Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0408 | 0.1574 | 0.1573 |
Onchocerca volvulus | 0.0034 | 0.0005 | 0.0021 | |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0408 | 0.1574 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.2417 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0073 | 0.0167 | 0.0165 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.024 | 0.0867 | 0.0865 |
Loa Loa (eye worm) | carboxylesterase | 0.2417 | 1 | 1 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0041 | 0.0032 | 0.003 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0337 | 0.1274 | 0.4711 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0034 | 0.0005 | 0.0005 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0337 | 0.1274 | 1 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0408 | 0.1574 | 0.1573 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0408 | 0.1574 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0337 | 0.1274 | 0.4711 |
Loa Loa (eye worm) | hypothetical protein | 0.2417 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.0167 | 0.0165 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0408 | 0.1574 | 0.1574 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0408 | 0.1574 | 0.1573 |
Brugia malayi | Pre-SET motif family protein | 0.024 | 0.0867 | 0.0865 |
Brugia malayi | TAR-binding protein | 0.0073 | 0.0167 | 0.0165 |
Loa Loa (eye worm) | carboxylesterase | 0.0408 | 0.1574 | 0.1573 |
Echinococcus granulosus | tar DNA binding protein | 0.0073 | 0.0167 | 0.0167 |
Loa Loa (eye worm) | hypothetical protein | 0.0408 | 0.1574 | 0.1573 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0337 | 0.1274 | 0.4711 |
Schistosoma mansoni | gliotactin | 0.0408 | 0.1574 | 0.1573 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0034 | 0.0005 | 0.0003 |
Brugia malayi | Carboxylesterase family protein | 0.0408 | 0.1574 | 0.1573 |
Echinococcus granulosus | carboxylesterase 5A | 0.2417 | 1 | 1 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.0034 | 0.0002 | 0.0002 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0408 | 0.1574 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0073 | 0.0167 | 0.0165 |
Echinococcus multilocularis | carboxylesterase 5A | 0.2417 | 1 | 1 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0408 | 0.1574 | 0.1573 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0164 | 0.0551 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 0.0591 | 0.059 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0041 | 0.0032 | 0.003 |
Loa Loa (eye worm) | hypothetical protein | 0.0408 | 0.1574 | 0.1573 |
Loa Loa (eye worm) | RNA binding protein | 0.0073 | 0.0167 | 0.0165 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0337 | 0.1274 | 0.4711 |
Loa Loa (eye worm) | hypothetical protein | 0.0408 | 0.1574 | 0.1573 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0337 | 0.1274 | 0.4711 |
Echinococcus multilocularis | neuroligin | 0.0408 | 0.1574 | 0.1573 |
Echinococcus multilocularis | tar DNA binding protein | 0.0073 | 0.0167 | 0.0165 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0408 | 0.1574 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0408 | 0.1574 | 0.1573 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0069 | 0.0152 | 0.015 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0337 | 0.1274 | 0.4711 |
Onchocerca volvulus | 0.0408 | 0.1574 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0408 | 0.1574 | 0.1573 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0408 | 0.1574 | 0.1573 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0337 | 0.1274 | 0.5 |
Onchocerca volvulus | 0.0408 | 0.1574 | 1 | |
Schistosoma mansoni | acetylcholinesterase | 0.0408 | 0.1574 | 0.1573 |
Onchocerca volvulus | 0.0408 | 0.1574 | 1 | |
Schistosoma mansoni | jumonji domain containing protein | 0.0087 | 0.0228 | 0.0226 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0408 | 0.1574 | 0.1573 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0047 | 0.0057 | 0.0055 |
Brugia malayi | Carboxylesterase family protein | 0.0408 | 0.1574 | 0.1573 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0408 | 0.1574 | 0.1573 |
Echinococcus granulosus | neuroligin | 0.0408 | 0.1574 | 0.1574 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0034 | 0.0005 | 0.0003 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0408 | 0.1574 | 0.1574 |
Brugia malayi | Carboxylesterase family protein | 0.0408 | 0.1574 | 0.1573 |
Brugia malayi | jmjC domain containing protein | 0.0041 | 0.0032 | 0.003 |
Brugia malayi | jmjC domain containing protein | 0.011 | 0.0323 | 0.0321 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0034 | 0.0005 | 0.0003 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0337 | 0.1274 | 0.4711 |
Echinococcus granulosus | acetylcholinesterase | 0.2417 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.2417 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.2417 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.2417 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.2417 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0073 | 0.0167 | 0.0165 |
Brugia malayi | Pre-SET motif family protein | 0.0034 | 0.0005 | 0.0003 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0034 | 0.0005 | 0.0003 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0103 | 0.0101 |
Brugia malayi | hypothetical protein | 0.0408 | 0.1574 | 0.1573 |
Echinococcus granulosus | jumonji domain containing protein | 0.0047 | 0.0057 | 0.0057 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.2417 | 1 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0408 | 0.1574 | 1 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0337 | 0.1274 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0337 | 0.1274 | 0.4711 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0034 | 0.0005 | 0.0003 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.011 | 0.0323 | 0.0321 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.0167 | 0.0165 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.0167 | 0.0165 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0041 | 0.0032 | 0.003 |
Brugia malayi | hypothetical protein | 0.0174 | 0.0591 | 0.059 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0034 | 0.0005 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0408 | 0.1574 | 0.1573 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0337 | 0.1274 | 0.5 |
Onchocerca volvulus | 0.0273 | 0.1006 | 0.6385 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0408 | 0.1574 | 0.1573 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0408 | 0.1574 | 0.1574 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0408 | 0.1574 | 1 |
Onchocerca volvulus | 0.0408 | 0.1574 | 1 | |
Loa Loa (eye worm) | carboxylesterase | 0.0408 | 0.1574 | 0.1573 |
Onchocerca volvulus | 0.0408 | 0.1574 | 1 | |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.011 | 0.0323 | 0.0323 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.0167 | 0.0165 |
Loa Loa (eye worm) | hypothetical protein | 0.2417 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0408 | 0.1574 | 0.1573 |
Loa Loa (eye worm) | hypothetical protein | 0.0408 | 0.1574 | 0.1573 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0005 | 0.0003 |
Onchocerca volvulus | 0.0174 | 0.0591 | 0.3749 | |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0034 | 0.0005 | 0.0003 |
Plasmodium vivax | SET domain protein, putative | 0.0034 | 0.0005 | 1 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0041 | 0.0032 | 0.0032 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.0167 | 0.0165 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0041 | 0.0032 | 0.003 |
Plasmodium falciparum | phd finger protein, putative | 0.0034 | 0.0002 | 0.5 |
Brugia malayi | RNA binding protein | 0.0073 | 0.0167 | 0.0165 |
Echinococcus granulosus | peregrin | 0.0034 | 0.0002 | 0.0002 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Latency (functional) | = 7.5 | Latency time measured by mouse hot plate test after subcutaneous administration at 200 mg/kg | ChEMBL. | 8410971 |
Latency (functional) | = 7.5 | Latency time measured by mouse hot plate test after subcutaneous administration at 200 mg/kg | ChEMBL. | 8410971 |
Response (functional) | = 0 | Ratio of the number of responders to the number of animals tested; 0/8 | ChEMBL. | 8410971 |
Response (functional) | = 0 | Ratio of the number of responders to the number of animals tested; 0/8 | ChEMBL. | 8410971 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.