaminase, putative | 0.028 | 0.979 | 1 |
Schistosoma mansoni | glutaminase | 0.028 | 0.979 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 3.1623 um | PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 3.2944 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 8.9125 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.