Detailed information for compound 1451458

Basic information

Technical information
  • TDR Targets ID: 1451458
  • Name: N-(2-chlorophenyl)-2-methylquinoline-3-carbox amide
  • MW: 296.751 | Formula: C17H13ClN2O
  • H donors: 1 H acceptors: 2 LogP: 4.05 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1cc2ccccc2nc1C)Nc1ccccc1Cl
  • InChi: 1S/C17H13ClN2O/c1-11-13(10-12-6-2-4-8-15(12)19-11)17(21)20-16-9-5-3-7-14(16)18/h2-10H,1H3,(H,20,21)
  • InChiKey: LHLOMIJABKAKQQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(2-chlorophenyl)-2-methyl-quinoline-3-carboxamide
  • N-(2-chlorophenyl)-2-methyl-3-quinolinecarboxamide
  • 6432-52-6
  • T5259749
  • MLS001010828
  • SMR000352967
  • ZINC00353066
  • AF-399/42255561

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0193 0.1341 0.2394
Loa Loa (eye worm) hypothetical protein 0.0031 0.0063 0.0063
Onchocerca volvulus 0.0135 0.0882 1
Echinococcus multilocularis isocitrate dehydrogenase 0.0079 0.0443 0.0791
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0079 0.0443 0.0791
Brugia malayi Pax transcription activation domain interacting protein 0.0031 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0031 0.0063 0.0063
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0954 0.0954
Brugia malayi hypothetical protein 0.0031 0.0063 0.0063
Brugia malayi hypothetical protein 0.0034 0.0089 0.0089
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0031 0.0063 1
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0079 0.0443 0.5026
Echinococcus multilocularis carnitine O palmitoyltransferase 1, liver 0.0736 0.5601 1
Brugia malayi DKFZp564C0469 protein 0.0031 0.0063 0.0063
Schistosoma mansoni tar DNA-binding protein 0.0389 0.2882 0.9284
Trypanosoma cruzi hypothetical protein, conserved 0.0135 0.0882 0.1574
Brugia malayi hypothetical protein 0.0053 0.0236 0.0236
Schistosoma mansoni hypothetical protein 0.0193 0.1341 0.432
Trypanosoma cruzi FHA domain containing protein, putative 0.0031 0.0063 0.0112
Trypanosoma cruzi hypothetical protein, conserved 0.0135 0.0882 0.1574
Echinococcus granulosus GPCR family 2 0.0193 0.1341 0.2394
Loa Loa (eye worm) choline O-acetyltransferase 0.0135 0.0882 0.0882
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0193 0.1341 0.2394
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0079 0.0443 0.1428
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0611 0.4623 0.4623
Schistosoma mansoni topbp1 0.0031 0.0063 0.0203
Loa Loa (eye worm) hypothetical protein 0.0031 0.0063 0.0063
Brugia malayi TAR-binding protein 0.0389 0.2882 0.2882
Schistosoma mansoni hypothetical protein 0.0193 0.1341 0.432
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0031 0.0063 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0236 0.0236
Echinococcus granulosus tar DNA binding protein 0.0389 0.2882 0.5144
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0079 0.0443 0.0791
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0031 0.0063 0.0063
Loa Loa (eye worm) carnitine O-palmitoyltransferase I isoform 0.0135 0.0882 0.0882
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.0135 0.0882 0.1574
Schistosoma mansoni choline o-acyltransferase 0.0135 0.0882 0.284
Trypanosoma cruzi carnitine O-palmitoyltransferase II, putative 0.0135 0.0882 0.1574
Onchocerca volvulus 0.0135 0.0882 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0236 0.0422
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0031 0.0063 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0193 0.1341 0.1341
Schistosoma mansoni hypothetical protein 0.0418 0.3104 1
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0031 0.0063 1
Trichomonas vaginalis replication factor C large subunit, putative 0.0031 0.0063 1
Trypanosoma brucei carnitine O-palmitoyltransferase II, putative 0.0135 0.0882 1
Onchocerca volvulus 0.0135 0.0882 1
Loa Loa (eye worm) hypothetical protein 0.0193 0.1341 0.1341
Leishmania major carnitine palmitoyltransferase-like protein 0.0135 0.0882 0.1574
Leishmania major carnitine/choline acetyltransferase, putative 0.0135 0.0882 0.1574
Echinococcus multilocularis GPCR, family 2 0.0193 0.1341 0.2394
Brugia malayi RNA binding protein 0.0389 0.2882 0.2882
Schistosoma mansoni chromosome transmission fidelity factor 0.0031 0.0063 0.0203
Leishmania major choline/Carnitine o-acyltransferase-like protein 0.0736 0.5601 1
Trypanosoma cruzi hypothetical protein, conserved 0.0135 0.0882 0.1574
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.0135 0.0882 0.0882
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0008 0.0013
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0611 0.4623 0.4623
Brugia malayi hypothetical protein 0.0031 0.0063 0.0063
Giardia lamblia Replication factor C, subunit 1 0.0031 0.0063 1
Loa Loa (eye worm) TAR-binding protein 0.0389 0.2882 0.2882
Plasmodium falciparum replication factor C subunit 1, putative 0.0031 0.0063 0.1419
Echinococcus multilocularis choline O acetyltransferase 0.0135 0.0882 0.1574
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0031 0.0063 1
Echinococcus granulosus nibrin 0.0031 0.0063 0.0112
Leishmania major hypothetical protein, conserved 0.0053 0.0236 0.0422
Echinococcus multilocularis tar DNA binding protein 0.0389 0.2882 0.5144
Echinococcus granulosus choline O acetyltransferase 0.0135 0.0882 0.1574
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0079 0.0443 0.5026
Trypanosoma brucei carnitine O-palmitoyltransferase, putative 0.0135 0.0882 1
Echinococcus multilocularis carnitine O palmitoyltransferase 2 0.0135 0.0882 0.1574
Brugia malayi MH2 domain containing protein 0.0144 0.0954 0.0954
Loa Loa (eye worm) isocitrate dehydrogenase 0.0079 0.0443 0.0443
Loa Loa (eye worm) hypothetical protein 0.0031 0.0063 0.0063
Brugia malayi topoisomerase 0.0031 0.0063 0.0063
Toxoplasma gondii isocitrate dehydrogenase 0.0079 0.0443 1
Toxoplasma gondii LsmAD domain-containing protein 0.0053 0.0236 0.5331
Schistosoma mansoni hypothetical protein 0.0193 0.1341 0.432
Echinococcus granulosus replication factor c subunit 1 0.0031 0.0063 0.0112
Trypanosoma cruzi choline/carnitine O-acetyltransferase, putative 0.0135 0.0882 0.1574
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0063 1
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0079 0.0443 1
Trypanosoma cruzi carnitine/choline acetyltransferase, putative 0.0135 0.0882 0.1574
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0063 1
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0031 0.0063 0.0112
Schistosoma mansoni tar DNA-binding protein 0.0389 0.2882 0.9284
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0236 0.0422
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0389 0.2882 0.2882
Brugia malayi Calcitonin receptor-like protein seb-1 0.0611 0.4623 0.4623
Brugia malayi Isocitrate dehydrogenase 0.0079 0.0443 0.0443
Loa Loa (eye worm) latrophilin receptor protein 2 0.0193 0.1341 0.1341
Trypanosoma brucei carnitine O-palmitoyltransferase II, putative 0.0135 0.0882 1
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0079 0.0443 0.0791
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.0063 0.0112
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.0031 0.0063 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.0063 0.0112
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0079 0.0443 0.0791
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0031 0.0063 1
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.0736 0.5601 1
Echinococcus granulosus carnitine O palmitoyltransferase 2 0.0135 0.0882 0.1574
Echinococcus multilocularis nibrin 0.0031 0.0063 0.0112
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0079 0.0443 0.0791
Loa Loa (eye worm) hypothetical protein 0.1295 1 1
Chlamydia trachomatis DNA ligase 0.0031 0.0063 0.5
Plasmodium vivax ataxin-2 like protein, putative 0.0053 0.0236 0.5331
Schistosoma mansoni tar DNA-binding protein 0.0389 0.2882 0.9284
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0031 0.0063 0.1419
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0079 0.0443 0.0791
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.0736 0.5601 1
Trypanosoma brucei hypothetical protein, conserved 0.0135 0.0882 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0079 0.0443 0.0791
Trypanosoma brucei PAB1-binding protein , putative 0.0053 0.0236 0.2679
Schistosoma mansoni tar DNA-binding protein 0.0389 0.2882 0.9284
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0079 0.0443 1
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0063 1
Brugia malayi latrophilin 2 splice variant baaae 0.0418 0.3104 0.3104
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0236 0.5331
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0954 0.0954
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0031 0.0063 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0193 0.1341 0.2394
Loa Loa (eye worm) RNA binding protein 0.0389 0.2882 0.2882
Loa Loa (eye worm) hypothetical protein 0.0135 0.0882 0.0882
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0063 1
Loa Loa (eye worm) hypothetical protein 0.0611 0.4623 0.4623
Trypanosoma cruzi hypothetical protein, conserved 0.0135 0.0882 0.1574
Brugia malayi RNA recognition motif domain containing protein 0.0389 0.2882 0.2882
Schistosoma mansoni hypothetical protein 0.0193 0.1341 0.432
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0079 0.0443 0.0791
Trypanosoma cruzi hypothetical protein, conserved 0.0135 0.0882 0.1574
Plasmodium vivax replication factor C subunit 1, putative 0.0031 0.0063 0.1419
Trypanosoma cruzi carnitine O-acetyltransferase, putative 0.0135 0.0882 0.1574
Onchocerca volvulus 0.0135 0.0882 1
Schistosoma mansoni DNA ligase IV 0.0031 0.0063 0.0203
Schistosoma mansoni hypothetical protein 0.0024 0.0008 0.0024
Brugia malayi Choline O-acetyltransferase 0.0135 0.0882 0.0882
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0236 0.5331
Toxoplasma gondii isocitrate dehydrogenase 0.0079 0.0443 1
Echinococcus multilocularis replication factor c subunit 1 0.0031 0.0063 0.0112
Trypanosoma brucei carnitine O-acetyltransferase, putative 0.0135 0.0882 1
Brugia malayi Choline O-acetyltransferase 0.0135 0.0882 0.0882
Schistosoma mansoni tar DNA-binding protein 0.0389 0.2882 0.9284
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0008 0.0013
Entamoeba histolytica hypothetical protein 0.0031 0.0063 1
Schistosoma mansoni topbp1 0.0031 0.0063 0.0203
Treponema pallidum DNA ligase (lig) 0.0031 0.0063 1
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0079 0.0443 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0193 0.1341 0.2394
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0063 1
Brugia malayi Latrophilin receptor protein 2 0.0193 0.1341 0.1341
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.0135 0.0882 0.0882
Toxoplasma gondii ATPase, AAA family protein 0.0031 0.0063 0.1419
Trypanosoma cruzi carnitine/choline acetyltransferase, putative 0.0135 0.0882 0.1574
Loa Loa (eye worm) hypothetical protein 0.0418 0.3104 0.3104
Schistosoma mansoni choline o-acyltransferase 0.0135 0.0882 0.284
Brugia malayi isocitrate dehydrogenase 0.0079 0.0443 0.0443
Loa Loa (eye worm) hypothetical protein 0.0031 0.0063 0.0063
Loa Loa (eye worm) choline/Carnitine O-acyltransferase 0.0135 0.0882 0.0882
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0031 0.0063 0.0713
Echinococcus granulosus carnitine O palmitoyltransferase 1 liver 0.0736 0.5601 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0063 0.0063

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.4467 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.9811 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.7157 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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