Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Equus caballus | Ferritin light chain | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | apoferritin-2 | Ferritin light chain | 175 aa | 142 aa | 29.6 % |
Schistosoma mansoni | ferritin | Ferritin light chain | 175 aa | 171 aa | 43.9 % |
Schistosoma mansoni | ferritin | Ferritin light chain | 175 aa | 171 aa | 44.4 % |
Schistosoma mansoni | apoferritin-2 | Ferritin light chain | 175 aa | 146 aa | 28.8 % |
Schistosoma japonicum | Ferritin, putative | Ferritin light chain | 175 aa | 144 aa | 24.3 % |
Echinococcus granulosus | expressed protein | Ferritin light chain | 175 aa | 146 aa | 28.8 % |
Echinococcus multilocularis | expressed protein | Ferritin light chain | 175 aa | 146 aa | 30.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.1505 | 0.3998 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0007 | 0.0074 | 0.0074 |
Echinococcus multilocularis | tar DNA binding protein | 0.0135 | 0.3148 | 0.3097 |
Schistosoma mansoni | tar DNA-binding protein | 0.0135 | 0.3148 | 0.3148 |
Schistosoma mansoni | apoferritin-2 | 0.001 | 0.0144 | 0.0144 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0642 | 0.0642 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.0608 | 0.0608 |
Echinococcus multilocularis | cpg binding protein | 0.0031 | 0.0648 | 0.0578 |
Echinococcus granulosus | geminin | 0.0174 | 0.4083 | 0.4039 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0031 | 0.0642 | 0.1518 |
Schistosoma mansoni | ferritin light chain | 0.001 | 0.0144 | 0.0144 |
Schistosoma mansoni | hypothetical protein | 0.042 | 1 | 1 |
Schistosoma mansoni | ferritin | 0.001 | 0.0144 | 0.0144 |
Schistosoma mansoni | tar DNA-binding protein | 0.0135 | 0.3148 | 0.3148 |
Brugia malayi | Muscleblind-like protein | 0.0154 | 0.3587 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0098 | 0.2249 | 0.6145 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.3587 | 1 |
Mycobacterium ulcerans | bacterioferritin BfrB | 0.001 | 0.0144 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0135 | 0.3148 | 0.8734 |
Schistosoma mansoni | tar DNA-binding protein | 0.0135 | 0.3148 | 0.3148 |
Brugia malayi | CXXC zinc finger family protein | 0.003 | 0.0608 | 0.1419 |
Brugia malayi | RNA binding protein | 0.0135 | 0.3148 | 0.8735 |
Echinococcus multilocularis | geminin | 0.0174 | 0.4083 | 0.4039 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0154 | 0.3587 | 0.3539 |
Schistosoma mansoni | ferritin | 0.001 | 0.0144 | 0.0144 |
Echinococcus granulosus | ferritin | 0.001 | 0.0144 | 0.007 |
Treponema pallidum | bacterioferrin (TpF1) | 0.001 | 0.0144 | 0.5 |
Onchocerca volvulus | 0.003 | 0.0608 | 0.5 | |
Echinococcus granulosus | expressed protein | 0.001 | 0.0144 | 0.007 |
Schistosoma mansoni | ferritin light chain | 0.001 | 0.0144 | 0.0144 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0642 | 0.0642 |
Loa Loa (eye worm) | RNA binding protein | 0.0135 | 0.3148 | 0.8734 |
Schistosoma mansoni | tar DNA-binding protein | 0.0135 | 0.3148 | 0.3148 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.0642 | 0.0572 |
Loa Loa (eye worm) | TAR-binding protein | 0.0135 | 0.3148 | 0.8734 |
Schistosoma mansoni | cpg binding protein | 0.0031 | 0.0648 | 0.0648 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0098 | 0.2249 | 0.6145 |
Echinococcus multilocularis | expressed protein | 0.001 | 0.0144 | 0.007 |
Mycobacterium tuberculosis | Probable bacterioferritin BfrA | 0.001 | 0.0144 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0642 | 0.1511 |
Schistosoma mansoni | tar DNA-binding protein | 0.0135 | 0.3148 | 0.3148 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.2249 | 0.6142 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.3587 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.0642 | 0.0572 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0063 | 0.1403 | 0.1403 |
Brugia malayi | TAR-binding protein | 0.0135 | 0.3148 | 0.8735 |
Schistosoma mansoni | hypothetical protein | 0.0174 | 0.4083 | 0.4083 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.0642 | 0.0572 |
Schistosoma mansoni | ferritin | 0.001 | 0.0144 | 0.0144 |
Schistosoma mansoni | ferritin | 0.001 | 0.0144 | 0.0144 |
Wolbachia endosymbiont of Brugia malayi | bacterioferritin/cytochrome b1 | 0.001 | 0.0144 | 0.5 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0031 | 0.0642 | 0.1511 |
Schistosoma mansoni | hypothetical protein | 0.0067 | 0.1505 | 0.1505 |
Echinococcus multilocularis | muscleblind protein | 0.0154 | 0.3587 | 0.3539 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0056 | 0.1242 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0642 | 0.0642 |
Schistosoma mansoni | hypothetical protein | 0.0174 | 0.4083 | 0.4083 |
Echinococcus granulosus | muscleblind protein | 0.0154 | 0.3587 | 0.3539 |
Mycobacterium tuberculosis | Bacterioferritin BfrB | 0.001 | 0.0144 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0098 | 0.2249 | 0.6142 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.0642 | 0.0572 |
Schistosoma mansoni | cpg binding protein | 0.0031 | 0.0648 | 0.0648 |
Mycobacterium ulcerans | bacterioferritin BfrA | 0.001 | 0.0144 | 0.5 |
Schistosoma mansoni | apoferritin-2 | 0.001 | 0.0144 | 0.0144 |
Echinococcus multilocularis | ferritin | 0.001 | 0.0144 | 0.007 |
Trichomonas vaginalis | ferritin, putative | 0.001 | 0.0144 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0031 | 0.0642 | 0.0572 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.003 | 0.0608 | 0.1412 |
Echinococcus granulosus | tar DNA binding protein | 0.0135 | 0.3148 | 0.3097 |
Echinococcus multilocularis | dnaJ subfamily B | 0.042 | 1 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0031 | 0.0642 | 0.0572 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0118 | 0.0044 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0031 | 0.0642 | 0.1518 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0642 | 0.0642 |
Mycobacterium leprae | PROBABLE BACTERIOFERRITIN BFRA | 0.001 | 0.0144 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0135 | 0.3148 | 0.8735 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0118 | 0.0044 |
Echinococcus granulosus | cpg binding protein | 0.0031 | 0.0648 | 0.0578 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0067 | 0.1505 | 0.4003 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.5012 um | PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 0.7943 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (binding) | = 1.7783 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (functional) | 9.285 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | ||
Homo sapiens | ChEMBL23 | ||
Saccharomyces cerevisiae | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.